GB1012840A - 2,3 - dichloro - pyrazine - Google Patents
2,3 - dichloro - pyrazineInfo
- Publication number
- GB1012840A GB1012840A GB45393/64A GB4539364A GB1012840A GB 1012840 A GB1012840 A GB 1012840A GB 45393/64 A GB45393/64 A GB 45393/64A GB 4539364 A GB4539364 A GB 4539364A GB 1012840 A GB1012840 A GB 1012840A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrazine
- dichloropyrazine
- methoxy
- amino
- piperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
2,3-Dichloropyrazine is prepared by reacting phosgene with an aqueous solution of piperazine hexahydrate in the presence of an acid acceptor and a chlorine containing C1- 4 aliphatic hydrocarbon at from - 10 DEG to +20 DEG C. to yield N,N1-bis-chlorocarbonyl-piperazine which is then treated with clorine at from 150 DEG to 170 DEG C. in the presence of an aluminium chloride, ferric chloride or antimony chloride catalyst. The second step is preferably carried out under ultra-violet or visible irradiation. Examples are given. It is stated that 2,3-dichloropyrazine may be reacted with ammonia to give 2-amino-3-chloro-pyrazine, which compound, on reaction with an alkali metal methylate, gives 2-amino-3-methoxy-pyrazine, from which 3 - methoxy - 2 - sulphonilamido - pyrazine may be obtained by sulphonation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2305863 | 1963-11-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1012840A true GB1012840A (en) | 1965-12-08 |
Family
ID=11203329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB45393/64A Expired GB1012840A (en) | 1963-11-11 | 1964-11-06 | 2,3 - dichloro - pyrazine |
Country Status (2)
Country | Link |
---|---|
US (1) | US3287451A (en) |
GB (1) | GB1012840A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1100890A (en) * | 1965-12-14 | 1968-01-24 | Ici Ltd | Process for the production of monochloropyrazine |
US4132702A (en) * | 1974-03-27 | 1979-01-02 | Ciba-Geigy Corporation | Phenol esters and amides and polymers stabilized therewith |
-
1964
- 1964-11-06 GB GB45393/64A patent/GB1012840A/en not_active Expired
- 1964-11-09 US US409980A patent/US3287451A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US3287451A (en) | 1966-11-22 |
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