GB1104938A - Improvements in or relating to 7-aminocephalosporanic acid - Google Patents
Improvements in or relating to 7-aminocephalosporanic acidInfo
- Publication number
- GB1104938A GB1104938A GB22155/64A GB2215564A GB1104938A GB 1104938 A GB1104938 A GB 1104938A GB 22155/64 A GB22155/64 A GB 22155/64A GB 2215564 A GB2215564 A GB 2215564A GB 1104938 A GB1104938 A GB 1104938A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- aca
- salt
- solution
- sulphonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 title abstract 8
- 150000003839 salts Chemical class 0.000 abstract 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- -1 hydrocarbyl sulphonic acid Chemical compound 0.000 abstract 2
- AJYXPNIENRLELY-UHFFFAOYSA-N 2-thiophen-2-ylacetyl chloride Chemical compound ClC(=O)CC1=CC=CS1 AJYXPNIENRLELY-UHFFFAOYSA-N 0.000 abstract 1
- BLUNNZYDUZHPAD-UHFFFAOYSA-N 4-methylbenzenesulfonic acid;dihydrate Chemical compound O.O.CC1=CC=C(S(O)(=O)=O)C=C1 BLUNNZYDUZHPAD-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 150000004996 alkyl benzenes Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 235000011114 ammonium hydroxide Nutrition 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- UIJGNTRUPZPVNG-UHFFFAOYSA-N benzenecarbothioic s-acid Chemical compound SC(=O)C1=CC=CC=C1 UIJGNTRUPZPVNG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- E—FIXED CONSTRUCTIONS
- E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
- E02F—DREDGING; SOIL-SHIFTING
- E02F7/00—Equipment for conveying or separating excavated material
- E02F7/10—Pipelines for conveying excavated materials
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Mining & Mineral Resources (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Civil Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Structural Engineering (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB22155/64A GB1104938A (en) | 1964-05-28 | 1964-05-28 | Improvements in or relating to 7-aminocephalosporanic acid |
| US458446A US3507860A (en) | 1964-05-28 | 1965-05-24 | Process for the purification of crude 7-aminocephalosporanic acid and acid addition salts of 7 - amino - cephalosporanic acid employed therein |
| IL23589A IL23589A (en) | 1964-05-28 | 1965-05-24 | Preparation of 7-aminocephalosporanic acid |
| CH745265A CH549051A (de) | 1964-05-28 | 1965-05-28 | Verfahren zum reinigen von 7-amino-cephalosporansaeure. |
| DK270065AA DK137191B (da) | 1964-05-28 | 1965-05-28 | 7-Aminocephalosporansyresalte til anvendelse i rensningsprocesser for rå 7-aminocephalosporansyre. |
| FR18642A FR1457319A (fr) | 1964-05-28 | 1965-05-28 | Procédé de purification de l'acide 7-aminocéphalosporanique |
| NL656506820A NL144281B (nl) | 1964-05-28 | 1965-05-28 | Werkwijze voor het zuiveren van ruw 7-aminocefalosporanzuur. |
| AT488765A AT266315B (de) | 1964-05-28 | 1965-05-28 | Verfahren zur Reinigung von roher 7-Aminocephalosporansäure |
| JP40031152A JPS499475B1 (https=) | 1964-05-28 | 1965-05-28 | |
| SE7039/65A SE317079B (https=) | 1964-05-28 | 1965-05-28 | |
| BE664646D BE664646A (https=) | 1964-05-28 | 1965-05-28 | |
| DE19651795694 DE1795694A1 (de) | 1964-05-28 | 1965-05-28 | Verfahren zur reinigung von 7-aminocephalosporansaeure |
| DE1545898A DE1545898C3 (de) | 1964-05-28 | 1965-05-28 | Verfahren zur Reinigung von 7-Aminocephalosporansäure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB22155/64A GB1104938A (en) | 1964-05-28 | 1964-05-28 | Improvements in or relating to 7-aminocephalosporanic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1104938A true GB1104938A (en) | 1968-03-06 |
Family
ID=26255771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22155/64A Expired GB1104938A (en) | 1964-05-28 | 1964-05-28 | Improvements in or relating to 7-aminocephalosporanic acid |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3507860A (https=) |
| JP (1) | JPS499475B1 (https=) |
| AT (1) | AT266315B (https=) |
| BE (1) | BE664646A (https=) |
| CH (1) | CH549051A (https=) |
| DE (2) | DE1545898C3 (https=) |
| DK (1) | DK137191B (https=) |
| FR (1) | FR1457319A (https=) |
| GB (1) | GB1104938A (https=) |
| IL (1) | IL23589A (https=) |
| NL (1) | NL144281B (https=) |
| SE (1) | SE317079B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4754030A (en) * | 1985-02-01 | 1988-06-28 | Bristol-Myers Company | Cefbuperazone crystalline triethylamine salt |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824238A (en) * | 1972-04-05 | 1974-07-16 | Squibb & Sons Inc | Method for the purification of 7-amino-desacetoxycephalosporanic acid |
| JPS5113988U (https=) * | 1974-07-13 | 1976-01-31 | ||
| SK165399A3 (en) * | 1997-06-04 | 2000-05-16 | Biochemie Gmbh | Process for the preparation of rosettes or agglomerates of 7-aminocephalosporanic acid (7-aca) |
| US6518420B2 (en) * | 1997-06-04 | 2003-02-11 | Biochemie Gesellschaft M.B.H. | Precipitation process of 7-aminocephalosporanic acid (7-ACA) |
| FR2866942B1 (fr) | 2004-03-01 | 2006-04-14 | Inst Francais Du Petrole | Connecteur pour colonne montante haute pression |
| CN102321099A (zh) * | 2011-08-15 | 2012-01-18 | 华北制药河北华民药业有限责任公司 | 一种头孢烷酸的结晶方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB953695A (en) * | 1959-08-04 | 1964-03-25 | Nat Res Dev | Derivatives of cephalosporin c |
| US3216999A (en) * | 1961-08-23 | 1965-11-09 | Lilly Co Eli | Carbocyclic cephalosporins |
-
1964
- 1964-05-28 GB GB22155/64A patent/GB1104938A/en not_active Expired
-
1965
- 1965-05-24 IL IL23589A patent/IL23589A/en unknown
- 1965-05-24 US US458446A patent/US3507860A/en not_active Expired - Lifetime
- 1965-05-28 DK DK270065AA patent/DK137191B/da unknown
- 1965-05-28 NL NL656506820A patent/NL144281B/xx not_active IP Right Cessation
- 1965-05-28 BE BE664646D patent/BE664646A/xx not_active IP Right Cessation
- 1965-05-28 DE DE1545898A patent/DE1545898C3/de not_active Expired
- 1965-05-28 SE SE7039/65A patent/SE317079B/xx unknown
- 1965-05-28 FR FR18642A patent/FR1457319A/fr not_active Expired
- 1965-05-28 JP JP40031152A patent/JPS499475B1/ja active Pending
- 1965-05-28 DE DE19651795694 patent/DE1795694A1/de active Pending
- 1965-05-28 CH CH745265A patent/CH549051A/de not_active IP Right Cessation
- 1965-05-28 AT AT488765A patent/AT266315B/de active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4754030A (en) * | 1985-02-01 | 1988-06-28 | Bristol-Myers Company | Cefbuperazone crystalline triethylamine salt |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1545898A1 (de) | 1970-04-30 |
| NL144281B (nl) | 1974-12-16 |
| DK137191B (da) | 1978-01-30 |
| BE664646A (https=) | 1965-11-29 |
| AT266315B (de) | 1968-11-11 |
| DE1795694A1 (de) | 1974-02-28 |
| DE1545898C3 (de) | 1975-11-06 |
| CH549051A (de) | 1974-05-15 |
| SE317079B (https=) | 1969-11-10 |
| US3507860A (en) | 1970-04-21 |
| NL6506820A (https=) | 1965-11-29 |
| IL23589A (en) | 1969-04-30 |
| FR1457319A (fr) | 1966-11-04 |
| DE1545898B2 (de) | 1975-03-13 |
| DK137191C (https=) | 1978-07-03 |
| JPS499475B1 (https=) | 1974-03-05 |
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