GB1453643A - Bis-benzyl-acetic acid derivatives - Google Patents

Bis-benzyl-acetic acid derivatives

Info

Publication number
GB1453643A
GB1453643A GB695374A GB695374A GB1453643A GB 1453643 A GB1453643 A GB 1453643A GB 695374 A GB695374 A GB 695374A GB 695374 A GB695374 A GB 695374A GB 1453643 A GB1453643 A GB 1453643A
Authority
GB
United Kingdom
Prior art keywords
compounds
ethyl
methyl
hydrogen
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB695374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1453643A publication Critical patent/GB1453643A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1453643 Bis(p - acyl - benzyl) - acetic acids and -malonic acid esters SANDOZ Ltd 15 Feb 1974 [20 Feb 1973 3 Oct 1973] 6953/74 Heading C2C The invention comprises novel compounds of the Formula I in which R 1 is hydrogen, fluorine, chlorine, or straight chain C 1-4 alkoxy, R 2 is methyl or ethyl, R 3 is methyl or ethyl wherein each R 1 , R 2 and/ or R 3 may be the same or different and either (i) X is hydrogen and Y is COOH or (ii) both X and Y are COOR 4 wherein each R 4 is C 1-4 alkyl provided that when the R 1 's are hydrogen and the R 2 's and R 3 's are methyl, both R 4 's are not ethyl, and salts of (i). The compounds (ii) may be prepared by reacting a compound of the Formula III wherein X is bromine or chlorine with a compound of the Formula IV wherein D is an alkali metal and the compounds (i) may be prepared by hydrolysis followed by decarboxylation of the compounds (1). α-Bromo-p-pivaloyltoluene may be prepared by forming a Grignard reagent from 4-bromotoluene and reacting it with pivaloyl chloride to yield p-pivaloyltoluene followed by free radical bromination. Pharmaceutical compositions of the compounds I when administered orally with the usual excipients show hypolipidemic and especially hypolipoproteinemic activity.
GB695374A 1973-02-20 1974-02-15 Bis-benzyl-acetic acid derivatives Expired GB1453643A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33389273A 1973-02-20 1973-02-20
US40322573A 1973-10-03 1973-10-03

Publications (1)

Publication Number Publication Date
GB1453643A true GB1453643A (en) 1976-10-27

Family

ID=26988943

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2533876A Expired GB1453644A (en) 1973-02-20 1974-02-15 Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by
GB695374A Expired GB1453643A (en) 1973-02-20 1974-02-15 Bis-benzyl-acetic acid derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2533876A Expired GB1453644A (en) 1973-02-20 1974-02-15 Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by

Country Status (16)

Country Link
JP (1) JPS5029534A (en)
AT (1) AT346308B (en)
CA (1) CA1043807A (en)
CH (1) CH591418A5 (en)
CS (1) CS170510B2 (en)
DD (1) DD110033A5 (en)
DE (1) DE2406881A1 (en)
ES (1) ES423376A1 (en)
FR (1) FR2218106B1 (en)
GB (2) GB1453644A (en)
HU (1) HU168102B (en)
IE (1) IE39419B1 (en)
IL (1) IL44224A (en)
NL (1) NL7402093A (en)
PH (1) PH10682A (en)
SE (1) SE399554B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3607728A1 (en) * 1986-01-25 1987-07-30 Telefonbau & Normalzeit Gmbh TERMINAL OF A TELECOMMUNICATION SYSTEM

Also Published As

Publication number Publication date
FR2218106B1 (en) 1978-01-13
GB1453644A (en) 1976-10-27
DE2406881A1 (en) 1974-08-29
DD110033A5 (en) 1974-12-05
AU6577274A (en) 1975-08-21
HU168102B (en) 1976-02-28
CA1043807A (en) 1978-12-05
NL7402093A (en) 1974-08-22
AT346308B (en) 1978-11-10
IL44224A0 (en) 1974-05-16
IE39419B1 (en) 1978-10-11
CH591418A5 (en) 1977-09-15
PH10682A (en) 1977-08-10
ATA125874A (en) 1978-03-15
ES423376A1 (en) 1976-09-16
JPS5029534A (en) 1975-03-25
CS170510B2 (en) 1976-08-27
SE399554B (en) 1978-02-20
IE39419L (en) 1974-08-20
FR2218106A1 (en) 1974-09-13
IL44224A (en) 1977-11-30

Similar Documents

Publication Publication Date Title
GB1291639A (en) Xanthenyl alkanoic acid derivatives and pharmaceutical compositions containing them
GB1369542A (en) Substituted indenylalkanoic acids
GB1467110A (en) 4-phenyl-5-oxo-heptenoic acids
GB1453643A (en) Bis-benzyl-acetic acid derivatives
GB1228615A (en)
GB1430693A (en) Preparation of phenyl propionic acid derivatives
GB1496491A (en) Dihydroergopeptine derivatives
GB1252329A (en)
GB1273705A (en) A method for producing 3,5-diaryl-4-pyrazole acetic acids
GB1164555A (en) New Tropine Derivatives
GB1370028A (en) Substituted indenyl acetic acid derivatives
GB1481465A (en) Thiazole derivatives and the production thereof
GB1411700A (en) Penicillins and production thereof
GB1382267A (en) Phenylalkanoic acid derivatives
GB1306404A (en) Indenopyridine derivatives
GB1257266A (en)
GB1512537A (en) 2-(2'-aryl-6'-chromonyl) propionic acids and analgesic and anti-inflammatory derivatives thereof
GB1430912A (en) 8-beta-hydroxyethyl-ergoline derivatives
GB1310606A (en) Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them
GB1147626A (en) Thiazole derivatives
GB1200981A (en) Novel bis-p-chlorophenoxy-acetic acid esters, the preparation thereof and compositions containing the same
GB1457066A (en) Thiazolo 5,4-f-quinoline-8-carboxylic acid derivatives and a method for the preparation thereof
IE34016B1 (en) New omikron-anilino-phenylethyl alcohols, the production thereof and compositions containing same
GB1389164A (en) 2- 1-aminoethyl phenothiazines and compositions containing them
GB1428094A (en) Derivatives of 2-methylchromone and preparation thereof

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee