GB902703A - Penicillins - Google Patents

Penicillins

Info

Publication number
GB902703A
GB902703A GB29345/60A GB2934560A GB902703A GB 902703 A GB902703 A GB 902703A GB 29345/60 A GB29345/60 A GB 29345/60A GB 2934560 A GB2934560 A GB 2934560A GB 902703 A GB902703 A GB 902703A
Authority
GB
United Kingdom
Prior art keywords
penicillanic acid
acid
amino
aminophenylacetamido
pencillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29345/60A
Inventor
Frank Peter Doyle
John Herbert Charles Nayler
Harry Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Priority to GB29345/60A priority Critical patent/GB902703A/en
Priority to BE604187A priority patent/BE604187R/en
Priority to CH638961A priority patent/CH407126A/en
Priority to ES0267993A priority patent/ES267993A2/en
Priority to FR863883A priority patent/FR12F/en
Priority to DK340861AA priority patent/DK128166B/en
Publication of GB902703A publication Critical patent/GB902703A/en
Priority to OA50918A priority patent/OA060E/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Relates to the epimers of a -aminobenzyl-pencillin, 6-[D(-)a -aminophenylacetamido]-penicillanic acid and 6-[L(+)a -aminophenyl-acetamido]-penicillanic acid and non-toxic salts thereof, which may be prepared by coupling 6-amino-penicillanic acid with the D-or L-form of a -aminophenylacetic acid having its amino group protected, or a salt thereof, and thereafter removing the protecting group under sufficiently mild conditions to avoid destruction of the penicillin nucleus, e.g. by catalytic hydrogenation.
GB29345/60A 1958-10-06 1960-08-25 Penicillins Expired GB902703A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB29345/60A GB902703A (en) 1960-08-25 1960-08-25 Penicillins
BE604187A BE604187R (en) 1960-08-25 1961-05-25 Improvements made to penicillin derivatives
CH638961A CH407126A (en) 1958-10-06 1961-06-01 Process for the preparation of epimeric α-amino-benzylpenicillins
ES0267993A ES267993A2 (en) 1960-08-25 1961-06-05 Penicillins
FR863883A FR12F (en) 1958-10-06 1961-06-05 Penicillin derivatives and their preparation process.
DK340861AA DK128166B (en) 1960-08-25 1961-08-25 Process for the preparation of 6- (D (-) - α-aminophenylacetamido) penicillanic acid or a salt thereof.
OA50918A OA060E (en) 1960-08-25 1964-12-18

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB29345/60A GB902703A (en) 1960-08-25 1960-08-25 Penicillins

Publications (1)

Publication Number Publication Date
GB902703A true GB902703A (en) 1962-08-09

Family

ID=10290076

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29345/60A Expired GB902703A (en) 1958-10-06 1960-08-25 Penicillins

Country Status (5)

Country Link
BE (1) BE604187R (en)
DK (1) DK128166B (en)
ES (1) ES267993A2 (en)
GB (1) GB902703A (en)
OA (1) OA060E (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1208302B (en) * 1962-08-28 1966-01-05 Novo Terapeutisk Labor As Process for the preparation of D (-) - and L (ú½) -alpha-aminobenzylpenicillin
US6544991B2 (en) 2000-06-30 2003-04-08 Pharmacia & Upjohn Company Compositions and methods for treating bacterial infections

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1208302B (en) * 1962-08-28 1966-01-05 Novo Terapeutisk Labor As Process for the preparation of D (-) - and L (ú½) -alpha-aminobenzylpenicillin
US6544991B2 (en) 2000-06-30 2003-04-08 Pharmacia & Upjohn Company Compositions and methods for treating bacterial infections

Also Published As

Publication number Publication date
ES267993A2 (en) 1961-10-16
OA060E (en) 1970-12-15
BE604187R (en) 1961-09-18
DK128166B (en) 1974-03-11

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