ES267993A2 - Penicillins - Google Patents

Penicillins

Info

Publication number
ES267993A2
ES267993A2 ES0267993A ES267993A ES267993A2 ES 267993 A2 ES267993 A2 ES 267993A2 ES 0267993 A ES0267993 A ES 0267993A ES 267993 A ES267993 A ES 267993A ES 267993 A2 ES267993 A2 ES 267993A2
Authority
ES
Spain
Prior art keywords
penicillanic acid
acid
amino
aminophenylacetamido
pencillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0267993A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Publication of ES267993A2 publication Critical patent/ES267993A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Relates to the epimers of a -aminobenzyl-pencillin, 6-[D(-)a -aminophenylacetamido]-penicillanic acid and 6-[L(+)a -aminophenyl-acetamido]-penicillanic acid and non-toxic salts thereof, which may be prepared by coupling 6-amino-penicillanic acid with the D-or L-form of a -aminophenylacetic acid having its amino group protected, or a salt thereof, and thereafter removing the protecting group under sufficiently mild conditions to avoid destruction of the penicillin nucleus, e.g. by catalytic hydrogenation.
ES0267993A 1960-08-25 1961-06-05 Penicillins Expired ES267993A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB29345/60A GB902703A (en) 1960-08-25 1960-08-25 Penicillins

Publications (1)

Publication Number Publication Date
ES267993A2 true ES267993A2 (en) 1961-10-16

Family

ID=10290076

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0267993A Expired ES267993A2 (en) 1960-08-25 1961-06-05 Penicillins

Country Status (5)

Country Link
BE (1) BE604187R (en)
DK (1) DK128166B (en)
ES (1) ES267993A2 (en)
GB (1) GB902703A (en)
OA (1) OA060E (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297126A (en) * 1962-08-28
US6544991B2 (en) 2000-06-30 2003-04-08 Pharmacia & Upjohn Company Compositions and methods for treating bacterial infections

Also Published As

Publication number Publication date
BE604187R (en) 1961-09-18
GB902703A (en) 1962-08-09
DK128166B (en) 1974-03-11
OA060E (en) 1970-12-15

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