FR2514355A1 - Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments - Google Patents

Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments Download PDF

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Publication number
FR2514355A1
FR2514355A1 FR8119316A FR8119316A FR2514355A1 FR 2514355 A1 FR2514355 A1 FR 2514355A1 FR 8119316 A FR8119316 A FR 8119316A FR 8119316 A FR8119316 A FR 8119316A FR 2514355 A1 FR2514355 A1 FR 2514355A1
Authority
FR
France
Prior art keywords
phenyl
biphenyl
piperazine
formula
propionate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8119316A
Other languages
English (en)
French (fr)
Other versions
FR2514355B1 (enExample
Inventor
Henri Cousse
Gilbert Mouzin
Jean-Pierre Tarayre
Jean-Pierre Rieu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR8119316A priority Critical patent/FR2514355A1/fr
Priority to DE8282401870T priority patent/DE3260465D1/de
Priority to US06/433,987 priority patent/US4510142A/en
Priority to AT82401870T priority patent/ATE8618T1/de
Priority to EP82401870A priority patent/EP0077720B1/fr
Priority to JP57181195A priority patent/JPS5877849A/ja
Publication of FR2514355A1 publication Critical patent/FR2514355A1/fr
Application granted granted Critical
Publication of FR2514355B1 publication Critical patent/FR2514355B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
FR8119316A 1981-10-14 1981-10-14 Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments Granted FR2514355A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR8119316A FR2514355A1 (fr) 1981-10-14 1981-10-14 Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments
DE8282401870T DE3260465D1 (en) 1981-10-14 1982-10-12 Biphenyl alkyl carboxylated derivatives, process for their preparation and their use as medicines
US06/433,987 US4510142A (en) 1981-10-14 1982-10-12 Derivatives of biphenyl alkyl carboxylates and their use as medicaments
AT82401870T ATE8618T1 (de) 1981-10-14 1982-10-12 Derivate von biphenyl-alkyl-carboxylaten, deren herstellungsverfahren und deren verwendung als arzneimittel.
EP82401870A EP0077720B1 (fr) 1981-10-14 1982-10-12 Dérivés de biphényl alcoyl carboxylates, leur procédé de préparation et leur utilisation comme médicaments
JP57181195A JPS5877849A (ja) 1981-10-14 1982-10-14 ビフエニルアルキルカルボン酸エステル誘導体、その製造法及びこれを含む医薬

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8119316A FR2514355A1 (fr) 1981-10-14 1981-10-14 Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments

Publications (2)

Publication Number Publication Date
FR2514355A1 true FR2514355A1 (fr) 1983-04-15
FR2514355B1 FR2514355B1 (enExample) 1984-01-13

Family

ID=9263029

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8119316A Granted FR2514355A1 (fr) 1981-10-14 1981-10-14 Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments

Country Status (6)

Country Link
US (1) US4510142A (enExample)
EP (1) EP0077720B1 (enExample)
JP (1) JPS5877849A (enExample)
AT (1) ATE8618T1 (enExample)
DE (1) DE3260465D1 (enExample)
FR (1) FR2514355A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1201127A (en) * 1982-09-10 1986-02-25 Katsuhiro Uchida Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same
IT1212840B (it) * 1983-11-28 1989-11-30 Zambeletti Spa L Derivati di acidi bifenililalcanoici, loro preparazione e composizioni farmaceutiche che licontengono.
JPH0764834B2 (ja) * 1985-11-29 1995-07-12 サントリー株式会社 プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途
DK406686D0 (da) * 1986-08-26 1986-08-26 Hans Bundgaard Carboxylsyrederivater
JPS6425782A (en) * 1987-03-27 1989-01-27 Yoshitomi Pharmaceutical Benzopyranopyridineacetic acid ester compound
US4916209A (en) * 1987-12-23 1990-04-10 Pfizer Inc. Bioabsorbable polydepsipeptide, preparation and use thereof
DE60234453D1 (de) * 2001-07-02 2009-12-31 High Point Pharmaceuticals Llc Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
US6900233B2 (en) * 2002-02-28 2005-05-31 Aventis Pharma Deutschland Gmbh Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof
AU2015209759B2 (en) * 2014-01-23 2018-11-29 Sixera Pharma Ab New kallikrein 7 inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5737M (enExample) * 1964-01-24 1968-03-04
FR6978M (enExample) * 1967-12-13 1969-05-27
FR2185410A1 (enExample) * 1972-05-23 1974-01-04 Zambeletti Spa L

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS185694B2 (en) * 1974-07-17 1978-10-31 Ishihara Sangyo Kaisha Herbicidal agent
CA1110628A (en) * 1978-08-25 1981-10-13 Tosaku Miki N-phenethylacetamide compounds and process for preparation thereof
DE2964097D1 (en) * 1978-09-08 1982-12-30 Ici Plc Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture
US4390715A (en) * 1980-07-18 1983-06-28 Commonwealth Scientific And Industrial Research Organization Pentafluorobenzyl esters

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5737M (enExample) * 1964-01-24 1968-03-04
FR6978M (enExample) * 1967-12-13 1969-05-27
FR2185410A1 (enExample) * 1972-05-23 1974-01-04 Zambeletti Spa L

Also Published As

Publication number Publication date
EP0077720A1 (fr) 1983-04-27
DE3260465D1 (en) 1984-08-30
ATE8618T1 (de) 1984-08-15
FR2514355B1 (enExample) 1984-01-13
US4510142A (en) 1985-04-09
JPS5877849A (ja) 1983-05-11
EP0077720B1 (fr) 1984-07-25

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