FR2944284A1 - Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique - Google Patents

Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique Download PDF

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Publication number
FR2944284A1
FR2944284A1 FR0901809A FR0901809A FR2944284A1 FR 2944284 A1 FR2944284 A1 FR 2944284A1 FR 0901809 A FR0901809 A FR 0901809A FR 0901809 A FR0901809 A FR 0901809A FR 2944284 A1 FR2944284 A1 FR 2944284A1
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FR
France
Prior art keywords
alkyl
compound
treatment
disorders
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR0901809A
Other languages
English (en)
French (fr)
Inventor
Gihad Dargazanli
Bouhtou Genevieve Estenne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0901809A priority Critical patent/FR2944284A1/fr
Priority to ARP100101220A priority patent/AR076276A1/es
Priority to KR1020117026894A priority patent/KR20120013378A/ko
Priority to SG2011075017A priority patent/SG175222A1/en
Priority to AU2010238409A priority patent/AU2010238409A1/en
Priority to MX2011010929A priority patent/MX2011010929A/es
Priority to TW099111503A priority patent/TW201041581A/zh
Priority to JP2012505205A priority patent/JP2012523448A/ja
Priority to BRPI1015484A priority patent/BRPI1015484A2/pt
Priority to EP10723665A priority patent/EP2419431A1/fr
Priority to PCT/FR2010/050711 priority patent/WO2010119222A1/fr
Priority to CA2758367A priority patent/CA2758367A1/fr
Priority to UY0001032561A priority patent/UY32561A/es
Publication of FR2944284A1 publication Critical patent/FR2944284A1/fr
Priority to IL215673A priority patent/IL215673A0/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR0901809A 2009-04-14 2009-04-14 Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique Withdrawn FR2944284A1 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FR0901809A FR2944284A1 (fr) 2009-04-14 2009-04-14 Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
ARP100101220A AR076276A1 (es) 2009-04-14 2010-04-12 Derivados de n-[(7-aza-biciclo[2.2.1]hept-1-il)-aril-metil]-benzamida, su prepara-cion y su aplicacion en terapeutica
JP2012505205A JP2012523448A (ja) 2009-04-14 2010-04-13 Ｎ−［（７−アザ−ビシクロ［２．２．１］ヘプト−１−イル）−アリール−メチル］−ベンズアミドの誘導体、これらの調製およびこれらの治療上の使用
EP10723665A EP2419431A1 (fr) 2009-04-14 2010-04-13 Derives de n-[(7-aza-bicyclo[2.2.1]hept-1-yl)-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique
AU2010238409A AU2010238409A1 (en) 2009-04-14 2010-04-13 Derivatives of N-[(7-aza-bicyclo[2.2.1]hept-1-yl)-aryl-methyl]-benzamide, preparation thereof, and therapeutic use thereof
MX2011010929A MX2011010929A (es) 2009-04-14 2010-04-13 Derivados de n-[7-aza-biciclo[2.2.1]hept-1-il)-aril-metil]-benzami da, su preparacion y su uso en terapeutica.
TW099111503A TW201041581A (en) 2009-04-14 2010-04-13 N-[(7-azabicyclo[2.2.1]hept-1-yl)-aryl-methyl] benzamide derivatives, preparation thereof and therapeutic use thereof
KR1020117026894A KR20120013378A (ko) 2009-04-14 2010-04-13 Ｎ-［(7-아자-비시클로［2.2.1］헵트-1-일)-아릴-메틸］-벤즈아미드의 유도체, 그의 제조법, 및 그의 치료 용도
BRPI1015484A BRPI1015484A2 (pt) 2009-04-14 2010-04-13 derivados de n-[(7-aza-biciclo [2.2.1] hept-1-il)-aril-metil]-benzamida, o respectivo preparo e a respectiva aplicação em terapêutica
SG2011075017A SG175222A1 (en) 2009-04-14 2010-04-13 Derivatives of n-[(7-aza-bicyclo[2.2.1]hept-1-yl)-aryl-methyl]-benzamide, preparation thereof, and therapeutic use thereof
PCT/FR2010/050711 WO2010119222A1 (fr) 2009-04-14 2010-04-13 Derives de n-[(7-aza-bicyclo[2.2.1]hept-1-yl)-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique
CA2758367A CA2758367A1 (fr) 2009-04-14 2010-04-13 Derives de n-[(7-aza-bicyclo[2.2.1]hept-1-yl)-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique
UY0001032561A UY32561A (es) 2009-04-14 2010-04-14 Derivados de n-[(7-aza-biciclo[2.2.1]hept-1-il)-aril-metil]-benzamida, su preparación y su aplicación en terapéutica.
IL215673A IL215673A0 (en) 2009-04-14 2011-10-10 Derivatives of n-[(7-aza-bicyclo[2.2.1]hept-1-yl)-aryl-methyl]-benzamide, preparation thereof, and therapeutic use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901809A FR2944284A1 (fr) 2009-04-14 2009-04-14 Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
FR2944284A1 true FR2944284A1 (fr) 2010-10-15

Family

ID=41228015

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0901809A Withdrawn FR2944284A1 (fr) 2009-04-14 2009-04-14 Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique

Country Status (14)

Country Link
EP (1) EP2419431A1 (pt)
JP (1) JP2012523448A (pt)
KR (1) KR20120013378A (pt)
AR (1) AR076276A1 (pt)
AU (1) AU2010238409A1 (pt)
BR (1) BRPI1015484A2 (pt)
CA (1) CA2758367A1 (pt)
FR (1) FR2944284A1 (pt)
IL (1) IL215673A0 (pt)
MX (1) MX2011010929A (pt)
SG (1) SG175222A1 (pt)
TW (1) TW201041581A (pt)
UY (1) UY32561A (pt)
WO (1) WO2010119222A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160045182A (ko) 2014-10-16 2016-04-27 현대자동차주식회사 실린더 라이너용 회주철 및 이를 이용한 실린더 라이너의 제조방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842804A1 (fr) * 2002-07-29 2004-01-30 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076A1 (fr) * 2003-10-17 2005-04-22 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2008065500A2 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
WO2009013535A1 (en) * 2007-07-23 2009-01-29 Astrazeneca Ab 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842804A1 (fr) * 2002-07-29 2004-01-30 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076A1 (fr) * 2003-10-17 2005-04-22 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2008065500A2 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
WO2009013535A1 (en) * 2007-07-23 2009-01-29 Astrazeneca Ab 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor

Also Published As

Publication number Publication date
BRPI1015484A2 (pt) 2016-04-26
WO2010119222A1 (fr) 2010-10-21
SG175222A1 (en) 2011-11-28
TW201041581A (en) 2010-12-01
AU2010238409A1 (en) 2011-11-03
MX2011010929A (es) 2011-11-02
EP2419431A1 (fr) 2012-02-22
UY32561A (es) 2010-11-30
JP2012523448A (ja) 2012-10-04
IL215673A0 (en) 2012-01-31
KR20120013378A (ko) 2012-02-14
AR076276A1 (es) 2011-06-01
CA2758367A1 (fr) 2010-10-21

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Effective date: 20121228