GB0611405D0 - FKBP-L: A novel inhibitor of angiogenesis - Google Patents

FKBP-L: A novel inhibitor of angiogenesis

Info

Publication number
GB0611405D0
GB0611405D0 GBGB0611405.2A GB0611405A GB0611405D0 GB 0611405 D0 GB0611405 D0 GB 0611405D0 GB 0611405 A GB0611405 A GB 0611405A GB 0611405 D0 GB0611405 D0 GB 0611405D0
Authority
GB
United Kingdom
Prior art keywords
fkbp
angiogenesis
novel inhibitor
inhibitor
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0611405.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALMAC SCIENCES LIMITED
Original Assignee
Queens University of Belfast
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queens University of Belfast filed Critical Queens University of Belfast
Priority to GBGB0611405.2A priority Critical patent/GB0611405D0/en
Publication of GB0611405D0 publication Critical patent/GB0611405D0/en
Priority to CA2657947A priority patent/CA2657947C/fr
Priority to EP07733118.9A priority patent/EP2040728B1/fr
Priority to JP2009513764A priority patent/JP5474535B2/ja
Priority to PL07733118T priority patent/PL2040728T3/pl
Priority to ES07733118.9T priority patent/ES2548332T3/es
Priority to DK07733118.9T priority patent/DK2040728T3/en
Priority to US12/303,343 priority patent/US9381228B2/en
Priority to PCT/GB2007/002107 priority patent/WO2007141533A2/fr
Priority to NZ573425A priority patent/NZ573425A/en
Priority to HUE07733118A priority patent/HUE028099T2/en
Priority to PT77331189T priority patent/PT2040728E/pt
Priority to CN2007800276683A priority patent/CN101489575B/zh
Priority to SI200731701T priority patent/SI2040728T1/sl
Priority to NZ600690A priority patent/NZ600690A/en
Priority to AU2007255196A priority patent/AU2007255196B2/en
Priority to IL195580A priority patent/IL195580A/en
Priority to ZA2008/10323A priority patent/ZA200810323B/en
Priority to CY20151101070T priority patent/CY1116970T1/el
Priority to US15/169,460 priority patent/US10577406B2/en
Priority to US15/169,452 priority patent/US20160340401A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y502/00—Cis-trans-isomerases (5.2)
    • C12Y502/01—Cis-trans-Isomerases (5.2.1)
    • C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
GBGB0611405.2A 2006-06-09 2006-06-09 FKBP-L: A novel inhibitor of angiogenesis Ceased GB0611405D0 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
GBGB0611405.2A GB0611405D0 (en) 2006-06-09 2006-06-09 FKBP-L: A novel inhibitor of angiogenesis
AU2007255196A AU2007255196B2 (en) 2006-06-09 2007-06-08 FKBP-L and uses thereof
HUE07733118A HUE028099T2 (en) 2006-06-09 2007-06-08 Use as FKBP-L and angiogenesis inhibitor
CN2007800276683A CN101489575B (zh) 2006-06-09 2007-06-08 Fkbp-l及其用途
JP2009513764A JP5474535B2 (ja) 2006-06-09 2007-06-08 Ｆｋｂｐ−ｌおよびその使用
PL07733118T PL2040728T3 (pl) 2006-06-09 2007-06-08 FKBP-L i jego zastosowanie jako inhibitora angiogenezy
ES07733118.9T ES2548332T3 (es) 2006-06-09 2007-06-08 FKBP-L y usos del mismo como inhibidor de la angiogénesis
DK07733118.9T DK2040728T3 (en) 2006-06-09 2007-06-08 FKBP-L and uses thereof such as angiogenesis inhibitors
US12/303,343 US9381228B2 (en) 2006-06-09 2007-06-08 FKBP-L and uses thereof
PCT/GB2007/002107 WO2007141533A2 (fr) 2006-06-09 2007-06-08 Fkbp-l et ses utilisations
NZ573425A NZ573425A (en) 2006-06-09 2007-06-08 Fkbp-l and uses thereof
CA2657947A CA2657947C (fr) 2006-06-09 2007-06-08 Fkbp-l et ses utilisations
PT77331189T PT2040728E (pt) 2006-06-09 2007-06-08 Fkbp-l e seus usos como inibidores de angiogénese
EP07733118.9A EP2040728B1 (fr) 2006-06-09 2007-06-08 Fkbp-l et ses utilisations dans l'inhibition de l'angiogenese
SI200731701T SI2040728T1 (sl) 2006-06-09 2007-06-08 FKBP-L in njegova uporaba za zaviranje angiogeneze
NZ600690A NZ600690A (en) 2006-06-09 2007-06-08 Fkbp-l and uses thereof
IL195580A IL195580A (en) 2006-06-09 2008-11-27 L – fkbp polypeptides, preparations containing them, methods of preparation and use
ZA2008/10323A ZA200810323B (en) 2006-06-09 2008-12-04 Fkbp-l and uses thereof
CY20151101070T CY1116970T1 (el) 2006-06-09 2015-11-26 Fkbp-l και χρησεις αυτων ως αναστολεις αγγειογενεσης
US15/169,460 US10577406B2 (en) 2006-06-09 2016-05-31 FKBP-L polypeptides and uses in angiogenesis-mediated disorders
US15/169,452 US20160340401A1 (en) 2006-06-09 2016-05-31 Fkbp-l and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0611405.2A GB0611405D0 (en) 2006-06-09 2006-06-09 FKBP-L: A novel inhibitor of angiogenesis

Publications (1)

Publication Number Publication Date
GB0611405D0 true GB0611405D0 (en) 2006-07-19

Family

ID=36745574

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0611405.2A Ceased GB0611405D0 (en) 2006-06-09 2006-06-09 FKBP-L: A novel inhibitor of angiogenesis

Country Status (18)

Country Link
US (3) US9381228B2 (fr)
EP (1) EP2040728B1 (fr)
JP (1) JP5474535B2 (fr)
CN (1) CN101489575B (fr)
AU (1) AU2007255196B2 (fr)
CA (1) CA2657947C (fr)
CY (1) CY1116970T1 (fr)
DK (1) DK2040728T3 (fr)
ES (1) ES2548332T3 (fr)
GB (1) GB0611405D0 (fr)
HU (1) HUE028099T2 (fr)
IL (1) IL195580A (fr)
NZ (2) NZ573425A (fr)
PL (1) PL2040728T3 (fr)
PT (1) PT2040728E (fr)
SI (1) SI2040728T1 (fr)
WO (1) WO2007141533A2 (fr)
ZA (1) ZA200810323B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
ES2586387T3 (es) 2003-11-05 2016-10-14 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular
US7507842B2 (en) 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
WO2008121767A2 (fr) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Polypeptides cousus
GB0724393D0 (en) * 2007-12-14 2008-01-23 Univ Ulster Use of FKBPL gene to identify a cause of infertility
WO2010011313A2 (fr) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligature de polypeptides agrafés
EP2342221B1 (fr) 2008-09-22 2018-11-07 Aileron Therapeutics, Inc. Procédés pour préparer des compositions de polypeptide purifié
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
GB0908589D0 (en) 2009-05-19 2009-06-24 Univ Belfast Assay method
CA2768299C (fr) 2009-07-13 2018-03-20 President And Fellows Of Harvard College Peptides bifonctionnels inseres et leurs utilisations
JP2013505300A (ja) 2009-09-22 2013-02-14 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
RU2582678C2 (ru) 2010-08-13 2016-04-27 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
WO2012174423A1 (fr) 2011-06-17 2012-12-20 President And Fellows Of Harvard College Polypeptides stabilisés comme régulateurs de fonction gtpase rab
US20140308260A1 (en) * 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
JP6450191B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
EP2819688A4 (fr) 2012-02-15 2015-10-28 Aileron Therapeutics Inc Macrocycles peptidomimétiques réticulés par triazole et par thioéther
RS61957B1 (sr) 2012-09-26 2021-07-30 Harvard College Uvezani peptidi blokirani prolinom i njihove upotrebe
WO2014071241A1 (fr) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Acides aminés disubstitués et procédés de préparation et d'utilisation de ceux-ci
CA2909620A1 (fr) 2013-03-13 2014-10-02 President And Fellows Of Harvard College Polypeptides a agrafes et a suture et leurs utilisations
EP3008081B1 (fr) 2013-06-14 2017-08-30 President and Fellows of Harvard College Modulateurs stabilisés du récepteur de l'insuline polypeptidique
JP6759109B2 (ja) 2014-05-21 2020-09-23 プレジデント アンド フェローズ オブ ハーバード カレッジ Ｒａｓ抑制性ペプチドおよびその使用
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
KR102570210B1 (ko) 2014-09-24 2023-08-23 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 제제
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
WO2017004548A1 (fr) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
KR20190040931A (ko) 2016-01-11 2019-04-19 에피센트알엑스, 인코포레이티드 2-브로모-1-(3,3-디니트로아제티딘-1-일)에타논의 정맥내 투여를 위한 조성물 및 방법
US20190381127A1 (en) 2016-02-02 2019-12-19 Splash Pharmaceuticals, Inc. Combination therapy with a6, chemotherapeutic agents, radiation therapy, or a combination thereof for the treatment of cancer
WO2017221011A1 (fr) * 2016-06-22 2017-12-28 Almac Discovery Limited Traitement de maladie oculaire
CN110352190A (zh) 2016-10-14 2019-10-18 埃皮辛特瑞柯斯公司 用于医疗用途的磺氧基烷基有机硝基和相关化合物和药物组合物
US11376308B2 (en) 2016-10-19 2022-07-05 Royal College Of Surgeons In Ireland Use of FKBP-L polypeptides and nucleic acids for the treatment of obesity
CN108362870A (zh) * 2017-01-27 2018-08-03 武汉三鹰生物技术有限公司 一种用于人fkbpl蛋白的酶联免疫检测及制备方法
BR112020000196A2 (pt) 2017-07-07 2020-07-07 Epicentrx, Inc. composições para administração parenteral de agentes terapêuticos
WO2019164593A2 (fr) 2018-01-08 2019-08-29 Epicentrx, Inc. Méthodes et compositions utilisant une polythérapie rrx-001 pour la radioprotection
CN111603567A (zh) * 2019-02-22 2020-09-01 博瑞生物医药（苏州）股份有限公司 Cd44靶向多臂偶联物
CN113702632A (zh) * 2021-09-02 2021-11-26 深圳市光与生物科技有限公司 一种快速检测子痫前期的免疫层析检测卡及其制备方法与应用

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194732A (en) 1960-10-03 1965-07-13 Neuhauser Irene Assisting healing of skin-denuded areas on the body with dried non-fibrous egg-shellmembrane products and compositions therefor
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
AU7757581A (en) 1980-11-19 1982-05-27 United Energy Technologies Inc. Enhanced surface tubing
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
DE3464682D1 (en) 1983-05-09 1987-08-13 Gen Electric Co Plc Cathode ray tube display device
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4615885A (en) 1983-11-01 1986-10-07 Terumo Kabushiki Kaisha Pharmaceutical composition containing urokinase
JP3065628B2 (ja) * 1988-12-19 2000-07-17 三井化学株式会社 ヒト免疫グロブリン遺伝子関連ｄｎａ断片及び該ｄｎａ断片を用いる診断方法
US5766883A (en) * 1989-04-29 1998-06-16 Delta Biotechnology Limited Polypeptides
FR2650598B1 (fr) 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
AU648140B2 (en) * 1991-02-01 1994-04-14 Virtual Drug Development, Inc. Reverse antimicrobial peptides and antimicrobial compositions
IL99120A0 (en) * 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
DE69332981T2 (de) 1992-10-23 2004-05-19 Immunex Corp., Seattle Methoden zur herstellung löslicher, oligomerer proteine
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
NZ266622A (en) * 1993-06-29 1997-10-24 Chiron Corp Keratinocyte growth factor fragment (kgf) with at least a 2-fold increase in mitogenic activity compared to a full length kgf; dna molecules, expression vectors, host cells, and conjugates
ES2293137T3 (es) * 1995-10-11 2008-03-16 Novartis Vaccines And Diagnostics, Inc. Combinacion de pdgf, kgf,igf e igfbp para curacion de heridas.
EP0980432A1 (fr) 1997-05-01 2000-02-23 Amgen, Inc. Polypeptides opg chimeres
US6583168B1 (en) 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US6180095B1 (en) * 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
WO1999065939A1 (fr) * 1998-06-18 1999-12-23 Curagen Corporation INTERACTION DE p27(KIPL) AVEC FKBP-12
CN1281465A (zh) * 1998-10-09 2001-01-24 上海第二医科大学 人fk506结合蛋白(fkbp)
JP4821031B2 (ja) 1999-04-13 2011-11-24 株式会社林原生物化学研究所 シアニン色素
AU771904B2 (en) * 1999-06-22 2004-04-08 Research Development Foundation Enhanced wound coverage to enhance wound healing
CA2378116A1 (fr) * 1999-07-06 2001-01-11 Incyte Genomics, Inc. Molecules de reponse immunologique humaines
US6413507B1 (en) * 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
US20030125246A9 (en) * 2000-01-31 2003-07-03 Rosen Craig A. Nucleic acids, proteins, and antibodies
AU2002241524A1 (en) * 2000-11-28 2002-06-11 Wyeth Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
AU2002255478A1 (en) * 2001-01-10 2002-09-12 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7244819B2 (en) 2001-06-22 2007-07-17 Roche Diagnostics Operations, Inc. Fusion polypeptides, vaccines and compositions of FKBP chaperones and target polypeptides
US6856185B2 (en) * 2001-10-23 2005-02-15 Arris International, Inc. Simple RMS to DC converter
US20040053388A1 (en) * 2002-01-03 2004-03-18 Eckert Jorg H. Detection of protein conformation using a split ubiquitin reporter system
US20040047835A1 (en) * 2002-09-06 2004-03-11 Cell Therapeutics, Inc. Combinatorial drug therapy using polymer drug conjugates
JP2008546387A (ja) * 2005-06-13 2008-12-25 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法

Also Published As

Publication number Publication date
EP2040728A2 (fr) 2009-04-01
ZA200810323B (en) 2013-05-29
JP2009539367A (ja) 2009-11-19
US10577406B2 (en) 2020-03-03
DK2040728T3 (en) 2015-10-26
PL2040728T3 (pl) 2016-02-29
CA2657947C (fr) 2017-11-21
JP5474535B2 (ja) 2014-04-16
IL195580A (en) 2013-07-31
AU2007255196B2 (en) 2013-10-03
PT2040728E (pt) 2015-10-29
US20160340402A1 (en) 2016-11-24
CN101489575A (zh) 2009-07-22
AU2007255196A1 (en) 2007-12-13
US20090192085A1 (en) 2009-07-30
ES2548332T3 (es) 2015-10-15
HUE028099T2 (en) 2016-11-28
NZ573425A (en) 2012-07-27
CA2657947A1 (fr) 2007-12-13
WO2007141533A3 (fr) 2008-07-31
US9381228B2 (en) 2016-07-05
EP2040728B1 (fr) 2015-09-02
US20160340401A1 (en) 2016-11-24
CY1116970T1 (el) 2017-04-05
IL195580A0 (en) 2011-08-01
SI2040728T1 (sl) 2015-12-31
CN101489575B (zh) 2013-08-28
NZ600690A (en) 2014-03-28
WO2007141533A2 (fr) 2007-12-13

Similar Documents

Publication Publication Date Title
GB0611405D0 (en) FKBP-L: A novel inhibitor of angiogenesis
PT2094708E (pt) Pirrolopirazina como inibidor da cinase syk
PL2402317T3 (pl) Inhibitor DGAT
PL2361922T3 (pl) Produkty pośrednie do wytwarzania inhibitorów nukleozydowych HCV
EP2005957A4 (fr) Inhibiteur de secretion d'acide
HK1200440A1 (zh) 種抑制劑的結晶形式
IL196067A0 (en) New cxcr2 inhibitors
HK1141538A1 (zh) 血管生成的抑制
LT2295410T (lt) Hdac inhibitorius
IL195031A0 (en) Uses of dpp-iv inhibitors
EP2282755A4 (fr) Inhibition de l'angiogenèse
HK1191861A1 (zh) 胃酸分泌的快速作用抑制劑
EP2201946A4 (fr) Inhibiteur de la production de pai-1
GB0623381D0 (en) Use of a compound as VEGF inhibitor
EP2177529A4 (fr) Nouvel inhibiteur de -sécrétase
EP2036894A4 (fr) Inhibiteur d'aurora
IL205453A0 (en) Uses of a glycoprotein vi (gpvi) inhibitor
GB0625270D0 (en) Angiogenesis
HK1102210A2 (en) A kind of mending -mouth of pole-charge
EP2172217A4 (fr) Inhibiteur de fibrose
EP2076490A4 (fr) Inhibiteurs de la cathepsine b
AU2007238785A8 (en) Tetrahalogenated compounds useful as inhibitors of angiogenesis
EP2089379A4 (fr) Nouvelle forme cristalline du lansoprazole
TWI316060B (en) Neuraminidase inhibitor
GB0712761D0 (en) Novel angiogenisis inhibitor

Legal Events

Date Code Title Description
COOA Change in applicant's name or ownership of the application

Owner name: ALMAC SCIENCES LIMITED

Free format text: FORMER APPLICANT(S): QUEEN S UNIVERSITY OF BELFAST, THE

AT Applications terminated before publication under section 16(1)