ATE509910T1 - Vitamin d derivate mit einem 22-oxa- oder 22-thia-atom, einer sauer-, ester- oder amid- substitutierten c17-seitenkette und einer 16(17)- doppelbindung - Google Patents
Vitamin d derivate mit einem 22-oxa- oder 22-thia-atom, einer sauer-, ester- oder amid- substitutierten c17-seitenkette und einer 16(17)- doppelbindungInfo
- Publication number
- ATE509910T1 ATE509910T1 AT01938659T AT01938659T ATE509910T1 AT E509910 T1 ATE509910 T1 AT E509910T1 AT 01938659 T AT01938659 T AT 01938659T AT 01938659 T AT01938659 T AT 01938659T AT E509910 T1 ATE509910 T1 AT E509910T1
- Authority
- AT
- Austria
- Prior art keywords
- vitamin
- derivatives
- oxa
- ester
- acid
- Prior art date
Links
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 150000001408 amides Chemical group 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 2
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000121 hypercalcemic effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000179251 | 2000-06-15 | ||
| JP2000351412 | 2000-11-17 | ||
| JP2000375024 | 2000-12-08 | ||
| PCT/JP2001/005062 WO2001096293A1 (fr) | 2000-06-15 | 2001-06-14 | Derives de vitamine d |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE509910T1 true ATE509910T1 (de) | 2011-06-15 |
Family
ID=27343730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01938659T ATE509910T1 (de) | 2000-06-15 | 2001-06-14 | Vitamin d derivate mit einem 22-oxa- oder 22-thia-atom, einer sauer-, ester- oder amid- substitutierten c17-seitenkette und einer 16(17)- doppelbindung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7985744B2 (de) |
| EP (1) | EP1295871B1 (de) |
| JP (2) | JP3706104B2 (de) |
| KR (2) | KR100734799B1 (de) |
| CN (2) | CN102617690B (de) |
| AT (1) | ATE509910T1 (de) |
| AU (2) | AU2001264280B2 (de) |
| CA (2) | CA2664720C (de) |
| DK (1) | DK1295871T3 (de) |
| HK (2) | HK1054373B (de) |
| IL (3) | IL153395A0 (de) |
| NO (2) | NO328868B1 (de) |
| NZ (1) | NZ528622A (de) |
| TW (1) | TWI288131B (de) |
| WO (1) | WO2001096293A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| JP2004504295A (ja) * | 2000-07-18 | 2004-02-12 | ボーン ケア インターナショナル インコーポレイテッド | 安定化１α−ヒドロキシビタミンＤ |
| US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
| US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| WO2006059768A1 (ja) * | 2004-12-03 | 2006-06-08 | Nippon Shinyaku Co., Ltd. | ９，１０－セコプレグナン誘導体及び医薬 |
| WO2006093291A1 (ja) * | 2005-03-04 | 2006-09-08 | Tokyo Medical And Dental University | １９－ノルビタミンｄ誘導体 |
| JP5095413B2 (ja) * | 2005-11-30 | 2012-12-12 | 中外製薬株式会社 | 光反応を用いるビタミンｄ誘導体の製法 |
| US8173824B2 (en) | 2005-12-02 | 2012-05-08 | Chugai Seiyaku Kabushiki Kaisha | Process for producing vitamin D derivative using convergent method |
| EP2025667B1 (de) * | 2006-06-02 | 2016-08-10 | Nippon Shinyaku Co., Ltd. | 9, 10-secopregnanderivat und arzneimittel |
| CA2684741A1 (en) * | 2007-04-18 | 2008-10-30 | Johns Hopkins University | Low calcemic, highly antiproliferative, analogs of calcitriol |
| US8551463B2 (en) | 2007-10-22 | 2013-10-08 | Living Proof, Inc. | Hair care compositions and methods of treating hair |
| DE102009028939A1 (de) * | 2009-08-27 | 2011-03-03 | Ludwig-Maximilians-Universität München | Verfahren zur Herstellung von Arylaluminiumhalogeniden und deren Verwendung |
| JP5652723B2 (ja) * | 2012-08-17 | 2015-01-14 | フォーモサ・ラボラトリーズ・インコーポレーテッド | マキサカルシトールの新しい結晶形態 |
| CN106279239B (zh) | 2015-05-29 | 2019-06-28 | 上海彩迩文生化科技有限公司 | 多烯化合物、制备方法及其应用 |
| US10548908B2 (en) * | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
| CN113105517B (zh) * | 2021-04-10 | 2022-03-01 | 台州仙琚药业有限公司 | 雄甾-1,4,9-三烯-3,17-二酮的合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| RU2139276C1 (ru) * | 1991-11-07 | 1999-10-10 | Рисерч Инститьют фор Медсин энд Кемистри | Производные амида витамина d и фармацевтическая композиция |
| JP3493037B2 (ja) * | 1991-12-18 | 2004-02-03 | 中外製薬株式会社 | ２２−オキサコレカルシフェロール誘導体とその製造方法 |
| GB9226877D0 (en) | 1992-12-23 | 1993-02-17 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9309422D0 (en) * | 1993-05-07 | 1993-06-23 | Res Inst Medicine Chem | Chemical compounds |
| US5361722A (en) | 1993-06-16 | 1994-11-08 | Universal Dairy Equipment Inc. | Milking facility with service alley |
| ATE195513T1 (de) | 1994-04-11 | 2000-09-15 | Chugai Pharmaceutical Co Ltd | 22-thiavitamin-d3-derivate |
| JP3759639B2 (ja) | 1994-04-11 | 2006-03-29 | 中外製薬株式会社 | ２２−チアビタミン▲ｄ３▼誘導体 |
| PE28297A1 (es) * | 1995-01-26 | 1997-08-20 | Hoffmann La Roche | Empleo dermatologico de derivados de vitamina d |
| US6184398B1 (en) * | 1996-12-20 | 2001-02-06 | Chugai Seiyaku Kabushiki Kaisha | 16-ene-vitamin D derivatives |
| JP4012293B2 (ja) | 1996-12-20 | 2007-11-21 | 中外製薬株式会社 | １６−エン−ビタミンｄ誘導体 |
| ES2206758T3 (es) * | 1996-12-20 | 2004-05-16 | Chugai Seiyaku Kabushiki Kaisha | Derivados de vitamina d 16-ene. |
| AU743514B2 (en) * | 1997-05-16 | 2002-01-24 | Women & Infants Hospital | Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof |
| EP1275643A4 (de) * | 2000-04-19 | 2009-06-03 | Chugai Pharmaceutical Co Ltd | Vitamin d derivate |
| JP5095413B2 (ja) * | 2005-11-30 | 2012-12-12 | 中外製薬株式会社 | 光反応を用いるビタミンｄ誘導体の製法 |
| US8173824B2 (en) * | 2005-12-02 | 2012-05-08 | Chugai Seiyaku Kabushiki Kaisha | Process for producing vitamin D derivative using convergent method |
-
2001
- 2001-06-14 DK DK01938659.8T patent/DK1295871T3/da active
- 2001-06-14 AT AT01938659T patent/ATE509910T1/de not_active IP Right Cessation
- 2001-06-14 JP JP2002510437A patent/JP3706104B2/ja not_active Expired - Lifetime
- 2001-06-14 NZ NZ528622A patent/NZ528622A/en not_active IP Right Cessation
- 2001-06-14 IL IL15339501A patent/IL153395A0/xx unknown
- 2001-06-14 CA CA2664720A patent/CA2664720C/en not_active Expired - Lifetime
- 2001-06-14 AU AU2001264280A patent/AU2001264280B2/en not_active Expired
- 2001-06-14 CA CA2411409A patent/CA2411409C/en not_active Expired - Lifetime
- 2001-06-14 AU AU6428001A patent/AU6428001A/xx active Pending
- 2001-06-14 KR KR1020067010749A patent/KR100734799B1/ko active IP Right Grant
- 2001-06-14 KR KR1020027017120A patent/KR100786053B1/ko active IP Right Grant
- 2001-06-14 WO PCT/JP2001/005062 patent/WO2001096293A1/ja active Application Filing
- 2001-06-14 US US10/311,538 patent/US7985744B2/en not_active Expired - Fee Related
- 2001-06-14 CN CN201210043161.XA patent/CN102617690B/zh not_active Expired - Lifetime
- 2001-06-14 CN CNB018111254A patent/CN100469764C/zh not_active Expired - Lifetime
- 2001-06-14 EP EP01938659A patent/EP1295871B1/de not_active Expired - Lifetime
- 2001-06-14 TW TW090114462A patent/TWI288131B/zh not_active IP Right Cessation
-
2002
- 2002-12-11 IL IL153395A patent/IL153395A/en active IP Right Grant
- 2002-12-13 NO NO20026014A patent/NO328868B1/no not_active IP Right Cessation
-
2003
- 2003-09-17 HK HK03106679.2A patent/HK1054373B/zh not_active IP Right Cessation
- 2003-11-24 HK HK03108563.7A patent/HK1056163A1/xx not_active IP Right Cessation
-
2004
- 2004-09-13 JP JP2004265562A patent/JP4233504B2/ja not_active Expired - Lifetime
-
2006
- 2006-09-27 IL IL178350A patent/IL178350A/en active IP Right Grant
-
2009
- 2009-08-13 NO NO20092832A patent/NO332310B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |