MXPA05004114A - Derivados de 3-(ciclopenten-1-il)-bencil-0 3-(ciclopenten-1-il)-heteroarilmetil-amina y uso de los mismos como medicinas para tratar esquizofrenia. - Google Patents

Derivados de 3-(ciclopenten-1-il)-bencil-0 3-(ciclopenten-1-il)-heteroarilmetil-amina y uso de los mismos como medicinas para tratar esquizofrenia.

Info

Publication number
MXPA05004114A
MXPA05004114A MXPA05004114A MXPA05004114A MXPA05004114A MX PA05004114 A MXPA05004114 A MX PA05004114A MX PA05004114 A MXPA05004114 A MX PA05004114A MX PA05004114 A MXPA05004114 A MX PA05004114A MX PA05004114 A MXPA05004114 A MX PA05004114A
Authority
MX
Mexico
Prior art keywords
group
cyclopenten
carbon atom
atom bearing
heteroarylmethyl
Prior art date
Application number
MXPA05004114A
Other languages
English (en)
Inventor
Bernard Vacher
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of MXPA05004114A publication Critical patent/MXPA05004114A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/48—Aldehydo radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La invencion se refiere a compuestos de formula general (1), (ver formula (1) en donde: (a) representa un enlace sencillo o un doble enlace; W representa un grupo CH, CH2, CHCH3, CCH3 o C(CH3)2, un grupo C(CH2)2 (es decir, un atomo de carbono que lleva dos grupos metileno unidos para formar una unidad espiro-ciclopropano) o un grupo (C(CH2)3 (es decir, un atomo de carbono que lleva dos grupos metileno unidos para formar una unidad espiro-ciclobutano) siempre que cuando (a) sea un doble enlace, entonces W represente exclusivamente un grupo CH o CCH3, y que cuando (a) sea un enlace sencillo, entonces W represente exclusivamente un grupo CH2, CHCH3, C(CH3)2, C(CH2)2 o C(CH2)3; X es un atomo de carbono que lleva un atomo de hidrogeno (CH) o un atomo de nitrogeno; Y es un atomo de carbono que lleva un atomo de hidrogeno o un atomo de fluor; sus sales de adicion y opcionalmente los hidratos de las sales de adicion con acidos organicos o acidos minerales farmaceuticamente aceptables, asi como tambien sus formas tautomericas, enantiomeros puros y mezclas de enantiomeros ya sea racemicos o no racemicos.
MXPA05004114A 2002-10-16 2003-10-16 Derivados de 3-(ciclopenten-1-il)-bencil-0 3-(ciclopenten-1-il)-heteroarilmetil-amina y uso de los mismos como medicinas para tratar esquizofrenia. MXPA05004114A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0212854A FR2845992B1 (fr) 2002-10-16 2002-10-16 Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie
PCT/FR2003/003053 WO2004035561A1 (fr) 2002-10-16 2003-10-16 Derives de 3-(cyclopenten-1-yl)-benzyl- ou 3-(cyclopenten-1-yl)-heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie

Publications (1)

Publication Number Publication Date
MXPA05004114A true MXPA05004114A (es) 2005-06-22

Family

ID=32050432

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05004114A MXPA05004114A (es) 2002-10-16 2003-10-16 Derivados de 3-(ciclopenten-1-il)-bencil-0 3-(ciclopenten-1-il)-heteroarilmetil-amina y uso de los mismos como medicinas para tratar esquizofrenia.

Country Status (16)

Country Link
US (2) US7163957B2 (es)
EP (1) EP1551821B1 (es)
JP (1) JP4566749B2 (es)
CN (1) CN1319962C (es)
AT (1) ATE326456T1 (es)
AU (1) AU2003301277B2 (es)
BR (1) BR0315365A (es)
CA (1) CA2502528C (es)
DE (1) DE60305339T2 (es)
ES (1) ES2264780T3 (es)
FR (1) FR2845992B1 (es)
HK (1) HK1073112A1 (es)
MX (1) MXPA05004114A (es)
PT (1) PT1551821E (es)
WO (1) WO2004035561A1 (es)
ZA (1) ZA200503822B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2898601A1 (fr) * 2006-03-14 2007-09-21 Pierre Fabre Medicament Sa Procede de preparation de derives (2-(2,3-dihydro-benzofuran ou benzofuran-7-yloxy)-ethyl)-(3-cyclopenten-1-yl-benzyl) amines et intermediaire de synthese
US20090288701A1 (en) * 2008-05-23 2009-11-26 E.I.Du Pont De Nemours And Company Solar cell laminates having colored multi-layer encapsulant sheets

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05125024A (ja) * 1991-11-05 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアリールオキシアルキルアミン誘導体又はその塩
JPH05255302A (ja) * 1992-03-09 1993-10-05 Yamanouchi Pharmaceut Co Ltd 新規なクロマニルオキシアルキルアミン誘導体
US5955495A (en) * 1996-05-03 1999-09-21 Hoffmann-La Roche Inc. Method of treating diseases of the CNS
WO1998008819A1 (en) * 1996-08-27 1998-03-05 American Home Products Corporation 4-aminoethoxy indolone derivatives
WO1999051575A1 (en) * 1998-04-08 1999-10-14 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents)
SK17212000A3 (sk) * 1998-05-14 2001-05-10 Egis Gy�Gyszergy�R Rt. Benzofuránové deriváty, farmaceutické kompozície ich obsahujúce a spôsob prípravy aktívnej zložky
FR2791676B1 (fr) * 1999-03-29 2001-06-22 Pf Medicament Nouveaux derives de [(2-substitue-5-[thienyl])-benzyl]- [2-([isopropoxy-5-fluoro]-phenoxy) ethyl]-amine, leur procede de preparation et leur utilisation a titre de medicaments

Also Published As

Publication number Publication date
EP1551821A1 (fr) 2005-07-13
AU2003301277B2 (en) 2009-06-18
AU2003301277A1 (en) 2004-05-04
ZA200503822B (en) 2006-03-29
JP2006508080A (ja) 2006-03-09
CN1705653A (zh) 2005-12-07
ES2264780T3 (es) 2007-01-16
ATE326456T1 (de) 2006-06-15
WO2004035561A1 (fr) 2004-04-29
PT1551821E (pt) 2006-09-29
FR2845992A1 (fr) 2004-04-23
US20060264471A1 (en) 2006-11-23
CN1319962C (zh) 2007-06-06
CA2502528A1 (fr) 2004-04-29
BR0315365A (pt) 2005-08-23
DE60305339T2 (de) 2007-02-01
EP1551821B1 (fr) 2006-05-17
US20060014827A1 (en) 2006-01-19
CA2502528C (fr) 2011-12-13
JP4566749B2 (ja) 2010-10-20
US7163957B2 (en) 2007-01-16
HK1073112A1 (en) 2005-09-23
DE60305339D1 (de) 2006-06-22
US7235568B2 (en) 2007-06-26
FR2845992B1 (fr) 2005-02-04

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