GB1119082A - New steroids - Google Patents
New steroidsInfo
- Publication number
- GB1119082A GB1119082A GB145167A GB145167A GB1119082A GB 1119082 A GB1119082 A GB 1119082A GB 145167 A GB145167 A GB 145167A GB 145167 A GB145167 A GB 145167A GB 1119082 A GB1119082 A GB 1119082A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- oxazoline
- group
- halohydroxylation
- steroid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises steroido-oxazolines of the formula <FORM:1119082/C2/1> wherein X represents a halogen atom, R represents hydrogen or a hydroxy or acyloxy group and R1 represents hydrogen, an alkyl group having up to eight carbon atoms or a phenyl group and a process for the production of a 9a -halo-11b -hydroxy-[17a , 16a -d]-oxazoline steroid of the pregnane series which comprises subjecting a corresponding pregn- 9 (11)-ene-[17a , 16a -d] -oxazoline steroid to halohydroxylation to introduce a 9a -halogen atom and an 11b -hydroxy group or by cle*?*ving the epoxy group of a corresponding [17a , 16a -d]-oxazoline of the pregnane series with a hydrohalogenating agent. Halohydroxylation may be effected by means of an N-haloamide of an aliphatic monocarboxylic acid or an N-haloimide of an aliphatic dicarboxylic acid followed by a hydroxylating agent such as perchloric acid. The 9b , 11b -epoxide may be obtained by epoxidation of a corresponding 9a -halo-11b -hydroxy-compound by reaction with a base. Pharmaceutical compositions having anti-inflammatory properties comprise the above compounds and a pharmaceutical carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB145267 | 1966-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1119082A true GB1119082A (en) | 1968-07-10 |
Family
ID=9722244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB145167A Expired GB1119082A (en) | 1966-07-11 | 1966-01-11 | New steroids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1119082A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2245042A1 (en) * | 2007-12-21 | 2010-11-03 | Schering Corporation | C20-c21 substituted glucocorticoid receptor agonists |
-
1966
- 1966-01-11 GB GB145167A patent/GB1119082A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2245042A1 (en) * | 2007-12-21 | 2010-11-03 | Schering Corporation | C20-c21 substituted glucocorticoid receptor agonists |
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