GB1453643A - Bis-benzyl-acetic acid derivatives - Google Patents
Bis-benzyl-acetic acid derivativesInfo
- Publication number
- GB1453643A GB1453643A GB695374A GB695374A GB1453643A GB 1453643 A GB1453643 A GB 1453643A GB 695374 A GB695374 A GB 695374A GB 695374 A GB695374 A GB 695374A GB 1453643 A GB1453643 A GB 1453643A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- ethyl
- methyl
- hydrogen
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1453643 Bis(p - acyl - benzyl) - acetic acids and -malonic acid esters SANDOZ Ltd 15 Feb 1974 [20 Feb 1973 3 Oct 1973] 6953/74 Heading C2C The invention comprises novel compounds of the Formula I in which R 1 is hydrogen, fluorine, chlorine, or straight chain C 1-4 alkoxy, R 2 is methyl or ethyl, R 3 is methyl or ethyl wherein each R 1 , R 2 and/ or R 3 may be the same or different and either (i) X is hydrogen and Y is COOH or (ii) both X and Y are COOR 4 wherein each R 4 is C 1-4 alkyl provided that when the R 1 's are hydrogen and the R 2 's and R 3 's are methyl, both R 4 's are not ethyl, and salts of (i). The compounds (ii) may be prepared by reacting a compound of the Formula III wherein X is bromine or chlorine with a compound of the Formula IV wherein D is an alkali metal and the compounds (i) may be prepared by hydrolysis followed by decarboxylation of the compounds (1). α-Bromo-p-pivaloyltoluene may be prepared by forming a Grignard reagent from 4-bromotoluene and reacting it with pivaloyl chloride to yield p-pivaloyltoluene followed by free radical bromination. Pharmaceutical compositions of the compounds I when administered orally with the usual excipients show hypolipidemic and especially hypolipoproteinemic activity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33389273A | 1973-02-20 | 1973-02-20 | |
US40322573A | 1973-10-03 | 1973-10-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1453643A true GB1453643A (en) | 1976-10-27 |
Family
ID=26988943
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2533876A Expired GB1453644A (en) | 1973-02-20 | 1974-02-15 | Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by |
GB695374A Expired GB1453643A (en) | 1973-02-20 | 1974-02-15 | Bis-benzyl-acetic acid derivatives |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2533876A Expired GB1453644A (en) | 1973-02-20 | 1974-02-15 | Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS5029534A (en) |
AT (1) | AT346308B (en) |
CA (1) | CA1043807A (en) |
CH (1) | CH591418A5 (en) |
CS (1) | CS170510B2 (en) |
DD (1) | DD110033A5 (en) |
DE (1) | DE2406881A1 (en) |
ES (1) | ES423376A1 (en) |
FR (1) | FR2218106B1 (en) |
GB (2) | GB1453644A (en) |
HU (1) | HU168102B (en) |
IE (1) | IE39419B1 (en) |
IL (1) | IL44224A (en) |
NL (1) | NL7402093A (en) |
PH (1) | PH10682A (en) |
SE (1) | SE399554B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3607728A1 (en) * | 1986-01-25 | 1987-07-30 | Telefonbau & Normalzeit Gmbh | TERMINAL OF A TELECOMMUNICATION SYSTEM |
-
1974
- 1974-02-08 CH CH176774A patent/CH591418A5/xx not_active IP Right Cessation
- 1974-02-11 SE SE7401786A patent/SE399554B/en unknown
- 1974-02-13 DE DE19742406881 patent/DE2406881A1/en not_active Withdrawn
- 1974-02-15 GB GB2533876A patent/GB1453644A/en not_active Expired
- 1974-02-15 NL NL7402093A patent/NL7402093A/xx not_active Application Discontinuation
- 1974-02-15 GB GB695374A patent/GB1453643A/en not_active Expired
- 1974-02-18 CS CS1168A patent/CS170510B2/cs unknown
- 1974-02-18 AT AT125874A patent/AT346308B/en not_active IP Right Cessation
- 1974-02-18 DD DD176622A patent/DD110033A5/xx unknown
- 1974-02-18 JP JP49018655A patent/JPS5029534A/ja active Pending
- 1974-02-18 ES ES423376A patent/ES423376A1/en not_active Expired
- 1974-02-18 HU HUSA2595A patent/HU168102B/hu unknown
- 1974-02-18 CA CA192,776A patent/CA1043807A/en not_active Expired
- 1974-02-18 IL IL44224A patent/IL44224A/en unknown
- 1974-02-19 IE IE333/74A patent/IE39419B1/en unknown
- 1974-02-20 PH PH15530A patent/PH10682A/en unknown
- 1974-02-20 FR FR7405671A patent/FR2218106B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2218106B1 (en) | 1978-01-13 |
GB1453644A (en) | 1976-10-27 |
DE2406881A1 (en) | 1974-08-29 |
DD110033A5 (en) | 1974-12-05 |
AU6577274A (en) | 1975-08-21 |
HU168102B (en) | 1976-02-28 |
CA1043807A (en) | 1978-12-05 |
NL7402093A (en) | 1974-08-22 |
AT346308B (en) | 1978-11-10 |
IL44224A0 (en) | 1974-05-16 |
IE39419B1 (en) | 1978-10-11 |
CH591418A5 (en) | 1977-09-15 |
PH10682A (en) | 1977-08-10 |
ATA125874A (en) | 1978-03-15 |
ES423376A1 (en) | 1976-09-16 |
JPS5029534A (en) | 1975-03-25 |
CS170510B2 (en) | 1976-08-27 |
SE399554B (en) | 1978-02-20 |
IE39419L (en) | 1974-08-20 |
FR2218106A1 (en) | 1974-09-13 |
IL44224A (en) | 1977-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |