FR2525603A1 - Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique - Google Patents
Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique Download PDFInfo
- Publication number
- FR2525603A1 FR2525603A1 FR8207203A FR8207203A FR2525603A1 FR 2525603 A1 FR2525603 A1 FR 2525603A1 FR 8207203 A FR8207203 A FR 8207203A FR 8207203 A FR8207203 A FR 8207203A FR 2525603 A1 FR2525603 A1 FR 2525603A1
- Authority
- FR
- France
- Prior art keywords
- spiro
- formula
- salt
- dione
- isoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8207203A FR2525603A1 (fr) | 1982-04-27 | 1982-04-27 | Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique |
AT0125383A ATA125383A (de) | 1982-04-27 | 1983-04-08 | Verfahren zur herstellung von neuen benzoazacycloalkyl-spiro-imidazolidinen |
LU84770A LU84770A1 (fr) | 1982-04-27 | 1983-04-25 | Benzoazacycloalkyl-spiro-imidazolidines,leur preparation et leur application en therapeutique |
DD83250187A DD209833A5 (de) | 1982-04-27 | 1983-04-25 | Verfahren zur herstellung von benzoazacycloalkyl-spiro-imidazolidinen |
PT76595A PT76595B (fr) | 1982-04-27 | 1983-04-26 | Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines |
SE8302347A SE8302347L (sv) | 1982-04-27 | 1983-04-26 | Bensoazacykloalkyl-spiro-imidazolidiner, framstellning derav och farmaceutiska kompositioner innehallande dem |
IT48155/83A IT1167123B (it) | 1982-04-27 | 1983-04-26 | Benzoazacicloalchilspiro-imidazolidine,procedimento per prepararle e composizioni farmaceutiche che le contengono |
NO831473A NO831473L (no) | 1982-04-27 | 1983-04-26 | Fremgangsmaate ved fremstilling av benzoazacykloalkyl-spiro-imidazolidiner |
ZA832927A ZA832927B (en) | 1982-04-27 | 1983-04-26 | Benzoazacycloalkyl-spiro-imidazolidines,their preparation and compositions containing them |
GR71214A GR78481B (sv) | 1982-04-27 | 1983-04-26 | |
BE0/210633A BE896572A (fr) | 1982-04-27 | 1983-04-26 | Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique |
AU13953/83A AU1395383A (en) | 1982-04-27 | 1983-04-26 | Benzoazacycloalkyl-spiro-imidazolidines |
IL68497A IL68497A0 (en) | 1982-04-27 | 1983-04-26 | Benzoazacycloalkyl-spiro-imidazolidines,their preparation and pharmaceutical compositions containing them |
DK183583A DK183583A (da) | 1982-04-27 | 1983-04-26 | Fremgangsmaade til fremstilling af benzoazacycloalkyl-spiro-imidazolidiner |
KR1019830001753A KR840004428A (ko) | 1982-04-27 | 1983-04-26 | 벤조 아자시클로 알킬-스피로-이미다졸리딘의 제조방법 |
JP58073687A JPS5910584A (ja) | 1982-04-27 | 1983-04-26 | イミダゾリジン誘導体 |
NL8301476A NL8301476A (nl) | 1982-04-27 | 1983-04-26 | Benzoazacycloalkylspiroimidazolidines, hun bereiding en farmaceutische samenstellingen welke deze bevatten. |
DE19833315106 DE3315106A1 (de) | 1982-04-27 | 1983-04-27 | Benzoazacycloalkyl-spiro-imidazolidine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen |
MA20003A MA19783A1 (fr) | 1982-04-27 | 1983-04-27 | Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines. |
OA57984A OA07412A (fr) | 1982-04-27 | 1983-04-27 | Benzoazacycloalhyl-spiro-imidazolidines leur préparation et leur application en thérapeutique. |
GB08311508A GB2133401B (en) | 1982-04-27 | 1983-04-27 | Benzoazacycloalkyl-spiro-imidazolidines |
ES521895A ES8405796A1 (es) | 1982-04-27 | 1983-04-27 | Procedimiento de preparacion de benzoazacicloalquil-espiroimidazolidina, asi como de sus sales obtenidas con bases minerales u organicas farmaceuticamente aceptables. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8207203A FR2525603A1 (fr) | 1982-04-27 | 1982-04-27 | Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2525603A1 true FR2525603A1 (fr) | 1983-10-28 |
FR2525603B1 FR2525603B1 (sv) | 1984-09-14 |
Family
ID=9273425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8207203A Granted FR2525603A1 (fr) | 1982-04-27 | 1982-04-27 | Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique |
Country Status (22)
Country | Link |
---|---|
JP (1) | JPS5910584A (sv) |
KR (1) | KR840004428A (sv) |
AT (1) | ATA125383A (sv) |
AU (1) | AU1395383A (sv) |
BE (1) | BE896572A (sv) |
DD (1) | DD209833A5 (sv) |
DE (1) | DE3315106A1 (sv) |
DK (1) | DK183583A (sv) |
ES (1) | ES8405796A1 (sv) |
FR (1) | FR2525603A1 (sv) |
GB (1) | GB2133401B (sv) |
GR (1) | GR78481B (sv) |
IL (1) | IL68497A0 (sv) |
IT (1) | IT1167123B (sv) |
LU (1) | LU84770A1 (sv) |
MA (1) | MA19783A1 (sv) |
NL (1) | NL8301476A (sv) |
NO (1) | NO831473L (sv) |
OA (1) | OA07412A (sv) |
PT (1) | PT76595B (sv) |
SE (1) | SE8302347L (sv) |
ZA (1) | ZA832927B (sv) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
MXPA05013364A (es) | 2003-06-17 | 2006-03-17 | Arena Pharm Inc | Procedimiento para preparar 3-benzazepinas. |
CN101792417A (zh) | 2003-06-17 | 2010-08-04 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
SI1838677T1 (sl) | 2004-12-21 | 2010-01-29 | Arena Pharm Inc | Kristalne oblike (R)-8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepin hidroklorida |
EA015012B1 (ru) | 2004-12-23 | 2011-04-29 | Арена Фармасьютикалз, Инк. | Композиция, содержащая фентермин и избирательный агонист рецептора 5ht, и ее применение |
SG10201508066VA (en) | 2006-04-03 | 2015-10-29 | Arena Pharm Inc | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto |
ES2522587T3 (es) | 2006-12-05 | 2014-11-17 | Arena Pharmaceuticals, Inc. | Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma |
WO2009111004A1 (en) | 2008-03-04 | 2009-09-11 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
EP2443080A2 (en) | 2009-06-18 | 2012-04-25 | Arena Pharmaceuticals, Inc. | Process for the preparation of 5-ht2c receptor agonists |
WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
EP2611782A1 (en) | 2010-09-01 | 2013-07-10 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
KR20180118801A (ko) | 2010-09-01 | 2018-10-31 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리에 유용한 5-ht2c 작동제의 변형-방출 투여 형태 |
EP2611433A2 (en) | 2010-09-01 | 2013-07-10 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
SG188365A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Administration of lorcaserin to individuals with renal impairment |
KR20190128001A (ko) | 2012-10-09 | 2019-11-13 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리 방법 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0021704A1 (en) * | 1979-06-13 | 1981-01-07 | Pfizer Inc. | Spiro-hydantoin derivatives, process for their preparation and pharmaceutical compositions thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/fr active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/de not_active IP Right Cessation
- 1983-04-25 LU LU84770A patent/LU84770A1/fr unknown
- 1983-04-25 DD DD83250187A patent/DD209833A5/de unknown
- 1983-04-26 SE SE8302347A patent/SE8302347L/sv not_active Application Discontinuation
- 1983-04-26 BE BE0/210633A patent/BE896572A/fr not_active IP Right Cessation
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-26 IT IT48155/83A patent/IT1167123B/it active
- 1983-04-26 IL IL68497A patent/IL68497A0/xx unknown
- 1983-04-26 DK DK183583A patent/DK183583A/da not_active Application Discontinuation
- 1983-04-26 PT PT76595A patent/PT76595B/pt unknown
- 1983-04-26 NL NL8301476A patent/NL8301476A/nl not_active Application Discontinuation
- 1983-04-26 ZA ZA832927A patent/ZA832927B/xx unknown
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 NO NO831473A patent/NO831473L/no unknown
- 1983-04-26 JP JP58073687A patent/JPS5910584A/ja active Pending
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/ko not_active Application Discontinuation
- 1983-04-27 ES ES521895A patent/ES8405796A1/es not_active Expired
- 1983-04-27 OA OA57984A patent/OA07412A/xx unknown
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 MA MA20003A patent/MA19783A1/fr unknown
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/de not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0021704A1 (en) * | 1979-06-13 | 1981-01-07 | Pfizer Inc. | Spiro-hydantoin derivatives, process for their preparation and pharmaceutical compositions thereof |
Also Published As
Publication number | Publication date |
---|---|
DK183583D0 (da) | 1983-04-26 |
ZA832927B (en) | 1984-06-27 |
IT8348155A0 (it) | 1983-04-26 |
KR840004428A (ko) | 1984-10-15 |
MA19783A1 (fr) | 1983-12-31 |
ES521895A0 (es) | 1984-06-16 |
GB2133401A (en) | 1984-07-25 |
SE8302347L (sv) | 1983-10-28 |
GR78481B (sv) | 1984-09-27 |
GB8311508D0 (en) | 1983-06-02 |
IL68497A0 (en) | 1983-07-31 |
OA07412A (fr) | 1984-11-30 |
LU84770A1 (fr) | 1984-11-28 |
IT1167123B (it) | 1987-05-13 |
DD209833A5 (de) | 1984-05-23 |
PT76595B (fr) | 1986-01-21 |
DK183583A (da) | 1983-10-28 |
GB2133401B (en) | 1985-10-23 |
NL8301476A (nl) | 1983-11-16 |
DE3315106A1 (de) | 1983-11-03 |
AU1395383A (en) | 1983-11-03 |
ES8405796A1 (es) | 1984-06-16 |
PT76595A (fr) | 1983-05-01 |
SE8302347D0 (sv) | 1983-04-26 |
JPS5910584A (ja) | 1984-01-20 |
FR2525603B1 (sv) | 1984-09-14 |
BE896572A (fr) | 1983-10-26 |
NO831473L (no) | 1983-10-28 |
ATA125383A (de) | 1986-05-15 |
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Legal Events
Date | Code | Title | Description |
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ST | Notification of lapse |