FR2509689A1 - Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle - Google Patents

Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle Download PDF

Info

Publication number
FR2509689A1
FR2509689A1 FR8114012A FR8114012A FR2509689A1 FR 2509689 A1 FR2509689 A1 FR 2509689A1 FR 8114012 A FR8114012 A FR 8114012A FR 8114012 A FR8114012 A FR 8114012A FR 2509689 A1 FR2509689 A1 FR 2509689A1
Authority
FR
Grant status
Application
Patent type
Prior art keywords
valve
piston
flask
hypodermic needle
device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8114012A
Other languages
French (fr)
Inventor
Didier Leray
Bruno Eyssautier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carbonisation et Charbons Actifs (CECA) SA
Original Assignee
Carbonisation et Charbons Actifs (CECA) SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04Heat
    • A61L2/06Hot gas
    • A61L2/07Steam
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00Packaging plastic material, semi-liquids, liquids, or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B3/003Filling medical containers such as ampoules, vials, syringes or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2037Separating means having valve means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2051Connecting means having tap means, e.g. tap means activated by sliding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2065Connecting means having aligning and guiding means

Abstract

The tube (12) contains a valve (3) with its actuator (5,6,7) and extends between a container (1) opening (2) and a hypodermic needle (9), being used to transfer liq. from the container to a flask (11) under aseptic conditions. A further valve (13) injects steam into the tube, the needle and the tube end (15) being housed by an open cylindrical casing (14). A hollow piston (18) closes and seals the casing whilst locating the flask, being connected by a bayonet fastener (22,23,24), and moving forward whilst being made fast to effect the penetration of the needle into the flask opening (10). A valve (16,17) fitted to the casing provides for the evacuation of steam, entailing a steam-sterilising of accessible parts followed by needle penetration, valve actuation and transfer.

Description

Dispositif et procédé pour assurer le transfert de façon aseptique d'un liquide contenu dans un récipient jusqu'3 un autre récipient. Apparatus and method for transferring aseptically with a liquid contained in a container upto 3 another container.

La présente invention concerne un dispositif et un procédé pour assurer le transfert de façon aseptique d'un liquide contenu dans un récipient jusqu'à un autre récipient (appelé flacon). The present invention relates to a device and a method for transferring aseptically with a liquid contained in a vessel to another vessel (called vial).

Le dispositif le plus couramment utilisé pour transférer, de façon aseptique, un liquide contenu dans un récipient jusqu'à un flacon comporte The most commonly used device for transferring aseptically, a liquid contained in a container to a bottle comprises
- une ouverture, pratiquée dans la paroi dudit récipient, pouvant etre obstruée à l'aide d'une soupape commandée, - an opening in the wall of said container, which can be obstructed by means of a controlled valve,
- un dispositif de commande de ladite soupape, ce dispositif et ladite soupape pouvant etre conçus de façon à former un robinet, - a control of said valve device, said device and said valve being designed to form a valve,
- un dispositif d'amenée du liquide dans ledit flacon ce dispositif est généralement constitué par une aiguille hypodermique apte à percer le bouchon dudit flacon - a feed device of the liquid in said bottle this device is generally constituted by a hypodermic needle capable of piercing the stopper of said vial
- un tube de transfert du liquide reliant l'ouverture pratiquée dans la paroi du récipient et le dispositif d'amenée du liquide dans le flacon dans le cas où on utilise un robinet, ce tube de transfert incluant dans son trajet ledit robinet, et - a fluid transfer tube connecting the opening in the container wall and the feed device of the liquid in the vial in the case where a valve is used, this transfer tube including in its path said tap, and
- un moyen permettant d'admettre dans le tube de transfert de la vapeur d'eau afin de stériliser l'intérieur dudit tube et de ladite aiguille. - means for admitting the water vapor transfer tube in order to sterilize the interior of said tube and said needle.

Mais ce dispositif oblige, pour opérer dans les meilleures conditions d'aseptie, de stériliser à la flamme la surface extérieure du dispositif d'amenée du liquide dans le flacon; But this device requires to operate under optimum aseptic conditions, sterilize the flame outer surface of the feed device of the liquid in the bottle; il convient de plus de prévoir une stérilisation adéquate et difficile de la surface extérieure du bouchon du flacon, bouchon au travers duquel sera introduit le dispositif (aiguille) d'amenée du liquide dans le flacon. it should be more difficult and provide for adequate sterilization of the outer surface of the bottle cap, plug through which will be introduced the device (needle) for delivering the liquid into the vial.

La présente invention vise un dispositif et un procédé pour réaliser de façon complètement aseptique le transfert d'un liquide contenu dans un récipient jusqu'à unflacon. The present invention aims a device and a method for producing completely aseptically transferring a liquid contained in a container until unflacon.

Le dispositif selon la présente invention comporte The device according to the present invention comprises
- une ouverture,pratiquée dans la paroi du récipient, pouvant etre obstruée à l'aide d'une soupape commandée, - an opening in the wall of the container, which can be obstructed by means of a controlled valve,
- un dispositif de commande de ladite soupape, ce dispositif et la soupape pouvant former un robinet, - a control device for said valve, this valve device and capable of forming a tap,
- une aiguille hypodermique apte à percer le bouchon du flacon récepteur, - a hypodermic needle capable of piercing the stopper of the receiving flask,
- un tube de transfert reliant ladite ouverture et ladite aiguille, - a transfer tube connecting said opening and said needle,
- un moyen permettant d'admettre, dans ledit tube de transfert, de la vapeur d'eau, ce dispositif étant caractérisé en ce que l'extrémité du tube de transfert et l'aiguille hypodermique sont entourées d'une enceinte cylindrique ouverte apte à recevoir un piston-bottier obstruant de façon étanche cette ouverture et dans lequel le flacon est inséré, ledit piston-boStier ayant un couvercle muni d'une ouverture qui sera dirigée vers ladite aiguille hypodermique lorsque le piston-bottier sera inséré dans l'enceinte, l'enceinte cylindrique et le pistonbottier étant pourvus de moyens respectifs permettant, après mise en place du piston-bottier, d'assurer un déplacement de ce pistonbottier de façon que l'aiguille hypodermique vienne percer le bouchon du flacon contenu dans ce piston-bottier, l'enceinte étant en outre munie d'un dispositif d'évacuation de vapeur d'eau. - means for admitting into said transfer tube, water vapor, said device being characterized in that the end of the transfer tube and the hypodermic needle are surrounded by an open cylindrical chamber adapted to receive a piston-stacked sealingly occluding said opening and wherein the bottle is inserted, said piston-boStier having a lid with an opening which is directed towards said hypodermic needle when the piston-stacked will be inserted into the enclosure, the cylindrical enclosure and the pistonbottier being provided with respective means, after establishment of pistonbottier, to ensure a displacement of the pistonbottier so that the hypodermic needle comes pierce the stopper of the vial contained in this pistonbottier , the chamber being further provided with a steam discharge device.

L'invention sera mieux comprise à l'aide de l'exemple non limitatif suivant qui représente un mode de réalisation de l'invention et qui est schématisé sur les figures 1, 2 et 3. The invention will be better understood using the following non-limiting example representing an embodiment of the invention and which is shown diagrammatically in Figures 1, 2 and 3.

La figure 1 est une vue en coupe en élévation médiane du dispositif de prélèvement pendant la période de stérilisation. Figure 1 is a median sectional elevation view of the sampling device during the sterilization period.

La figure 2 est une vue partielle de dessus d'un dispositif commode de déplacement relatif de l'enceinte et du pis ton-bottier. Figure 2 is a partial top view of a dresser device for relative displacement of the enclosure and udder-tone stacked.

La figure 3 est une vue en coupe en élévation médiane de ce meme dispositif pendant la période de transfert. Figure 3 is a median sectional elevation view of the same device during the transfer period.

Sur les figures 1 et 2, on peut voir In Figures 1 and 2, it can be seen
- en 1, la paroi du récipient (par exemple un fermenteur) contenant le liquide que l'on veut prélever; - in 1, the container wall (e.g., fermentor) containing the liquid which it is desired sample; cette paroi comporte une ouverture 2 munie d'une soupape 3 comportant un joint d'étan cherté 4, said wall has an opening 2 provided with a valve 3 including a seal etan expensiveness 4,
- la commande de la soupape est assurée par une tige filetée 7 solidaire d'un bouton moleté 6, l'ensemble commandant une tige 5, solidaire de la soupape 3, cette tige étant elle-mEme munie de joints d'étanchéité 8 (cet ensemble constituant un robinet), - the control valve is ensured by a threaded rod 7 attached to a knurled knob 6, the whole controlling a rod 5 integral with the valve 3, said rod being itself provided with gaskets 8 (this together constituting a tap)
- une aiguille hypodermique 9 apte à percer le bouchon 10 d'un flacon récepteur 11, - a hypodermic needle 9 adapted to pierce the stopper 10 of a receiving flask 11,
- un tube de transfert 12 sur lequel est fixé ledit robinet relie l'ouverture pratiquée dans la paroi du récipient à l'aiguille hypodermique; - a transfer tube 12 on which is fixed said valve connects the opening in the container wall to the hypodermic needle; sur ce robinet est fixée une vanne 13 par laquelle on peut admettre à l'intérieur du corps du robinet et du tube de transfert, et sortant par l'aiguille hypodermique, de la vapeur d'eau. this valve is attached a valve 13 by which it can be assumed within the valve body and the transfer tube, and out through the hypodermic needle, from the water vapor. Cette vapeur d'eau est à une température suffisante pour réaliser une stérilisation des surfaces rencontrées, à savoir les surfaces internes du robinet du tube de transfert et de l'aiguille hypodermique. This steam is at a temperature sufficient to achieve sterilization of surfaces encountered, namely, the inner surfaces of the valve of the transfer tube and hypodermic needle.

Selon l'invention, le dispositif de prélèvement comporte autour de l'extrémité du tube de transfert et de aiguille hypodermique une enceinte cylindrique 14; According to the invention, the sampling device comprises around the end of the transfer tube and a hypodermic needle cylindrical housing 14; cette enceinte est soudée 15 sur le tube et est ouverte; this chamber 15 is welded on the tube and is open; l'axe de cette enceinte est de préférence, mais non nécessairement, le meme que l'axe de l'aiguille hypodermique. the axis of this chamber is preferably, but not necessarily, the same as the axis of the hypodermic needle.

L'enceinte comporte une tubulure latérale 16 munie d'une vanne 17 qui peut etre par exemple, comme la vanne 13, une vanne à membrane. The enclosure comprises a side tube 16 provided with a valve 17 which can be for example, as the valve 13, a diaphragm valve.

Dans cette enceinte cylindrique 14, est introduit un piston-bottier 18 dont l'étanchéité sur la paroi interne de l'enceinte cylindrique est assurée par des joints toriques 19. Ce piston-boitier est constitué d'un corps cylindrique creux dans lequel on met en place le flacon de prélèvement 20; In this cylindrical housing 14, is inserted a piston 18 whose sealing stacked on the inner wall of the cylindrical enclosure is provided by O-rings 19. This box-piston consists of a hollow cylindrical body, which comprises bringing up the sampling bottle 20; ce flacon est maintenu en place par le bouchon 21 muni, comme le piston-boitier, d'un pas de vis ou de tout autre moyen équivalent. this bottle is held in place by the cap 21 provided as the plunger-casing, a screw or any other equivalent means.

La face dudit piston-bottier qui entre dans la chambre 14 (face que l'on peut appeler couvercle) est munie d'une ouverture par laquelle on pourra attendre, à l'aide de l'aiguille 9, le flacon monté dans ledit piston-bottier. The face of said piston-stacked which enters the chamber 14 (facing the cover may be called) is provided with an opening through which can be expected, with the needle 9, the vial mounted in said piston -bottier.

Les parois de l'enceinte cylindrique et du piston-boitier sont évidées, ainsi qu'on le constate sur la figure 2, de façon qu'on puisse voir le flacon. The walls of the cylindrical enclosure and the housing and piston are recessed, as will be seen in Figure 2, so that we can see the vial.

Sur cette figure, on constate aussi que la paroi de l'enceinte cylindrique porte un évidement 22 de forme spéciale dans lequel s'insère un ergot 23 porté par le piston-bottier. In this figure, there is also the wall of the cylindrical enclosure carries a recess 22 of special form in which is inserted a pin 23 carried by the piston-stacked.

En imprimant à ce dernier une rotation, une poussée et une seconde rotation, on amène l'ergot en position 24 et le piston-botier est donc introduit plus profondément dans l'enceinte cylindrique. By imparting to the latter a rotation, a thrust and a second rotation, causes the lug 24 in position and the piston-watch case is inserted deeper into the cylindrical enclosure.

Le dispositif ainsi décrit est mis en oeuvre de la façon suivante. The device thus described is implemented as follows.

Le robinet commandant la soupape 3 est en position fermée comme dans la figure 1; The valve controlling the valve 3 is in closed position as in Figure 1; le flacon de prélèvement est en place, immobilisé par le bouchon 21. the sample bottle is in place, fixed by the stopper 21.

On procède à la stérilisation de l'ensemble en maintenant ouverte la vanne 13 et en introduisant de la vapeur d'eau par la vanne 13. On stérilise ainsi la chambre du robinet, la tubulure 12, l'aiguille hypodermique 9 et l'intérieur 25 de l'enceinte cylindrique, ainsi que la surface du bouchon-plasma 26 du flacon. The procedure for sterilizing the assembly by the now open valve 13 and introducing steam through the valve 13. Thus sterilizes the valve chamber, the tubing 12, the hypodermic needle 9 and the inner 25 of the cylindrical enclosure and the surface of the plasma-stopper 26 of the vial.

Lorsque la stérilisation est obtenue au bout d'un temps suffisant qui peut etre de l'ordre d'une demi-heure, on ferme successivement la vanne 13 et la vanne 17. When sterilization is achieved after a sufficient time which may be of the order of half an hour, successively closes the valve 13 and valve 17.

Par la manoeuvre de rotation et de poussée du pistonbottier décrite précédemment, on place ce dernier dans la position de la figure 3 où l'aiguille hypodermique traverse le bouchon-plasma et débouche donc à l'intérieur du flacon stérile. By actuating rotation and thrust of pistonbottier described above, it moves it into the position of Figure 3 where the hypodermic needle through the stopper and plasma thus opens out inside the sterile bottle. On ouvre alors le robinet commandant la soupape 3, le milieu s'écoule par la tubulure 12, l'aiguille hypodermique 9 et emplit le flacon 11. Du fait qu'on voit une partie du flacon, on peut suivre le remplissage qu'on arrente au moment opportun en refermant le robinet. then opens the valve controlling the valve 3, the medium flows through the pipe 12, the hypodermic needle 9 and fills the bottle 11. As a result we see a part of the bottle, one can follow the filling that Arrente timely closing the tap.

I1 suffit alors de ramener le piston-bottier dans la position de la figure 15 le bouchon 21 étant maintenu en place. I1 is then sufficient to bring the piston in the stacked position of Figure 15 the plug 21 being held in place. On ouvre la vanne 17 et,par la vanne 13, on réintroduit de la vapeur d'eau pour chasser le milieu, nettoyer les circuits et stériliser les enceintes. and valve 17 is opened by the valve 13, reintroduced the steam to drive the middle, clean and sterilize circuits pregnant.

Le bouchon 21 est dévissé et le flacon 11 retiré. The cap 21 is unscrewed and the container 11 removed. Le dispositif est alors pret pour une nouvelle opération. The device is then ready for a new operation.

Le dispositif ainsi décrit représente une forme préférée de l'invention qui peut etre réalisée par tout moyen équivalent. The device thus described represents a preferred form of the invention which can be carried out by any equivalent means.

L'aiguille hypodermique est raccordée à la tubulure par tout moyen connu permettant un changement commode de cette aiguille. The hypodermic needle is connected to the pipe by any known means enabling a convenient change of this needle.

On peut aussi concevoir de fixer sur la tubulure 12 un raccord muni d'une vanne; It is also conceivable to fix the pipe 12 a connector provided with a valve; cette vanne sert alors à l'introduction de la vapeur qui est évacuée par les vannes 13 et 17. this valve is then used for the introduction of the steam that is discharged through the valves 13 and 17.

Ainsi qu'il apparaît, le procédé permet donc d'assurer la stérilisation totale de tout le circuit de prélèvement en toute sécurité. As shown, the process thus ensures complete sterilization of all the sampling circuit safely.

Claims (3)

    REVENDICATIONS
  1. 1. Dispositif de transfert, dans des conditions aseptiques, d'un liquide contenu dans un récipient (1) jusqu'S un flacon (11), dispositif comportant 1. Device for transferring under aseptic conditions a liquid contained in a container (1) until'S a vial (11), which device comprises
    - une ouverture, pratiquée dans la paroi du récipient, pouvant Stre obstruée à l'aide d'une soupape (3) commandée, - an opening in the wall of the container, can Stre blocked with a valve (3) controlled,
    - un dispositif de commande (5), (6), (7) de ladite soupape, ce dispositif et la soupape pouvant former un robinet, - a control device (5), (6), (7) of said valve, this valve device and capable of forming a tap,
    - une aiguille hypodermique (9) apte à percer le bouchon (10) du flacon récepteur, - a hypodermic needle (9) adapted to pierce the stopper (10) of the receiving flask,
    - un tube de transfert (12) reliant ladite ouverture et ladite aiguille, et - a transfer tube (12) connecting said opening and said needle, and
    - un moyen (13) permettant d'admettre, dans ledit tube de transfert, de la vapeur d'eau, ce dispositif étant caractérisé en ce que l'extrémité du tube de transfert et l'aiguille hypodermique sont entourées d'une enceinte cylindrique ouverte (14), apte à recevoir un piston-hoîtier (18) obstruant de façon étanche cette ouverture et dans lequel le flacon est inséré, ledit piston-boitier ayant un couvercle muni d'une ouverture qui sera dirigée vers ladite aiguille hypodermique lorsque le piston-bottier sera inséré dans l'enceinte, l'enceinte cylindrique et le pistonbottier étant pourvus de moyens respectifs (22), (23), (24) permettant, après mise en place du piston-boitier, d'assurer un déplacement de ce piston-boîtier de façon que l'aiguille hypodermique vienne percer le bouchon du flacon contenu dans ce piston-boitier, l'enceinte étant en outre munie d'un dispositif (17) d'évacuation de vapeur d'eau. - means (13) for admitting into said transfer tube, water vapor, said device being characterized in that the end of the transfer tube and the hypodermic needle are surrounded by a cylindrical chamber open (14) adapted to receive a piston-hoîtier (18) sealingly occluding said opening and wherein the bottle is inserted, said housing having a piston cover with an opening which is directed towards said hypodermic needle when the pistonbottier will be inserted into the chamber, the cylindrical enclosure and the pistonbottier being provided with respective means (22), (23), (24), after positioning of the housing-piston, to ensure a displacement the piston housing so that the hypodermic needle comes pierce the stopper of the vial contained in the piston housing, the enclosure being further equipped with a device (17) of water vapor evacuation.
  2. 2. Dispositif selon la revendication 1, caractérisé en ce que les moyens permettant d'assurer un déplacement du piston-bottier par rapport a l'enceinte sont constitués par la combinaison d'un ergot porté par le piston-bottier et d'un évidement convenable réalisé dans la paroi de l'enceinte. 2. Device according to Claim 1, characterized in that the means for ensuring displacement of the piston-stacked with respect to the enclosure are constituted by the combination of a stud carried by the piston-stacked and a recess suitable formed in the wall of the chamber.
  3. 3. Procédé pour assurer le transfert, de façon aseptique, d'un liquide contenu dans un récipient jusqu'à un flacon, procédé utilisant le dispositif selon la revendication 1, caractérisé en ce que, après mise en place du piston-boitier (18) dans l'ouverture de l'enceinte cylindrique (14), on procède à une stérilisation des surfaces accessibles par admission de vapeur d'eau par la vanne (13), puis, en manoeuvrant le piston-boitier par rapport à l'enceinte, on provoque l'introduction de l'aiguille hypodermique (9) dans le flacon à travers le bouchon de celui-ci, puis on ouvre la soupape (3) pour provoquer l'écoulement du liquide depuis le récipient jusqu'audit flacon. 3. A method for transferring aseptically, a liquid contained in a container to a flask method using the apparatus according to claim 1, characterized in that, after positioning of the housing-piston (18 ) in the opening of the cylindrical enclosure (14) is carried out a sterilization of surfaces accessible by steam admission through valve (13), then, by operating the piston housing relative to the chamber , it causes the introduction of the hypodermic needle (9) into the bottle through the cap thereof, and the valve is opened (3) to cause flow of liquid from the container to said vial.
FR8114012A 1981-07-17 1981-07-17 Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle Pending FR2509689A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8114012A FR2509689A1 (en) 1981-07-17 1981-07-17 Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8114012A FR2509689A1 (en) 1981-07-17 1981-07-17 Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle

Publications (1)

Publication Number Publication Date
FR2509689A1 true true FR2509689A1 (en) 1983-01-21

Family

ID=9260634

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8114012A Pending FR2509689A1 (en) 1981-07-17 1981-07-17 Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle

Country Status (1)

Country Link
FR (1) FR2509689A1 (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155560A2 (en) * 1984-03-19 1985-09-25 Abbott Laboratories Drug delivery system
FR2719018A1 (en) * 1994-04-26 1995-10-27 Py Daniel C A method for filling under aseptic conditions a closed container.
WO2000062820A3 (en) * 1999-04-20 2001-03-08 Baxter Int Method and apparatus for manipulating pre-sterilized components in an active sterile field
WO2002034198A1 (en) * 2000-10-20 2002-05-02 Baxter International Inc. Multi-dose container system
US6604561B2 (en) 2000-02-11 2003-08-12 Medical Instill Technologies, Inc. Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US7032631B2 (en) 2000-02-11 2006-04-25 Medical Instill Technologies, Inc. Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US7100646B2 (en) 2000-02-11 2006-09-05 Medical Instill Technologies, Inc. Sealed containers and methods of making and filling same
US7243689B2 (en) 2000-02-11 2007-07-17 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7669390B2 (en) 2004-03-08 2010-03-02 Medical Instill Technologies, Inc. Method for molding and assembling containers with stoppers and filling same
US7707807B2 (en) 2004-03-08 2010-05-04 Medical Instill Technologies, Inc. Apparatus for molding and assembling containers with stoppers and filling same
US7779609B2 (en) 2001-10-03 2010-08-24 Medical Instill Technologies, Inc. Method of filling a device
US7798185B2 (en) 2005-08-01 2010-09-21 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile food product
US8071009B2 (en) 2005-10-17 2011-12-06 Medical Instill Technologies, Inc. Sterile de-molding apparatus and method
US8240521B2 (en) 2000-10-23 2012-08-14 Medical Instill Technologies, Inc. Fluid dispenser having a one-way valve, pump, variable-volume storage chamber, and a needle penetrable and laser resealable portion
US8272411B2 (en) 2003-04-28 2012-09-25 Medical Instill Technologies, Inc. Lyophilization method and device
EP2559414A1 (en) * 2011-08-18 2013-02-20 Weibel CDS AG Adapter for a transfer device for a fluid and transfer device
US8757436B2 (en) 2000-10-23 2014-06-24 Medical Instill Technologies, Inc. Method for dispensing ophthalmic fluid
US9296498B2 (en) 2002-06-19 2016-03-29 Medinstill Development Llc Methods of filling a sealed device
DE202015101758U1 (en) * 2015-04-10 2016-07-13 Bürkert Werke GmbH Kalibrierflüssigkeitskartusche

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB503545A (en) * 1937-10-09 1939-04-11 Harold Eric Chapman An improved machine for filling with pharmaceutical and medicinal liquids flasks or bottles having caps or covers of puncturable material
FR2071717A5 (en) * 1969-11-10 1971-09-17 Godelaine Jozef
FR2315149A1 (en) * 1975-06-16 1977-01-14 Union Carbide Corp Protective shield assembly for filling an injection syringe - with radioactive material, with radiation protection for the operator (BE151276)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB503545A (en) * 1937-10-09 1939-04-11 Harold Eric Chapman An improved machine for filling with pharmaceutical and medicinal liquids flasks or bottles having caps or covers of puncturable material
FR2071717A5 (en) * 1969-11-10 1971-09-17 Godelaine Jozef
FR2315149A1 (en) * 1975-06-16 1977-01-14 Union Carbide Corp Protective shield assembly for filling an injection syringe - with radioactive material, with radiation protection for the operator (BE151276)

Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155560A2 (en) * 1984-03-19 1985-09-25 Abbott Laboratories Drug delivery system
EP0155560A3 (en) * 1984-03-19 1987-06-24 Abbott Laboratories Drug delivery system
FR2719018A1 (en) * 1994-04-26 1995-10-27 Py Daniel C A method for filling under aseptic conditions a closed container.
EP0679574A1 (en) * 1994-04-26 1995-11-02 Daniel Py Method and apparatus for filling a closed container in aseptical conditions
US5641004A (en) * 1994-04-26 1997-06-24 Py; Daniel Process for filling a sealed receptacle under aseptic conditions
WO2000062820A3 (en) * 1999-04-20 2001-03-08 Baxter Int Method and apparatus for manipulating pre-sterilized components in an active sterile field
US7264771B2 (en) 1999-04-20 2007-09-04 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
US7655198B2 (en) 1999-04-20 2010-02-02 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
US8347923B2 (en) 2000-02-11 2013-01-08 Medical Instill Technologies, Inc. Device with penetrable and resealable portion and related method
US6805170B2 (en) 2000-02-11 2004-10-19 Medical Instill Technologies, Inc. Method for filling a vial
US7032631B2 (en) 2000-02-11 2006-04-25 Medical Instill Technologies, Inc. Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US7100646B2 (en) 2000-02-11 2006-09-05 Medical Instill Technologies, Inc. Sealed containers and methods of making and filling same
US8960242B2 (en) 2000-02-11 2015-02-24 Medinstill Development Llc Sealed containers and methods of filling and resealing same
US6684916B2 (en) 2000-02-11 2004-02-03 Medical Instill Technologies, Inc. Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US7445033B2 (en) 2000-02-11 2008-11-04 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7490639B2 (en) 2000-02-11 2009-02-17 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7500498B2 (en) 2000-02-11 2009-03-10 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US6604561B2 (en) 2000-02-11 2003-08-12 Medical Instill Technologies, Inc. Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US9051064B2 (en) 2000-02-11 2015-06-09 Medinstill Development Llc Resealable containers and methods of making, filling and resealing same
US7967034B2 (en) 2000-02-11 2011-06-28 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7726352B2 (en) 2000-02-11 2010-06-01 Medical Instill Technologies, Inc. Sealed containers and methods of making and filling same
US7726357B2 (en) 2000-02-11 2010-06-01 Medical Instill Technologies, Inc. Resealable containers and assemblies for filling and resealing same
US9102097B2 (en) 2000-02-11 2015-08-11 Medinstill Development Llc Resealable member and method of resealing same
US9637251B2 (en) 2000-02-11 2017-05-02 Medinstill Development Llc Sealed containers and methods of filling and resealing same
US7810529B2 (en) 2000-02-11 2010-10-12 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion
US7243689B2 (en) 2000-02-11 2007-07-17 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7980276B2 (en) 2000-02-11 2011-07-19 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
US7992597B2 (en) 2000-02-11 2011-08-09 Medical Instill Technologies, Inc. Sealed containers and methods of filling and resealing same
US9549874B2 (en) 2000-02-11 2017-01-24 Medinstill Development Llc Device with penetrable and resealable portion and related method
US8631838B2 (en) 2000-02-11 2014-01-21 Medical Instill Technologies, Inc. Device with penetrable and resealable portion and related method
WO2002034198A1 (en) * 2000-10-20 2002-05-02 Baxter International Inc. Multi-dose container system
US9668914B2 (en) 2000-10-23 2017-06-06 Dr. Py Institute Llc Method for dispensing ophthalmic fluid
US9725228B2 (en) 2000-10-23 2017-08-08 Dr. Py Institute Llc Fluid dispenser having a one-way valve, pump, variable-volume storage chamber, and a needle penetrable and laser resealable portion
US8757436B2 (en) 2000-10-23 2014-06-24 Medical Instill Technologies, Inc. Method for dispensing ophthalmic fluid
US8240521B2 (en) 2000-10-23 2012-08-14 Medical Instill Technologies, Inc. Fluid dispenser having a one-way valve, pump, variable-volume storage chamber, and a needle penetrable and laser resealable portion
US7779609B2 (en) 2001-10-03 2010-08-24 Medical Instill Technologies, Inc. Method of filling a device
US8220507B2 (en) 2001-10-16 2012-07-17 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile product
US9630755B2 (en) 2001-10-16 2017-04-25 Medinstill Development Llc Dispenser and method for storing and dispensing sterile product
US9296498B2 (en) 2002-06-19 2016-03-29 Medinstill Development Llc Methods of filling a sealed device
US8272411B2 (en) 2003-04-28 2012-09-25 Medical Instill Technologies, Inc. Lyophilization method and device
US7669390B2 (en) 2004-03-08 2010-03-02 Medical Instill Technologies, Inc. Method for molding and assembling containers with stoppers and filling same
US7707807B2 (en) 2004-03-08 2010-05-04 Medical Instill Technologies, Inc. Apparatus for molding and assembling containers with stoppers and filling same
US8112972B2 (en) 2004-03-08 2012-02-14 Medical Instill Technologies, Inc. Method for molding and assembling containers with stoppers and filling same
US7798185B2 (en) 2005-08-01 2010-09-21 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile food product
US8550799B2 (en) 2005-10-17 2013-10-08 Medical Instill Technologies, Inc. Sterile de-molding apparatus and method
US8071009B2 (en) 2005-10-17 2011-12-06 Medical Instill Technologies, Inc. Sterile de-molding apparatus and method
WO2013024120A1 (en) * 2011-08-18 2013-02-21 Weibel Cds Ag Adapter for a transfer device for a fluid, and transfer device
EP2559414A1 (en) * 2011-08-18 2013-02-20 Weibel CDS AG Adapter for a transfer device for a fluid and transfer device
US9744101B2 (en) 2011-08-18 2017-08-29 Weibel Cds Ag Adapter for a transfer device for a fluid, and transfer device
DE202015101758U1 (en) * 2015-04-10 2016-07-13 Bürkert Werke GmbH Kalibrierflüssigkeitskartusche

Similar Documents

Publication Publication Date Title
US4580452A (en) Device for taking a liquid from a conduit which contains the liquid or for injecting a liquid into the conduit
US4703865A (en) Sealing cap
US5907110A (en) Fluid sampling tool
EP0468080A1 (en) Method for extracting open coffee-cartridges, coffee-cartridge and extraction device for implementing this method
US4351451A (en) Rubber sealed metal vacuum bottle and stopper caps therefor
FR2798868A1 (en) Liquid supply unit for spray gun comprises liquid inlet, reservoir and pouring neck, removable mask covers part of interior wall, peripheral strips form discrete contact zone between supply element and mask
US4805378A (en) Aseptic filling station
US3792799A (en) Method and apparatus for opening plastic containers
EP0236107A1 (en) Aseptic filling station
FR2502174A1 (en) Horizontal cylindrical digester to produce methane from organic waste - in baskets which can be changed without interrupting gas prodn.
FR2627977A1 (en) Gel distributor for medical ultrasonic analyser - is of echomography, doppler type, with gel fed from end of flexible pipe by distributor
FR2630712A1 (en) Container with a dispensing device for a liquid or pasty product
FR2639260A1 (en) Stick applicator for a pasty product
US5031469A (en) Fluid sampler
EP0114145A2 (en) Syringe for medical use
US7082848B2 (en) Method of transferring a representative fluid sample from a pressurized source into a sample bottle
EP0341115A1 (en) Device for introducing a dosed quantity of a product in a enclosed space
FR2623488A1 (en) Methods, devices, stoppers and cabinets for dispensing fluid products contained in containers
EP0078211A1 (en) Device for sampling liquids and equipment using such a device
FR2629706A1 (en) Liquid injection apparatus, in particular for use in dental care
FR2659074A1 (en) Drawing-off (tapping) and rinsing device for the dispensing of beer
FR2596130A1 (en) Safety device for flexible hose supplying water to household appliances
FR2800723A1 (en) Liquid filling nozzle, for bottles and other containers, has level detection and air release tubes fitted concentrically in valve-controlled filler tube
US20020092867A1 (en) Closable container, and methods for filling containers
WO2000035773A1 (en) Container with pressure control device for dispensing fluid