HUP0000233A2 - Pirazolinon-származékok alkalmazása potenciazavarok kezelésére szolgáló gyógyszerkészítmények előállítására - Google Patents
Pirazolinon-származékok alkalmazása potenciazavarok kezelésére szolgáló gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0000233A2 HUP0000233A2 HU0000233A HUP0000233A HUP0000233A2 HU P0000233 A2 HUP0000233 A2 HU P0000233A2 HU 0000233 A HU0000233 A HU 0000233A HU P0000233 A HUP0000233 A HU P0000233A HU P0000233 A2 HUP0000233 A2 HU P0000233A2
- Authority
- HU
- Hungary
- Prior art keywords
- atoms
- carbon atoms
- potency
- group
- so2nr4r5
- Prior art date
Links
- XBYRMPXUBGMOJC-UHFFFAOYSA-N 1,2-dihydropyrazol-3-one Chemical class OC=1C=CNN=1 XBYRMPXUBGMOJC-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- -1 nitro- Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 229910018830 PO3H Chemical group 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical class [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgya (I) általános képletű vegyületek alkalmazása - ahol R1 jelentése szubsztituálatlan vagy egyszer alkoxicsoporttalszubsztituált benzilcsoport, szubsztituálatlan vagy egyszer, kétszervagy háromszor halogénatommal, nitro-, ciano-, karboxil-, karbamido-,CONHA, CONAA', NH2, NH-CO-A, NH-SO2A, NA-SO2A', NH-CO-OA, SO3H, SO2NH-CO-A, SO2NR4R5, CO-NHSO3H, CO-NHSO2A vagy tetrazolil- vagy PO3Hcsoporttal szubsztituált fenil- vagy piridilcsoport; R2 jelentése A, alkoxi-karbonil-alkilén-, hidroxi-karbonil-alkilén-vagy hidroxi-alkilén-csoport; R3 jelentése H, A, alkoxi-, amino-, NHA, NA', NH-CO-A vagy SO2NR4R5képletű csoport; R4 és R5 egymástól függetlenül lehet hidrogénatom vagy A; R4 és R5 együtt képezhet telített vagy részben vagy teljesentelítetlen 4-5 tagú alkilénláncot, amelyben 1-3 szénatomot nitrogén-és/vagy 1-2 szénatomot 1-2 oxigén- és/vagy kénatom helyettesíthet; A, A' jelentése egymástól függetlenül 1-6 szénatomos alkilcsoport,ahol 1-7 hidrogénatomot fluor- és/vagy klóratom helyettesíthet; Hal jelentése fluor-, klór-, bróm- vagy jódatom - potenciazavarokkezelésére és/vagy gyógyítására szolgáló gyógyszerkészítményekelőállítására. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19642284A DE19642284A1 (de) | 1996-10-14 | 1996-10-14 | Pyrazolinone zur Behandlung von Potenzstörungen |
| PCT/EP1997/005532 WO1998016224A1 (de) | 1996-10-14 | 1997-10-08 | Pyrazolinone zur behandlung von potenzstörungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000233A2 true HUP0000233A2 (hu) | 2001-04-28 |
| HUP0000233A3 HUP0000233A3 (en) | 2001-06-28 |
Family
ID=7808669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000233A HUP0000233A3 (en) | 1996-10-14 | 1997-10-08 | Use of pyrazolinone derivatives for producing pharmaceutical compositions useful for treating disturbances of potency |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0930881A1 (hu) |
| JP (1) | JP2001501958A (hu) |
| KR (1) | KR20000049086A (hu) |
| CN (1) | CN1233178A (hu) |
| AR (1) | AR008494A1 (hu) |
| AU (1) | AU4945297A (hu) |
| BR (1) | BR9712307A (hu) |
| CA (1) | CA2268823A1 (hu) |
| DE (1) | DE19642284A1 (hu) |
| HU (1) | HUP0000233A3 (hu) |
| NO (1) | NO991734L (hu) |
| PL (1) | PL332821A1 (hu) |
| WO (1) | WO1998016224A1 (hu) |
| ZA (1) | ZA979151B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
| US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
| US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
| US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
| US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
| US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
| US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
| US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
| US6875575B1 (en) | 1998-11-25 | 2005-04-05 | Osi Pharmaceuticals, Inc. | Diagnostic methods for neoplasia |
| US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| DE19518082A1 (de) * | 1995-05-17 | 1996-11-21 | Merck Patent Gmbh | 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one |
-
1996
- 1996-10-14 DE DE19642284A patent/DE19642284A1/de not_active Withdrawn
-
1997
- 1997-10-08 JP JP10517987A patent/JP2001501958A/ja active Pending
- 1997-10-08 CA CA002268823A patent/CA2268823A1/en not_active Abandoned
- 1997-10-08 EP EP97912141A patent/EP0930881A1/de not_active Withdrawn
- 1997-10-08 PL PL97332821A patent/PL332821A1/xx unknown
- 1997-10-08 HU HU0000233A patent/HUP0000233A3/hu unknown
- 1997-10-08 BR BR9712307-2A patent/BR9712307A/pt not_active Application Discontinuation
- 1997-10-08 WO PCT/EP1997/005532 patent/WO1998016224A1/de not_active Application Discontinuation
- 1997-10-08 AU AU49452/97A patent/AU4945297A/en not_active Abandoned
- 1997-10-08 KR KR1019990703161A patent/KR20000049086A/ko not_active Application Discontinuation
- 1997-10-08 CN CN97198764A patent/CN1233178A/zh active Pending
- 1997-10-13 ZA ZA9709151A patent/ZA979151B/xx unknown
- 1997-10-14 AR ARP970104715A patent/AR008494A1/es unknown
-
1999
- 1999-04-13 NO NO991734A patent/NO991734L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0930881A1 (de) | 1999-07-28 |
| HUP0000233A3 (en) | 2001-06-28 |
| JP2001501958A (ja) | 2001-02-13 |
| WO1998016224A1 (de) | 1998-04-23 |
| ZA979151B (en) | 1998-05-11 |
| AR008494A1 (es) | 2000-01-19 |
| PL332821A1 (en) | 1999-10-11 |
| CA2268823A1 (en) | 1998-04-23 |
| BR9712307A (pt) | 1999-08-31 |
| AU4945297A (en) | 1998-05-11 |
| CN1233178A (zh) | 1999-10-27 |
| DE19642284A1 (de) | 1998-04-16 |
| NO991734D0 (no) | 1999-04-13 |
| NO991734L (no) | 1999-04-13 |
| KR20000049086A (ko) | 2000-07-25 |
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