GB1283442A - Triamcinolone acetonide esters and preparation thereof - Google Patents
Triamcinolone acetonide esters and preparation thereofInfo
- Publication number
- GB1283442A GB1283442A GB5172870A GB5172870A GB1283442A GB 1283442 A GB1283442 A GB 1283442A GB 5172870 A GB5172870 A GB 5172870A GB 5172870 A GB5172870 A GB 5172870A GB 1283442 A GB1283442 A GB 1283442A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- triamcinolone acetonide
- compounds
- oct
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003862 glucocorticoid Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003096 thymolvtic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 229960002117 triamcinolone acetonide Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT6078469 | 1969-10-31 | ||
| IT2572170A IT1045260B (it) | 1970-06-09 | 1970-06-09 | Estere del triamcinolone acetonide per l impiego antiflogistico topico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1283442A true GB1283442A (en) | 1972-07-26 |
Family
ID=26328615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5172870A Expired GB1283442A (en) | 1969-10-31 | 1970-10-30 | Triamcinolone acetonide esters and preparation thereof |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5335945B1 (enrdf_load_stackoverflow) |
| CH (1) | CH534672A (enrdf_load_stackoverflow) |
| DK (1) | DK132441C (enrdf_load_stackoverflow) |
| FR (1) | FR2070186B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1283442A (enrdf_load_stackoverflow) |
| IN (1) | IN149611B (enrdf_load_stackoverflow) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1205537B (de) * | 1961-08-19 | 1965-11-25 | Thomae Gmbh Dr K | Verfahren zur Herstellung neuer Steroidester |
-
1970
- 1970-10-26 CH CH1580170A patent/CH534672A/it not_active IP Right Cessation
- 1970-10-30 FR FR7039334A patent/FR2070186B1/fr not_active Expired
- 1970-10-30 DK DK553270A patent/DK132441C/da not_active IP Right Cessation
- 1970-10-30 GB GB5172870A patent/GB1283442A/en not_active Expired
- 1970-10-31 JP JP9635570A patent/JPS5335945B1/ja active Pending
-
1978
- 1978-06-17 IN IN672/CAL/78A patent/IN149611B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2070186B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| DK132441C (da) | 1976-05-10 |
| JPS5335945B1 (enrdf_load_stackoverflow) | 1978-09-29 |
| DK132441B (da) | 1975-12-08 |
| CH534672A (it) | 1973-03-15 |
| DE2047218A1 (de) | 1971-05-13 |
| FR2070186A1 (enrdf_load_stackoverflow) | 1971-09-10 |
| IN149611B (enrdf_load_stackoverflow) | 1982-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |