FR2845992B1 - Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie - Google Patents
Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenieInfo
- Publication number
- FR2845992B1 FR2845992B1 FR0212854A FR0212854A FR2845992B1 FR 2845992 B1 FR2845992 B1 FR 2845992B1 FR 0212854 A FR0212854 A FR 0212854A FR 0212854 A FR0212854 A FR 0212854A FR 2845992 B1 FR2845992 B1 FR 2845992B1
- Authority
- FR
- France
- Prior art keywords
- cyclopenten
- benzyl
- heteroarylmethyl
- schizophrenia
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- -1 CYCLOPENTEN-1YL Chemical class 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title 1
- 201000000980 schizophrenia Diseases 0.000 title 1
- 125000005241 heteroarylamino group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- 125000006519 CCH3 Chemical group 0.000 abstract 1
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 abstract 1
- IPZJQDSFZGZEOY-UHFFFAOYSA-N dimethylmethylene Chemical compound C[C]C IPZJQDSFZGZEOY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0212854A FR2845992B1 (fr) | 2002-10-16 | 2002-10-16 | Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
| DE60305339T DE60305339T2 (de) | 2002-10-16 | 2003-10-16 | 3-(cyclopenten-1-yl)-benzyl- oder 3-(cyclopenten-1-yl)heteroarylmethylaminderivate und deren verwendung als arzneimittel zur behandlung von schizophrenie |
| HK05106801.1A HK1073112B (en) | 2002-10-16 | 2003-10-16 | 3-(cyclopenten-1-yl)-benzyl- or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia |
| PCT/FR2003/003053 WO2004035561A1 (fr) | 2002-10-16 | 2003-10-16 | Derives de 3-(cyclopenten-1-yl)-benzyl- ou 3-(cyclopenten-1-yl)-heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
| JP2004544396A JP4566749B2 (ja) | 2002-10-16 | 2003-10-16 | ３−（シクロペンテン−１−イル）−ベンジル−または３−（シクロペンテン−１−イル）−ヘテロアリールメチルアミン誘導体および統合失調症を治療するための医薬としてのそれらの使用 |
| AT03808761T ATE326456T1 (de) | 2002-10-16 | 2003-10-16 | 3-(cyclopenten-1-yl)-benzyl- oder 3-(cyclopenten- 1-yl)heteroarylmethylaminderivate und deren verwendung als arzneimittel zur behandlung von schizophrenie |
| CNB200380101676XA CN1319962C (zh) | 2002-10-16 | 2003-10-16 | 3－(环戊烯－1－基)－苄基(或杂芳基甲基)胺衍生物及其制备治疗精神分裂症的药物的用途 |
| BR0315365-7A BR0315365A (pt) | 2002-10-16 | 2003-10-16 | Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroarilmetilamina e uso destes como medicamentos para tratamento da esquizofrenia |
| US10/531,587 US7163957B2 (en) | 2002-10-16 | 2003-10-16 | 3-(Cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia |
| MXPA05004114A MXPA05004114A (es) | 2002-10-16 | 2003-10-16 | Derivados de 3-(ciclopenten-1-il)-bencil-0 3-(ciclopenten-1-il)-heteroarilmetil-amina y uso de los mismos como medicinas para tratar esquizofrenia. |
| ES03808761T ES2264780T3 (es) | 2002-10-16 | 2003-10-16 | Derivados de 3-(ciclopenten-1-il)-bencil- o 3-(ciclopenten-1-il)-heteroarilmetil-aminas y su uso como medicamentos para el tratamiento de la esquizofrenia. |
| PT03808761T PT1551821E (pt) | 2002-10-16 | 2003-10-16 | Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroairlmentilaminas e a sua utilizacao a titulo de medicamentos para o tratamento da esquizofrenia |
| EP03808761A EP1551821B1 (fr) | 2002-10-16 | 2003-10-16 | Derives de 3-(cyclopenten-1-yl)-benzyl- ou 3-(cyclopenten-1-yl)-heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
| CA2502528A CA2502528C (fr) | 2002-10-16 | 2003-10-16 | Derives de 3-(cyclopenten-1-yl)-benzyl- ou 3-(cyclopenten-1-yl)-heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
| AU2003301277A AU2003301277B2 (en) | 2002-10-16 | 2003-10-16 | 3-(cyclopenten-1-yl)-benzyl- or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia |
| ZA200503822A ZA200503822B (en) | 2002-10-16 | 2005-05-12 | 3-(cyclopenten-1-yl)-benzyl or 3-(cyclopenten-1-yl)-hetero-arylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia |
| US11/494,697 US7235568B2 (en) | 2002-10-16 | 2006-07-28 | 3-(cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0212854A FR2845992B1 (fr) | 2002-10-16 | 2002-10-16 | Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2845992A1 FR2845992A1 (fr) | 2004-04-23 |
| FR2845992B1 true FR2845992B1 (fr) | 2005-02-04 |
Family
ID=32050432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0212854A Expired - Fee Related FR2845992B1 (fr) | 2002-10-16 | 2002-10-16 | Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7163957B2 (https=) |
| EP (1) | EP1551821B1 (https=) |
| JP (1) | JP4566749B2 (https=) |
| CN (1) | CN1319962C (https=) |
| AT (1) | ATE326456T1 (https=) |
| AU (1) | AU2003301277B2 (https=) |
| BR (1) | BR0315365A (https=) |
| CA (1) | CA2502528C (https=) |
| DE (1) | DE60305339T2 (https=) |
| ES (1) | ES2264780T3 (https=) |
| FR (1) | FR2845992B1 (https=) |
| MX (1) | MXPA05004114A (https=) |
| PT (1) | PT1551821E (https=) |
| WO (1) | WO2004035561A1 (https=) |
| ZA (1) | ZA200503822B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2898601A1 (fr) * | 2006-03-14 | 2007-09-21 | Pierre Fabre Medicament Sa | Procede de preparation de derives (2-(2,3-dihydro-benzofuran ou benzofuran-7-yloxy)-ethyl)-(3-cyclopenten-1-yl-benzyl) amines et intermediaire de synthese |
| US20090288701A1 (en) * | 2008-05-23 | 2009-11-26 | E.I.Du Pont De Nemours And Company | Solar cell laminates having colored multi-layer encapsulant sheets |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05125024A (ja) * | 1991-11-05 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアリールオキシアルキルアミン誘導体又はその塩 |
| JPH05255302A (ja) * | 1992-03-09 | 1993-10-05 | Yamanouchi Pharmaceut Co Ltd | 新規なクロマニルオキシアルキルアミン誘導体 |
| US5955495A (en) * | 1996-05-03 | 1999-09-21 | Hoffmann-La Roche Inc. | Method of treating diseases of the CNS |
| AU4088897A (en) * | 1996-08-27 | 1998-03-19 | American Home Products Corporation | 4-aminoethoxy indolone derivatives |
| AU3386199A (en) * | 1998-04-08 | 1999-10-25 | American Home Products Corporation | N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents) |
| CA2332275A1 (en) * | 1998-05-14 | 1999-11-18 | Zoltan Tamas Nagy | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| FR2791676B1 (fr) * | 1999-03-29 | 2001-06-22 | Pf Medicament | Nouveaux derives de [(2-substitue-5-[thienyl])-benzyl]- [2-([isopropoxy-5-fluoro]-phenoxy) ethyl]-amine, leur procede de preparation et leur utilisation a titre de medicaments |
-
2002
- 2002-10-16 FR FR0212854A patent/FR2845992B1/fr not_active Expired - Fee Related
-
2003
- 2003-10-16 CA CA2502528A patent/CA2502528C/fr not_active Expired - Fee Related
- 2003-10-16 BR BR0315365-7A patent/BR0315365A/pt not_active IP Right Cessation
- 2003-10-16 AT AT03808761T patent/ATE326456T1/de not_active IP Right Cessation
- 2003-10-16 AU AU2003301277A patent/AU2003301277B2/en not_active Ceased
- 2003-10-16 DE DE60305339T patent/DE60305339T2/de not_active Expired - Lifetime
- 2003-10-16 EP EP03808761A patent/EP1551821B1/fr not_active Expired - Lifetime
- 2003-10-16 WO PCT/FR2003/003053 patent/WO2004035561A1/fr not_active Ceased
- 2003-10-16 JP JP2004544396A patent/JP4566749B2/ja not_active Expired - Fee Related
- 2003-10-16 PT PT03808761T patent/PT1551821E/pt unknown
- 2003-10-16 ES ES03808761T patent/ES2264780T3/es not_active Expired - Lifetime
- 2003-10-16 US US10/531,587 patent/US7163957B2/en not_active Expired - Fee Related
- 2003-10-16 MX MXPA05004114A patent/MXPA05004114A/es active IP Right Grant
- 2003-10-16 CN CNB200380101676XA patent/CN1319962C/zh not_active Expired - Fee Related
-
2005
- 2005-05-12 ZA ZA200503822A patent/ZA200503822B/en unknown
-
2006
- 2006-07-28 US US11/494,697 patent/US7235568B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003301277B2 (en) | 2009-06-18 |
| EP1551821A1 (fr) | 2005-07-13 |
| US20060014827A1 (en) | 2006-01-19 |
| CN1319962C (zh) | 2007-06-06 |
| CA2502528C (fr) | 2011-12-13 |
| US20060264471A1 (en) | 2006-11-23 |
| AU2003301277A1 (en) | 2004-05-04 |
| JP4566749B2 (ja) | 2010-10-20 |
| ATE326456T1 (de) | 2006-06-15 |
| CA2502528A1 (fr) | 2004-04-29 |
| MXPA05004114A (es) | 2005-06-22 |
| BR0315365A (pt) | 2005-08-23 |
| US7163957B2 (en) | 2007-01-16 |
| US7235568B2 (en) | 2007-06-26 |
| DE60305339T2 (de) | 2007-02-01 |
| FR2845992A1 (fr) | 2004-04-23 |
| JP2006508080A (ja) | 2006-03-09 |
| CN1705653A (zh) | 2005-12-07 |
| ES2264780T3 (es) | 2007-01-16 |
| ZA200503822B (en) | 2006-03-29 |
| HK1073112A1 (en) | 2005-09-23 |
| WO2004035561A1 (fr) | 2004-04-29 |
| DE60305339D1 (de) | 2006-06-22 |
| EP1551821B1 (fr) | 2006-05-17 |
| PT1551821E (pt) | 2006-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |
Effective date: 20080630 |