GB1216523A - Basically substituted dibenzoxazepines, dibenzothiazepines and dibenzodiazepines - Google Patents
Basically substituted dibenzoxazepines, dibenzothiazepines and dibenzodiazepinesInfo
- Publication number
- GB1216523A GB1216523A GB00561/68A GB1056168A GB1216523A GB 1216523 A GB1216523 A GB 1216523A GB 00561/68 A GB00561/68 A GB 00561/68A GB 1056168 A GB1056168 A GB 1056168A GB 1216523 A GB1216523 A GB 1216523A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- amino
- carbon atoms
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008533 dibenzodiazepines Chemical class 0.000 title abstract 2
- 150000008509 dibenzothiazepines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 19
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- -1 sulphinyl Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 239000005864 Sulphur Substances 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000003951 lactams Chemical class 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- VLXRWIXNACCNRU-UHFFFAOYSA-N 10-methyl-7-piperazin-1-ylbenzo[b][1,4]benzoxazepine Chemical compound CC1=CC=C(C=2C=NC3=C(OC21)C=CC=C3)N3CCNCC3 VLXRWIXNACCNRU-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- WQGVWPPXBQPKCE-UHFFFAOYSA-N 6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-8-amine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2OC2=CC=C(N)C=C12 WQGVWPPXBQPKCE-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000007192 Meerwein reaction reaction Methods 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000012320 chlorinating reagent Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 238000006193 diazotization reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 150000002828 nitro derivatives Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electromagnets (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH358267 | 1967-03-13 | ||
| CH410367A CH481133A (de) | 1967-03-22 | 1967-03-22 | Verfahren zur Herstellung basisch substituierter Heterocyclen |
| CH655767A CH484924A (de) | 1967-05-09 | 1967-05-09 | Verfahren zur Herstellung basisch substituierter Heterocyclen |
| CH1011567A CH485752A (de) | 1967-07-14 | 1967-07-14 | Verfahren zur Herstellung basisch substituierter Heterocyclen |
| CH1545367 | 1967-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1216523A true GB1216523A (en) | 1970-12-23 |
Family
ID=27509145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB00561/68A Expired GB1216523A (en) | 1967-03-13 | 1968-03-05 | Basically substituted dibenzoxazepines, dibenzothiazepines and dibenzodiazepines |
Country Status (9)
| Country | Link |
|---|---|
| AT (3) | AT292718B (enExample) |
| BE (1) | BE712114A (enExample) |
| DE (1) | DE1720007A1 (enExample) |
| FR (1) | FR8046M (enExample) |
| GB (1) | GB1216523A (enExample) |
| IL (1) | IL29571A (enExample) |
| NL (1) | NL6803570A (enExample) |
| NO (1) | NO123459B (enExample) |
| SE (1) | SE364277B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996029316A1 (en) * | 1995-03-19 | 1996-09-26 | Wikstroem Haakan | NEW SULFONE ESTER ANALOGUES OF iso-CLOZAPINE AND RELATED STRUCTURES: ATYPICAL NEUROLEPTICS |
| WO2005063254A3 (en) * | 2003-12-22 | 2005-09-15 | Acadia Pharm Inc | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| WO2007053618A1 (en) * | 2005-10-31 | 2007-05-10 | Acadia Pharmaceuticals Inc. | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| EP1951694A4 (en) * | 2005-11-18 | 2010-09-22 | Astrazeneca Ab | FORMS OF SALTS |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2441867C2 (ru) * | 2010-05-13 | 2012-02-10 | Общество С Ограниченной Ответственностью "Валентек" | ПРОИЗВОДНЫЕ 5H-ДИБЕНЗО[b, e][1, 4]ДИАЗЕПИНА И ИХ ПРИМЕНЕНИЕ |
| WO2013070107A1 (ru) * | 2011-11-09 | 2013-05-16 | Общество С Ограниченной Ответственностью "Валентек" | ПРОИЗВОДНЫЕ 5Н-ДИБЕНЗО[b,е] [1,4]ДИАЗЕПИНA И ИХ ПРИМЕНЕНИЕ |
-
1968
- 1968-03-04 IL IL2957168A patent/IL29571A/en unknown
- 1968-03-04 DE DE19681720007 patent/DE1720007A1/de active Pending
- 1968-03-05 GB GB00561/68A patent/GB1216523A/en not_active Expired
- 1968-03-05 AT AT00206/70A patent/AT292718B/de not_active IP Right Cessation
- 1968-03-05 AT AT215368A patent/AT292707B/de not_active IP Right Cessation
- 1968-03-05 AT AT00204/70A patent/AT292716B/de not_active IP Right Cessation
- 1968-03-08 SE SE03129/68A patent/SE364277B/xx unknown
- 1968-03-12 NO NO94668A patent/NO123459B/no unknown
- 1968-03-12 FR FR143389A patent/FR8046M/fr not_active Expired
- 1968-03-13 NL NL6803570A patent/NL6803570A/xx unknown
- 1968-03-13 BE BE712114D patent/BE712114A/xx unknown
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996029316A1 (en) * | 1995-03-19 | 1996-09-26 | Wikstroem Haakan | NEW SULFONE ESTER ANALOGUES OF iso-CLOZAPINE AND RELATED STRUCTURES: ATYPICAL NEUROLEPTICS |
| WO2005063254A3 (en) * | 2003-12-22 | 2005-09-15 | Acadia Pharm Inc | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| US7491715B2 (en) | 2003-12-22 | 2009-02-17 | Acadia Pharmaceuticals, Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| US7517871B2 (en) | 2003-12-22 | 2009-04-14 | Acadia Pharmaceuticals, Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| US7550454B2 (en) | 2003-12-22 | 2009-06-23 | Acadia Pharmaceuticals, Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| US7622461B2 (en) | 2003-12-22 | 2009-11-24 | Acadia Pharmaceuticals Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| WO2007053618A1 (en) * | 2005-10-31 | 2007-05-10 | Acadia Pharmaceuticals Inc. | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| EP1951694A4 (en) * | 2005-11-18 | 2010-09-22 | Astrazeneca Ab | FORMS OF SALTS |
Also Published As
| Publication number | Publication date |
|---|---|
| FR8046M (enExample) | 1970-08-10 |
| NL6803570A (enExample) | 1968-09-16 |
| AT292716B (de) | 1971-08-15 |
| BE712114A (enExample) | 1968-09-13 |
| DE1720007A1 (de) | 1971-05-19 |
| NO123459B (enExample) | 1971-11-22 |
| IL29571A (en) | 1972-04-27 |
| AT292707B (de) | 1971-09-10 |
| AT292718B (de) | 1971-08-15 |
| SE364277B (enExample) | 1974-02-18 |
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