GB1043859A - Novel phenanthrene derivatives and a process for the manufacture thereof - Google Patents
Novel phenanthrene derivatives and a process for the manufacture thereofInfo
- Publication number
- GB1043859A GB1043859A GB9271/65A GB927165A GB1043859A GB 1043859 A GB1043859 A GB 1043859A GB 9271/65 A GB9271/65 A GB 9271/65A GB 927165 A GB927165 A GB 927165A GB 1043859 A GB1043859 A GB 1043859A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- atoms
- ring
- halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000001792 phenanthrenyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical compound C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- -1 cycloalkane carboxylic acid Chemical class 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH283764A CH446370A (de) | 1964-03-05 | 1964-03-05 | Verfahren zur Herstellung von Phenanthren-Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1043859A true GB1043859A (en) | 1966-09-28 |
Family
ID=4242707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9271/65A Expired GB1043859A (en) | 1964-03-05 | 1965-03-04 | Novel phenanthrene derivatives and a process for the manufacture thereof |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE660533A (en:Method) |
| CH (1) | CH446370A (en:Method) |
| DK (1) | DK107485C (en:Method) |
| ES (1) | ES310125A1 (en:Method) |
| FR (2) | FR1428671A (en:Method) |
| GB (1) | GB1043859A (en:Method) |
| NL (1) | NL6502391A (en:Method) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0184041A1 (en) * | 1984-11-13 | 1986-06-11 | Miles Inc. | 6-Methylene morphinan purification technique |
| US5260286A (en) * | 1992-10-16 | 1993-11-09 | Japan Tobacco, Inc. | 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2538075A1 (de) | 1975-08-27 | 1977-03-17 | Boehringer Sohn Ingelheim | N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung |
-
1964
- 1964-03-05 CH CH283764A patent/CH446370A/de unknown
-
1965
- 1965-02-25 NL NL6502391A patent/NL6502391A/xx unknown
- 1965-03-02 FR FR7526A patent/FR1428671A/fr not_active Expired
- 1965-03-03 FR FR7698A patent/FR4249M/fr not_active Expired
- 1965-03-03 BE BE660533D patent/BE660533A/xx unknown
- 1965-03-04 GB GB9271/65A patent/GB1043859A/en not_active Expired
- 1965-03-04 ES ES0310125A patent/ES310125A1/es not_active Expired
- 1965-03-05 DK DK114465AA patent/DK107485C/da active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0184041A1 (en) * | 1984-11-13 | 1986-06-11 | Miles Inc. | 6-Methylene morphinan purification technique |
| US5260286A (en) * | 1992-10-16 | 1993-11-09 | Japan Tobacco, Inc. | 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| ES310125A1 (es) | 1965-12-01 |
| BE660533A (en:Method) | 1965-09-03 |
| FR4249M (en:Method) | 1966-07-29 |
| DK107485C (da) | 1967-06-05 |
| NL6502391A (en:Method) | 1965-09-06 |
| CH446370A (de) | 1967-11-15 |
| FR1428671A (fr) | 1966-02-18 |
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