FR2636947A1 - Composes de pyrrolidinone et de piperidinone et compositions pharmaceutiques les contenant - Google Patents
Composes de pyrrolidinone et de piperidinone et compositions pharmaceutiques les contenantInfo
- Publication number
- FR2636947A1 FR2636947A1 FR8911400A FR8911400A FR2636947A1 FR 2636947 A1 FR2636947 A1 FR 2636947A1 FR 8911400 A FR8911400 A FR 8911400A FR 8911400 A FR8911400 A FR 8911400A FR 2636947 A1 FR2636947 A1 FR 2636947A1
- Authority
- FR
- France
- Prior art keywords
- pyrrolidinone
- pharmaceutical compositions
- compositions containing
- group
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical class O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 title 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
Le composé est caractérisé en ce qu'il est choisi parmi : (CF DESSIN DANS BOPI) où : - R est un élément choisi dans le groupe constitué par hydrogène, alkyle, alcanoyle et aroyle; - R**1-R**8 sont identiques ou différents et représentent un élément choisi dans le groupe constitué par hydrogène et alkyle inférieur, à la condition que, lorsque R**1 et R**3 représentent hydrogène, R**2 et R**4 puissent être réunis pour former une chaîne hydrocarbylène ayant quatre atomes de carbone entre leurs points d'attachement au noyau hétérocyclique; et - X**3 et X**4 sont identiques ou différents et représentent un élément choisi dans le groupe constitué par alkyle tertiaire et triméthylsilyle; et les sels pharmacologiquement acceptables, non toxiques, de ce composé.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/248,942 US4959482A (en) | 1988-09-26 | 1988-09-26 | Pyrrolidinone compounds and pharamaceutical compositions containing same |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2636947A1 true FR2636947A1 (fr) | 1990-03-30 |
FR2636947B1 FR2636947B1 (fr) | 1994-10-28 |
Family
ID=22941364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8911400A Expired - Fee Related FR2636947B1 (fr) | 1988-09-26 | 1989-08-30 | Composes de pyrrolidinone et de piperidinone et compositions pharmaceutiques les contenant |
Country Status (8)
Country | Link |
---|---|
US (1) | US4959482A (fr) |
JP (1) | JPH02129167A (fr) |
AU (1) | AU3893289A (fr) |
BE (1) | BE1003692A4 (fr) |
DE (1) | DE3932068A1 (fr) |
FR (1) | FR2636947B1 (fr) |
GB (1) | GB2223014B (fr) |
SE (1) | SE500670C2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5128330A (en) * | 1991-02-19 | 1992-07-07 | Biofor, Ltd. | Oxazinone substituted phosphines |
US5256091A (en) * | 1991-11-06 | 1993-10-26 | Outboard Marine Corporation | Shift interlock system |
EP0570563A1 (fr) * | 1991-11-15 | 1993-11-24 | Cytec Technology Corp. | Procede de preparation d'un agent de reticulation triazine tris-lactame, et compositions durcissables contenant cet agent |
BRPI0715355A2 (pt) * | 2006-08-09 | 2013-06-18 | Smithkline Beecham Corp | anilinas pirrolidonas com moduladores de recepÇço de progesteronas |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3718743A (en) * | 1970-11-19 | 1973-02-27 | Merck & Co Inc | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation |
EP0059090A1 (fr) * | 1981-02-19 | 1982-09-01 | Yamanouchi Pharmaceutical Co., Ltd. | Composés hétérocycliques substitués par le groupement di-tert-butyl-3,5 hydroxy-4 phényle |
EP0106988A1 (fr) * | 1982-09-02 | 1984-05-02 | The Wellcome Foundation Limited | Dérivés de lactame ayant des propriétés pharmaceutiques |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE754141A (fr) * | 1969-08-04 | 1971-02-01 | Pfizer | Esters d'alpha-carboxyarylmethyl penicillines |
US3717659A (en) * | 1970-06-09 | 1973-02-20 | Merck & Co Inc | Heterocyclic salicylic acid derivatives |
US3790597A (en) * | 1971-04-12 | 1974-02-05 | Ciba Geigy Corp | Sulfur derivatives of alkylhydroxyphenyl maleimides and compositions thereof |
US3906002A (en) * | 1973-12-28 | 1975-09-16 | John F Stephen | Hindered phenolic norbornane-2,3-dicarboximides |
US4124725A (en) * | 1977-05-16 | 1978-11-07 | Riker Laboratories, Inc. | Anti-inflammatory method |
US4172082A (en) * | 1977-05-16 | 1979-10-23 | Riker Laboratories, Inc. | Substituted thiophenes |
US4357345A (en) * | 1981-11-23 | 1982-11-02 | Riker Laboratories, Inc. | Substituted furans |
US4743606A (en) * | 1986-03-25 | 1988-05-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | 3-[2-(3',5'-di-t-butyl-4'-hydroxyphenyl)ethenyl]pyridine having anti-inflammatory and anti-arthritic properties |
-
1988
- 1988-09-26 US US07/248,942 patent/US4959482A/en not_active Expired - Fee Related
-
1989
- 1989-07-25 AU AU38932/89A patent/AU3893289A/en not_active Abandoned
- 1989-07-27 SE SE8902608A patent/SE500670C2/sv unknown
- 1989-08-30 FR FR8911400A patent/FR2636947B1/fr not_active Expired - Fee Related
- 1989-09-05 BE BE8900947A patent/BE1003692A4/fr not_active IP Right Cessation
- 1989-09-07 GB GB8920270A patent/GB2223014B/en not_active Expired - Fee Related
- 1989-09-26 JP JP1248226A patent/JPH02129167A/ja active Pending
- 1989-09-26 DE DE3932068A patent/DE3932068A1/de not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3718743A (en) * | 1970-11-19 | 1973-02-27 | Merck & Co Inc | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation |
EP0059090A1 (fr) * | 1981-02-19 | 1982-09-01 | Yamanouchi Pharmaceutical Co., Ltd. | Composés hétérocycliques substitués par le groupement di-tert-butyl-3,5 hydroxy-4 phényle |
EP0106988A1 (fr) * | 1982-09-02 | 1984-05-02 | The Wellcome Foundation Limited | Dérivés de lactame ayant des propriétés pharmaceutiques |
Also Published As
Publication number | Publication date |
---|---|
SE8902608D0 (sv) | 1989-07-27 |
FR2636947B1 (fr) | 1994-10-28 |
BE1003692A4 (fr) | 1992-05-26 |
AU3893289A (en) | 1990-03-29 |
GB8920270D0 (en) | 1989-10-18 |
DE3932068A1 (de) | 1990-03-29 |
US4959482A (en) | 1990-09-25 |
GB2223014A (en) | 1990-03-28 |
GB2223014B (en) | 1992-03-18 |
JPH02129167A (ja) | 1990-05-17 |
SE500670C2 (sv) | 1994-08-08 |
SE8902608L (sv) | 1990-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |