GB1094808A - Unsaturated des-a steroid compounds, and processes for their preparation - Google Patents
Unsaturated des-a steroid compounds, and processes for their preparationInfo
- Publication number
- GB1094808A GB1094808A GB17463/67A GB1746367A GB1094808A GB 1094808 A GB1094808 A GB 1094808A GB 17463/67 A GB17463/67 A GB 17463/67A GB 1746367 A GB1746367 A GB 1746367A GB 1094808 A GB1094808 A GB 1094808A
- Authority
- GB
- United Kingdom
- Prior art keywords
- des
- dinor
- pregn
- dialkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel des-A-steroids having the formulae <FORM:1094808/C2/1> <FORM:1094808/C2/2> <FORM:1094808/C2/3> <FORM:1094808/C2/4> wherein R and R1 are each an alkyl radical containing 1-4 carbon atoms, "Acyl" represents an acyl group and R2 and R3 are each an alkyl group or, together with the nitrogen atom, form a heterocyclic ring system, are obtained by subjecting a 5-methoxy-13b ,17a -alkyl-20-hydroxy - des - A - 18,19 - dinor - pregna-5,7,9-triene to a Birch reduction and to treatment with a weak organic acid or dilute mineral acid so as to form the desired 13b ,17a -dialkyl-20-hydroxy - des - A - 18,19 - dinor - pregn - 8 - en-5-one, reacting the latter with a concentrated mineral acid so as to form the corresponding 13b ,17a - dialkyl - 20 - hydroxy - des - A - 18,19-dinor-pregn -9-en-5-one, acylating the latter so as to form the corresponding 13b ,17a -dialkyl-20 - acyloxy - des - A - 18,19 - dinor - pregn-9-en-5-one and reacting the latter with a secondary amine R2R3NH (wherein R2 and R3 are each an alkyl group or together with the nitrogen atom, form a heterocyclic ring system) so as to form the desired 5-enamino-13b ,17a -dialkyl-20-acyloxy - des - A - 18,19 - nor - pregn - 5(10), 9(11)-diene.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR993811A FR1492772A (en) | 1964-11-04 | 1964-11-04 | New triene steroid derivatives and method of preparation |
| FR15549A FR6534M (en) | 1964-11-04 | 1965-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1094808A true GB1094808A (en) | 1967-12-13 |
Family
ID=26163557
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17462/67A Expired GB1094807A (en) | 1964-11-04 | 1965-11-04 | Unsaturated des-a steroid compounds, and processes for their preparation |
| GB17463/67A Expired GB1094808A (en) | 1964-11-04 | 1965-11-04 | Unsaturated des-a steroid compounds, and processes for their preparation |
| GB46744/65A Expired GB1094806A (en) | 1964-11-04 | 1965-11-04 | Unsaturated steroid compounds and processes for their preparation |
| GB17465/67A Expired GB1094810A (en) | 1964-11-04 | 1965-11-04 | Unsaturated 4,5-seco-steroid compounds, and processes for their preparation |
| GB17464/67A Expired GB1094809A (en) | 1964-11-04 | 1965-11-04 | Unsaturated 4,5-seco-steroid compounds, and processes for their preparation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17462/67A Expired GB1094807A (en) | 1964-11-04 | 1965-11-04 | Unsaturated des-a steroid compounds, and processes for their preparation |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB46744/65A Expired GB1094806A (en) | 1964-11-04 | 1965-11-04 | Unsaturated steroid compounds and processes for their preparation |
| GB17465/67A Expired GB1094810A (en) | 1964-11-04 | 1965-11-04 | Unsaturated 4,5-seco-steroid compounds, and processes for their preparation |
| GB17464/67A Expired GB1094809A (en) | 1964-11-04 | 1965-11-04 | Unsaturated 4,5-seco-steroid compounds, and processes for their preparation |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE671482A (en) |
| BR (2) | BR6574582D0 (en) |
| CH (2) | CH448079A (en) |
| DE (1) | DE1468940A1 (en) |
| DK (2) | DK111891B (en) |
| FR (2) | FR1492772A (en) |
| GB (5) | GB1094807A (en) |
| IL (4) | IL24528A (en) |
| NL (3) | NL6514226A (en) |
| SE (2) | SE309234B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2305099C2 (en) * | 2001-12-19 | 2007-08-27 | Орто-Макнейл Фармасьютикал, Инк. | Tetracyclic heterocompounds as estrogen receptor modulating agents |
| US7105679B2 (en) | 2001-12-19 | 2006-09-12 | Kanojia Ramesh M | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
| US7329654B2 (en) | 2001-12-19 | 2008-02-12 | Janssen Pharmaceutica N.V. | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
-
0
- NL NL124481D patent/NL124481C/xx active
-
1964
- 1964-11-04 FR FR993811A patent/FR1492772A/en not_active Expired
-
1965
- 1965-05-03 FR FR15549A patent/FR6534M/fr not_active Expired
- 1965-10-25 DE DE19651468940 patent/DE1468940A1/en not_active Withdrawn
- 1965-10-27 IL IL24528A patent/IL24528A/en unknown
- 1965-10-27 IL IL33395A patent/IL33395A/en unknown
- 1965-10-27 BE BE671482D patent/BE671482A/xx unknown
- 1965-10-27 IL IL34614A patent/IL34614A/en unknown
- 1965-11-03 NL NL6514226A patent/NL6514226A/xx unknown
- 1965-11-03 DK DK564865AA patent/DK111891B/en unknown
- 1965-11-03 NL NL6514225A patent/NL6514225A/xx unknown
- 1965-11-03 SE SE14214/65A patent/SE309234B/xx unknown
- 1965-11-03 DK DK564965AA patent/DK112031B/en unknown
- 1965-11-03 SE SE14215/65A patent/SE323367B/xx unknown
- 1965-11-04 BR BR174582/65A patent/BR6574582D0/en unknown
- 1965-11-04 BR BR174583/65A patent/BR6574583D0/en unknown
- 1965-11-04 GB GB17462/67A patent/GB1094807A/en not_active Expired
- 1965-11-04 GB GB17463/67A patent/GB1094808A/en not_active Expired
- 1965-11-04 GB GB46744/65A patent/GB1094806A/en not_active Expired
- 1965-11-04 CH CH1522665A patent/CH448079A/en unknown
- 1965-11-04 GB GB17465/67A patent/GB1094810A/en not_active Expired
- 1965-11-04 GB GB17464/67A patent/GB1094809A/en not_active Expired
- 1965-11-04 CH CH1522565A patent/CH448078A/en unknown
- 1965-11-27 IL IL33432A patent/IL33432A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR6574582D0 (en) | 1973-09-06 |
| BE671482A (en) | 1966-04-27 |
| GB1094806A (en) | 1967-12-13 |
| NL6514225A (en) | 1966-05-05 |
| BR6574583D0 (en) | 1973-09-06 |
| DK112031B (en) | 1968-11-04 |
| GB1094810A (en) | 1967-12-13 |
| FR1492772A (en) | 1967-08-25 |
| DE1468941A1 (en) | 1969-03-13 |
| SE323367B (en) | 1970-05-04 |
| IL33432A (en) | 1970-11-30 |
| SE309234B (en) | 1969-03-17 |
| IL24528A (en) | 1970-09-17 |
| DE1468940A1 (en) | 1969-02-06 |
| CH448078A (en) | 1967-12-15 |
| IL33395A (en) | 1970-10-30 |
| NL6514226A (en) | 1966-05-05 |
| GB1094807A (en) | 1967-12-13 |
| NL124481C (en) | |
| IL34614A (en) | 1970-11-30 |
| CH448079A (en) | 1967-12-15 |
| FR6534M (en) | 1968-12-16 |
| DK111891B (en) | 1968-10-21 |
| GB1094809A (en) | 1967-12-13 |
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