FR2826009B1 - Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2826009B1
FR2826009B1 FR0107718A FR0107718A FR2826009B1 FR 2826009 B1 FR2826009 B1 FR 2826009B1 FR 0107718 A FR0107718 A FR 0107718A FR 0107718 A FR0107718 A FR 0107718A FR 2826009 B1 FR2826009 B1 FR 2826009B1
Authority
FR
France
Prior art keywords
alkyl
aryl
optionally substituted
groups
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0107718A
Other languages
English (en)
French (fr)
Other versions
FR2826009A1 (fr
Inventor
Michel Wierzbicki
Marie Francoise Boussard
Anne Rousseau
Ghanem Atassi
John Hickman
Alain Pierre
Stephane Leonce
Nicolas Guilbaud
Berthier Laurence Kraus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to FR0107718A priority Critical patent/FR2826009B1/fr
Priority to SK834-2002A priority patent/SK286055B6/sk
Priority to MXPA02005808A priority patent/MXPA02005808A/es
Priority to AU45903/02A priority patent/AU781768B2/en
Priority to KR10-2002-0032814A priority patent/KR100466068B1/ko
Priority to JP2002171000A priority patent/JP3837090B2/ja
Priority to EP02291463A priority patent/EP1266887B1/fr
Priority to PT02291463T priority patent/PT1266887E/pt
Priority to ES02291463T priority patent/ES2247282T3/es
Priority to NO20022794A priority patent/NO322709B1/no
Priority to SI200230176T priority patent/SI1266887T1/sl
Priority to ARP020102206A priority patent/AR034471A1/es
Priority to DK02291463T priority patent/DK1266887T3/da
Priority to AT02291463T priority patent/ATE302183T1/de
Priority to NZ519522A priority patent/NZ519522A/en
Priority to DE60205538T priority patent/DE60205538T2/de
Priority to BR0202279-6A priority patent/BR0202279A/pt
Priority to US10/171,191 priority patent/US6627650B2/en
Priority to ZA200204757A priority patent/ZA200204757B/xx
Priority to HU0201992A priority patent/HUP0201992A3/hu
Priority to CA002389766A priority patent/CA2389766C/fr
Priority to EA200200563A priority patent/EA004571B1/ru
Priority to CZ20022083A priority patent/CZ20022083A3/cs
Priority to PL02354472A priority patent/PL354472A1/xx
Priority to CNB021213054A priority patent/CN1156446C/zh
Publication of FR2826009A1 publication Critical patent/FR2826009A1/fr
Priority to HK03102396A priority patent/HK1052172A1/xx
Application granted granted Critical
Publication of FR2826009B1 publication Critical patent/FR2826009B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0107718A 2001-06-13 2001-06-13 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2826009B1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR0107718A FR2826009B1 (fr) 2001-06-13 2001-06-13 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MXPA02005808A MXPA02005808A (es) 2001-06-13 2002-06-11 Nuevos compuestos de indenoindolona, un proceso para su preparacion y las composiciones farmaceuticas que los contienen.
AU45903/02A AU781768B2 (en) 2001-06-13 2002-06-11 New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them
SK834-2002A SK286055B6 (sk) 2001-06-13 2002-06-11 Indenoindolónové zlúčeniny, spôsob ich prípravy afarmaceutické kompozície s ich obsahom
DE60205538T DE60205538T2 (de) 2001-06-13 2002-06-12 Indenoindolin Derivate, Verfahren zur Herstellung dieser Derivate und diese enthaltende pharmazeutische Präparate
EP02291463A EP1266887B1 (fr) 2001-06-13 2002-06-12 Dérivés d'indénoindolones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
PT02291463T PT1266887E (pt) 2001-06-13 2002-06-12 Derivados de indenoindolonas, processo para a sua preparacao e as composicoes farmaceuticas que os contem
ES02291463T ES2247282T3 (es) 2001-06-13 2002-06-12 Derivados de indenoindolonas, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
NO20022794A NO322709B1 (no) 2001-06-13 2002-06-12 Nye indenoindolonforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem
SI200230176T SI1266887T1 (sl) 2001-06-13 2002-06-12 Derivati indenoindolona, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
ARP020102206A AR034471A1 (es) 2001-06-13 2002-06-12 Compuestos de indenoindolona, un procedimiento para su preparacion, y composiciones farmaceuticas que los contienen
DK02291463T DK1266887T3 (da) 2001-06-13 2002-06-12 Indenoindolonderivater, fremgangsmåde til fremstilling af disse derivater og farmaceutiske sammensætninger indeholdende disse
AT02291463T ATE302183T1 (de) 2001-06-13 2002-06-12 Indenoindolin derivate, verfahren zur herstellung dieser derivate und diese enthaltende pharmazeutische präparate
NZ519522A NZ519522A (en) 2001-06-13 2002-06-12 New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them
KR10-2002-0032814A KR100466068B1 (ko) 2001-06-13 2002-06-12 인데노인돌론 화합물, 이의 제조 방법 및 이를 함유하는약제 조성물
JP2002171000A JP3837090B2 (ja) 2001-06-13 2002-06-12 新規なインデノインドロン化合物、それらの調製方法及びそれらを含有する医薬組成物
BR0202279-6A BR0202279A (pt) 2001-06-13 2002-06-13 Compostos de indenoindolona, processo para sua preparação e composições farmacêuticas contendo eles
ZA200204757A ZA200204757B (en) 2001-06-13 2002-06-13 Indenoidolone compounds, a process for their preparation and pharmaceutical compositions containing them.
HU0201992A HUP0201992A3 (en) 2001-06-13 2002-06-13 Indenoindolone derivatives, process for their preparation and pharmaceutical compositions containing the compounds and their use
CA002389766A CA2389766C (fr) 2001-06-13 2002-06-13 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA200200563A EA004571B1 (ru) 2001-06-13 2002-06-13 Новые соединения инденоиндолона, способ их получения и фармацевтические композиции их содержащие
CZ20022083A CZ20022083A3 (cs) 2001-06-13 2002-06-13 Nové indenoindolonové sloučeniny, způsob jejich přípravy a farmaceutické kompozice, jež je obsahují
US10/171,191 US6627650B2 (en) 2001-06-13 2002-06-13 Indenoindolone compounds
CNB021213054A CN1156446C (zh) 2001-06-13 2002-06-13 茚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物
PL02354472A PL354472A1 (en) 2001-06-13 2002-06-13 Novel indenoindolone compounds, method of obtaining them, pharmacological compositions containing such compounds and their application
HK03102396A HK1052172A1 (en) 2001-06-13 2003-04-03 New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0107718A FR2826009B1 (fr) 2001-06-13 2001-06-13 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2826009A1 FR2826009A1 (fr) 2002-12-20
FR2826009B1 true FR2826009B1 (fr) 2003-08-15

Family

ID=8864253

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0107718A Expired - Fee Related FR2826009B1 (fr) 2001-06-13 2001-06-13 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (26)

Country Link
US (1) US6627650B2 (pt)
EP (1) EP1266887B1 (pt)
JP (1) JP3837090B2 (pt)
KR (1) KR100466068B1 (pt)
CN (1) CN1156446C (pt)
AR (1) AR034471A1 (pt)
AT (1) ATE302183T1 (pt)
AU (1) AU781768B2 (pt)
BR (1) BR0202279A (pt)
CA (1) CA2389766C (pt)
CZ (1) CZ20022083A3 (pt)
DE (1) DE60205538T2 (pt)
DK (1) DK1266887T3 (pt)
EA (1) EA004571B1 (pt)
ES (1) ES2247282T3 (pt)
FR (1) FR2826009B1 (pt)
HK (1) HK1052172A1 (pt)
HU (1) HUP0201992A3 (pt)
MX (1) MXPA02005808A (pt)
NO (1) NO322709B1 (pt)
NZ (1) NZ519522A (pt)
PL (1) PL354472A1 (pt)
PT (1) PT1266887E (pt)
SI (1) SI1266887T1 (pt)
SK (1) SK286055B6 (pt)
ZA (1) ZA200204757B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
EP3147323B2 (de) 2015-09-28 2022-12-28 Henkel AG & Co. KGaA Thermisch expandierbare zusammensetzungen mit polysaccharid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6256471A (ja) * 1985-09-05 1987-03-12 Teikoku Hormone Mfg Co Ltd 含窒素四環式化合物
SE8902274D0 (sv) * 1989-06-22 1989-06-22 Univ Cincinnati Indenoidole compounds ii
SE8902273D0 (sv) * 1989-06-22 1989-06-22 Univ Cincinnati Indenoindole compounds i
SE9302431D0 (sv) * 1993-07-16 1993-07-16 Ab Astra Use of indenoindole compounds
US6069153A (en) * 1998-05-12 2000-05-30 American Home Products Corporation Indenoindoles and benzocarbazoles as estrogenic agents
FR2821843B1 (fr) * 2001-03-12 2003-05-09 Servier Lab Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
KR100466068B1 (ko) 2005-01-13
SK8342002A3 (en) 2003-01-09
HUP0201992A3 (en) 2004-04-28
HK1052172A1 (en) 2003-09-05
AU781768B2 (en) 2005-06-09
CZ20022083A3 (cs) 2003-04-16
PL354472A1 (en) 2002-12-16
EP1266887A2 (fr) 2002-12-18
CA2389766C (fr) 2007-09-25
AR034471A1 (es) 2004-02-25
DK1266887T3 (da) 2005-10-31
ZA200204757B (en) 2003-02-17
EP1266887A3 (fr) 2003-07-02
CN1156446C (zh) 2004-07-07
MXPA02005808A (es) 2004-12-13
FR2826009A1 (fr) 2002-12-20
EA200200563A1 (ru) 2002-12-26
KR20020094914A (ko) 2002-12-18
CA2389766A1 (fr) 2002-12-13
HU0201992D0 (pt) 2002-08-28
AU4590302A (en) 2002-12-19
JP3837090B2 (ja) 2006-10-25
HUP0201992A2 (hu) 2003-04-28
EA004571B1 (ru) 2004-06-24
PT1266887E (pt) 2005-10-31
NO322709B1 (no) 2006-11-27
EP1266887B1 (fr) 2005-08-17
NO20022794D0 (no) 2002-06-12
SK286055B6 (sk) 2008-02-05
US6627650B2 (en) 2003-09-30
NZ519522A (en) 2003-11-28
JP2003012644A (ja) 2003-01-15
DE60205538D1 (de) 2005-09-22
BR0202279A (pt) 2003-04-29
SI1266887T1 (sl) 2005-12-31
ATE302183T1 (de) 2005-09-15
CN1390834A (zh) 2003-01-15
DE60205538T2 (de) 2006-06-14
NO20022794L (no) 2002-12-16
ES2247282T3 (es) 2006-03-01
US20030125369A1 (en) 2003-07-03

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20080229