GB1389164A - 2- 1-aminoethyl phenothiazines and compositions containing them - Google Patents
2- 1-aminoethyl phenothiazines and compositions containing themInfo
- Publication number
- GB1389164A GB1389164A GB1217173A GB1217173A GB1389164A GB 1389164 A GB1389164 A GB 1389164A GB 1217173 A GB1217173 A GB 1217173A GB 1217173 A GB1217173 A GB 1217173A GB 1389164 A GB1389164 A GB 1389164A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethyl
- phenothiazines
- chloro
- march
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1389164 2-(1-Amino-ethyl)-phenothiazines BOTTU 14 March 1973 [23 March 1972] 12171/72 Heading C2C Novel compounds I and their acid addition salts, in which R is alkyl or dialkylaminoalkyl and X is hydrogen, halogen or alkoxy in the 7- or 8- position are prepared by reacting a compound II with a mixture of ammonium formate and formamide in the presence of magnesium chloride at a temperature of 150‹ to 190‹ C. and hydrolysing the intermediate formed in the presence of concentrated hydrochloric acid X is hydrogen, 8-chloro or 7-methoxy and R is methyl, ethyl, butyl or dimethylaminopropyl. 8 - Chloro - 2 - (1 - formamido - ethyl) - 10- methyl phenothiazine was isolated as an intermediate in one of the above reactions. Compounds I have anti-inflammatory and analgesic activity and form with a suitable vehicle a pharmaceutical composition which may be administered orally, parenterally or rectally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7210210A FR2176555B1 (en) | 1972-03-23 | 1972-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1389164A true GB1389164A (en) | 1975-04-03 |
Family
ID=9095696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1217173A Expired GB1389164A (en) | 1972-03-23 | 1973-03-14 | 2- 1-aminoethyl phenothiazines and compositions containing them |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS4911888A (en) |
BE (1) | BE796840A (en) |
CH (1) | CH565779A5 (en) |
DE (1) | DE2314041A1 (en) |
FR (1) | FR2176555B1 (en) |
GB (1) | GB1389164A (en) |
NL (1) | NL7303822A (en) |
-
1972
- 1972-03-23 FR FR7210210A patent/FR2176555B1/fr not_active Expired
-
1973
- 1973-03-14 GB GB1217173A patent/GB1389164A/en not_active Expired
- 1973-03-16 BE BE2052604A patent/BE796840A/en unknown
- 1973-03-19 NL NL7303822A patent/NL7303822A/xx not_active Application Discontinuation
- 1973-03-21 DE DE19732314041 patent/DE2314041A1/en active Pending
- 1973-03-21 CH CH409173A patent/CH565779A5/xx not_active IP Right Cessation
- 1973-03-23 JP JP3338373A patent/JPS4911888A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NL7303822A (en) | 1973-09-25 |
CH565779A5 (en) | 1975-08-29 |
FR2176555B1 (en) | 1975-08-01 |
FR2176555A1 (en) | 1973-11-02 |
BE796840A (en) | 1973-07-16 |
JPS4911888A (en) | 1974-02-01 |
DE2314041A1 (en) | 1973-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
746 | Register noted 'licences of right' (sect. 46/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |