RS51438B - Formamide derivatives useful as adrenoceptor - Google Patents

Formamide derivatives useful as adrenoceptor

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Publication number
RS51438B
RS51438B RSP-2010/0339A RSP20100339A RS51438B RS 51438 B RS51438 B RS 51438B RS P20100339 A RSP20100339 A RS P20100339A RS 51438 B RS51438 B RS 51438B
Authority
RS
Serbia
Prior art keywords
group
alkyl
halo
cycloalkyl
adrenoceptor
Prior art date
Application number
RSP-2010/0339A
Other languages
Serbian (sr)
Inventor
Kim James
Alan Daniel Brown
Mark Edward Bunnage
Charlotte Alice Louise Lane
Russell Andrew Lewthwaite
David Anthony Price
Paul Alan Glossop
Original Assignee
Pfizer Inc.
Pfizer Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., Pfizer Limited filed Critical Pfizer Inc.
Publication of RS51438B publication Critical patent/RS51438B/en

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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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Abstract

Jedinjenje opšte formule (1), gde (CH2)n-C(=O)Q1 grupa je u meta ili para položaju,- R1 i R2 su nezavino odabrani od H i C1-C4 alkil;- n je 0, 1 ili 2;- Q1 je grupa odabrana od,Gde p je 1 ili 2 i q je 1 ili 2, data grupa je po izboru premošćena jednim atomom ugljenika, i grupa *-NR8-Q2-A gde Q2 je C1-C4 alkilen, R8 je H ili C1-C4 alkil i A je piridil, C3-C10 cikloalkil, dati cikloalkil je po izboru premošćen jednim ili više atoma ugljenika, tetrahidropiranil, piperidinil, tetrahidrotiopiranil ili grupa- R3, R4, R5, R6 i R7 su isti ili različiti i odabrani od H, C1-C4 alkil, OR9, SR9, SOR9, SO2R9, halo, CO2R9 CF3, CN, OCF3, SO2NR9R10, CONR9R10, NR9R10 , NHCOR10 i fenil po izboru supstituisan sa 1 to 3 grupe odabrane od OR9, halo i C1-C4 alkil;- R9 i R10 su isti ili različiti i odabrani od H ili C1-C4 alkil i * predstavlja mesto vezivanja karbonil grupe;ili, po potrebi, njegove farmaceutski prihvatljive soli i/ili izomeri, tautomeri, solvati ili njihove izotopske varijante.Prijava sadrži još 23 zavisna patentna zahteva.A compound of general formula (1), wherein the (CH2) nC (= O) Q1 group is in the meta or para position, - R1 and R2 are independently selected from H and C1-C4 alkyl; - n is 0, 1 or 2; Q1 is a group selected from, Where p is 1 or 2 and q is 1 or 2, said group is optionally bridged by one carbon atom, and a group * -NR8-Q2-A wherein Q2 is C1-C4 alkylene, R8 is H or C1 -C4 alkyl and A is pyridyl, C3-C10 cycloalkyl, said cycloalkyl is optionally bridged by one or more carbon atoms, tetrahydropyranyl, piperidinyl, tetrahydrothiopyranyl or a group- R3, R4, R5, R6 and R7 are the same or different and selected from H , C1-C4 alkyl, OR9, SR9, SOR9, SO2R9, halo, CO2R9 CF3, CN, OCF3, SO2NR9R10, CONR9R10, NR9R10, NHCOR10 and phenyl optionally substituted with 1 to 3 groups selected from OR9, halo and C1-C4 alkyl ; - R 9 and R 10 are the same or different and selected from H or C 1 -C 4 alkyl and * represents the binding site of the carbonyl group, or, if necessary, its pharmaceutically acceptable salts and / or isomers, tautomers, solvates or isotopic variants thereof. another 23 dependent patent claims.

RSP-2010/0339A 2004-03-23 2005-03-10 Formamide derivatives useful as adrenoceptor RS51438B (en)

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EP04290767 2004-03-23
GB0425054A GB0425054D0 (en) 2004-03-23 2004-11-12 Formamide derivatives for the treatment of diseases

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DOP2005000045A (en) 2005-11-15
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UY28819A1 (en) 2005-10-31
KR20060122969A (en) 2006-11-30
HRP20100402T1 (en) 2010-09-30
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