GB1283442A - Triamcinolone acetonide esters and preparation thereof - Google Patents

Triamcinolone acetonide esters and preparation thereof

Info

Publication number
GB1283442A
GB1283442A GB5172870A GB5172870A GB1283442A GB 1283442 A GB1283442 A GB 1283442A GB 5172870 A GB5172870 A GB 5172870A GB 5172870 A GB5172870 A GB 5172870A GB 1283442 A GB1283442 A GB 1283442A
Authority
GB
United Kingdom
Prior art keywords
formula
triamcinolone acetonide
compounds
oct
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5172870A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT2572170A external-priority patent/IT1045260B/en
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of GB1283442A publication Critical patent/GB1283442A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1283442 Triamcinolone acetonide esters SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SpA 30 Oct 1970 [31 Oct 1969 9 June 1970] 51728/70 Headings C2C and C2U Novel compounds of formula (wherein R is -COCH 3 or -COC 6 H 5 and X is a C 2-10 straight or branched alkylene groups) are prepared from triamcinolone acetonide by reaction with a compound of formula in an inert dry organic solvent at a temp. of 10-50‹ C. in the presence of a hydrogen halideacceptor. Compounds of Formula II are prepared from the corresponding acids by reaction with thionyl chloride. Compounds of Formula I are stated to possess antiphlogistic, thymolytic and glucocorticoid effects and may be made up with carriers into pharmaceutical compositions for topical administration.
GB5172870A 1969-10-31 1970-10-30 Triamcinolone acetonide esters and preparation thereof Expired GB1283442A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT6078469 1969-10-31
IT2572170A IT1045260B (en) 1970-06-09 1970-06-09 Triamcinolone-acetonide-21-acetyl-n benzyl - carboxylic acid esters

Publications (1)

Publication Number Publication Date
GB1283442A true GB1283442A (en) 1972-07-26

Family

ID=26328615

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5172870A Expired GB1283442A (en) 1969-10-31 1970-10-30 Triamcinolone acetonide esters and preparation thereof

Country Status (6)

Country Link
JP (1) JPS5335945B1 (en)
CH (1) CH534672A (en)
DK (1) DK132441C (en)
FR (1) FR2070186B1 (en)
GB (1) GB1283442A (en)
IN (1) IN149611B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1205537B (en) * 1961-08-19 1965-11-25 Thomae Gmbh Dr K Process for making new steroid esters

Also Published As

Publication number Publication date
DK132441B (en) 1975-12-08
CH534672A (en) 1973-03-15
FR2070186B1 (en) 1974-08-30
IN149611B (en) 1982-02-13
JPS5335945B1 (en) 1978-09-29
DE2047218A1 (en) 1971-05-13
FR2070186A1 (en) 1971-09-10
DK132441C (en) 1976-05-10

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years