GB1195066A - Quinazolinones and Pharmaceutical Compositions thereof - Google Patents
Quinazolinones and Pharmaceutical Compositions thereofInfo
- Publication number
- GB1195066A GB1195066A GB3835867A GB3835867A GB1195066A GB 1195066 A GB1195066 A GB 1195066A GB 3835867 A GB3835867 A GB 3835867A GB 3835867 A GB3835867 A GB 3835867A GB 1195066 A GB1195066 A GB 1195066A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- general formula
- compound
- quinazoline
- chlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- WHRYTRKRNRTOMA-UHFFFAOYSA-N 4-(4-chlorophenyl)-1,4-dihydroquinazoline Chemical compound ClC1=CC=C(C=C1)C1NC=NC2=CC=CC=C12 WHRYTRKRNRTOMA-UHFFFAOYSA-N 0.000 abstract 1
- FWPKSFDJKMOBHR-UHFFFAOYSA-N 4-(4-chlorophenyl)quinazoline Chemical compound C1=CC(Cl)=CC=C1C1=NC=NC2=CC=CC=C12 FWPKSFDJKMOBHR-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- SXTULILTUYKOHV-UHFFFAOYSA-N [Li]C1=CC=C(Cl)C=C1 Chemical compound [Li]C1=CC=C(Cl)C=C1 SXTULILTUYKOHV-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57551166A | 1966-08-29 | 1966-08-29 | |
| US63601567A | 1967-05-04 | 1967-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1195066A true GB1195066A (en) | 1970-06-17 |
Family
ID=27076715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3835867A Expired GB1195066A (en) | 1966-08-29 | 1967-08-21 | Quinazolinones and Pharmaceutical Compositions thereof |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH487902A (enrdf_load_stackoverflow) |
| DE (1) | DE1695769C3 (enrdf_load_stackoverflow) |
| ES (2) | ES344534A1 (enrdf_load_stackoverflow) |
| FR (1) | FR1571271A (enrdf_load_stackoverflow) |
| GB (1) | GB1195066A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102782A3 (en) * | 2001-06-15 | 2003-05-01 | Novartis Ag | QUINAZOLINE DERIVATIVES which PROMOTE THE RELEASE OF PARATHYROID_HORMONE |
| US7696216B2 (en) | 2002-12-23 | 2010-04-13 | Novartis Ag | Aryl-quinazoline/aryl-2-amino-phenyl methanone derivatives |
-
1967
- 1967-08-16 CH CH1152967A patent/CH487902A/de not_active IP Right Cessation
- 1967-08-21 GB GB3835867A patent/GB1195066A/en not_active Expired
- 1967-08-25 DE DE1967S0111538 patent/DE1695769C3/de not_active Expired
- 1967-08-28 ES ES344534A patent/ES344534A1/es not_active Expired
- 1967-08-28 FR FR1571271D patent/FR1571271A/fr not_active Expired
- 1967-09-23 ES ES345400A patent/ES345400A1/es not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102782A3 (en) * | 2001-06-15 | 2003-05-01 | Novartis Ag | QUINAZOLINE DERIVATIVES which PROMOTE THE RELEASE OF PARATHYROID_HORMONE |
| EP2191832A1 (en) * | 2001-06-15 | 2010-06-02 | Novartis AG | Quinazoline derivatives which promote the release of parathyroid hormone |
| US8476286B2 (en) | 2001-06-15 | 2013-07-02 | Novartis Ag | Quinazoline derivatives which promote the release of parathyroid hormone |
| US7696216B2 (en) | 2002-12-23 | 2010-04-13 | Novartis Ag | Aryl-quinazoline/aryl-2-amino-phenyl methanone derivatives |
| US8569317B2 (en) | 2002-12-23 | 2013-10-29 | Novartis Ag | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1571271A (enrdf_load_stackoverflow) | 1969-06-20 |
| DE1695769B2 (de) | 1979-07-05 |
| DE1695769A1 (de) | 1971-04-29 |
| ES345400A1 (es) | 1969-02-01 |
| CH487902A (de) | 1970-03-31 |
| ES344534A1 (es) | 1968-12-16 |
| DE1695769C3 (de) | 1980-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |