FR2678275B1 - Nouveaux sterouides 16-methyl substitue derives de la pregna 1,4-diene 3,20-dione leur preparation, leur application a la preparation de sterouides 16-methylene et nouveaux intermediaires. - Google Patents

Nouveaux sterouides 16-methyl substitue derives de la pregna 1,4-diene 3,20-dione leur preparation, leur application a la preparation de sterouides 16-methylene et nouveaux intermediaires.

Info

Publication number
FR2678275B1
FR2678275B1 FR9107784A FR9107784A FR2678275B1 FR 2678275 B1 FR2678275 B1 FR 2678275B1 FR 9107784 A FR9107784 A FR 9107784A FR 9107784 A FR9107784 A FR 9107784A FR 2678275 B1 FR2678275 B1 FR 2678275B1
Authority
FR
France
Prior art keywords
preparation
sterouides
application
methylene
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9107784A
Other languages
English (en)
French (fr)
Other versions
FR2678275A1 (fr
Inventor
Boivin Jean
Chauvet Christine
Zard Samir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR9107784A priority Critical patent/FR2678275B1/fr
Priority to MX9202972A priority patent/MX9202972A/es
Priority to CA002072053A priority patent/CA2072053C/fr
Priority to AU18478/92A priority patent/AU646342B2/en
Priority to JP4188932A priority patent/JP3037508B2/ja
Priority to HU0003008A priority patent/HU226413B1/hu
Priority to AT92401764T priority patent/ATE152119T1/de
Priority to KR1019920010983A priority patent/KR100220540B1/ko
Priority to ES92401764T priority patent/ES2100315T3/es
Priority to DE69219217T priority patent/DE69219217T2/de
Priority to DK92401764.3T priority patent/DK0520879T3/da
Priority to EP92401764A priority patent/EP0520879B1/fr
Priority to SU925011969A priority patent/RU2099346C1/ru
Priority to HU9202100A priority patent/HU213674B/hu
Priority to HU9503063A priority patent/HU219486B/hu
Priority to ZA924665A priority patent/ZA924665B/xx
Priority to US07/903,886 priority patent/US5248773A/en
Priority to CN92105005A priority patent/CN1035948C/zh
Priority to TW081106015A priority patent/TW290551B/zh
Publication of FR2678275A1 publication Critical patent/FR2678275A1/fr
Priority to US08/086,240 priority patent/US5412091A/en
Priority to US08/372,295 priority patent/US5616743A/en
Application granted granted Critical
Publication of FR2678275B1 publication Critical patent/FR2678275B1/fr
Priority to GR960402901T priority patent/GR3023294T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0084—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkylene group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
FR9107784A 1991-06-25 1991-06-25 Nouveaux sterouides 16-methyl substitue derives de la pregna 1,4-diene 3,20-dione leur preparation, leur application a la preparation de sterouides 16-methylene et nouveaux intermediaires. Expired - Fee Related FR2678275B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR9107784A FR2678275B1 (fr) 1991-06-25 1991-06-25 Nouveaux sterouides 16-methyl substitue derives de la pregna 1,4-diene 3,20-dione leur preparation, leur application a la preparation de sterouides 16-methylene et nouveaux intermediaires.
MX9202972A MX9202972A (es) 1991-06-25 1992-06-18 Nuevos esteroides sustituidos con metilo en la posicion 16 derivados de la pregna-1, 4-dieno-3,20-diona, su preparacion, su aplicacion a la preparacion de esteroides sustituidos con metileno en la posicion 16, y nuevos compuestos intermedios.
CA002072053A CA2072053C (fr) 1991-06-25 1992-06-23 Steroides 16-methyl substitue derives de la pregna 1,4-diene 3,20-dione, leur preparation, leur application a la preparation de steroides 16-methylene et nouveaux intermediaires
HU9503063A HU219486B (hu) 1991-06-25 1992-06-24 Új 16-(szubsztituált metil)-pregna-1,4,9(11)-trién-3,20-dion-származékok és eljárás előállításukra
HU0003008A HU226413B1 (en) 1991-06-25 1992-06-24 Novel 16-(nitro-substituted methyl)pregna-1,4-dien-3,20-dion derivatives and process for producing them
AT92401764T ATE152119T1 (de) 1991-06-25 1992-06-24 Neue 16-methyl substituierte steroidderivate von pregna-1,4-dien-3,20-dion, ihre herstellung, ihre verwendung zur herstellung von 16-methylene- substituierte steroide und neue zwischenprodukten dafür
KR1019920010983A KR100220540B1 (ko) 1991-06-25 1992-06-24 프레그나-1,4-디엔-3,20-디온의 치환 16-메틸 스테로이드 유도체, 그의 제조방법, 16-메틸렌 스테로이드 제조에서의 그의 용도 및 중간체
ES92401764T ES2100315T3 (es) 1991-06-25 1992-06-24 Nuevos esteroides 16-metilo sustituidos derivados de la pregna-1,4-dieno-3,20-diona, su preparacion, su aplicacion a la preparacion de esteroides 16-metileno y nuevos productos intermedios.
DE69219217T DE69219217T2 (de) 1991-06-25 1992-06-24 Neue 16-Methyl substituierte Steroidderivate von Pregna-1,4-dien-3,20-dion, ihre Herstellung, ihre Verwendung zur Herstellung von 16-Methylene-substituierte Steroide und neue Zwischenprodukten dafür
DK92401764.3T DK0520879T3 (da) 1991-06-25 1992-06-24 16-methylsubstituerede derivater af pregna-1,4-dien-3,20-dion, deres fremstilling, deres anvendelse til fremstilling af 16-methylensteroider og hidtil ukendte mellemprodukter
EP92401764A EP0520879B1 (fr) 1991-06-25 1992-06-24 Nouveaux stéroides 16-méthyl substitués dérivés de la pregna 1,4-diène 3,20-dione, leur préparation, leur application à la préparation de steroides 16-méthylène et nouveaux intermédiaires
SU925011969A RU2099346C1 (ru) 1991-06-25 1992-06-24 Стероиды, способ получения стероидов, способ получения 16-метиленстероидов, соединения
AU18478/92A AU646342B2 (en) 1991-06-25 1992-06-24 New substituted 16-methyl steroid derivatives of pregna-1,4-diene-3,20-dione, their preparation, their use in the preparation of 16-methylene steroids and new intermediates
JP4188932A JP3037508B2 (ja) 1991-06-25 1992-06-24 プレグナ−１，４−ジエン−３，２０−ジオンの新規な置換された１６−メチルステロイド誘導体、それらの製造法、それらの１６−メチレンステロイドの製造への用途及び新規な中間体
ZA924665A ZA924665B (en) 1991-06-25 1992-06-24 Substituted 16-methyl steroid derivatives of pregna-1, 4-dien-3,20-doine, their preparation, their use in the preparation of 16-methylene steroids and intermediates.
HU9202100A HU213674B (en) 1991-06-25 1992-06-24 New process for producing 16-methylene steroid derivatives
US07/903,886 US5248773A (en) 1991-06-25 1992-06-25 16-methyl-Δ1,4-pregnadiene-3,20-diones
CN92105005A CN1035948C (zh) 1991-06-25 1992-06-25 孕甾-1，4-二烯-3，20-二酮衍生物的制备方法
TW081106015A TW290551B (https=) 1991-06-25 1992-07-29
US08/086,240 US5412091A (en) 1991-06-25 1993-07-01 16-methyl-Δ1,4-pregnadiene-3,20-dione
US08/372,295 US5616743A (en) 1991-06-25 1995-01-13 16-methyl-Δ1,4 -pregnadiene-3,20-diones
GR960402901T GR3023294T3 (en) 1991-06-25 1997-04-30 New 16-methyl substituted steroid derivatives of pregna-1,4-dien-3,20-dione, their preparation, their use in the preparation of 16-methylene substituted steroids and new intermediates therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9107784A FR2678275B1 (fr) 1991-06-25 1991-06-25 Nouveaux sterouides 16-methyl substitue derives de la pregna 1,4-diene 3,20-dione leur preparation, leur application a la preparation de sterouides 16-methylene et nouveaux intermediaires.
CN92105005A CN1035948C (zh) 1991-06-25 1992-06-25 孕甾-1，4-二烯-3，20-二酮衍生物的制备方法

Publications (2)

Publication Number Publication Date
FR2678275A1 FR2678275A1 (fr) 1992-12-31
FR2678275B1 true FR2678275B1 (fr) 1995-06-23

Family

ID=36781528

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9107784A Expired - Fee Related FR2678275B1 (fr) 1991-06-25 1991-06-25 Nouveaux sterouides 16-methyl substitue derives de la pregna 1,4-diene 3,20-dione leur preparation, leur application a la preparation de sterouides 16-methylene et nouveaux intermediaires.

Country Status (17)

Country Link
US (1) US5248773A (https=)
EP (1) EP0520879B1 (https=)
JP (1) JP3037508B2 (https=)
KR (1) KR100220540B1 (https=)
CN (1) CN1035948C (https=)
AT (1) ATE152119T1 (https=)
AU (1) AU646342B2 (https=)
CA (1) CA2072053C (https=)
DE (1) DE69219217T2 (https=)
DK (1) DK0520879T3 (https=)
ES (1) ES2100315T3 (https=)
FR (1) FR2678275B1 (https=)
GR (1) GR3023294T3 (https=)
HU (1) HU213674B (https=)
MX (1) MX9202972A (https=)
RU (1) RU2099346C1 (https=)
ZA (1) ZA924665B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226413B1 (en) * 1991-06-25 2008-11-28 Aventis Pharma Sa Novel 16-(nitro-substituted methyl)pregna-1,4-dien-3,20-dion derivatives and process for producing them
FR2692266B1 (fr) * 1992-06-11 1994-08-05 Roussel Uclaf Nouveau procede de preparation de sterouides 16 alpha-methyles.
CN1061984C (zh) * 1996-04-18 2001-02-14 上海华联制药有限公司 甾体激素化合物中引入9-11双键的一种方法
JP5780521B2 (ja) 2008-05-28 2015-09-16 リベラジェン・バイオファーマ・インコーポレイテッドＲｅｖｅｒａＧｅｎ ＢｉｏＰｈａｒｍａ，Ｉｎｃ． 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子
WO2011127048A2 (en) 2010-04-05 2011-10-13 Validus Biopharma NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179496A1 (en) * 1982-09-20 1986-04-30 The Upjohn Company 16-Sulfinylmethyl-steroids, their preparation and use
EP0148616B1 (en) * 1984-01-05 1991-04-17 The Upjohn Company Stabilised monolithium acetylide and the ethynylation of steroids

Also Published As

Publication number Publication date
EP0520879A2 (fr) 1992-12-30
HU213674B (en) 1997-09-29
MX9202972A (es) 1993-04-01
CN1068120A (zh) 1993-01-20
ATE152119T1 (de) 1997-05-15
EP0520879B1 (fr) 1997-04-23
AU646342B2 (en) 1994-02-17
CA2072053A1 (fr) 1992-12-26
DK0520879T3 (da) 1997-10-20
CN1035948C (zh) 1997-09-24
ZA924665B (en) 1993-06-24
HU9202100D0 (en) 1992-10-28
CA2072053C (fr) 2003-10-21
JPH05186496A (ja) 1993-07-27
US5248773A (en) 1993-09-28
KR100220540B1 (ko) 1999-10-01
RU2099346C1 (ru) 1997-12-20
DE69219217T2 (de) 1997-11-13
JP3037508B2 (ja) 2000-04-24
DE69219217D1 (de) 1997-05-28
ES2100315T3 (es) 1997-06-16
AU1847892A (en) 1993-01-07
GR3023294T3 (en) 1997-07-30
EP0520879A3 (https=) 1995-04-12
KR930000534A (ko) 1993-01-15
FR2678275A1 (fr) 1992-12-31
HUT61569A (en) 1993-01-28

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