GB1123229A - 5-hydroxy-6-methyl-cinchomeronitrile - Google Patents
5-hydroxy-6-methyl-cinchomeronitrileInfo
- Publication number
- GB1123229A GB1123229A GB2175766A GB2175766A GB1123229A GB 1123229 A GB1123229 A GB 1123229A GB 2175766 A GB2175766 A GB 2175766A GB 2175766 A GB2175766 A GB 2175766A GB 1123229 A GB1123229 A GB 1123229A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- oxazol
- alkoxy
- alkali metal
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/42—One oxygen atom attached in position 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
<FORM:1123229/C2/1> <FORM:1123229/C2/2> 5 - Hydroxy - 6 - methyl cinchomeronitrile (I) is made by reacting a (5-C1- 3 alkoxy-oxazol-4-yl) -acetic acid or an alkali metal salt thereof (IV) with fumaronitrile. The reaction is preferably effected at below 50 DEG C. in the presence of a solvent for fumaronitrile, e.g. water, or a C1- 3 carboxylic acid. Nitrogen gas may be passed into the reaction solution to assist removal of carbon dioxide evolved in the reaction. The (5 - C1- 3 alkoxy - oxazol - 4 - yl) acetic acid and the alkali metal salts thereof are prepared by reacting a di-C1- 3 alkyl N-formylaspartate (II) with phosphorus pentoxide to yield the C1- 3 alkyl (5-C1- 3 alkoxy-oxazol-4-yl) acetate (III) which is hydrolysed with an alkali metal hydroxide or carbonate to the salt of the corresponding acid; the free acid may be liberated from the salt by treatment with dilute mineral acid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2959265 | 1965-05-21 | ||
| JP4746365A JPS4811713B1 (en) | 1965-08-06 | 1965-08-06 | |
| JP7481565 | 1965-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1123229A true GB1123229A (en) | 1968-08-14 |
Family
ID=27286643
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3252667A Expired GB1123230A (en) | 1965-05-21 | 1966-05-17 | 5-hydroxy-6-methyl-cinchomeronitrile |
| GB2175766A Expired GB1123229A (en) | 1965-05-21 | 1966-05-17 | 5-hydroxy-6-methyl-cinchomeronitrile |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3252667A Expired GB1123230A (en) | 1965-05-21 | 1966-05-17 | 5-hydroxy-6-methyl-cinchomeronitrile |
Country Status (4)
| Country | Link |
|---|---|
| CH (2) | CH464919A (en) |
| DE (1) | DE1670524A1 (en) |
| GB (2) | GB1123230A (en) |
| NL (1) | NL6607005A (en) |
-
1966
- 1966-05-03 CH CH241268A patent/CH464919A/en unknown
- 1966-05-03 CH CH649866A patent/CH456595A/en unknown
- 1966-05-17 GB GB3252667A patent/GB1123230A/en not_active Expired
- 1966-05-17 GB GB2175766A patent/GB1123229A/en not_active Expired
- 1966-05-20 NL NL6607005A patent/NL6607005A/xx unknown
- 1966-05-20 DE DE19661670524 patent/DE1670524A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE1670524A1 (en) | 1972-04-20 |
| NL6607005A (en) | 1966-11-22 |
| CH456595A (en) | 1968-07-31 |
| CH464919A (en) | 1968-11-15 |
| GB1123230A (en) | 1968-08-14 |
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