FR2838444B1 - Nouveaux peptides et leur application en therapeutique - Google Patents

Nouveaux peptides et leur application en therapeutique

Info

Publication number
FR2838444B1
FR2838444B1 FR0204464A FR0204464A FR2838444B1 FR 2838444 B1 FR2838444 B1 FR 2838444B1 FR 0204464 A FR0204464 A FR 0204464A FR 0204464 A FR0204464 A FR 0204464A FR 2838444 B1 FR2838444 B1 FR 2838444B1
Authority
FR
France
Prior art keywords
peptide
immunogenic compound
cytokine
derivative
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0204464A
Other languages
English (en)
French (fr)
Other versions
FR2838444A1 (fr
Inventor
Jean Francois Zagury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaxconsulting Fr
Original Assignee
Neovacs SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0204464A priority Critical patent/FR2838444B1/fr
Application filed by Neovacs SA filed Critical Neovacs SA
Priority to AU2003260031A priority patent/AU2003260031B2/en
Priority to CA2480996A priority patent/CA2480996C/fr
Priority to MXPA04009841A priority patent/MXPA04009841A/es
Priority to NZ536351A priority patent/NZ536351A/en
Priority to DK10183953.8T priority patent/DK2314311T3/en
Priority to AT03740584T priority patent/ATE526985T1/de
Priority to KR1020047016042A priority patent/KR101101004B1/ko
Priority to ES10183953.8T priority patent/ES2550030T3/es
Priority to RU2004132871/13A priority patent/RU2326125C2/ru
Priority to EP03740584A priority patent/EP1492814B1/fr
Priority to SI200332450T priority patent/SI2314311T1/sl
Priority to ES03740584T priority patent/ES2375053T3/es
Priority to JP2003582175A priority patent/JP2005530723A/ja
Priority to EP10183953.8A priority patent/EP2314311B1/fr
Priority to PCT/FR2003/001120 priority patent/WO2003084979A2/fr
Priority to CNA038100606A priority patent/CN1649898A/zh
Priority to EP10183961A priority patent/EP2314312A3/fr
Priority to US10/510,116 priority patent/US7393523B2/en
Publication of FR2838444A1 publication Critical patent/FR2838444A1/fr
Priority to MA27884A priority patent/MA27191A1/fr
Priority to IL16442904A priority patent/IL164429A0/xx
Priority to TNP2004000200A priority patent/TNSN04200A1/fr
Priority to ZA2004/08451A priority patent/ZA200408451B/en
Priority to US12/134,743 priority patent/US7641895B2/en
Priority to US12/628,826 priority patent/US7892529B2/en
Priority to US13/004,588 priority patent/US8147819B2/en
Priority to US13/362,234 priority patent/US8277792B2/en
Priority to US13/593,823 priority patent/US8529881B2/en
Application granted granted Critical
Publication of FR2838444B1 publication Critical patent/FR2838444B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5409—IL-5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5437—IL-13
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR0204464A 2002-04-10 2002-04-10 Nouveaux peptides et leur application en therapeutique Expired - Lifetime FR2838444B1 (fr)

Priority Applications (28)

Application Number Priority Date Filing Date Title
FR0204464A FR2838444B1 (fr) 2002-04-10 2002-04-10 Nouveaux peptides et leur application en therapeutique
PCT/FR2003/001120 WO2003084979A2 (fr) 2002-04-10 2003-04-09 Peptides et leur application en therapeutique
MXPA04009841A MXPA04009841A (es) 2002-04-10 2003-04-09 Nuevos peptidos y su aplicacion en terapeutica.
NZ536351A NZ536351A (en) 2002-04-10 2003-04-09 Peptides and the application thereof in therapy
DK10183953.8T DK2314311T3 (en) 2002-04-10 2003-04-09 Peptides and therapeutic use thereof
AT03740584T ATE526985T1 (de) 2002-04-10 2003-04-09 Aus interleukin-1-beta abgeleitetes peptid und therapeutische verwendung davon
KR1020047016042A KR101101004B1 (ko) 2002-04-10 2003-04-09 신규한 펩티드 및 그들의 치료 용도
ES10183953.8T ES2550030T3 (es) 2002-04-10 2003-04-09 Péptidos y su aplicación en terapéutica
EP10183961A EP2314312A3 (fr) 2002-04-10 2003-04-09 Peptides et leur application en thérapeutique
EP03740584A EP1492814B1 (fr) 2002-04-10 2003-04-09 Peptide dérivé de l'interleukine-1-beta et son application thérapeutique
SI200332450T SI2314311T1 (sl) 2002-04-10 2003-04-09 Peptidi in njihova terapevtska uporaba
ES03740584T ES2375053T3 (es) 2002-04-10 2003-04-09 Péptido derivado de la interleucina-1-beta y su aplicación terapéutica.
JP2003582175A JP2005530723A (ja) 2002-04-10 2003-04-09 新規ペプチド及び治療を目的とするその利用
EP10183953.8A EP2314311B1 (fr) 2002-04-10 2003-04-09 Péptides et leur application en thérapeutique
AU2003260031A AU2003260031B2 (en) 2002-04-10 2003-04-09 Novel peptides and the application thereof in therapy
US10/510,116 US7393523B2 (en) 2002-04-10 2003-04-09 Peptides for active anti-cytokine immunization
RU2004132871/13A RU2326125C2 (ru) 2002-04-10 2003-04-09 Новые пептиды и их применение в терапии
CA2480996A CA2480996C (fr) 2002-04-10 2003-04-09 Peptides derives ou provenant de cytokine et leur application en therapeutique
CNA038100606A CN1649898A (zh) 2002-04-10 2003-04-09 新型肽及其的治疗中的应用
MA27884A MA27191A1 (fr) 2002-04-10 2004-10-01 Peptides et leur application en therapeutique
IL16442904A IL164429A0 (en) 2002-04-10 2004-10-05 Novel peptides and the application thereof in therapy
TNP2004000200A TNSN04200A1 (fr) 2002-04-10 2004-10-08 Peptides et leur application en therapeutique
ZA2004/08451A ZA200408451B (en) 2002-04-10 2004-10-19 Novel peptides and the application thereof in therapy
US12/134,743 US7641895B2 (en) 2002-04-10 2008-06-06 Peptides for active anti-cytokine immunization
US12/628,826 US7892529B2 (en) 2002-04-10 2009-12-01 Peptides for active anti-cytokine immunization
US13/004,588 US8147819B2 (en) 2002-04-10 2011-01-11 Peptides for active anti-cytokine immunization
US13/362,234 US8277792B2 (en) 2002-04-10 2012-01-31 Peptides for active anti-cytokine immunization
US13/593,823 US8529881B2 (en) 2002-04-10 2012-08-24 Peptides for active anti-cytokine immunization

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0204464A FR2838444B1 (fr) 2002-04-10 2002-04-10 Nouveaux peptides et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2838444A1 FR2838444A1 (fr) 2003-10-17
FR2838444B1 true FR2838444B1 (fr) 2016-01-01

Family

ID=28459716

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0204464A Expired - Lifetime FR2838444B1 (fr) 2002-04-10 2002-04-10 Nouveaux peptides et leur application en therapeutique

Country Status (20)

Country Link
US (6) US7393523B2 (https=)
EP (3) EP2314311B1 (https=)
JP (1) JP2005530723A (https=)
KR (1) KR101101004B1 (https=)
CN (1) CN1649898A (https=)
AT (1) ATE526985T1 (https=)
AU (1) AU2003260031B2 (https=)
CA (1) CA2480996C (https=)
DK (1) DK2314311T3 (https=)
ES (2) ES2550030T3 (https=)
FR (1) FR2838444B1 (https=)
IL (1) IL164429A0 (https=)
MA (1) MA27191A1 (https=)
MX (1) MXPA04009841A (https=)
NZ (1) NZ536351A (https=)
RU (1) RU2326125C2 (https=)
SI (1) SI2314311T1 (https=)
TN (1) TNSN04200A1 (https=)
WO (1) WO2003084979A2 (https=)
ZA (1) ZA200408451B (https=)

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US7422743B2 (en) * 2000-05-10 2008-09-09 Schering Corporation Mammalian receptor protein DCRS5;methods of treatment
FR2859725B1 (fr) * 2003-09-16 2006-03-10 Neovacs Procede a haut rendement pour l'obtention d'anticorps humains neutralisant l'activite biologique d'une cytokine humaine
AU2005220156B2 (en) * 2004-02-27 2011-06-02 Vaxconsulting Peptides of IL1 beta and TNF alpha and method of treatment using same
NZ566971A (en) 2005-09-28 2011-06-30 Cytos Biotechnology Ag Vaccine containing a virus like particle linked with an interleukin-1 molecule
NZ592943A (en) * 2008-11-17 2012-09-28 Uinv Kobenhavns Il-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases
EP2480251B1 (en) 2009-09-21 2025-12-03 Peptinov Carrier conjugates of il-23-peptides and their induced antibodies
WO2011143280A2 (en) 2010-05-11 2011-11-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptide-based inhibitor of interleukin-10 or interferon-gamma signaling
WO2013140785A1 (ja) * 2012-03-18 2013-09-26 国立大学法人九州大学 疾患サンプル分析装置、分析システム及び分析方法
US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules
US10576131B2 (en) * 2015-06-03 2020-03-03 Affiris Ag IL-23-p19 vaccines
EP3696547B1 (en) * 2017-10-13 2025-08-13 Nibec Co., Ltd. Grp78-derived peptide for identifying high-efficiency stem cells
EP3966230A1 (en) * 2019-05-10 2022-03-16 Bimyo GmbH Bnip3 peptides for treatment of reperfusion injury
EP4486389A1 (en) 2022-02-28 2025-01-08 Tridem Bioscience GmbH & Co KG A conjugate comprising at least a beta-glucan

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ATE136906T1 (de) * 1989-12-20 1996-05-15 Schering Corp Antikörperantagonisten gegen humanes interleukin- 4
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FR2677654B1 (fr) * 1991-06-17 1995-11-17 Pasteur Merieux Serums Vacc Composes a effet immunogene anti-cytokine, a effet immunogene anticytostatique ou a effet vaccinal anti-infection a hiv.
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EP1492814B1 (fr) 2011-10-05
DK2314311T3 (en) 2015-10-12
WO2003084979A3 (fr) 2004-04-08
EP2314311A3 (fr) 2011-08-17
EP1492814A2 (fr) 2005-01-05
US20080260689A1 (en) 2008-10-23
CN1649898A (zh) 2005-08-03
EP2314311A2 (fr) 2011-04-27
US20120121627A1 (en) 2012-05-17
AU2003260031A1 (en) 2003-10-20
TNSN04200A1 (fr) 2007-03-12
ATE526985T1 (de) 2011-10-15
KR101101004B1 (ko) 2011-12-29
US8277792B2 (en) 2012-10-02
KR20040108709A (ko) 2004-12-24
EP2314311B1 (fr) 2015-07-15
CA2480996A1 (fr) 2003-10-16
ES2375053T3 (es) 2012-02-24
ES2550030T3 (es) 2015-11-04
IL164429A0 (en) 2005-12-18
EP2314312A2 (fr) 2011-04-27
WO2003084979A2 (fr) 2003-10-16
US20110171169A1 (en) 2011-07-14
RU2004132871A (ru) 2005-09-20
NZ536351A (en) 2007-03-30
US7393523B2 (en) 2008-07-01
US20120321652A1 (en) 2012-12-20
MA27191A1 (fr) 2005-01-03
ZA200408451B (en) 2006-01-25
SI2314311T1 (sl) 2015-12-31
US8147819B2 (en) 2012-04-03
JP2005530723A (ja) 2005-10-13
US7641895B2 (en) 2010-01-05
US7892529B2 (en) 2011-02-22
EP2314312A3 (fr) 2011-08-31
CA2480996C (fr) 2016-06-21
US20060241286A1 (en) 2006-10-26
US20100150957A1 (en) 2010-06-17
AU2003260031B2 (en) 2009-10-29
US8529881B2 (en) 2013-09-10
FR2838444A1 (fr) 2003-10-17
RU2326125C2 (ru) 2008-06-10
MXPA04009841A (es) 2005-06-17

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