GB1012840A - 2,3 - dichloro - pyrazine - Google Patents

2,3 - dichloro - pyrazine

Info

Publication number
GB1012840A
GB1012840A GB45393/64A GB4539364A GB1012840A GB 1012840 A GB1012840 A GB 1012840A GB 45393/64 A GB45393/64 A GB 45393/64A GB 4539364 A GB4539364 A GB 4539364A GB 1012840 A GB1012840 A GB 1012840A
Authority
GB
United Kingdom
Prior art keywords
pyrazine
dichloropyrazine
methoxy
amino
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45393/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB1012840A publication Critical patent/GB1012840A/en
Expired legal-status Critical Current

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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

2,3-Dichloropyrazine is prepared by reacting phosgene with an aqueous solution of piperazine hexahydrate in the presence of an acid acceptor and a chlorine containing C1- 4 aliphatic hydrocarbon at from - 10 DEG to +20 DEG C. to yield N,N1-bis-chlorocarbonyl-piperazine which is then treated with clorine at from 150 DEG to 170 DEG C. in the presence of an aluminium chloride, ferric chloride or antimony chloride catalyst. The second step is preferably carried out under ultra-violet or visible irradiation. Examples are given. It is stated that 2,3-dichloropyrazine may be reacted with ammonia to give 2-amino-3-chloro-pyrazine, which compound, on reaction with an alkali metal methylate, gives 2-amino-3-methoxy-pyrazine, from which 3 - methoxy - 2 - sulphonilamido - pyrazine may be obtained by sulphonation.
GB45393/64A 1963-11-11 1964-11-06 2,3 - dichloro - pyrazine Expired GB1012840A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2305863 1963-11-11

Publications (1)

Publication Number Publication Date
GB1012840A true GB1012840A (en) 1965-12-08

Family

ID=11203329

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45393/64A Expired GB1012840A (en) 1963-11-11 1964-11-06 2,3 - dichloro - pyrazine

Country Status (2)

Country Link
US (1) US3287451A (en)
GB (1) GB1012840A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1100890A (en) * 1965-12-14 1968-01-24 Ici Ltd Process for the production of monochloropyrazine
US4132702A (en) * 1974-03-27 1979-01-02 Ciba-Geigy Corporation Phenol esters and amides and polymers stabilized therewith

Also Published As

Publication number Publication date
US3287451A (en) 1966-11-22

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