GB1259578A - - Google Patents

Info

Publication number
GB1259578A
GB1259578A GB1259578DA GB1259578A GB 1259578 A GB1259578 A GB 1259578A GB 1259578D A GB1259578D A GB 1259578DA GB 1259578 A GB1259578 A GB 1259578A
Authority
GB
United Kingdom
Prior art keywords
urea
acid
salt
orotic
hydrogen peroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1259578A publication Critical patent/GB1259578A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,259,578. Orotic acid. LONZA Ltd. 27 May, 1970 [28 May, 1969], No. 25353/70. Heading C2C. Orotic acid or a salt thereof is prepared by chlorinating diketene in an inert organic solvent, reacting the resulting solution of γ- chloroacetoacetic acid chloride with urea, said chlorination and reaction being carried out at a temperature of from - 10‹ to - 30‹ C., the urea being added as a pyridine/glacial acetic acid solution in an amount such that it is immediately consumed, isolating the 4-chloromethyluracil so formed and oxidizing it by means of alkaline hydrogen peroxide, and optionally, liberating the free orotic salt from the salt so formed by the addition of an aqueous mineral acid. The chloromethyl-uracil is preferably dried before being reacted with the hydrogen peroxide which has preferably been heated to from 50‹ to 60‹ C. The γ-chloroacetoacetic acid chloride is preferably reacted immediatey with the urea.
GB1259578D 1969-05-28 1970-05-27 Expired GB1259578A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH807769A CH512496A (en) 1969-05-28 1969-05-28 Process for the production of orotic acid

Publications (1)

Publication Number Publication Date
GB1259578A true GB1259578A (en) 1972-01-05

Family

ID=4334782

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1259578D Expired GB1259578A (en) 1969-05-28 1970-05-27

Country Status (7)

Country Link
CH (1) CH512496A (en)
DE (1) DE2025247B2 (en)
FR (1) FR2048923A5 (en)
GB (1) GB1259578A (en)
IT (1) IT1049257B (en)
NL (1) NL7007736A (en)
SU (1) SU385447A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH596192A5 (en) * 1975-08-11 1978-03-15 Lonza Ag

Also Published As

Publication number Publication date
FR2048923A5 (en) 1971-03-19
DE2025247B2 (en) 1978-09-14
CH512496A (en) 1971-09-15
IT1049257B (en) 1981-01-20
NL7007736A (en) 1970-12-01
DE2025247A1 (en) 1970-12-03
SU385447A3 (en) 1973-05-29

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee