ES2058627T3 - Sistema terapeutico para la administracion retardada y dirigida a traves de la piel o de las mucosas de sustancias activas. - Google Patents

Sistema terapeutico para la administracion retardada y dirigida a traves de la piel o de las mucosas de sustancias activas.

Info

Publication number
ES2058627T3
ES2058627T3 ES90102771T ES90102771T ES2058627T3 ES 2058627 T3 ES2058627 T3 ES 2058627T3 ES 90102771 T ES90102771 T ES 90102771T ES 90102771 T ES90102771 T ES 90102771T ES 2058627 T3 ES2058627 T3 ES 2058627T3
Authority
ES
Spain
Prior art keywords
active substance
layer
reservoir
active substances
mucous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90102771T
Other languages
English (en)
Inventor
Walter Dr Dipl-Chem Muller
Heinrich Kindel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Application granted granted Critical
Publication of ES2058627T3 publication Critical patent/ES2058627T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)

Abstract

SE PRESENTA UN SISTEMA TERAPEUTICO PARA EL SUMINISTRO TRANSDERMAL O TRANSMUCOSAL RETARDADO Y CONTROLADO DE SUSTANCIAS ACTIVADORAS QUE SE COMPONE DE UNA CAPA TRASERA IMPERMEABLE, UN DEPOSITO QUE CONTIENE UNA SUSTANCIA ACTIVADORA, UNA CAPA ESENCIALMENTE EXENTA DE, PERO PERMEABLE PARA LA SUSTANCIA ACTIVADORA Y UNA CAPA PROTECTORA DESPRENDIBLE. LA CAPA EXENTA DE SUSTANCIA ACTIVADORA SE PONE EN CONTACTO CON EL DEPOSITO DE SUSTANCIA ACTIVADORA, INMEDIATAMENTE ANTES O DESPUES DE LA APLICACION, Y PARA ESO SE SITUA ENTRE EL DEPOSITO Y LA SUPERFICIE DE APLICACION. AL DIFUNDIRSE LA SUSTANCIA ACTIVADORA DEL DEPOSITO A LA CAPA EXENTA, AL MENOS UNA PARTE DE ESTA SUSTANCIA SE TRANSFORMA A UN ESTADO NO BIODISPONIBLE. ESTA TRANSFORMACION SE PUEDE LLEVAR A CABO INMOVILIZANDO LA SUSTANCIA MEDIANTE UNA REACCION QUIMICA O UN EFECTO RECIPROCO FISICO.
ES90102771T 1989-02-18 1990-02-13 Sistema terapeutico para la administracion retardada y dirigida a traves de la piel o de las mucosas de sustancias activas. Expired - Lifetime ES2058627T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3905051A DE3905051A1 (de) 1989-02-18 1989-02-18 Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i)

Publications (1)

Publication Number Publication Date
ES2058627T3 true ES2058627T3 (es) 1994-11-01

Family

ID=6374443

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90102771T Expired - Lifetime ES2058627T3 (es) 1989-02-18 1990-02-13 Sistema terapeutico para la administracion retardada y dirigida a traves de la piel o de las mucosas de sustancias activas.

Country Status (8)

Country Link
US (1) US5215751A (es)
EP (1) EP0384267B1 (es)
JP (1) JP2538372B2 (es)
AT (1) ATE89756T1 (es)
CA (1) CA2010225C (es)
DE (2) DE3905051A1 (es)
DK (1) DK0384267T3 (es)
ES (1) ES2058627T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL105073A0 (en) † 1992-03-17 1993-07-08 Becton Dickinson Co User activated iontophoretic device and method for using same
AU5354994A (en) * 1992-10-15 1994-05-09 Alza Corporation Delayed onset transdermal delivery device
DE4301781C2 (de) * 1993-01-23 1995-07-20 Lohmann Therapie Syst Lts Nitroglycerinhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung
AU4657896A (en) * 1995-01-19 1996-08-07 Cygnus, Inc. Polyisobutylene adhesives containing high TG tackifier for transdermal devices
US5730721A (en) 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
DE19814083C2 (de) 1998-03-30 2002-02-07 Lohmann Therapie Syst Lts Verfahren zur Herstellung von transdermalen therapeutischen Systemen unter Verwendung von basischen Alkalimetallsalzen zur Umwandlung von Wirkstoffsalzen in die freien Basen
DE19814087A1 (de) 1998-03-30 1999-10-14 Lohmann Therapie Syst Lts Feuchtigkeitsaktivierbares therapeutisches System
DE19943317C1 (de) * 1999-09-10 2001-03-15 Lohmann Therapie Syst Lts Kunststofffolien, insbesondere für die Verwendung in einem dermalen oder transdermalen therapeutischen System und Verfahren zu ihrer Herstellung
KR100373447B1 (ko) * 2000-07-04 2003-02-25 강진양 약용탄을 이용한 파프제
DE10141651B4 (de) * 2001-08-24 2007-02-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
JP2003300873A (ja) * 2002-04-12 2003-10-21 Nitto Denko Corp 貼付剤およびその製造方法
DE102008013701A1 (de) 2008-03-11 2009-09-17 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System mit stabilisierter Membran
DE102009022915A1 (de) * 2009-05-27 2010-12-09 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit gesteuertem Wirkstofffluss

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810499A (en) * 1984-10-01 1989-03-07 Biotek, Inc. Transdermal drug delivery system and method
US4756710A (en) * 1985-04-05 1988-07-12 Merck & Co., Inc. pH-Mediated drug delivery system
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US4816258A (en) * 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
JPS6425717A (en) * 1987-05-08 1989-01-27 Eastman Kodak Co Method and apparatus for preventing organic nitric acid ester resistance
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device

Also Published As

Publication number Publication date
ATE89756T1 (de) 1993-06-15
DE3905051A1 (de) 1990-08-30
DK0384267T3 (da) 1993-10-04
DE59001522D1 (de) 1993-07-01
US5215751A (en) 1993-06-01
EP0384267A3 (en) 1990-12-19
DE3905051C2 (es) 1991-08-08
JPH02258717A (ja) 1990-10-19
EP0384267A2 (de) 1990-08-29
CA2010225C (en) 1998-04-28
CA2010225A1 (en) 1990-08-18
EP0384267B1 (de) 1993-05-26
JP2538372B2 (ja) 1996-09-25

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