FR2656307B1 - Derives du (n-methyl-n-alcoyl)amino-3 methoxymethylene-2 propane 1-ol, ainsi que leur procede de preparation. - Google Patents

Derives du (n-methyl-n-alcoyl)amino-3 methoxymethylene-2 propane 1-ol, ainsi que leur procede de preparation.

Info

Publication number
FR2656307B1
FR2656307B1 FR909015901A FR9015901A FR2656307B1 FR 2656307 B1 FR2656307 B1 FR 2656307B1 FR 909015901 A FR909015901 A FR 909015901A FR 9015901 A FR9015901 A FR 9015901A FR 2656307 B1 FR2656307 B1 FR 2656307B1
Authority
FR
France
Prior art keywords
alcoyl
methoxymethylene
propane
derivatives
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR909015901A
Other languages
English (en)
Other versions
FR2656307A1 (fr
Inventor
Braquet Pierre
Broquet Colette
Principe-Nicolas Paola
Vandamme Benedicte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of FR2656307A1 publication Critical patent/FR2656307A1/fr
Application granted granted Critical
Publication of FR2656307B1 publication Critical patent/FR2656307B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
FR909015901A 1989-12-19 1990-12-19 Derives du (n-methyl-n-alcoyl)amino-3 methoxymethylene-2 propane 1-ol, ainsi que leur procede de preparation. Expired - Fee Related FR2656307B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898928580A GB8928580D0 (en) 1989-12-19 1989-12-19 3-(n-methyl-n-alkylamino)-methoxymethyl-propanol phosphocholine derivatives

Publications (2)

Publication Number Publication Date
FR2656307A1 FR2656307A1 (fr) 1991-06-28
FR2656307B1 true FR2656307B1 (fr) 1992-09-18

Family

ID=10668132

Family Applications (2)

Application Number Title Priority Date Filing Date
FR909015901A Expired - Fee Related FR2656307B1 (fr) 1989-12-19 1990-12-19 Derives du (n-methyl-n-alcoyl)amino-3 methoxymethylene-2 propane 1-ol, ainsi que leur procede de preparation.
FR909015900A Expired - Fee Related FR2656797B1 (fr) 1989-12-19 1990-12-19 Compositions therapeutiques a base de derives du (n-methyl-n-alcoyl)amino-3 methoxymethylene-2 propane 1-ol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR909015900A Expired - Fee Related FR2656797B1 (fr) 1989-12-19 1990-12-19 Compositions therapeutiques a base de derives du (n-methyl-n-alcoyl)amino-3 methoxymethylene-2 propane 1-ol.

Country Status (32)

Country Link
US (1) US5118674A (fr)
JP (1) JPH04208256A (fr)
KR (1) KR910011759A (fr)
AR (1) AR246742A1 (fr)
AT (1) AT400333B (fr)
AU (1) AU630056B2 (fr)
BE (1) BE1004089A3 (fr)
CA (1) CA2032224C (fr)
CH (1) CH681624A5 (fr)
DE (1) DE4040685A1 (fr)
DK (1) DK171298B1 (fr)
DZ (1) DZ1471A1 (fr)
ES (1) ES2023607A6 (fr)
FI (1) FI906162A (fr)
FR (2) FR2656307B1 (fr)
GB (2) GB8928580D0 (fr)
GR (1) GR1000893B (fr)
HK (1) HK118093A (fr)
IE (1) IE65888B1 (fr)
IN (1) IN173969B (fr)
IT (1) IT1243412B (fr)
LU (1) LU87853A1 (fr)
MA (1) MA22013A1 (fr)
MY (1) MY104781A (fr)
NL (1) NL9002582A (fr)
NO (1) NO177146C (fr)
NZ (1) NZ236213A (fr)
OA (1) OA09475A (fr)
PT (1) PT96265B (fr)
SE (1) SE469383B (fr)
TN (1) TNSN90152A1 (fr)
ZA (1) ZA909663B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
ATE244570T1 (de) 1993-09-09 2003-07-15 Lorus Therapeutics Inc Immunmodulierende zusammensetzungen aus galle
KR19980703088A (ko) 1995-03-16 1998-09-05 라카일레 지, 필리페 신규의 침전탄산칼슘 안료를 포함하는 잉크젯 기록지
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
DE19711758C2 (de) * 1997-03-21 2003-06-18 Degussa Verfahren zur Herstellung von 1,3-Dioxanverbindungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2732263A1 (de) * 1977-07-16 1979-02-01 Schuler Gmbh L Vorrichtung zum herstellen einer sicke am umfang eines hohlzylinders
DE2820893C2 (de) * 1978-05-12 1986-02-20 A. Nattermann & Cie GmbH, 5000 Köln Strukturanaloga von natürlichen Phospholipiden und Verfahren zur Herstellung dieser Verbindungen
US4737518A (en) * 1984-04-03 1988-04-12 Takeda Chemical Industries, Ltd. Lipid derivatives, their production and use
WO1989007099A1 (fr) * 1988-02-05 1989-08-10 Schering Corporation Glycerol 2,2-disubstitue et composes analogues au glycerol, compositions et modes d'utilisation
JP2534893B2 (ja) * 1988-06-24 1996-09-18 日本ケミファ株式会社 新規なグリセリン誘導体およびその誘導体を含有する血小板凝集抑制剤
DE3906952A1 (de) * 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel
GR1000688B (el) * 1989-12-22 1992-10-08 Sod Conseils Rech Applic Μεθοδος παρασκευης παραγωγων γλυκερινης.

Also Published As

Publication number Publication date
ES2023607A6 (es) 1992-01-16
IE904567A1 (en) 1991-06-19
PT96265A (pt) 1991-09-30
CA2032224C (fr) 1996-12-10
FI906162A0 (fi) 1990-12-14
DK171298B1 (da) 1996-08-26
NO177146B (no) 1995-04-18
MY104781A (en) 1994-05-31
ZA909663B (en) 1991-09-25
LU87853A1 (fr) 1991-05-07
MA22013A1 (fr) 1991-07-01
DE4040685A1 (de) 1991-06-20
DZ1471A1 (fr) 2004-09-13
SE9004039D0 (sv) 1990-12-18
GB8928580D0 (en) 1990-02-21
SE9004039L (sv) 1991-06-20
NO905373D0 (no) 1990-12-12
AT400333B (de) 1995-12-27
KR910011759A (ko) 1991-08-07
DK299590D0 (da) 1990-12-18
GR900100812A (en) 1992-05-12
GR1000893B (el) 1993-03-16
GB9027421D0 (en) 1991-02-06
PT96265B (pt) 1998-06-30
FI906162A (fi) 1991-06-20
NZ236213A (en) 1993-03-26
FR2656797A1 (fr) 1991-07-12
NO905373L (no) 1991-06-20
CH681624A5 (fr) 1993-04-30
GB2239239A (en) 1991-06-26
ATA259590A (de) 1995-04-15
FR2656797B1 (fr) 1992-09-18
OA09475A (fr) 1992-11-15
IT9022438A0 (it) 1990-12-19
AU630056B2 (en) 1992-10-15
NL9002582A (nl) 1991-07-16
IN173969B (fr) 1994-08-13
FR2656307A1 (fr) 1991-06-28
IT9022438A1 (it) 1992-06-19
GB2239239B (en) 1993-06-02
TNSN90152A1 (fr) 1991-03-05
IT1243412B (it) 1994-06-10
AR246742A1 (es) 1994-09-30
JPH04208256A (ja) 1992-07-29
HK118093A (en) 1993-11-12
IE65888B1 (en) 1995-11-29
NO177146C (no) 1995-07-26
DK299590A (da) 1991-06-20
AU6814290A (en) 1991-06-27
BE1004089A3 (fr) 1992-09-22
CA2032224A1 (fr) 1991-06-20
US5118674A (en) 1992-06-02
SE469383B (sv) 1993-06-28

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Legal Events

Date Code Title Description
ST Notification of lapse