GB1241844A - Penicillins - Google Patents

Penicillins

Info

Publication number
GB1241844A
GB1241844A GB40319/68A GB4031968A GB1241844A GB 1241844 A GB1241844 A GB 1241844A GB 40319/68 A GB40319/68 A GB 40319/68A GB 4031968 A GB4031968 A GB 4031968A GB 1241844 A GB1241844 A GB 1241844A
Authority
GB
United Kingdom
Prior art keywords
acid
group
amino
isomer
penicillanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40319/68A
Other languages
English (en)
Inventor
Anthony Alfred Walter Long
John Herber Charles Nayler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10414312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1241844(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to AT807969A priority Critical patent/AT316740B/de
Priority to GB40319/68A priority patent/GB1241844A/en
Priority to IL32844A priority patent/IL32844A/en
Priority to US851062A priority patent/US3674776A/en
Priority to SE6911472A priority patent/SE383634B/xx
Priority to IE1172/69A priority patent/IE33574B1/xx
Priority to CY1081A priority patent/CY1081A/xx
Priority to DE1967083A priority patent/DE1967083C2/de
Priority to DE1942693A priority patent/DE1942693C2/de
Priority to DE1967313A priority patent/DE1967313C2/de
Priority to DK449169A priority patent/DK127000C/da
Priority to BE737848D priority patent/BE737848A/xx
Priority to FI2446/69A priority patent/FI50425B/fi
Priority to NL6912905A priority patent/NL6912905A/xx
Priority to RO60866A priority patent/RO56335A/ro
Priority to CH1280969A priority patent/CH542878A/de
Priority to BR211795/69A priority patent/BR6911795D0/pt
Priority to FR6928824A priority patent/FR2016283B1/fr
Priority to ES370756A priority patent/ES370756A1/es
Priority to OA53775A priority patent/OA03164A/xx
Publication of GB1241844A publication Critical patent/GB1241844A/en
Priority to US05/382,010 priority patent/USRE28744E/en
Priority to SE7405340A priority patent/SE432525B/xx
Priority to YU3087/75A priority patent/YU37168B/xx
Priority to CA262,207A priority patent/CA1012136B/xx
Priority to FI793921A priority patent/FI793921A7/fi
Priority to KE3073A priority patent/KE3073A/xx
Priority to HK560/80A priority patent/HK56080A/xx
Priority to MY196/81A priority patent/MY8100196A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GB40319/68A 1968-08-23 1968-08-23 Penicillins Expired GB1241844A (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
AT807969A AT316740B (de) 1968-08-23 1968-08-23 Verfahren zur herstellung eines neuen penicillins
GB40319/68A GB1241844A (en) 1968-08-23 1968-08-23 Penicillins
IE1172/69A IE33574B1 (en) 1968-08-23 1969-08-18 Penicillins
SE6911472A SE383634B (sv) 1968-08-23 1969-08-18 Analogiforfarande for framstellning av 6-((-)-alfa-amino-p-hydroxifenylacetamido) penicillansyratrihydrat eller salter eller salthydrater av 6-((-)-alfa-amino-p-hydroxifenylacetamido) penicillansyra
US851062A US3674776A (en) 1968-08-23 1969-08-18 P-hydroxyampicillin and salts thereof
IL32844A IL32844A (en) 1968-08-23 1969-08-18 6-((-)-alpha-amino-p-hydroxyphenyl-acet amido)penicillanic acid and its preparation
CY1081A CY1081A (en) 1968-08-23 1969-08-20 Penicillins
DE1967083A DE1967083C2 (de) 1968-08-23 1969-08-21 Arzneimittel mit antibiotischer Wirkung auf der Basis einer Kombination aus (-)-α-Amino-p-hydroxybenzylpenicillin und Flucloxacillin
DE1942693A DE1942693C2 (de) 1968-08-23 1969-08-21 Verfahren zur Herstellung von (-)-α-Amino-p-hydroxybenzylpenicillintrihydrat
DE1967313A DE1967313C2 (de) 1968-08-23 1969-08-21 Verwendung von (-)-α-Amino-p-hydroxybenzylpenicillin-trihydrat zur Herstellung eines Arzneimittels in oraler Applikationsform zur Bekämpfung bakterieller Infektionen des Menschen
DK449169A DK127000C (da) 1968-08-23 1969-08-21 Analogifremgangsmaade til fremstilling af 6-((-)-alfa-amino-p-hydroxyphenylacetamido)-penicillansyre-trihydrat eller salte eller salthydrater af 6-((-)-alfa-amino-p-hydroxyphenylacetamido)-penicillansyre
ES370756A ES370756A1 (es) 1968-08-23 1969-08-22 Un procedimiento para la preparacion de acido 6-((-)-alfa- amino-p- hidroxifenilacetamico) penicilanico y salesno toxi-cas del mismo.
NL6912905A NL6912905A (enExample) 1968-08-23 1969-08-22
FR6928824A FR2016283B1 (enExample) 1968-08-23 1969-08-22
FI2446/69A FI50425B (enExample) 1968-08-23 1969-08-22
BE737848D BE737848A (enExample) 1968-08-23 1969-08-22
RO60866A RO56335A (enExample) 1968-08-23 1969-08-22
CH1280969A CH542878A (de) 1968-08-23 1969-08-22 Verfahren zur Herstellung von 6-((-)-a-Amino-p-hydroxyphenylacetamido) penicillansäure
BR211795/69A BR6911795D0 (pt) 1968-08-23 1969-08-22 Um processo para obtencao do acido 6(c-d-amino-p-hidroxipenilacetamido) penicilanico e seus sais nao toxicos
OA53775A OA03164A (fr) 1968-08-23 1969-11-06 Nouveaux procédés de préparation de pénicilline et leur utilisation.
US05/382,010 USRE28744E (en) 1968-08-23 1973-07-23 Crystalline p-hydroxyampicillin and salts thereof
SE7405340A SE432525B (sv) 1968-08-23 1974-04-19 Forfarande for framstellning av ett farmaceutiskt penicillinpreparat med synergistisk, antibakteriell verkan
YU3087/75A YU37168B (en) 1968-08-23 1975-12-05 Process for obtaining (-/( -)-amino-p-hydroxyphenyl acetamino pennicillanic acid
CA262,207A CA1012136B (en) 1968-08-23 1976-09-28 Penicillins
FI793921A FI793921A7 (fi) 1968-08-23 1979-12-14 Analogiamenetelmä 6-/(-)- -amino-p- hydroksifenyyliaset- amido/penisillaanihappo-trihydraatin valmistamisevalmistamiseksi.
KE3073A KE3073A (en) 1968-08-23 1980-08-15 Penicillins
HK560/80A HK56080A (en) 1968-08-23 1980-10-02 Penicillins
MY196/81A MY8100196A (enExample) 1968-08-23 1981-12-30

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB40319/68A GB1241844A (en) 1968-08-23 1968-08-23 Penicillins

Publications (1)

Publication Number Publication Date
GB1241844A true GB1241844A (en) 1971-08-04

Family

ID=10414312

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40319/68A Expired GB1241844A (en) 1968-08-23 1968-08-23 Penicillins

Country Status (22)

Country Link
US (1) US3674776A (enExample)
BE (1) BE737848A (enExample)
BR (1) BR6911795D0 (enExample)
CA (1) CA1012136B (enExample)
CH (1) CH542878A (enExample)
CY (1) CY1081A (enExample)
DE (3) DE1967083C2 (enExample)
DK (1) DK127000C (enExample)
ES (1) ES370756A1 (enExample)
FI (2) FI50425B (enExample)
FR (1) FR2016283B1 (enExample)
GB (1) GB1241844A (enExample)
HK (1) HK56080A (enExample)
IE (1) IE33574B1 (enExample)
IL (1) IL32844A (enExample)
KE (1) KE3073A (enExample)
MY (1) MY8100196A (enExample)
NL (1) NL6912905A (enExample)
OA (1) OA03164A (enExample)
RO (1) RO56335A (enExample)
SE (2) SE383634B (enExample)
YU (1) YU37168B (enExample)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2527235A1 (de) * 1974-06-19 1976-01-08 Bristol Myers Co Verfahren zur herstellung von phenylglycinderivaten
US3971775A (en) * 1974-05-09 1976-07-27 Glaxo Laboratories Limited Process for preparing penicillin antibiotics
DE2721034A1 (de) * 1976-05-13 1977-12-01 Beecham Group Ltd Injizierbares arzneipraeparat
US4203972A (en) * 1971-11-01 1980-05-20 Astra Pharmaceutical Products, Inc. Penicillin composition
US4285884A (en) 1977-11-03 1981-08-25 Riedel-De Haen Aktiengesellschaft Process for resolution of racemic DL-α-aminocarboxylic acids
US4310460A (en) 1979-11-02 1982-01-12 Dobfar S.P.A. Process for the production of 6-D-α-amino-p-hydroxyphenylacetamido penicillanic acid
JPS57185291A (en) * 1981-05-09 1982-11-15 Toushin Seiyaku Kk Manufacture of cephalosporin compound utilizing novel silylating agent
US4369146A (en) 1979-05-03 1983-01-18 Chimica Bulciago S.R.L. Method for chlorinating the carboxylic group of α-aminoacids
EP0131147A1 (en) * 1983-06-10 1985-01-16 Beecham Group Plc Crystalline amoxycillin salt
US4760162A (en) * 1985-08-27 1988-07-26 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Inorganic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanylchloride and process for preparing the same
EP0261823B1 (en) * 1986-09-24 1991-01-02 Tanabe Seiyaku Co., Ltd. Stable hydrate of penicillin derivative and process for preparing same
EP0761218A1 (en) 1994-04-23 1997-03-12 Smithkline Beecham Corporation Process for preparing polymer coated tablet comprising amoxycillin and clavunalate
US8894994B2 (en) 2010-05-24 2014-11-25 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
CN104650119A (zh) * 2015-02-10 2015-05-27 中国科学院长春应用化学研究所 一种β-内酰胺化合物的制备方法
US9290754B2 (en) 2014-04-17 2016-03-22 Synthetic Biologics Inc. Beta-lactamases with improved properties for therapy
US9744221B2 (en) 2014-12-23 2017-08-29 Synthetic Biologics, Inc. Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
US10105322B2 (en) 2014-10-08 2018-10-23 Synthetic Biologics, Inc. Beta-lactamase formulations and uses thereof
US10548955B2 (en) 2015-02-23 2020-02-04 Synthetic Biologics, Inc. Carbapenemases for use with antibiotics for the protection of the intestinal microbiome
US10709773B2 (en) 2015-03-06 2020-07-14 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
US11034966B2 (en) 2014-08-28 2021-06-15 Synthetic Biologics, Inc. E. coli-based production of beta-lactamase

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873521A (en) * 1970-09-17 1975-03-25 Astra Laekemedel Ab Esters of {60 -amino penicillins
GB1413516A (en) * 1972-10-06 1975-11-12 Leo Pharm Prod Ltd Crystalline pivaloyloxymethal d - -alpha- aminobenzylpenicillinate
GB1465694A (en) * 1973-05-15 1977-02-23 Beecham Group Ltd Preparation of penicillin salts
US3932386A (en) * 1973-06-18 1976-01-13 American Home Products Corporation Sodium 6-(L-aminocyclohexane carboxamido)penicillanic acid
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
ES436565A1 (es) * 1974-06-05 1977-04-01 Bristol Myers Co Un procedimiento para la preparacion de acidos acetamidope- nicilanicos.
US3969524A (en) * 1974-08-13 1976-07-13 Hoffmann-La Roche Inc. Stable amoxicillin dosage form
AU8364875A (en) * 1974-08-21 1977-02-10 Hoffmann La Roche Choline and n-methyl-d-glucamine salts of amoxycillin
GB1463563A (en) * 1974-10-10 1977-02-02 Beecham Group Ltd Pharmaceutical compositions
GB1523278A (en) * 1974-10-21 1978-08-31 Gist Brocades Nv Penicillanic acid derivatives
JPS5186116A (en) * 1975-01-20 1976-07-28 Takeda Chemical Industries Ltd Dd arufua isobuchirusuruhobenjirupenishirinhanyobaiwabutsuketsushono seizoho
GB1532993A (en) * 1975-03-07 1978-11-22 Beecham Group Ltd Injectable antibiotic compositions
GB1527557A (en) * 1976-07-07 1978-10-04 Beecham Group Ltd Process for preparing solid sodium amoxycillin
GB1576731A (en) * 1976-08-10 1980-10-15 Beecham Group Ltd Process for the preparation of sodium amoxycillin
JPS5736298Y2 (enExample) * 1977-06-27 1982-08-11
NZ189945A (en) * 1978-04-01 1981-04-24 Beecham Group Ltd Ampicillin phthalidyl ester naphthalene 2-sulphonate also pharmaceutical compositions
US4240960A (en) * 1979-03-19 1980-12-23 Bristol-Myers Company Trimethylsilyl substituted penicillins
US4278600A (en) * 1979-03-19 1981-07-14 Bristol-Myers Company Production of penicillins
US4310458A (en) * 1979-03-19 1982-01-12 Bristol-Myers Company Production of penicillins
US4351766A (en) * 1979-07-12 1982-09-28 Bristol-Myers Company Production of penicillins
IE51516B1 (en) * 1980-10-06 1987-01-07 Leo Pharm Prod Ltd 1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate
AT412213B (de) * 2000-05-30 2004-11-25 Sandoz Ag Verfahren zur trocknung von amoxicillin oder amoxicillin-hältigen, oralen, festen pharmazeutischen zusammensetzungen unter verwendung eines gases mit einer definierten gasfeuchte
JP5113978B2 (ja) * 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
US7935377B2 (en) * 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
CN116735514B (zh) * 2023-08-11 2023-11-03 昆明理工大学 纳米酶结合液液微萃取快速检测天麻硫熏标志物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
DE1156078C2 (de) * 1960-08-25 1973-10-25 Beecham Res Lab Verfahren zur Herstellung von D(-)-ª‡-Aminobenzylpenicillin und von L(+)-ª‡-Aminobenzylpenicillin
FR1332557A (fr) * 1962-03-15 1963-07-19 Bristol Myers Co Procédé de fabrication d'alpha-amino-benzylpénicillines
BE639104A (enExample) * 1962-11-02
GB991586A (en) * 1963-02-28 1965-05-12 Beecham Res Lab Process for the preparation of penicillins

Cited By (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203972A (en) * 1971-11-01 1980-05-20 Astra Pharmaceutical Products, Inc. Penicillin composition
US3971775A (en) * 1974-05-09 1976-07-27 Glaxo Laboratories Limited Process for preparing penicillin antibiotics
DE2527235A1 (de) * 1974-06-19 1976-01-08 Bristol Myers Co Verfahren zur herstellung von phenylglycinderivaten
DE2721034A1 (de) * 1976-05-13 1977-12-01 Beecham Group Ltd Injizierbares arzneipraeparat
US4285884A (en) 1977-11-03 1981-08-25 Riedel-De Haen Aktiengesellschaft Process for resolution of racemic DL-α-aminocarboxylic acids
US4369146A (en) 1979-05-03 1983-01-18 Chimica Bulciago S.R.L. Method for chlorinating the carboxylic group of α-aminoacids
US4435333A (en) 1979-05-03 1984-03-06 Chimica Bulciago S.R.L. Acetonitrile solvate of an α-aminoacyl chloride hydrochloride
US4310460A (en) 1979-11-02 1982-01-12 Dobfar S.P.A. Process for the production of 6-D-α-amino-p-hydroxyphenylacetamido penicillanic acid
JPS57185291A (en) * 1981-05-09 1982-11-15 Toushin Seiyaku Kk Manufacture of cephalosporin compound utilizing novel silylating agent
EP0131147A1 (en) * 1983-06-10 1985-01-16 Beecham Group Plc Crystalline amoxycillin salt
US4760162A (en) * 1985-08-27 1988-07-26 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Inorganic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanylchloride and process for preparing the same
EP0261823B1 (en) * 1986-09-24 1991-01-02 Tanabe Seiyaku Co., Ltd. Stable hydrate of penicillin derivative and process for preparing same
EP0761218A1 (en) 1994-04-23 1997-03-12 Smithkline Beecham Corporation Process for preparing polymer coated tablet comprising amoxycillin and clavunalate
US8894994B2 (en) 2010-05-24 2014-11-25 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
US9034602B2 (en) 2010-05-24 2015-05-19 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
US11214787B2 (en) 2010-05-24 2022-01-04 Synthetic Biologies, Inc. Modified beta-lactamases and methods and uses related thereto
US10253306B2 (en) 2010-05-24 2019-04-09 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
US9301995B2 (en) 2010-05-24 2016-04-05 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
US9301996B2 (en) 2010-05-24 2016-04-05 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
US10041056B2 (en) 2010-05-24 2018-08-07 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
US9587234B2 (en) 2010-05-24 2017-03-07 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
US9765320B2 (en) 2010-05-24 2017-09-19 Synthetic Biologics, Inc. Modified beta-lactamases and methods and uses related thereto
US9783797B1 (en) 2014-04-17 2017-10-10 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US10087433B1 (en) 2014-04-17 2018-10-02 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US9695409B2 (en) 2014-04-17 2017-07-04 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US11236319B2 (en) 2014-04-17 2022-02-01 Synthetic Biologies, Inc. Beta-lactamases with improved properties for therapy
US9464280B1 (en) 2014-04-17 2016-10-11 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US9404103B1 (en) 2014-04-17 2016-08-02 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US10011824B2 (en) 2014-04-17 2018-07-03 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US9376673B1 (en) 2014-04-17 2016-06-28 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US10767171B2 (en) 2014-04-17 2020-09-08 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US10584326B2 (en) 2014-04-17 2020-03-10 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US11608494B2 (en) 2014-04-17 2023-03-21 Theriva Biologics, Inc. Beta-lactamases with improved properties for therapy
US9290754B2 (en) 2014-04-17 2016-03-22 Synthetic Biologics Inc. Beta-lactamases with improved properties for therapy
US10336995B2 (en) 2014-04-17 2019-07-02 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
US11034966B2 (en) 2014-08-28 2021-06-15 Synthetic Biologics, Inc. E. coli-based production of beta-lactamase
US11542510B2 (en) 2014-08-28 2023-01-03 Synthetic Biologics, Inc. E. coli-based production of beta-lactamase
US11981899B2 (en) 2014-08-28 2024-05-14 Theriva Biologics, Inc. E. coli-based production of beta-lactamase
US10105322B2 (en) 2014-10-08 2018-10-23 Synthetic Biologics, Inc. Beta-lactamase formulations and uses thereof
US12178917B2 (en) 2014-10-08 2024-12-31 Theriva Biologics, Inc. Beta-lactamase formulations and uses thereof
US10828260B2 (en) 2014-10-08 2020-11-10 Synthetic Biologics, Inc. Beta-lactamase formulations and uses thereof
US10046035B2 (en) 2014-12-23 2018-08-14 Synthetic Biologics, Inc. Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics
US10792346B2 (en) 2014-12-23 2020-10-06 Synthetic Biologics, Inc. Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
US11596674B2 (en) 2014-12-23 2023-03-07 Synthetic Biologies, Inc. Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
US11944669B2 (en) 2014-12-23 2024-04-02 Theriva Biologics, Inc. Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
US9744221B2 (en) 2014-12-23 2017-08-29 Synthetic Biologics, Inc. Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
CN104650119A (zh) * 2015-02-10 2015-05-27 中国科学院长春应用化学研究所 一种β-内酰胺化合物的制备方法
CN104650119B (zh) * 2015-02-10 2017-04-05 中国科学院长春应用化学研究所 一种β‑内酰胺化合物的制备方法
US11123413B2 (en) 2015-02-23 2021-09-21 Synthetic Biologies, Inc. Carbapenemases for use with antibiotics for the protection of the intestinal microbiome
US10548955B2 (en) 2015-02-23 2020-02-04 Synthetic Biologics, Inc. Carbapenemases for use with antibiotics for the protection of the intestinal microbiome
US11253577B2 (en) 2015-03-06 2022-02-22 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
US10709773B2 (en) 2015-03-06 2020-07-14 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
US11872268B2 (en) 2015-03-06 2024-01-16 Theriva Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection

Also Published As

Publication number Publication date
YU37168B (en) 1984-08-31
DE1967313C2 (de) 1986-05-28
FR2016283A1 (enExample) 1970-05-08
IL32844A (en) 1973-02-28
CA1012136B (en) 1977-06-14
YU308775A (en) 1983-04-27
HK56080A (en) 1980-10-10
BE737848A (enExample) 1970-02-25
FI793921A7 (fi) 1981-01-01
IE33574B1 (en) 1974-08-21
OA03164A (fr) 1970-12-15
FR2016283B1 (enExample) 1974-08-09
IL32844A0 (en) 1969-11-12
DE1942693A1 (de) 1970-02-26
BR6911795D0 (pt) 1973-01-11
NL6912905A (enExample) 1970-02-25
MY8100196A (enExample) 1981-12-31
RO56335A (enExample) 1974-11-11
IE33574L (en) 1970-02-23
CH542878A (de) 1973-10-15
SE383634B (sv) 1976-03-22
DK127000C (da) 1983-02-28
CY1081A (en) 1980-12-27
ES370756A1 (es) 1971-07-01
FI50425B (enExample) 1975-12-01
DE1942693C2 (de) 1984-03-08
DE1967083A1 (de) 1977-03-17
SE432525B (sv) 1984-04-09
DK127000B (da) 1973-09-10
KE3073A (en) 1980-08-29
US3674776A (en) 1972-07-04
DE1967083C2 (de) 1986-10-02

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