BR0315365A - Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroarilmetilamina e uso destes como medicamentos para tratamento da esquizofrenia - Google Patents

Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroarilmetilamina e uso destes como medicamentos para tratamento da esquizofrenia

Info

Publication number
BR0315365A
BR0315365A BR0315365-7A BR0315365A BR0315365A BR 0315365 A BR0315365 A BR 0315365A BR 0315365 A BR0315365 A BR 0315365A BR 0315365 A BR0315365 A BR 0315365A
Authority
BR
Brazil
Prior art keywords
cyclopenten
benzyl
heteroarylmethylamine
medicines
derivatives
Prior art date
Application number
BR0315365-7A
Other languages
English (en)
Inventor
Bernard Vacher
Stephane Cuisiat
Wouter Koek
Francis Colpaert
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR0315365A publication Critical patent/BR0315365A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/48—Aldehydo radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"DERIVADOS DE 3-(CICLOPENTEN-1-IL)-BENZIL-OU 3-(CICLOPENTEN-1-IL)-HETEROARILMETILAMINA E USO DESTES COMO MEDICAMENTOS PARA TRATAMENTO DA ESQUIZOFRENIA". A invenção refere-se a compostos de fórmula geral (I), em que: - (a) representa uma ligação simples ou uma ligação dupla, - w representa um grupo CH, CH~ 2~, CHCH~ 3~, CCH~ 3~ ou C(CH~ 3~)~ 2~, um grupo C(CH~ 2~)~ 2~ (Isto é um átomo de carbono portando dois grupos metileno ligados juntos de modo a formar uma unidade espiro-ciclopropano) ou um grupo C(CH~ 2~)~ 3~ (Isto é, um átomo de carbono portando dois grupos metileno ligados juntos, de modo a formar uma unidade espiro-ciclobutano), com a condição de que, quando (a), for uma ligação dupla então, W representa exclusivamente um grupo CH ou CCH~ 3~, e de que, quando (a) for uma ligação simples, então W representa exclusivamente, um grupo CH~ 2~, CHCH~ 3~, C(CH~ 3~)~ 2~ C(CH~ 2~)~ 2~ ou C(CH~ 2~)~ 3~, - X é um átomo de carbono portando um átomo de hidrogênio (CH) ou um átomo de nitrogênio, - Y é um átomo de carbono portando um átomo de hidrogênio ou um átomo de flúor, seus sais de adição e opcionalmente, os hidratos dos sais de adição, com ácidos inorgânicos farmaceuticamente aceitáveis ou ácidos orgânicos, bem como suas formas tautoméricas, os enantiómeros puros e misturas de enantiómeros racêmicos ou não-racêmicos.
BR0315365-7A 2002-10-16 2003-10-16 Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroarilmetilamina e uso destes como medicamentos para tratamento da esquizofrenia BR0315365A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0212854A FR2845992B1 (fr) 2002-10-16 2002-10-16 Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie
PCT/FR2003/003053 WO2004035561A1 (fr) 2002-10-16 2003-10-16 Derives de 3-(cyclopenten-1-yl)-benzyl- ou 3-(cyclopenten-1-yl)-heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie

Publications (1)

Publication Number Publication Date
BR0315365A true BR0315365A (pt) 2005-08-23

Family

ID=32050432

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315365-7A BR0315365A (pt) 2002-10-16 2003-10-16 Derivados de 3-(ciclopenten-1-il)-benzil- ou 3-(ciclopenten-1-il)-heteroarilmetilamina e uso destes como medicamentos para tratamento da esquizofrenia

Country Status (16)

Country Link
US (2) US7163957B2 (pt)
EP (1) EP1551821B1 (pt)
JP (1) JP4566749B2 (pt)
CN (1) CN1319962C (pt)
AT (1) ATE326456T1 (pt)
AU (1) AU2003301277B2 (pt)
BR (1) BR0315365A (pt)
CA (1) CA2502528C (pt)
DE (1) DE60305339T2 (pt)
ES (1) ES2264780T3 (pt)
FR (1) FR2845992B1 (pt)
HK (1) HK1073112A1 (pt)
MX (1) MXPA05004114A (pt)
PT (1) PT1551821E (pt)
WO (1) WO2004035561A1 (pt)
ZA (1) ZA200503822B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2898601A1 (fr) * 2006-03-14 2007-09-21 Pierre Fabre Medicament Sa Procede de preparation de derives (2-(2,3-dihydro-benzofuran ou benzofuran-7-yloxy)-ethyl)-(3-cyclopenten-1-yl-benzyl) amines et intermediaire de synthese
US20090288701A1 (en) * 2008-05-23 2009-11-26 E.I.Du Pont De Nemours And Company Solar cell laminates having colored multi-layer encapsulant sheets

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05125024A (ja) * 1991-11-05 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアリールオキシアルキルアミン誘導体又はその塩
JPH05255302A (ja) * 1992-03-09 1993-10-05 Yamanouchi Pharmaceut Co Ltd 新規なクロマニルオキシアルキルアミン誘導体
US5955495A (en) * 1996-05-03 1999-09-21 Hoffmann-La Roche Inc. Method of treating diseases of the CNS
ES2179362T3 (es) * 1996-08-27 2003-01-16 Wyeth Corp Derivados de 4-aminoetoxi indolona.
JP2002510675A (ja) * 1998-04-08 2002-04-09 アメリカン・ホーム・プロダクツ・コーポレイション うつ病治療用のｎ−アリールオキシエチル−インドリル−アルキルアミン（５−ｈｔ１ａ受容体活性薬）
AU753706B2 (en) * 1998-05-14 2002-10-24 Egis Gyogyszergyar Rt. Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
FR2791676B1 (fr) * 1999-03-29 2001-06-22 Pf Medicament Nouveaux derives de [(2-substitue-5-[thienyl])-benzyl]- [2-([isopropoxy-5-fluoro]-phenoxy) ethyl]-amine, leur procede de preparation et leur utilisation a titre de medicaments

Also Published As

Publication number Publication date
ES2264780T3 (es) 2007-01-16
EP1551821B1 (fr) 2006-05-17
HK1073112A1 (en) 2005-09-23
AU2003301277A1 (en) 2004-05-04
JP4566749B2 (ja) 2010-10-20
US7163957B2 (en) 2007-01-16
WO2004035561A1 (fr) 2004-04-29
ATE326456T1 (de) 2006-06-15
FR2845992A1 (fr) 2004-04-23
MXPA05004114A (es) 2005-06-22
US7235568B2 (en) 2007-06-26
DE60305339D1 (de) 2006-06-22
DE60305339T2 (de) 2007-02-01
JP2006508080A (ja) 2006-03-09
US20060264471A1 (en) 2006-11-23
ZA200503822B (en) 2006-03-29
CN1319962C (zh) 2007-06-06
PT1551821E (pt) 2006-09-29
FR2845992B1 (fr) 2005-02-04
CA2502528C (fr) 2011-12-13
EP1551821A1 (fr) 2005-07-13
CA2502528A1 (fr) 2004-04-29
CN1705653A (zh) 2005-12-07
US20060014827A1 (en) 2006-01-19
AU2003301277B2 (en) 2009-06-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]