ES8801987A1 - Metodo de fabricacion de un dispositivo medico para la administracion de una droga insoluble en grasas, altamente ionizadas. - Google Patents

Metodo de fabricacion de un dispositivo medico para la administracion de una droga insoluble en grasas, altamente ionizadas.

Info

Publication number
ES8801987A1
ES8801987A1 ES554169A ES554169A ES8801987A1 ES 8801987 A1 ES8801987 A1 ES 8801987A1 ES 554169 A ES554169 A ES 554169A ES 554169 A ES554169 A ES 554169A ES 8801987 A1 ES8801987 A1 ES 8801987A1
Authority
ES
Spain
Prior art keywords
permeation enhancer
reservoir
transdermal delivery
insoluble drugs
highly ionized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554169A
Other languages
English (en)
Other versions
ES554169A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of ES8801987A1 publication Critical patent/ES8801987A1/es
Publication of ES554169A0 publication Critical patent/ES554169A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

COMPRENDE: FORMAR UN RECEPTACULO (8), PARA LA DROGA A ADMINISTRAR, QUE SE ENCONTRARA GELIFICADA, POR MEDIO DE SILICE, AGAR, POLIISOPRENO Y OTROS EN UN 50% O MAS DE AGUA Y PREFERIBLEMENTE EN UNA CONCENTRACION SUPERIOR A LA SATURACION; SEPARADO DEL RECEPTACULO (7), QUE CONTIENE UN ACTIVADOR DE LA PENETRACION, QUE ES UN SURFACTANTE COMO EL ALQUIL-SULFOXIDO Y OTROS; POR UNA MEMBRANA HIDROFOBA (3) QUE CONTROLA LA VELOCIDAD DE LIBERACION DEL ACTIVADOR Y POR ENDE LA DE LA DROGA QUE PASA A LA PIEL A TRAVES DE LA MEMBRANA (4) HECHA DE POLIESTER HILADO DE TEJIDO DE MALLA, POR EJEMPLO. TODO EL DISPOSITIVO SE ENCUENTRA RODEADO DE LA CAPA (2) DE EVA (ETILENO/ACETATO VINILO) U OTROS Y SE ADHIERE A LA PIEL MEDIANTE UNA CAPA (5) DE ADHESIVO DE CONTACTO COMO EL POLIACRILATO NORWOOD, O MEDIANTE CORREAS.
ES554169A 1985-05-03 1986-04-18 Metodo de fabricacion de un dispositivo medico para la administracion de una droga insoluble en grasas, altamente ionizadas. Expired ES8801987A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/730,713 US4645502A (en) 1985-05-03 1985-05-03 Transdermal delivery of highly ionized fat insoluble drugs

Publications (2)

Publication Number Publication Date
ES8801987A1 true ES8801987A1 (es) 1988-03-16
ES554169A0 ES554169A0 (es) 1988-03-16

Family

ID=24936525

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554169A Expired ES8801987A1 (es) 1985-05-03 1986-04-18 Metodo de fabricacion de un dispositivo medico para la administracion de una droga insoluble en grasas, altamente ionizadas.

Country Status (8)

Country Link
US (1) US4645502A (es)
JP (1) JPH01170476A (es)
CA (1) CA1252361A (es)
DE (1) DE3614843A1 (es)
ES (1) ES8801987A1 (es)
FR (1) FR2581314A1 (es)
GB (1) GB2174605B (es)
IT (1) IT1203553B (es)

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Also Published As

Publication number Publication date
US4645502A (en) 1987-02-24
FR2581314A1 (fr) 1986-11-07
DE3614843C2 (es) 1989-04-27
GB8609219D0 (en) 1986-05-21
ES554169A0 (es) 1988-03-16
CA1252361A (en) 1989-04-11
IT8667361A0 (it) 1986-04-30
JPH01170476A (ja) 1989-07-05
IT1203553B (it) 1989-02-15
GB2174605A (en) 1986-11-12
DE3614843A1 (de) 1986-11-06
GB2174605B (en) 1988-09-01

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