BR0315365A - Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroarilmetilamina e uso destes como medicamentos para tratamento da esquizofrenia - Google Patents
Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroarilmetilamina e uso destes como medicamentos para tratamento da esquizofreniaInfo
- Publication number
- BR0315365A BR0315365A BR0315365-7A BR0315365A BR0315365A BR 0315365 A BR0315365 A BR 0315365A BR 0315365 A BR0315365 A BR 0315365A BR 0315365 A BR0315365 A BR 0315365A
- Authority
- BR
- Brazil
- Prior art keywords
- cyclopenten
- benzyl
- heteroarylmethylamine
- medicines
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"DERIVADOS DE 3-(CICLOPENTEN-1-IL)-BENZIL-OU 3-(CICLOPENTEN-1-IL)-HETEROARILMETILAMINA E USO DESTES COMO MEDICAMENTOS PARA TRATAMENTO DA ESQUIZOFRENIA". A invenção refere-se a compostos de fórmula geral (I), em que: - (a) representa uma ligação simples ou uma ligação dupla, - w representa um grupo CH, CH~ 2~, CHCH~ 3~, CCH~ 3~ ou C(CH~ 3~)~ 2~, um grupo C(CH~ 2~)~ 2~ (Isto é um átomo de carbono portando dois grupos metileno ligados juntos de modo a formar uma unidade espiro-ciclopropano) ou um grupo C(CH~ 2~)~ 3~ (Isto é, um átomo de carbono portando dois grupos metileno ligados juntos, de modo a formar uma unidade espiro-ciclobutano), com a condição de que, quando (a), for uma ligação dupla então, W representa exclusivamente um grupo CH ou CCH~ 3~, e de que, quando (a) for uma ligação simples, então W representa exclusivamente, um grupo CH~ 2~, CHCH~ 3~, C(CH~ 3~)~ 2~ C(CH~ 2~)~ 2~ ou C(CH~ 2~)~ 3~, - X é um átomo de carbono portando um átomo de hidrogênio (CH) ou um átomo de nitrogênio, - Y é um átomo de carbono portando um átomo de hidrogênio ou um átomo de flúor, seus sais de adição e opcionalmente, os hidratos dos sais de adição, com ácidos inorgânicos farmaceuticamente aceitáveis ou ácidos orgânicos, bem como suas formas tautoméricas, os enantiómeros puros e misturas de enantiómeros racêmicos ou não-racêmicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0212854A FR2845992B1 (fr) | 2002-10-16 | 2002-10-16 | Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
PCT/FR2003/003053 WO2004035561A1 (fr) | 2002-10-16 | 2003-10-16 | Derives de 3-(cyclopenten-1-yl)-benzyl- ou 3-(cyclopenten-1-yl)-heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0315365A true BR0315365A (pt) | 2005-08-23 |
Family
ID=32050432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0315365-7A BR0315365A (pt) | 2002-10-16 | 2003-10-16 | Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroarilmetilamina e uso destes como medicamentos para tratamento da esquizofrenia |
Country Status (16)
Country | Link |
---|---|
US (2) | US7163957B2 (pt) |
EP (1) | EP1551821B1 (pt) |
JP (1) | JP4566749B2 (pt) |
CN (1) | CN1319962C (pt) |
AT (1) | ATE326456T1 (pt) |
AU (1) | AU2003301277B2 (pt) |
BR (1) | BR0315365A (pt) |
CA (1) | CA2502528C (pt) |
DE (1) | DE60305339T2 (pt) |
ES (1) | ES2264780T3 (pt) |
FR (1) | FR2845992B1 (pt) |
HK (1) | HK1073112A1 (pt) |
MX (1) | MXPA05004114A (pt) |
PT (1) | PT1551821E (pt) |
WO (1) | WO2004035561A1 (pt) |
ZA (1) | ZA200503822B (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2898601A1 (fr) * | 2006-03-14 | 2007-09-21 | Pierre Fabre Medicament Sa | Procede de preparation de derives (2-(2,3-dihydro-benzofuran ou benzofuran-7-yloxy)-ethyl)-(3-cyclopenten-1-yl-benzyl) amines et intermediaire de synthese |
US20090288701A1 (en) * | 2008-05-23 | 2009-11-26 | E.I.Du Pont De Nemours And Company | Solar cell laminates having colored multi-layer encapsulant sheets |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05125024A (ja) * | 1991-11-05 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアリールオキシアルキルアミン誘導体又はその塩 |
JPH05255302A (ja) * | 1992-03-09 | 1993-10-05 | Yamanouchi Pharmaceut Co Ltd | 新規なクロマニルオキシアルキルアミン誘導体 |
US5955495A (en) * | 1996-05-03 | 1999-09-21 | Hoffmann-La Roche Inc. | Method of treating diseases of the CNS |
ES2179362T3 (es) * | 1996-08-27 | 2003-01-16 | Wyeth Corp | Derivados de 4-aminoetoxi indolona. |
JP2002510675A (ja) * | 1998-04-08 | 2002-04-09 | アメリカン・ホーム・プロダクツ・コーポレイション | うつ病治療用のn−アリールオキシエチル−インドリル−アルキルアミン(5−ht1a受容体活性薬) |
AU753706B2 (en) * | 1998-05-14 | 2002-10-24 | Egis Gyogyszergyar Rt. | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
FR2791676B1 (fr) * | 1999-03-29 | 2001-06-22 | Pf Medicament | Nouveaux derives de [(2-substitue-5-[thienyl])-benzyl]- [2-([isopropoxy-5-fluoro]-phenoxy) ethyl]-amine, leur procede de preparation et leur utilisation a titre de medicaments |
-
2002
- 2002-10-16 FR FR0212854A patent/FR2845992B1/fr not_active Expired - Fee Related
-
2003
- 2003-10-16 ES ES03808761T patent/ES2264780T3/es not_active Expired - Lifetime
- 2003-10-16 EP EP03808761A patent/EP1551821B1/fr not_active Expired - Lifetime
- 2003-10-16 BR BR0315365-7A patent/BR0315365A/pt not_active IP Right Cessation
- 2003-10-16 MX MXPA05004114A patent/MXPA05004114A/es active IP Right Grant
- 2003-10-16 US US10/531,587 patent/US7163957B2/en not_active Expired - Fee Related
- 2003-10-16 CA CA2502528A patent/CA2502528C/fr not_active Expired - Fee Related
- 2003-10-16 PT PT03808761T patent/PT1551821E/pt unknown
- 2003-10-16 CN CNB200380101676XA patent/CN1319962C/zh not_active Expired - Fee Related
- 2003-10-16 JP JP2004544396A patent/JP4566749B2/ja not_active Expired - Fee Related
- 2003-10-16 AU AU2003301277A patent/AU2003301277B2/en not_active Ceased
- 2003-10-16 AT AT03808761T patent/ATE326456T1/de not_active IP Right Cessation
- 2003-10-16 WO PCT/FR2003/003053 patent/WO2004035561A1/fr active IP Right Grant
- 2003-10-16 DE DE60305339T patent/DE60305339T2/de not_active Expired - Lifetime
-
2005
- 2005-05-12 ZA ZA200503822A patent/ZA200503822B/en unknown
- 2005-08-08 HK HK05106801A patent/HK1073112A1/xx not_active IP Right Cessation
-
2006
- 2006-07-28 US US11/494,697 patent/US7235568B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2264780T3 (es) | 2007-01-16 |
EP1551821B1 (fr) | 2006-05-17 |
HK1073112A1 (en) | 2005-09-23 |
AU2003301277A1 (en) | 2004-05-04 |
JP4566749B2 (ja) | 2010-10-20 |
US7163957B2 (en) | 2007-01-16 |
WO2004035561A1 (fr) | 2004-04-29 |
ATE326456T1 (de) | 2006-06-15 |
FR2845992A1 (fr) | 2004-04-23 |
MXPA05004114A (es) | 2005-06-22 |
US7235568B2 (en) | 2007-06-26 |
DE60305339D1 (de) | 2006-06-22 |
DE60305339T2 (de) | 2007-02-01 |
JP2006508080A (ja) | 2006-03-09 |
US20060264471A1 (en) | 2006-11-23 |
ZA200503822B (en) | 2006-03-29 |
CN1319962C (zh) | 2007-06-06 |
PT1551821E (pt) | 2006-09-29 |
FR2845992B1 (fr) | 2005-02-04 |
CA2502528C (fr) | 2011-12-13 |
EP1551821A1 (fr) | 2005-07-13 |
CA2502528A1 (fr) | 2004-04-29 |
CN1705653A (zh) | 2005-12-07 |
US20060014827A1 (en) | 2006-01-19 |
AU2003301277B2 (en) | 2009-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |