GB978178A - Penicillins - Google Patents

Penicillins

Info

Publication number
GB978178A
GB978178A GB4154162A GB4154162A GB978178A GB 978178 A GB978178 A GB 978178A GB 4154162 A GB4154162 A GB 4154162A GB 4154162 A GB4154162 A GB 4154162A GB 978178 A GB978178 A GB 978178A
Authority
GB
United Kingdom
Prior art keywords
penicillins
amino
hydroxy
penicillin
amino group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4154162A
Inventor
John Herbert Charles Nayler
Harry Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DENDAT1249280D priority Critical patent/DE1249280B/en
Priority to NL299897D priority patent/NL299897A/xx
Priority to BE639104D priority patent/BE639104A/xx
Priority claimed from GB31847/58A external-priority patent/GB873049A/en
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Priority to GB4154162A priority patent/GB978178A/en
Priority to SE11730/63A priority patent/SE349305B/xx
Priority to BR154032/63A priority patent/BR6354032D0/en
Priority to FI632107A priority patent/FI41745C/en
Priority to AT863363A priority patent/AT261803B/en
Priority to NO150636A priority patent/NO125391B/no
Priority to US320538A priority patent/US3192198A/en
Priority to FR952405A priority patent/FR3034M/en
Priority to DK515563AA priority patent/DK123871B/en
Priority to CH1351063A priority patent/CH444164A/en
Publication of GB978178A publication Critical patent/GB978178A/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to penicillins of general formula <FORM:0978178/C1/1> and non-toxic salts thereof, e.g. 6-(p-hydroxy-a -aminophenylacetamido)-penicillanic acid. Specified salts are the sodium, potassium, calcium, aluminium, ammonium, trialkylamine, procaine, dibenzylamine, l-ephenamine, N,N1-dibenzyl ethylene diamine, dehydroabietylamine, N,N1-bis-dehydroabi etylethylene diamine and N-benzyl -beta-phenethylamine. The penicillins are prepared by reacting 6-amino penicillanic acid, or a salt thereof, with a functional derivative of a carboxylic acid of formula <FORM:0978178/C1/2> where X is amino or a protected amino group which is subsequently converted to the amino group. Alternatively, a -bromo-hydroxybenzyl penicillin is first formed and then reacted with hexamethylenetetramine; or a -azido-hydroxy benzyl penicillin may be formed and then catalytically hydrogenated to the a -amino hydroxy benzyl penicillin. The penicillins may be used as nutritional supplements in animal feeds or as antibacterial agents for human and animal administration, e.g. mastitis in cattle.
GB4154162A 1958-10-06 1962-11-02 Penicillins Expired GB978178A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DENDAT1249280D DE1249280B (en) 1962-11-02 Process for the preparation of Hydroxybenzyl y amino-pemciUmen
NL299897D NL299897A (en) 1962-11-02
BE639104D BE639104A (en) 1962-11-02
GB4154162A GB978178A (en) 1958-10-06 1962-11-02 Penicillins
SE11730/63A SE349305B (en) 1962-11-02 1963-10-24
BR154032/63A BR6354032D0 (en) 1962-11-02 1963-10-25 PROCESS OF PREPARING A NEW PENICILLIN
AT863363A AT261803B (en) 1962-11-02 1963-10-29 Process for the production of new penicillins
FI632107A FI41745C (en) 1962-11-02 1963-10-29 Method for preparing alpha-aminooxybenzyl penicillins
NO150636A NO125391B (en) 1962-11-02 1963-10-30
US320538A US3192198A (en) 1962-11-02 1963-10-31 Penicillins
FR952405A FR3034M (en) 1962-11-02 1963-10-31 New derivative of penicillin.
DK515563AA DK123871B (en) 1962-11-02 1963-11-02 Analogous process for the preparation of α-amino-α- (hydroxyphenyl) -methylpenicillanic acids or salts thereof.
CH1351063A CH444164A (en) 1962-11-02 1963-11-04 Process for the production of new penicillins

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB31847/58A GB873049A (en) 1958-10-06 1958-10-06 Improvements in or relating to penicillin derivatives
GB1630359 1959-05-12
GB4154162A GB978178A (en) 1958-10-06 1962-11-02 Penicillins

Publications (1)

Publication Number Publication Date
GB978178A true GB978178A (en) 1964-12-16

Family

ID=27257367

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4154162A Expired GB978178A (en) 1958-10-06 1962-11-02 Penicillins

Country Status (1)

Country Link
GB (1) GB978178A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489746A (en) * 1967-09-05 1970-01-13 Bristol Myers Co Derivatives of alpha-aminobenzylpenicillin
US3517023A (en) * 1967-09-05 1970-06-23 Bristol Myers Co Derivatives of alpha-aminobenzylpenicillin
EP0606506A1 (en) 1993-01-12 1994-07-20 Yeong Sul Kim Beta-lactamase resistant antibacterial composition

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489746A (en) * 1967-09-05 1970-01-13 Bristol Myers Co Derivatives of alpha-aminobenzylpenicillin
US3517023A (en) * 1967-09-05 1970-06-23 Bristol Myers Co Derivatives of alpha-aminobenzylpenicillin
EP0606506A1 (en) 1993-01-12 1994-07-20 Yeong Sul Kim Beta-lactamase resistant antibacterial composition

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