GB1077392A - New steroids - Google Patents
New steroidsInfo
- Publication number
- GB1077392A GB1077392A GB17027/65A GB1702765A GB1077392A GB 1077392 A GB1077392 A GB 1077392A GB 17027/65 A GB17027/65 A GB 17027/65A GB 1702765 A GB1702765 A GB 1702765A GB 1077392 A GB1077392 A GB 1077392A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroid
- azido
- pregnane
- oxazolines
- acyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000003128 pregnanes Chemical class 0.000 abstract 3
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000003637 steroidlike Effects 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- JUINSXZKUKVTMD-UHFFFAOYSA-N hydrogen azide Chemical compound N=[N+]=[N-] JUINSXZKUKVTMD-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000002918 oxazolines Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0027—Azides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/0025—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
- C07J7/0035—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16 by a hydroxy group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0068—Nitrogen and oxygen at position 16(17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Machines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL128816D NL128816C (OSRAM) | 1965-04-22 | ||
| GB17027/65A GB1077392A (en) | 1965-04-22 | 1965-04-22 | New steroids |
| US538574A US3436389A (en) | 1965-04-22 | 1966-03-30 | Steroid-(17alpha,16alpha-d)oxazolines and method for their preparation |
| US538555A US3413286A (en) | 1965-04-22 | 1966-03-30 | [17alpha,16alpha-d]oxazoline pregnanes and process therefor |
| IL25494A IL25494A (en) | 1965-04-22 | 1966-03-30 | Pregnano(17alpha,16alpha-d)oxazolines |
| IL25493A IL25493A (en) | 1965-04-22 | 1966-03-30 | Pregnano(17alpha,16alpha-d)oxazolines |
| NO00162506A NO127346B (OSRAM) | 1965-04-22 | 1966-04-06 | |
| NO00162597A NO128152B (OSRAM) | 1965-04-22 | 1966-04-15 | |
| FI660985A FI44905C (fi) | 1965-04-22 | 1966-04-16 | Menetelmä 20-okso-pregnaani-, 20-okso-4-pregneeni- tai 20-okso-5(6)-pr egneeni-(17alfa, 16alfa-d)-oksatsoliinien valmistamiseksi |
| FI660986A FI44906C (fi) | 1965-04-22 | 1966-04-16 | Analogiamenetelmä terapeuttisesti aktiivisten 11beta, 21-dihydroksi-3, 20-dionien tai 21-hydroksi-3,11,20-trioni-pregna-1,4-dieeni-(17alfa,16 alfa-d)-2'-metyylioksatsoliinien tai näiden 21-esterien valmistamiseks i |
| BR178805/66A BR6678805D0 (pt) | 1965-04-22 | 1966-04-18 | Novos esteroides e processo de sua obtencao |
| NL6605174A NL6605174A (OSRAM) | 1965-04-22 | 1966-04-18 | |
| DE1793662A DE1793662C3 (de) | 1965-04-22 | 1966-04-20 | 4 Pregnen 3,20 dion eckige Klammer auf 17 alpha, 16 alpha d eckige Klammer zu 2' methyloxazohn und Verfahren zu seiner Herstellung Ausscheidung aus 1568950 |
| DE19661568950 DE1568950A1 (de) | 1965-04-22 | 1966-04-20 | Steroid-[17alpha,16alpha-d]-oxazoline und Verfahren zu ihrer Herstellung |
| DK204166AA DK117631B (da) | 1965-04-22 | 1966-04-21 | Fremgangsmåde til fremstilling af 20-oxopregnan-, 20-oxo-4-pregnen- eller 20-oxo-5(6)-pregnen-(17α, 16α-d)-oxazoliner. |
| DK204266AA DK116870B (da) | 1965-04-22 | 1966-04-21 | Analogifremgangsmåde til fremstilling af terapeutisk virksomme 11β,21-dihydroxy-3,20-dioxo- eller 21-hydroxy-3,11,20-trioxo-pregna-1,4-dien-(17α 16&alpha,-d)-2'metyloxazoliner eller 21-estere deraf. |
| BE679820D BE679820A (OSRAM) | 1965-04-22 | 1966-04-21 | |
| SE5443/66A SE323674B (OSRAM) | 1965-04-22 | 1966-04-21 | |
| ES0325755A ES325755A1 (es) | 1965-04-22 | 1966-04-21 | Procedimiento para la preparacion de una esteroide- (17 alfa16 alfa-d) - oxazolidina. |
| DE19661568951 DE1568951A1 (de) | 1965-04-22 | 1966-04-21 | Verfahren zur Herstellung von Steroid[17alpha,16alphad]-oxazolinen |
| NL6605375A NL6605375A (OSRAM) | 1965-04-22 | 1966-04-21 | |
| SE5444/66A SE323675B (OSRAM) | 1965-04-22 | 1966-04-21 | |
| BE679821A BE679821A (OSRAM) | 1965-04-22 | 1966-04-21 | |
| FR58756A FR1482237A (fr) | 1965-04-22 | 1966-04-22 | Procédé pour la préparation de stéroïde-[17alpha, 16alpha-d] oxazolines |
| FR58757A FR1477166A (fr) | 1965-04-22 | 1966-04-22 | Procédé de préparation de dérivés stéroïde-[17alpha, 16alpha-d] oxazolines, substitués en 21 |
| CH584666A CH471833A (fr) | 1965-04-22 | 1966-04-22 | Procédé de préparation de stéroïdes-oxazolines |
| CH584766A CH453351A (fr) | 1965-04-22 | 1966-04-22 | Procédé de préparation de stéroïdes |
| AT382266A AT265539B (de) | 1965-04-22 | 1966-04-22 | Verfahren zur Herstellung neuer Steroid- [17α,16α-d]-oxazoline |
| AT382766A AT260440B (de) | 1965-04-22 | 1966-04-22 | Verfahren zur Herstellung neuer Steroide |
| BR179615/66A BR6679615D0 (pt) | 1965-04-22 | 1966-05-18 | Novos esteroides e processo de sua obtencao |
| FR70013A FR5645M (OSRAM) | 1965-04-22 | 1966-07-20 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB17027/65A GB1077392A (en) | 1965-04-22 | 1965-04-22 | New steroids |
| GB3586565 | 1965-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1077392A true GB1077392A (en) | 1967-07-26 |
Family
ID=26252388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17027/65A Expired GB1077392A (en) | 1965-04-22 | 1965-04-22 | New steroids |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US3436389A (OSRAM) |
| AT (2) | AT260440B (OSRAM) |
| BE (2) | BE679820A (OSRAM) |
| BR (2) | BR6678805D0 (OSRAM) |
| CH (2) | CH471833A (OSRAM) |
| DE (3) | DE1793662C3 (OSRAM) |
| DK (2) | DK117631B (OSRAM) |
| ES (1) | ES325755A1 (OSRAM) |
| FI (2) | FI44906C (OSRAM) |
| FR (1) | FR5645M (OSRAM) |
| GB (1) | GB1077392A (OSRAM) |
| IL (2) | IL25494A (OSRAM) |
| NL (3) | NL6605174A (OSRAM) |
| NO (2) | NO127346B (OSRAM) |
| SE (2) | SE323674B (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3146785A1 (de) * | 1980-11-26 | 1982-07-01 | Gruppo Lepetit S.p.A., 20158 Milano | "verfahren zur herstellung von 16(alpha)-hydroxy-17(alpha)-aminopregnanderivaten und ihre verwendung" |
| CN101177443B (zh) * | 2006-11-09 | 2011-08-03 | 天津药业研究院有限公司 | 新的甾体化合物及其应用 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1119081A (en) * | 1966-01-11 | 1968-07-10 | Lepetit Spa | New steroids |
| IT1141930B (it) * | 1980-04-28 | 1986-10-08 | Lepetit Spa | Esteri idrosolubili di steroido-ossazoli e loro composizioni farmaceutiche |
| CA2537185A1 (en) * | 2003-08-29 | 2005-03-10 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-iv |
| EP1694655A2 (en) * | 2003-11-26 | 2006-08-30 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
| US20080009535A1 (en) * | 2004-08-30 | 2008-01-10 | Sarala Balachandran | Inhibitors of phosphodiesterase type-IV |
| WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| US20090054382A1 (en) * | 2005-10-19 | 2009-02-26 | Abhijit Ray | Compositions of phosphodiesterase type iv inhibitors |
| JP2009512676A (ja) | 2005-10-19 | 2009-03-26 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性受容体アンタゴニストの医薬組成物 |
| US20100029728A1 (en) * | 2006-09-22 | 2010-02-04 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
| AU2007298549A1 (en) * | 2006-09-22 | 2008-03-27 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-IV |
| EP1958947A1 (en) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type 4 |
| CN103497185A (zh) * | 2007-03-14 | 2014-01-08 | 兰贝克赛实验室有限公司 | 用作磷酸二酯酶抑制剂的吡唑并(3,4-b)吡啶衍生物 |
| EP2124943A1 (en) * | 2007-03-14 | 2009-12-02 | Ranbaxy Laboratories Limited | Pyrazolo [3, 4-b]pyridine derivatives as phosphodiesterase inhibitors |
| EP2111861A1 (en) | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2874154A (en) * | 1954-10-15 | 1959-02-17 | Syntex Sa | Process for the production of 20-keto-21-iodo steroids |
| US2923721A (en) * | 1955-12-13 | 1960-02-02 | Lab Francais Chimiotherapie | Method of preparing 3-keto delta1, 4 steroids |
| DE1223376B (de) * | 1963-12-14 | 1966-08-25 | Hoechst Ag | Verfahren zur Herstellung von 17alpha-Cyan-16alpha-hydroxy-steroiden der Pregnanreihe |
| US3349084A (en) * | 1965-05-17 | 1967-10-24 | Upjohn Co | Steroidal [16, 17-d]-2'-isoxazolines of the pregnane series |
-
0
- NL NL128816D patent/NL128816C/xx active
-
1965
- 1965-04-22 GB GB17027/65A patent/GB1077392A/en not_active Expired
-
1966
- 1966-03-30 US US538574A patent/US3436389A/en not_active Expired - Lifetime
- 1966-03-30 US US538555A patent/US3413286A/en not_active Expired - Lifetime
- 1966-03-30 IL IL25494A patent/IL25494A/xx unknown
- 1966-03-30 IL IL25493A patent/IL25493A/en unknown
- 1966-04-06 NO NO00162506A patent/NO127346B/no unknown
- 1966-04-15 NO NO00162597A patent/NO128152B/no unknown
- 1966-04-16 FI FI660986A patent/FI44906C/fi active
- 1966-04-16 FI FI660985A patent/FI44905C/fi active
- 1966-04-18 BR BR178805/66A patent/BR6678805D0/pt unknown
- 1966-04-18 NL NL6605174A patent/NL6605174A/xx unknown
- 1966-04-20 DE DE1793662A patent/DE1793662C3/de not_active Expired
- 1966-04-20 DE DE19661568950 patent/DE1568950A1/de active Pending
- 1966-04-21 DE DE19661568951 patent/DE1568951A1/de active Pending
- 1966-04-21 NL NL6605375A patent/NL6605375A/xx unknown
- 1966-04-21 BE BE679820D patent/BE679820A/xx not_active IP Right Cessation
- 1966-04-21 DK DK204166AA patent/DK117631B/da unknown
- 1966-04-21 SE SE5443/66A patent/SE323674B/xx unknown
- 1966-04-21 BE BE679821A patent/BE679821A/xx not_active IP Right Cessation
- 1966-04-21 DK DK204266AA patent/DK116870B/da unknown
- 1966-04-21 SE SE5444/66A patent/SE323675B/xx unknown
- 1966-04-21 ES ES0325755A patent/ES325755A1/es not_active Expired
- 1966-04-22 CH CH584666A patent/CH471833A/fr not_active IP Right Cessation
- 1966-04-22 AT AT382766A patent/AT260440B/de active
- 1966-04-22 AT AT382266A patent/AT265539B/de active
- 1966-04-22 CH CH584766A patent/CH453351A/fr unknown
- 1966-05-18 BR BR179615/66A patent/BR6679615D0/pt unknown
- 1966-07-20 FR FR70013A patent/FR5645M/fr not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3146785A1 (de) * | 1980-11-26 | 1982-07-01 | Gruppo Lepetit S.p.A., 20158 Milano | "verfahren zur herstellung von 16(alpha)-hydroxy-17(alpha)-aminopregnanderivaten und ihre verwendung" |
| CN101177443B (zh) * | 2006-11-09 | 2011-08-03 | 天津药业研究院有限公司 | 新的甾体化合物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1568950A1 (de) | 1970-11-26 |
| BR6678805D0 (pt) | 1973-09-18 |
| NL128816C (OSRAM) | |
| DE1568951A1 (de) | 1970-06-18 |
| NL6605375A (OSRAM) | 1966-10-24 |
| FR5645M (OSRAM) | 1967-12-26 |
| BE679821A (OSRAM) | 1966-10-03 |
| US3413286A (en) | 1968-11-26 |
| IL25494A (en) | 1970-03-22 |
| NO128152B (OSRAM) | 1973-10-08 |
| NL6605174A (OSRAM) | 1966-10-24 |
| IL25493A (en) | 1969-12-31 |
| DK117631B (da) | 1970-05-19 |
| DE1793662B2 (de) | 1973-04-19 |
| ES325755A1 (es) | 1967-02-16 |
| FI44906B (OSRAM) | 1971-11-01 |
| CH471833A (fr) | 1969-04-30 |
| US3436389A (en) | 1969-04-01 |
| CH453351A (fr) | 1968-06-14 |
| DE1793662C3 (de) | 1973-11-08 |
| FI44905B (OSRAM) | 1971-11-01 |
| DE1793662A1 (de) | 1972-08-03 |
| DK116870B (da) | 1970-02-23 |
| SE323675B (OSRAM) | 1970-05-11 |
| NO127346B (OSRAM) | 1973-06-12 |
| BR6679615D0 (pt) | 1973-10-23 |
| BE679820A (OSRAM) | 1966-10-03 |
| AT260440B (de) | 1968-03-11 |
| SE323674B (OSRAM) | 1970-05-11 |
| FI44906C (fi) | 1972-02-10 |
| AT265539B (de) | 1968-10-10 |
| FI44905C (fi) | 1972-02-10 |
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