FR2581314A1 - Dispositif medical pour l'administration transdermique de medicaments fortement ionises insolubles dans les corps gras - Google Patents

Dispositif medical pour l'administration transdermique de medicaments fortement ionises insolubles dans les corps gras Download PDF

Info

Publication number
FR2581314A1
FR2581314A1 FR8606278A FR8606278A FR2581314A1 FR 2581314 A1 FR2581314 A1 FR 2581314A1 FR 8606278 A FR8606278 A FR 8606278A FR 8606278 A FR8606278 A FR 8606278A FR 2581314 A1 FR2581314 A1 FR 2581314A1
Authority
FR
France
Prior art keywords
medical device
penetration enhancer
aqueous
reserve
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8606278A
Other languages
English (en)
French (fr)
Inventor
Robert M Gale
David J Enscore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of FR2581314A1 publication Critical patent/FR2581314A1/fr
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
FR8606278A 1985-05-03 1986-04-30 Dispositif medical pour l'administration transdermique de medicaments fortement ionises insolubles dans les corps gras Pending FR2581314A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/730,713 US4645502A (en) 1985-05-03 1985-05-03 Transdermal delivery of highly ionized fat insoluble drugs

Publications (1)

Publication Number Publication Date
FR2581314A1 true FR2581314A1 (fr) 1986-11-07

Family

ID=24936525

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8606278A Pending FR2581314A1 (fr) 1985-05-03 1986-04-30 Dispositif medical pour l'administration transdermique de medicaments fortement ionises insolubles dans les corps gras

Country Status (8)

Country Link
US (1) US4645502A (https=)
JP (1) JPH01170476A (https=)
CA (1) CA1252361A (https=)
DE (1) DE3614843A1 (https=)
ES (1) ES8801987A1 (https=)
FR (1) FR2581314A1 (https=)
GB (1) GB2174605B (https=)
IT (1) IT1203553B (https=)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000957A (en) * 1984-03-19 1991-03-19 Alza Corporation Dispenser comprising hydrophilic osmopolymer
US4772474A (en) * 1985-08-09 1988-09-20 Alza Corporation Dispenser with internal arrangement of lamina means for dispensing beneficial agent
US4844984A (en) * 1984-03-19 1989-07-04 Alza Corporation Dispensing system with means for increasing delivery of beneficial agent from the system
US4756710A (en) * 1985-04-05 1988-07-12 Merck & Co., Inc. pH-Mediated drug delivery system
US4904475A (en) * 1985-05-03 1990-02-27 Alza Corporation Transdermal delivery of drugs from an aqueous reservoir
US4917676A (en) * 1986-11-20 1990-04-17 Ciba-Geigy Corporation User-activated transdermal therapeutic system
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
US5006342A (en) * 1986-12-22 1991-04-09 Cygnus Corporation Resilient transdermal drug delivery device
AU607172B2 (en) * 1986-12-22 1991-02-28 Cygnus, Inc. Diffusion matrix for transdermal drug administration
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
US4788062A (en) * 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
GB2232892B (en) * 1988-02-23 1991-07-24 John Mark Tucker Occlusive body for administering a physiologically active substance
GB8804164D0 (en) * 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
DE3844247A1 (de) * 1988-12-29 1990-07-12 Minnesota Mining & Mfg Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments
EP0411146B1 (en) * 1989-02-06 1996-04-03 Hisamitsu Pharmaceutical Co., Inc. Interface for iontophoresis
DE3905051A1 (de) * 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i)
US5096715A (en) * 1989-11-20 1992-03-17 Alko Ltd. Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist
US5462744A (en) * 1989-12-01 1995-10-31 Boehringer Ingelheim Kg Transdermal system for the administration of pharmacological compounds under pH-controlled conditions
DE3939703C2 (de) * 1989-12-01 1998-07-02 Boehringer Ingelheim Kg Verbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen
DK0521988T3 (da) * 1990-03-30 1996-04-29 Alza Corp Anordning til iontoforetisk lægemiddeltilførsel
US5149719A (en) * 1990-04-27 1992-09-22 Minnesota Mining And Manufacturing Company Composition for transdermal penetration of medicaments
US5512292A (en) * 1990-10-29 1996-04-30 Alza Corporation Transdermal contraceptive formulations methods and devices
US5164190A (en) * 1990-12-11 1992-11-17 Theratech, Inc. Subsaturated transdermal drug delivery device exhibiting enhanced drug flux
CA2116036A1 (en) * 1991-10-18 1993-04-29 F. Eugene Yates Device for the transdermal administration of melatonin
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
DE69326848T2 (de) * 1992-05-13 2000-01-27 Alza Corp Oxybutynin zur transdermalen Verabreichung
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
DE4308649C2 (de) * 1993-03-18 1995-11-16 Lohmann Gmbh & Co Kg Medizinisches Pflastermaterial sowie Verfahren zu seiner Herstellung und dessen Verwendung
US5451407A (en) * 1993-06-21 1995-09-19 Alza Corporation Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
US5919478A (en) * 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
CA2165802A1 (en) * 1993-09-29 1995-04-06 Eun Soo Lee Monoglyceride/lactate ester permeation enhancer for oxybutynin
US5466465A (en) * 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
US5762955A (en) 1994-02-04 1998-06-09 Smith; Stephen Jay Method for application and maintenance of medication on body tissue
US5503843A (en) * 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
US5498417A (en) * 1994-05-12 1996-03-12 Coating Sciences, Inc. Transdermal delivery of appetite suppressant drug
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
US5562917A (en) * 1994-12-23 1996-10-08 Pentech Pharmaceuticals, Inc. Transdermal administration of apomorphine
FR2732896B1 (fr) * 1995-04-11 1997-06-13 Prographarm Lab Forme pharmaceutique transdermique pour l'administration percutanee de l'apomorphine
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US6572879B1 (en) * 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
US5840327A (en) * 1995-08-21 1998-11-24 Alza Corporation Transdermal drug delivery device having enhanced adhesion
US5730721A (en) * 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
SE9601528D0 (sv) * 1996-04-23 1996-04-23 Pharmacia Ab Transdermally administered dextromethorphan as antitissue agent
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
US5985317A (en) * 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
WO1998017315A2 (en) * 1996-10-24 1998-04-30 Alza Corporation Permeation enhancers for transdermal drug delivery compositions, devices, and methods
US6203817B1 (en) 1997-02-19 2001-03-20 Alza Corporation Reduction of skin reactions caused by transdermal drug delivery
US7150881B2 (en) 1997-06-26 2006-12-19 Mylan Technologies, Inc. Adhesive mixture for transdermal delivery of highly plasticizing drugs
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
AU1728099A (en) 1997-12-22 1999-07-12 Alza Corporation Monoglyceride and ethyl palmitate permeation enhancer compositions
US6096943A (en) * 1998-01-09 2000-08-01 Maiwald; Diane C Skin wound protector
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
EP2158903A3 (en) 1998-12-18 2010-04-14 ALZA Corporation Transparent Transdermal Nicotine Delivery Devices
ES2525553T3 (es) * 1999-03-25 2014-12-26 Metabolix, Inc. Dispositivos y aplicaciones médicas de polímeros polihidroxialcanoato
WO2000059483A2 (en) * 1999-04-01 2000-10-12 Alza Corporation Transdermal drug delivery devices comprising a polyurethane drug reservoir
US6696078B1 (en) * 1999-07-21 2004-02-24 Edwin J. Masters System and methods for local intradermal treatment
CA2382599C (en) 1999-08-30 2005-11-08 Tepha, Inc. Flushable disposable polymeric products
US6495229B1 (en) * 1999-09-17 2002-12-17 Avery Dennison Corporation Pattern coated adhesive article
JP4358978B2 (ja) * 2000-09-05 2009-11-04 日東電工株式会社 経皮吸収製剤
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
EP1390383B1 (en) * 2001-05-11 2012-02-29 Isis Pharmaceuticals, Inc. Antisense permeation enhancers
DE10141651B4 (de) * 2001-08-24 2007-02-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
JP4199485B2 (ja) * 2002-06-07 2008-12-17 久光製薬株式会社 貼付剤
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
AU2004233997C1 (en) * 2003-04-29 2014-01-30 Massachusetts Institiute Of Technology Methods and devices for the sustained release of multiple drugs
EP2860292B1 (en) 2003-05-08 2020-07-22 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
ES2395077T3 (es) * 2003-07-08 2013-02-08 Tepha, Inc. Matrices poli-4-hidroxibutirato para una administración prolongada de medicamentos
JP2007503221A (ja) * 2003-08-22 2007-02-22 テファ, インコーポレイテッド ポリヒドロキシアルカノエート神経再生デバイス
US7105263B2 (en) * 2003-12-30 2006-09-12 Samsung Electronics Company Dry toner comprising encapsulated pigment, methods and uses
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
US20070196452A1 (en) * 2004-06-07 2007-08-23 Jie Zhang Flux-enabling compositions and methods for dermal delivery of drugs
US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
US8741333B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
US20060008432A1 (en) * 2004-07-07 2006-01-12 Sebastiano Scarampi Gilsonite derived pharmaceutical delivery compositions and methods: nail applications
ES2362217T3 (es) * 2004-08-03 2011-06-29 Tepha, Inc. Suturas de polihidroxialcanoato no rizadas.
US8252320B2 (en) 2004-10-21 2012-08-28 Durect Corporation Transdermal delivery system for sufentanil
US8246977B2 (en) 2004-10-21 2012-08-21 Durect Corporation Transdermal delivery systems
ES2362221T3 (es) * 2005-01-28 2011-06-29 Tepha, Inc. Embolización con partículas poli-4-hidroxibutirato.
US20060223786A1 (en) * 2005-04-01 2006-10-05 Smith David J Transdermal pain control method and device
JP2007175117A (ja) * 2005-12-27 2007-07-12 Hisamitsu Pharmaceut Co Inc イオントフォレーシス装置及びその製造方法
JP2007175116A (ja) * 2005-12-27 2007-07-12 Hisamitsu Pharmaceut Co Inc イオントフォレーシス装置及びその製造方法
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
WO2007121188A2 (en) * 2006-04-10 2007-10-25 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US20070280972A1 (en) * 2006-04-25 2007-12-06 Zars, Inc. Adhesive solid gel-forming formulations for dermal drug delivery
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
ES2641272T3 (es) 2006-04-28 2017-11-08 Children's Hospital Medical Center Composiciones que comprenden proteínas o polipéptidos fusogénicos derivados de la prosaposina para aplicación en sistemas de suministro de fármacos transmembrana
ES2379117T3 (es) 2006-05-16 2012-04-20 Knopp Neurosciences, Inc. Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
CA2681110A1 (en) * 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
WO2009046155A1 (en) * 2007-10-01 2009-04-09 Michael Adams G Dressing, method and kit for skin crack repair
EP2259780A2 (en) 2008-02-28 2010-12-15 Syntropharma Limited Pharmaceutical composition comprising naltrexone
KR20110071064A (ko) * 2008-08-19 2011-06-28 크놉 뉴로사이언시스 인코포레이티드 (r)-프라미펙솔을 사용하는 조성물 및 방법
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
RU2012101792A (ru) * 2009-06-19 2013-07-27 Нопп Ньюросайенсиз, Инк. Композиции и способы для лечения бокового амиотрофического склероза
JP5927506B2 (ja) 2010-04-13 2016-06-01 レルマダ セラピューティクス、インク. 1−メチル−2’,6’−ピペコロキシリダイドの皮膚医薬組成物および使用方法
WO2012087749A1 (en) * 2010-12-20 2012-06-28 Polytherapeutics, Inc. Composition for transdermal administration of non-steroidal anti-inflammatory drug
WO2012096866A2 (en) 2011-01-10 2012-07-19 Inverseon, Inc. Use of beta-adrenergic inverse agonists for smoking cessation
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9682068B2 (en) 2013-05-20 2017-06-20 Mylan Inc. Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
EP3838271B1 (en) 2013-07-12 2025-09-03 Areteia Therapeutics, Inc. Treating elevated levels of eosinophils and/or basophils
CA2921381A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
WO2016025329A1 (en) 2014-08-15 2016-02-18 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
EP3230500B1 (en) 2014-12-11 2025-06-18 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2143564A1 (en) * 1969-04-01 1973-02-09 Alza Corp Impregnated bandage - for long term administration of pharmacologically active materials at controlled rates
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
GB2093694A (en) * 1981-02-17 1982-09-08 Alza Corp Dosage form for coadministering drug and percutaneous absorption enhancer
GB2100605A (en) * 1981-06-29 1983-01-06 Alza Corp Bandage for administering drugs.
FR2567761A1 (fr) * 1984-07-23 1986-01-24 Alza Corp Dispositif d'apport transdermique pour l'administration de fentanyl
EP0178140A2 (en) * 1984-10-09 1986-04-16 Alza Corporation Transdermal therapeutic systems for the administration of nalozone, naltrexone and nalbuphine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1510569A (en) * 1976-07-02 1978-05-10 American Home Prod Dosage form for the administration of a medicament to a moist body surface
US4460372A (en) * 1981-02-17 1984-07-17 Alza Corporation Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer
FR2534140B1 (fr) * 1982-10-12 1986-01-31 Fournier Laboratoires Nouveau dispositif pour l'administration percutanee de medicaments
JPS59155267A (ja) * 1983-02-23 1984-09-04 帝国製薬株式会社 経皮吸収用カプセルパツド貼付剤

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2143564A1 (en) * 1969-04-01 1973-02-09 Alza Corp Impregnated bandage - for long term administration of pharmacologically active materials at controlled rates
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
GB2093694A (en) * 1981-02-17 1982-09-08 Alza Corp Dosage form for coadministering drug and percutaneous absorption enhancer
GB2100605A (en) * 1981-06-29 1983-01-06 Alza Corp Bandage for administering drugs.
FR2567761A1 (fr) * 1984-07-23 1986-01-24 Alza Corp Dispositif d'apport transdermique pour l'administration de fentanyl
EP0178140A2 (en) * 1984-10-09 1986-04-16 Alza Corporation Transdermal therapeutic systems for the administration of nalozone, naltrexone and nalbuphine

Also Published As

Publication number Publication date
GB8609219D0 (en) 1986-05-21
ES554169A0 (es) 1988-03-16
GB2174605B (en) 1988-09-01
DE3614843A1 (de) 1986-11-06
IT8667361A0 (it) 1986-04-30
ES8801987A1 (es) 1988-03-16
JPH01170476A (ja) 1989-07-05
GB2174605A (en) 1986-11-12
IT1203553B (it) 1989-02-15
DE3614843C2 (https=) 1989-04-27
CA1252361A (en) 1989-04-11
US4645502A (en) 1987-02-24

Similar Documents

Publication Publication Date Title
FR2581314A1 (fr) Dispositif medical pour l'administration transdermique de medicaments fortement ionises insolubles dans les corps gras
ES2241083T3 (es) Parche de nicotina de actividad prolongada.
US5603947A (en) Method and device for providing nicotine replacement therapy transdermally/transbuccally
CA2315890C (en) Rate controlling membranes for controlled drug delivery devices
CA1297369C (en) Moisture activation of transdermal drug delivery system
US5633008A (en) Method of administering nicotine transdermally
US5135753A (en) Method and therapeutic system for smoking cessation
JP3011459B2 (ja) 皮膚透過において制御された時間変化で薬剤を経皮的に投与するためのデバイス
US4938759A (en) Transdermal delivery device having a rate controlling adhesive
ES2253331T3 (es) Estructuras y metodos para administrar cannabis a pacientes.
CA2652216C (en) Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux
CA2563110A1 (en) Rivastigmine comprised in a transdermal therapeutic system for use in the treatment of dementia or alzheimer disease
FR2567761A1 (fr) Dispositif d'apport transdermique pour l'administration de fentanyl
PT95002B (pt) Metodo e dispositivo para administracao transdermica de dexmedetomidina
JP4271869B2 (ja) 経皮投与用抗嘔吐剤組成物およびこれを含む製剤
ES2273042T3 (es) Sistema mejorado de suministro transdermico.
BRPI0721705A2 (pt) adesivo reservatàrio transdÉrmico de alcaloide de tabaco
AU3852189A (en) Subsaturated transdermal delivery device
CN100386073C (zh) 一种经皮给药系统
CN118141810A (zh) 用于治疗性治疗的包含加波沙朵的药物制剂
JP2007520480A (ja) 少なくとも一つの脂肪酸を含むジヒドロピリジンタイプのカルシウムアンタゴニスト用の経皮的デリバリー器具
RU2246937C2 (ru) Система для чрескожного введения никотина
Bhanu Malhotra et al. Polymers as biodegradable matrices in transdermal drug delivery systems.
JP2547726C (https=)