FR2509689A1 - Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle - Google Patents
Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle Download PDFInfo
- Publication number
- FR2509689A1 FR2509689A1 FR8114012A FR8114012A FR2509689A1 FR 2509689 A1 FR2509689 A1 FR 2509689A1 FR 8114012 A FR8114012 A FR 8114012A FR 8114012 A FR8114012 A FR 8114012A FR 2509689 A1 FR2509689 A1 FR 2509689A1
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- FR
- France
- Prior art keywords
- piston
- valve
- bottle
- flask
- hypodermic needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2037—Separating means having valve means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2065—Connecting means having aligning and guiding means
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Basic Packing Technique (AREA)
Abstract
Description
Dispositif et procédé pour assurer le transfert de façon aseptique d'un liquide contenu dans un récipient jusqu'3 un autre récipient.Device and method for ensuring the aseptic transfer of a liquid contained in a container to another container.
La présente invention concerne un dispositif et un procédé pour assurer le transfert de façon aseptique d'un liquide contenu dans un récipient jusqu'à un autre récipient (appelé flacon). The present invention relates to a device and a method for ensuring the aseptic transfer of a liquid contained in a container to another container (called a vial).
Le dispositif le plus couramment utilisé pour transférer, de façon aseptique, un liquide contenu dans un récipient jusqu'à un flacon comporte
- une ouverture, pratiquée dans la paroi dudit récipient, pouvant etre obstruée à l'aide d'une soupape commandée,
- un dispositif de commande de ladite soupape, ce dispositif et ladite soupape pouvant etre conçus de façon à former un robinet,
- un dispositif d'amenée du liquide dans ledit flacon ce dispositif est généralement constitué par une aiguille hypodermique apte à percer le bouchon dudit flacon
- un tube de transfert du liquide reliant l'ouverture pratiquée dans la paroi du récipient et le dispositif d'amenée du liquide dans le flacon dans le cas où on utilise un robinet, ce tube de transfert incluant dans son trajet ledit robinet, et
- un moyen permettant d'admettre dans le tube de transfert de la vapeur d'eau afin de stériliser l'intérieur dudit tube et de ladite aiguille.The most commonly used device for aseptically transferring a liquid from a container to a bottle has
- an opening, made in the wall of said container, which can be obstructed by means of a controlled valve,
a device for controlling said valve, this device and said valve being able to be designed so as to form a tap,
a device for bringing the liquid into said bottle, this device generally consists of a hypodermic needle capable of piercing the stopper of said bottle
a liquid transfer tube connecting the opening made in the wall of the container and the device for bringing the liquid into the bottle in the case where a tap is used, this transfer tube including in its path said tap, and
- A means for admitting water vapor into the transfer tube in order to sterilize the interior of said tube and said needle.
Mais ce dispositif oblige, pour opérer dans les meilleures conditions d'aseptie, de stériliser à la flamme la surface extérieure du dispositif d'amenée du liquide dans le flacon; il convient de plus de prévoir une stérilisation adéquate et difficile de la surface extérieure du bouchon du flacon, bouchon au travers duquel sera introduit le dispositif (aiguille) d'amenée du liquide dans le flacon. However, this device requires, in order to operate under the best aseptic conditions, to flame-sterilize the exterior surface of the device for bringing the liquid into the bottle; it should also provide adequate and difficult sterilization of the outer surface of the bottle stopper, stopper through which will be introduced the device (needle) for bringing the liquid into the bottle.
La présente invention vise un dispositif et un procédé pour réaliser de façon complètement aseptique le transfert d'un liquide contenu dans un récipient jusqu'à unflacon. The present invention relates to a device and a method for completely aseptically transferring a liquid contained in a container to a vial.
Le dispositif selon la présente invention comporte
- une ouverture,pratiquée dans la paroi du récipient, pouvant etre obstruée à l'aide d'une soupape commandée,
- un dispositif de commande de ladite soupape, ce dispositif et la soupape pouvant former un robinet,
- une aiguille hypodermique apte à percer le bouchon du flacon récepteur,
- un tube de transfert reliant ladite ouverture et ladite aiguille,
- un moyen permettant d'admettre, dans ledit tube de transfert, de la vapeur d'eau, ce dispositif étant caractérisé en ce que l'extrémité du tube de transfert et l'aiguille hypodermique sont entourées d'une enceinte cylindrique ouverte apte à recevoir un piston-bottier obstruant de façon étanche cette ouverture et dans lequel le flacon est inséré, ledit piston-boStier ayant un couvercle muni d'une ouverture qui sera dirigée vers ladite aiguille hypodermique lorsque le piston-bottier sera inséré dans l'enceinte, l'enceinte cylindrique et le pistonbottier étant pourvus de moyens respectifs permettant, après mise en place du piston-bottier, d'assurer un déplacement de ce pistonbottier de façon que l'aiguille hypodermique vienne percer le bouchon du flacon contenu dans ce piston-bottier, l'enceinte étant en outre munie d'un dispositif d'évacuation de vapeur d'eau.The device according to the present invention comprises
- an opening in the wall of the container, which can be obstructed using a controlled valve,
a device for controlling said valve, this device and the valve being able to form a tap,
- a hypodermic needle capable of piercing the stopper of the receiving bottle,
- a transfer tube connecting said opening and said needle,
a means for admitting water vapor into said transfer tube, this device being characterized in that the end of the transfer tube and the hypodermic needle are surrounded by an open cylindrical enclosure capable of receiving a plunger-blocker sealingly obstructing this opening and in which the bottle is inserted, said plunger-case having a cover provided with an opening which will be directed towards said hypodermic needle when the plunger-case is inserted in the enclosure, the cylindrical enclosure and the plungerbottier being provided with respective means allowing, after fitting of the plunger-boot, to ensure a displacement of this plunger-boot so that the hypodermic needle comes to pierce the stopper of the bottle contained in this plunger-boot , the enclosure being further provided with a water vapor evacuation device.
L'invention sera mieux comprise à l'aide de l'exemple non limitatif suivant qui représente un mode de réalisation de l'invention et qui est schématisé sur les figures 1, 2 et 3. The invention will be better understood using the following nonlimiting example which represents an embodiment of the invention and which is shown diagrammatically in FIGS. 1, 2 and 3.
La figure 1 est une vue en coupe en élévation médiane du dispositif de prélèvement pendant la période de stérilisation. Figure 1 is a sectional view in median elevation of the sampling device during the sterilization period.
La figure 2 est une vue partielle de dessus d'un dispositif commode de déplacement relatif de l'enceinte et du pis ton-bottier. Figure 2 is a partial top view of a convenient device for relative movement of the enclosure and the udder-bootmaker udder.
La figure 3 est une vue en coupe en élévation médiane de ce meme dispositif pendant la période de transfert. Figure 3 is a sectional view in median elevation of this same device during the transfer period.
Sur les figures 1 et 2, on peut voir
- en 1, la paroi du récipient (par exemple un fermenteur) contenant le liquide que l'on veut prélever; cette paroi comporte une ouverture 2 munie d'une soupape 3 comportant un joint d'étan cherté 4,
- la commande de la soupape est assurée par une tige filetée 7 solidaire d'un bouton moleté 6, l'ensemble commandant une tige 5, solidaire de la soupape 3, cette tige étant elle-mEme munie de joints d'étanchéité 8 (cet ensemble constituant un robinet),
- une aiguille hypodermique 9 apte à percer le bouchon 10 d'un flacon récepteur 11,
- un tube de transfert 12 sur lequel est fixé ledit robinet relie l'ouverture pratiquée dans la paroi du récipient à l'aiguille hypodermique; sur ce robinet est fixée une vanne 13 par laquelle on peut admettre à l'intérieur du corps du robinet et du tube de transfert, et sortant par l'aiguille hypodermique, de la vapeur d'eau. Cette vapeur d'eau est à une température suffisante pour réaliser une stérilisation des surfaces rencontrées, à savoir les surfaces internes du robinet du tube de transfert et de l'aiguille hypodermique.In Figures 1 and 2, we can see
- In 1, the wall of the container (for example a fermenter) containing the liquid that we want to sample; this wall has an opening 2 provided with a valve 3 comprising a costly seal 4,
- the valve is controlled by a threaded rod 7 secured to a knurled button 6, the assembly controlling a rod 5, secured to the valve 3, this rod being itself provided with seals 8 (this assembly constituting a tap),
a hypodermic needle 9 capable of piercing the stopper 10 of a receiving bottle 11,
- A transfer tube 12 on which said tap is fixed connects the opening made in the wall of the container to the hypodermic needle; on this tap is fixed a valve 13 by which one can admit inside the tap body and the transfer tube, and leaving by the hypodermic needle, water vapor. This water vapor is at a temperature sufficient to sterilize the surfaces encountered, namely the internal surfaces of the transfer tube tap and the hypodermic needle.
Selon l'invention, le dispositif de prélèvement comporte autour de l'extrémité du tube de transfert et de aiguille hypodermique une enceinte cylindrique 14; cette enceinte est soudée 15 sur le tube et est ouverte; l'axe de cette enceinte est de préférence, mais non nécessairement, le meme que l'axe de l'aiguille hypodermique. According to the invention, the sampling device comprises around the end of the transfer tube and hypodermic needle a cylindrical enclosure 14; this enclosure is welded to the tube and is open; the axis of this enclosure is preferably, but not necessarily, the same as the axis of the hypodermic needle.
L'enceinte comporte une tubulure latérale 16 munie d'une vanne 17 qui peut etre par exemple, comme la vanne 13, une vanne à membrane. The enclosure comprises a lateral tube 16 provided with a valve 17 which can be, for example, like the valve 13, a membrane valve.
Dans cette enceinte cylindrique 14, est introduit un piston-bottier 18 dont l'étanchéité sur la paroi interne de l'enceinte cylindrique est assurée par des joints toriques 19. Ce piston-boitier est constitué d'un corps cylindrique creux dans lequel on met en place le flacon de prélèvement 20; ce flacon est maintenu en place par le bouchon 21 muni, comme le piston-boitier, d'un pas de vis ou de tout autre moyen équivalent. In this cylindrical enclosure 14, is introduced a piston-boot 18 whose sealing on the internal wall of the cylindrical enclosure is ensured by O-rings 19. This piston-housing consists of a hollow cylindrical body in which one puts in place the sampling bottle 20; this bottle is held in place by the stopper 21 provided, like the piston-housing, with a screw thread or any other equivalent means.
La face dudit piston-bottier qui entre dans la chambre 14 (face que l'on peut appeler couvercle) est munie d'une ouverture par laquelle on pourra attendre, à l'aide de l'aiguille 9, le flacon monté dans ledit piston-bottier. The face of said piston-boot which enters the chamber 14 (face that can be called cover) is provided with an opening through which we can wait, using needle 9, the bottle mounted in said piston -bottler.
Les parois de l'enceinte cylindrique et du piston-boitier sont évidées, ainsi qu'on le constate sur la figure 2, de façon qu'on puisse voir le flacon. The walls of the cylindrical enclosure and of the piston-box are hollowed out, as can be seen in FIG. 2, so that one can see the bottle.
Sur cette figure, on constate aussi que la paroi de l'enceinte cylindrique porte un évidement 22 de forme spéciale dans lequel s'insère un ergot 23 porté par le piston-bottier. In this figure, it can also be seen that the wall of the cylindrical enclosure carries a recess 22 of special shape in which a lug 23 carried by the shoe-piston is inserted.
En imprimant à ce dernier une rotation, une poussée et une seconde rotation, on amène l'ergot en position 24 et le piston-botier est donc introduit plus profondément dans l'enceinte cylindrique. By imparting to the latter a rotation, a push and a second rotation, the lug is brought to position 24 and the piston-housing is therefore inserted deeper into the cylindrical enclosure.
Le dispositif ainsi décrit est mis en oeuvre de la façon suivante. The device thus described is implemented in the following manner.
Le robinet commandant la soupape 3 est en position fermée comme dans la figure 1; le flacon de prélèvement est en place, immobilisé par le bouchon 21. The valve controlling the valve 3 is in the closed position as in FIG. 1; the sampling bottle is in place, immobilized by the cap 21.
On procède à la stérilisation de l'ensemble en maintenant ouverte la vanne 13 et en introduisant de la vapeur d'eau par la vanne 13. On stérilise ainsi la chambre du robinet, la tubulure 12, l'aiguille hypodermique 9 et l'intérieur 25 de l'enceinte cylindrique, ainsi que la surface du bouchon-plasma 26 du flacon. The assembly is sterilized by keeping the valve 13 open and by introducing water vapor through the valve 13. The valve chamber, the tubing 12, the hypodermic needle 9 and the interior are thus sterilized 25 of the cylindrical enclosure, as well as the surface of the plasma stopper 26 of the bottle.
Lorsque la stérilisation est obtenue au bout d'un temps suffisant qui peut etre de l'ordre d'une demi-heure, on ferme successivement la vanne 13 et la vanne 17. When sterilization is obtained after a sufficient time which can be of the order of half an hour, the valve 13 and the valve 17 are successively closed.
Par la manoeuvre de rotation et de poussée du pistonbottier décrite précédemment, on place ce dernier dans la position de la figure 3 où l'aiguille hypodermique traverse le bouchon-plasma et débouche donc à l'intérieur du flacon stérile. On ouvre alors le robinet commandant la soupape 3, le milieu s'écoule par la tubulure 12, l'aiguille hypodermique 9 et emplit le flacon 11. Du fait qu'on voit une partie du flacon, on peut suivre le remplissage qu'on arrente au moment opportun en refermant le robinet. By the rotation and pushing operation of the plungerbottier described above, the latter is placed in the position of FIG. 3 where the hypodermic needle crosses the plasma stopper and therefore opens into the sterile bottle. The tap controlling the valve 3 is then opened, the medium flows through the tube 12, the hypodermic needle 9 and fills the bottle 11. Since we see part of the bottle, we can follow the filling that we arrives at the right time by closing the tap.
I1 suffit alors de ramener le piston-bottier dans la position de la figure 15 le bouchon 21 étant maintenu en place. On ouvre la vanne 17 et,par la vanne 13, on réintroduit de la vapeur d'eau pour chasser le milieu, nettoyer les circuits et stériliser les enceintes. I1 then suffices to return the boot piston to the position of FIG. 15, the plug 21 being held in place. Valve 17 is opened and, via valve 13, water vapor is reintroduced to expel the medium, clean the circuits and sterilize the enclosures.
Le bouchon 21 est dévissé et le flacon 11 retiré. Le dispositif est alors pret pour une nouvelle opération. The cap 21 is unscrewed and the bottle 11 removed. The device is then ready for a new operation.
Le dispositif ainsi décrit représente une forme préférée de l'invention qui peut etre réalisée par tout moyen équivalent. The device thus described represents a preferred form of the invention which can be carried out by any equivalent means.
L'aiguille hypodermique est raccordée à la tubulure par tout moyen connu permettant un changement commode de cette aiguille. The hypodermic needle is connected to the tubing by any known means allowing a convenient change of this needle.
On peut aussi concevoir de fixer sur la tubulure 12 un raccord muni d'une vanne; cette vanne sert alors à l'introduction de la vapeur qui est évacuée par les vannes 13 et 17. It is also conceivable to fix on the tubing 12 a fitting provided with a valve; this valve is then used for the introduction of the steam which is evacuated by the valves 13 and 17.
Ainsi qu'il apparaît, le procédé permet donc d'assurer la stérilisation totale de tout le circuit de prélèvement en toute sécurité. As it appears, the method therefore makes it possible to ensure total sterilization of the entire sampling circuit in complete safety.
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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FR8114012A FR2509689A1 (en) | 1981-07-17 | 1981-07-17 | Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8114012A FR2509689A1 (en) | 1981-07-17 | 1981-07-17 | Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle |
Publications (1)
Publication Number | Publication Date |
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FR2509689A1 true FR2509689A1 (en) | 1983-01-21 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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FR8114012A Pending FR2509689A1 (en) | 1981-07-17 | 1981-07-17 | Steam sterilised tap for aseptic transfer of contained liquid to flask - uses hollow piston to locate flask and push it onto hypodermic needle |
Country Status (1)
Country | Link |
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FR (1) | FR2509689A1 (en) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0155560A2 (en) * | 1984-03-19 | 1985-09-25 | Abbott Laboratories | Drug delivery system |
FR2719018A1 (en) * | 1994-04-26 | 1995-10-27 | Py Daniel C | Process for filling a closed container under aseptic conditions |
WO2000062820A3 (en) * | 1999-04-20 | 2001-03-08 | Baxter Int | Method and apparatus for manipulating pre-sterilized components in an active sterile field |
WO2002034198A1 (en) * | 2000-10-20 | 2002-05-02 | Baxter International Inc. | Multi-dose container system |
US6604561B2 (en) | 2000-02-11 | 2003-08-12 | Medical Instill Technologies, Inc. | Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial |
US7032631B2 (en) | 2000-02-11 | 2006-04-25 | Medical Instill Technologies, Inc. | Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial |
US7100646B2 (en) | 2000-02-11 | 2006-09-05 | Medical Instill Technologies, Inc. | Sealed containers and methods of making and filling same |
US7243689B2 (en) | 2000-02-11 | 2007-07-17 | Medical Instill Technologies, Inc. | Device with needle penetrable and laser resealable portion and related method |
US7669390B2 (en) | 2004-03-08 | 2010-03-02 | Medical Instill Technologies, Inc. | Method for molding and assembling containers with stoppers and filling same |
US7707807B2 (en) | 2004-03-08 | 2010-05-04 | Medical Instill Technologies, Inc. | Apparatus for molding and assembling containers with stoppers and filling same |
US7779609B2 (en) | 2001-10-03 | 2010-08-24 | Medical Instill Technologies, Inc. | Method of filling a device |
US7798185B2 (en) | 2005-08-01 | 2010-09-21 | Medical Instill Technologies, Inc. | Dispenser and method for storing and dispensing sterile food product |
US8071009B2 (en) | 2005-10-17 | 2011-12-06 | Medical Instill Technologies, Inc. | Sterile de-molding apparatus and method |
US8240521B2 (en) | 2000-10-23 | 2012-08-14 | Medical Instill Technologies, Inc. | Fluid dispenser having a one-way valve, pump, variable-volume storage chamber, and a needle penetrable and laser resealable portion |
US8272411B2 (en) | 2003-04-28 | 2012-09-25 | Medical Instill Technologies, Inc. | Lyophilization method and device |
EP2559414A1 (en) * | 2011-08-18 | 2013-02-20 | Weibel CDS AG | Adapter for a transfer device for a fluid and transfer device |
US8757436B2 (en) | 2000-10-23 | 2014-06-24 | Medical Instill Technologies, Inc. | Method for dispensing ophthalmic fluid |
US9296498B2 (en) | 2002-06-19 | 2016-03-29 | Medinstill Development Llc | Methods of filling a sealed device |
DE202015101758U1 (en) * | 2015-04-10 | 2016-07-13 | Bürkert Werke GmbH | Kalibrierflüssigkeitskartusche |
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GB503545A (en) * | 1937-10-09 | 1939-04-11 | Harold Eric Chapman | An improved machine for filling with pharmaceutical and medicinal liquids flasks or bottles having caps or covers of puncturable material |
FR2071717A5 (en) * | 1969-11-10 | 1971-09-17 | Godelaine Jozef | |
FR2315149A1 (en) * | 1975-06-16 | 1977-01-14 | Union Carbide Corp | Protective shield assembly for filling an injection syringe - with radioactive material, with radiation protection for the operator (BE151276) |
-
1981
- 1981-07-17 FR FR8114012A patent/FR2509689A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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GB503545A (en) * | 1937-10-09 | 1939-04-11 | Harold Eric Chapman | An improved machine for filling with pharmaceutical and medicinal liquids flasks or bottles having caps or covers of puncturable material |
FR2071717A5 (en) * | 1969-11-10 | 1971-09-17 | Godelaine Jozef | |
FR2315149A1 (en) * | 1975-06-16 | 1977-01-14 | Union Carbide Corp | Protective shield assembly for filling an injection syringe - with radioactive material, with radiation protection for the operator (BE151276) |
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US7798185B2 (en) | 2005-08-01 | 2010-09-21 | Medical Instill Technologies, Inc. | Dispenser and method for storing and dispensing sterile food product |
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