FR2675155A1 - Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques. - Google Patents

Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques. Download PDF

Info

Publication number
FR2675155A1
FR2675155A1 FR9104523A FR9104523A FR2675155A1 FR 2675155 A1 FR2675155 A1 FR 2675155A1 FR 9104523 A FR9104523 A FR 9104523A FR 9104523 A FR9104523 A FR 9104523A FR 2675155 A1 FR2675155 A1 FR 2675155A1
Authority
FR
France
Prior art keywords
sequences
seq
leu
ser
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR9104523A
Other languages
English (en)
French (fr)
Other versions
FR2675155B1 (Direct
Inventor
Hercend Thierry
Triebel Frederic
Roman-Roman Sergio
Ferradini Laurent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9104523A priority Critical patent/FR2675155A1/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to AU15445/92A priority patent/AU660306B2/en
Priority to CA002079881A priority patent/CA2079881C/fr
Priority to EP92906703A priority patent/EP0528007A1/fr
Priority to JP4506380A priority patent/JPH06502997A/ja
Priority to IE044792A priority patent/IE920447A1/en
Priority to PCT/FR1992/000130 priority patent/WO1992013950A2/fr
Priority to KR1019920702512A priority patent/KR100227303B1/ko
Publication of FR2675155A1 publication Critical patent/FR2675155A1/fr
Application granted granted Critical
Publication of FR2675155B1 publication Critical patent/FR2675155B1/fr
Priority to US08/423,383 priority patent/US5700907A/en
Priority to US08/437,353 priority patent/US5830758A/en
Priority to KR1019997004635A priority patent/KR100297082B1/ko
Priority to US10/095,672 priority patent/US7294712B2/en
Priority to US11/867,862 priority patent/US8709426B2/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FR9104523A 1990-06-04 1991-04-12 Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques. Granted FR2675155A1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR9104523A FR2675155A1 (fr) 1991-04-12 1991-04-12 Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques.
KR1019920702512A KR100227303B1 (ko) 1991-02-12 1992-02-12 인체 t 임파구 수용체의 베타 사슬의 가변성 영역을 코딩하는 뉴클레오티드 서열, 대응하는 펩티드 세그먼트 및 진단 및 치료 용도
EP92906703A EP0528007A1 (fr) 1991-02-12 1992-02-12 SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES $g(b) DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES
JP4506380A JPH06502997A (ja) 1991-02-12 1992-02-12 ヒトＴリンパ球レセプターのβ鎖の可変領域をコードするヌクレオチド配列対応するペプチドセグメント並びに診断及び治療への利用
IE044792A IE920447A1 (en) 1991-02-12 1992-02-12 NUCLEOTIDE SEQUENCES CODING FOR ß-CHAIN VARIABLE REGIONS OF¹HUMAN T-LYMPHOCYTE RECEPTORS, CORRESPONDING PEPTIDE SEGMENTS¹AND DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
PCT/FR1992/000130 WO1992013950A2 (fr) 1991-02-12 1992-02-12 SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES β DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES
AU15445/92A AU660306B2 (en) 1991-02-12 1992-02-12 Nucleotidic sequences coding for variable regions of beta chains of human T lymphocyte receptors, corresponding peptidic segments and diagnostic and therapeutic applications
CA002079881A CA2079881C (fr) 1991-02-12 1992-02-12 Sequences nucleotidiques codant pour des regions variables de chaines .beta. des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques
US08/423,383 US5700907A (en) 1991-02-12 1995-04-14 Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
US08/437,353 US5830758A (en) 1991-02-12 1995-05-09 Isolated Vβ TCR antibodies
KR1019997004635A KR100297082B1 (ko) 1991-02-12 1999-05-26 인체 Ｔ 임파구 수용체의 β 사슬의 가변성 영역을 코딩하는 뉴클레오티드 서열, 대응하는 펩티드 세그먼트 및 진단 및 치료 용도
US10/095,672 US7294712B2 (en) 1990-06-04 2002-03-12 Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
US11/867,862 US8709426B2 (en) 1991-02-12 2007-10-05 Nucleotide sequence coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9104523A FR2675155A1 (fr) 1991-04-12 1991-04-12 Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques.

Publications (2)

Publication Number Publication Date
FR2675155A1 true FR2675155A1 (fr) 1992-10-16
FR2675155B1 FR2675155B1 (Direct) 1995-01-20

Family

ID=9411791

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9104523A Granted FR2675155A1 (fr) 1990-06-04 1991-04-12 Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques.

Country Status (1)

Country Link
FR (1) FR2675155A1 (Direct)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006758A1 (en) * 1988-12-15 1990-06-28 T Cell Sciences, Inc. Monoclonal antibodies reactive with defined regions of the t cell antigen receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006758A1 (en) * 1988-12-15 1990-06-28 T Cell Sciences, Inc. Monoclonal antibodies reactive with defined regions of the t cell antigen receptor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
en entier * *
EUROPEAN JOURNAL IMMUNOLOGY vol. 21, no. 4, 8 Avril 1991, WEINHEIM DE pages 935 - 942; FERRADINI L. ET AL.: 'Studies on the human T *
NATURE. vol. 312, 6 Dé *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 82, no. 18, Septembre 1985, WASHINGTON US pages 6133 - 6137; S.NAKJIMA-IIJIMA ET AL.: 'Mole *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 83, no. 17, Septembre 1986, WASHINGTON US pages 6598 - 6602; P.CONCANNON ET AL.: 'Diversity and stru *
SCIENCE. vol. 233, no. 4766, 22 Août 1986, LANCASTER, PA US pages 879 - 883; J.P.TILLINGHAST ET AL.: 'Stru *
THE JOURNAL OF IMMUNOLOGY vol. 146, no. 12, 12 Juin 1991, BALTIMORE US pages 4392 - 4397; M.A.ROBINSON: 'The human T- *

Also Published As

Publication number Publication date
FR2675155B1 (Direct) 1995-01-20

Similar Documents

Publication Publication Date Title
CA2079881C (fr) Sequences nucleotidiques codant pour des regions variables de chaines .beta. des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques
EP0529033B1 (fr) Sequences nucleotidiques codant pour des regions variables de chaines alpha des recepteurs des lymphocytes humains ainsi que leurs applications
Asarnow et al. Limited diversity of γδ antigen receptor genes of Thy-1+ dendritic epidermal cells
US6545142B1 (en) Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
JPH05310596A (ja) 抗体を含有する免疫抑制剤
EP0566685B1 (fr) PROCEDE DE DESCRIPTION DES REPERTOIRES D'ANTICORPS (Ab) ET DES RECEPTEURS DES CELLULES T (TcR) DU SYSTEME IMMUNITAIRE D'UN INDIVIDU
CA2034593A1 (en) Recombinant human anti-cd18 antibodies
Siegel et al. Sequence analysis and expression of an X-linked, lymphocyte-regulated gene family (XLR).
CA2051651A1 (fr) Anticorps monoclonaux reconnaissant un peptide associe a un antigene majeur d'histocompatibilite
US7294712B2 (en) Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
FR2675155A1 (fr) Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques.
JPH06113881A (ja) ヒト型モノクローナル抗ペプチド抗体及びこれをコードするｄｎａ
CA2061266A1 (fr) Molecules d'adn recombinant codant pour une chaine du recepteur de l'antigene des cellules t, procede de preparation, anticorps et medicaments les renfermant
FR2672617A1 (fr) Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques.
FR2675156A1 (fr) Sequences nucleotidiques codant pour des regions variables de chaines alpha des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques.
FR2672616A1 (fr) Sequences nucleotidiques codant pour des regions variables de chaines alpha des recepteurs de lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques.
FR2722209A1 (fr) Recepteur opioide kappa humain, acides nucleiques et utilisations
EP0534878A1 (fr) Molécules d'ADN recombinants contenant la partie codante d'une chaîne Vbêta17 du récepteur pour l'antigène des cellules T et leurs utilisations
JPH0928385A (ja) 可溶形態のｃｄ２３のｄｎａ配列及びその使用方法
EP0524899A1 (fr) Nouvelles molécules d'ADN recombinants contenant la partie codante d'une chaîne VB2 du récepteur pour l'antigène des cellules T, procédé de préparation, anticorps et médicaments les renfermant
EP1263953A2 (fr) Famille de canaux potassium humains mecanosensibles et actives par les acides gras polyinsatures et leur utilisation
JPH0614783A (ja) 新規なタンパク質およびそれをコードする遺伝子
JPH05219982A (ja) 脳に分布する蛋白質に対するモノクローナル抗体