GB0425054D0 - Formamide derivatives for the treatment of diseases - Google Patents

Formamide derivatives for the treatment of diseases

Info

Publication number
GB0425054D0
GB0425054D0 GB0425054A GB0425054A GB0425054D0 GB 0425054 D0 GB0425054 D0 GB 0425054D0 GB 0425054 A GB0425054 A GB 0425054A GB 0425054 A GB0425054 A GB 0425054A GB 0425054 D0 GB0425054 D0 GB 0425054D0
Authority
GB
United Kingdom
Prior art keywords
diseases
treatment
formamide derivatives
formamide
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB0425054A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB0425054A priority Critical patent/GB0425054D0/en
Publication of GB0425054D0 publication Critical patent/GB0425054D0/en
Priority to SI200531057T priority patent/SI1730103T1/sl
Priority to PCT/IB2005/000619 priority patent/WO2005092840A1/en
Priority to GEAP20059631A priority patent/GEP20084455B/en
Priority to AP2006003765A priority patent/AP2315A/xx
Priority to KR1020067019640A priority patent/KR100806478B1/ko
Priority to AU2005225632A priority patent/AU2005225632B2/en
Priority to CA2560547A priority patent/CA2560547C/en
Priority to ES05708714T priority patent/ES2343808T3/es
Priority to PL05708714T priority patent/PL1730103T3/pl
Priority to AT05708714T priority patent/ATE469121T1/de
Priority to RSP-2010/0339A priority patent/RS51438B/en
Priority to BRPI0507877-6A priority patent/BRPI0507877A/pt
Priority to DK05708714.0T priority patent/DK1730103T3/da
Priority to DE602005021472T priority patent/DE602005021472D1/de
Priority to MXPA06011019A priority patent/MXPA06011019A/es
Priority to EP05708714A priority patent/EP1730103B1/en
Priority to NZ549839A priority patent/NZ549839A/en
Priority to PT05708714T priority patent/PT1730103E/pt
Priority to JP2007504493A priority patent/JP4033892B2/ja
Priority to EA200601544A priority patent/EA010133B1/ru
Priority to MYPI20051118A priority patent/MY144103A/en
Priority to SV2005002056A priority patent/SV2005002056A/es
Priority to HN2005000118A priority patent/HN2005000118A/es
Priority to US11/086,035 priority patent/US7241810B2/en
Priority to PE2005000321A priority patent/PE20060264A1/es
Priority to TW094108791A priority patent/TWI335312B/zh
Priority to NL1028597A priority patent/NL1028597C2/nl
Priority to ARP050101118A priority patent/AR050236A1/es
Priority to DO2005000045A priority patent/DOP2005000045A/es
Priority to UY28819A priority patent/UY28819A1/es
Priority to IL178102A priority patent/IL178102A/en
Priority to CR8649A priority patent/CR8649A/es
Priority to MA29335A priority patent/MA28480B1/fr
Priority to IS8552A priority patent/IS8552A/is
Priority to NO20064806A priority patent/NO20064806L/no
Priority to US11/773,012 priority patent/US7547731B2/en
Priority to JP2007239523A priority patent/JP4819770B2/ja
Priority to CY20101100620T priority patent/CY1112549T1/el
Priority to HR20100402T priority patent/HRP20100402T1/hr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
GB0425054A 2004-03-23 2004-11-12 Formamide derivatives for the treatment of diseases Ceased GB0425054D0 (en)

Priority Applications (40)

Application Number Priority Date Filing Date Title
GB0425054A GB0425054D0 (en) 2004-03-23 2004-11-12 Formamide derivatives for the treatment of diseases
EA200601544A EA010133B1 (ru) 2004-03-23 2005-03-10 Производные формамида, пригодные в качестве адренорецептора
PT05708714T PT1730103E (pt) 2004-03-23 2005-03-10 Derivados formamida uteis como adrenoceptores
DE602005021472T DE602005021472D1 (de) 2004-03-23 2005-03-10 Als adrenozeptor geeignete formamidderivate
GEAP20059631A GEP20084455B (en) 2004-03-23 2005-03-10 Use of formamide derivatives as adrenoceptor
AP2006003765A AP2315A (en) 2004-03-23 2005-03-10 Formamide derivatives useful as adrenoceptor.
KR1020067019640A KR100806478B1 (ko) 2004-03-23 2005-03-10 아드레날린 수용체로서 유용한 포름아마이드 유도체
AU2005225632A AU2005225632B2 (en) 2004-03-23 2005-03-10 Formamide derivatives useful as adrenoceptor
JP2007504493A JP4033892B2 (ja) 2004-03-23 2005-03-10 アドレナリン受容体として有用なホルムアミド誘導体
ES05708714T ES2343808T3 (es) 2004-03-23 2005-03-10 Derivados de formamida utiles como adrenoceptores.
PL05708714T PL1730103T3 (pl) 2004-03-23 2005-03-10 Pochodne formamidu użyteczne jako adrenoreceptor
AT05708714T ATE469121T1 (de) 2004-03-23 2005-03-10 Als adrenozeptor geeignete formamidderivate
RSP-2010/0339A RS51438B (en) 2004-03-23 2005-03-10 FORMAMID DERIVATIVES AS USEFUL ADRENOCEPTORS
BRPI0507877-6A BRPI0507877A (pt) 2004-03-23 2005-03-10 derivados de formamida, composição farmacêutica, uso dos mesmos e combinação
DK05708714.0T DK1730103T3 (da) 2004-03-23 2005-03-10 Som adrenoceptor anvendelige formamidderivater
PCT/IB2005/000619 WO2005092840A1 (en) 2004-03-23 2005-03-10 Formamide derivatives useful as adrenoceptor
MXPA06011019A MXPA06011019A (es) 2004-03-23 2005-03-10 Derivados de formamida utiles como adrenoceptores.
EP05708714A EP1730103B1 (en) 2004-03-23 2005-03-10 Formamide derivatives useful as adrenoceptor
NZ549839A NZ549839A (en) 2004-03-23 2005-03-10 Formamide derivatives useful as adrenoceptor
SI200531057T SI1730103T1 (sl) 2004-03-23 2005-03-10 Derivati formamida uporabni kot adrenoceptorji
CA2560547A CA2560547C (en) 2004-03-23 2005-03-10 Formamide derivatives useful as adrenoceptor
MYPI20051118A MY144103A (en) 2004-03-23 2005-03-16 Formamide derivatives useful as adrenoceptor
SV2005002056A SV2005002056A (es) 2004-03-23 2005-03-18 Derivados de formamida para el tratamiento de enfermedades ref. pc32168a
HN2005000118A HN2005000118A (es) 2004-03-23 2005-03-18 Derivados de formamida para el tratamiento de enfermedades
US11/086,035 US7241810B2 (en) 2004-03-23 2005-03-21 Formamide derivatives for the treatment of diseases
PE2005000321A PE20060264A1 (es) 2004-03-23 2005-03-21 DERIVADOS DE FORMAMIDA COMO AGONISTAS DE ß2
TW094108791A TWI335312B (en) 2004-03-23 2005-03-22 Formamide derivatives for the treatment of diseases
NL1028597A NL1028597C2 (nl) 2004-03-23 2005-03-22 Formamidederivaten voor de behandeling van ziekten.
ARP050101118A AR050236A1 (es) 2004-03-23 2005-03-22 Derivados de formamida. composiciones farmaceuticas.
UY28819A UY28819A1 (es) 2004-03-23 2005-03-23 Derivados de formamida para el tratamiento de enfermedades
DO2005000045A DOP2005000045A (es) 2004-03-23 2005-03-23 Derivados de formamida para el tratamiento de enfermedades
IL178102A IL178102A (en) 2004-03-23 2006-09-14 Formamide derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for therapy
CR8649A CR8649A (es) 2004-03-23 2006-09-22 Derivados de formamidina para el tratamiento de enfermedades
MA29335A MA28480B1 (fr) 2004-03-23 2006-09-22 Dérivés de formamide utiles comme adrénorécepteur
IS8552A IS8552A (is) 2004-03-23 2006-10-10 Formamíð afleiður gagnlegar sem adrenalín viðtaki
NO20064806A NO20064806L (no) 2004-03-23 2006-10-23 Formamidderivater anvendelige som adenoceptor
US11/773,012 US7547731B2 (en) 2004-03-23 2007-07-03 Formamide derivatives for the treatment of diseases
JP2007239523A JP4819770B2 (ja) 2004-03-23 2007-09-14 アドレナリン受容体として有用なホルムアミド誘導体
CY20101100620T CY1112549T1 (el) 2004-03-23 2010-07-05 Παραγωγα φορμαμιδιου χρησιμα ως αδρενεργικοι υποδοχεις
HR20100402T HRP20100402T1 (hr) 2004-03-23 2010-07-20 Formamidni derivati korisni kao ardrenoceptor

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GB0425054A GB0425054D0 (en) 2004-03-23 2004-11-12 Formamide derivatives for the treatment of diseases

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CH686869A5 (de) * 1991-04-05 1996-07-31 Sepracor Inc Beta (2) -bronchienerweiternde Arzneistoffe in Form ihrer Bronchienerweiternden Enantiomeren zur Verwendung fuer die Herstellung eines Mittels zur verbesserten Therapie.
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IS8552A (is) 2006-10-10
TW200531959A (en) 2005-10-01
JP2007530524A (ja) 2007-11-01
UY28819A1 (es) 2005-10-31
CY1112549T1 (el) 2015-12-09
JP2008056680A (ja) 2008-03-13
IL178102A (en) 2011-08-31
SV2005002056A (es) 2005-12-13
IL178102A0 (en) 2006-12-31
PE20060264A1 (es) 2006-04-01
JP4033892B2 (ja) 2008-01-16
MXPA06011019A (es) 2007-03-21
DOP2005000045A (es) 2005-11-15
NO20064806L (no) 2006-12-21
MA28480B1 (fr) 2007-03-01
ATE469121T1 (de) 2010-06-15
NZ549839A (en) 2010-01-29
GEP20084455B (en) 2008-08-10
JP4819770B2 (ja) 2011-11-24
NL1028597A1 (nl) 2005-09-26
HN2005000118A (es) 2011-02-25
TWI335312B (en) 2011-01-01
CA2560547A1 (en) 2005-10-06
KR20060122969A (ko) 2006-11-30
EA200601544A1 (ru) 2007-02-27
NL1028597C2 (nl) 2006-03-06
EA010133B1 (ru) 2008-06-30
PT1730103E (pt) 2010-07-21
MY144103A (en) 2011-08-15
SI1730103T1 (sl) 2010-09-30
DK1730103T3 (da) 2010-08-16
ES2343808T3 (es) 2010-08-10
KR100806478B1 (ko) 2008-02-21
DE602005021472D1 (de) 2010-07-08
RS51438B (en) 2011-04-30
CA2560547C (en) 2011-02-01
HRP20100402T1 (hr) 2010-09-30
AR050236A1 (es) 2006-10-11

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