FR2477148A1 - Nouvelles 2 (1h)-pyridones, leur preparation et leur application comme medicaments - Google Patents

Nouvelles 2 (1h)-pyridones, leur preparation et leur application comme medicaments Download PDF

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Publication number
FR2477148A1
FR2477148A1 FR8104152A FR8104152A FR2477148A1 FR 2477148 A1 FR2477148 A1 FR 2477148A1 FR 8104152 A FR8104152 A FR 8104152A FR 8104152 A FR8104152 A FR 8104152A FR 2477148 A1 FR2477148 A1 FR 2477148A1
Authority
FR
France
Prior art keywords
amino
group
pyridone
phenyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8104152A
Other languages
English (en)
French (fr)
Other versions
FR2477148B1 (show.php
Inventor
Gerhard Bormann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2477148A1 publication Critical patent/FR2477148A1/fr
Application granted granted Critical
Publication of FR2477148B1 publication Critical patent/FR2477148B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8104152A 1980-03-03 1981-02-27 Nouvelles 2 (1h)-pyridones, leur preparation et leur application comme medicaments Granted FR2477148A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH166880 1980-03-03
CH166980 1980-03-03
CH571780 1980-07-25
CH794780 1980-10-24

Publications (2)

Publication Number Publication Date
FR2477148A1 true FR2477148A1 (fr) 1981-09-04
FR2477148B1 FR2477148B1 (show.php) 1983-09-02

Family

ID=27428258

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8104152A Granted FR2477148A1 (fr) 1980-03-03 1981-02-27 Nouvelles 2 (1h)-pyridones, leur preparation et leur application comme medicaments

Country Status (16)

Country Link
CA (1) CA1183533A (show.php)
CH (1) CH652395A5 (show.php)
DE (1) DE3106460A1 (show.php)
DK (1) DK94481A (show.php)
ES (1) ES499971A0 (show.php)
FI (1) FI810558L (show.php)
FR (1) FR2477148A1 (show.php)
GB (1) GB2070606B (show.php)
IL (1) IL62246A (show.php)
IT (1) IT1142458B (show.php)
NL (1) NL8100964A (show.php)
NZ (1) NZ196385A (show.php)
PT (1) PT72596B (show.php)
SE (1) SE8101336L (show.php)
WO (1) WO1981002575A1 (show.php)
YU (1) YU51581A (show.php)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074091A3 (en) * 1981-09-08 1983-09-14 Sterling Drug Inc. 2(1h)-pyridinones and preparation thereof
FR2527206A1 (fr) * 1982-05-18 1983-11-25 Sandoz Sa Nouveaux derives de la 2(1h)-pyridinone, leur preparation et leur utilisation comme medicaments
US4526895A (en) * 1982-07-12 1985-07-02 Etablissements Nativelle S.A. 3-Pyridyl-5-alkoxy-pyrazole derivatives and pharmaceutical composition for use as a cardiotonic medication

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65278A0 (en) * 1981-03-30 1982-05-31 Sterling Drug Inc 3-amino-5-(substituted)-2(1h)-pyridinones and corresponding 3-cyano compounds,their preparation and pharmaceutical compositions containing them
US4515797A (en) * 1981-09-08 1985-05-07 Sterling Drug Inc. 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof
US4432979A (en) * 1981-10-26 1984-02-21 William H. Rorer, Inc. Pyridone compounds
US4539321A (en) * 1981-10-26 1985-09-03 William H. Rorer, Inc. 5-Diaza-aryl-3-substituted pyridone compounds
US4514400A (en) * 1981-10-26 1985-04-30 William H. Rorer, Inc. Cardiotonic 5-heteroaryl-pyridone
US4593028A (en) * 1981-10-26 1986-06-03 William H. Rorer, Inc. 5-hetero aryl-substituted-2-pyridones useful as cardiotonic agents for treatment of congestive heart failure
AT384021B (de) * 1982-05-18 1987-09-25 Sandoz Ag Verfahren zur herstellung neuer 2(1h)-pyridinon- derivate und ihrer salze
IT8367883A0 (it) * 1982-08-23 1983-08-22 Rorer Int Overseas Composti cardiotonici del 2 piridone 5 biciclico eteroaril sostituito e relative composizioni farmaceutiche
US4503061A (en) * 1983-07-22 1985-03-05 Warner-Lambert Company Substituted phenyl-pyridinones as cardiotonic agents
IL69407A (en) * 1982-08-23 1987-10-20 Warner Lambert Co 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
US4517192A (en) * 1983-01-31 1985-05-14 Sterling Drug Inc. 6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics
ES521644A0 (es) * 1983-04-20 1985-10-16 Quimicos Y Farmaceuticos Abel Un nuevo procedimiento para la preparacion de 5-azinil-1,2-dihidroazin-2-onas.
US4568751A (en) * 1983-04-29 1986-02-04 Merrell Dow Pharmaceuticals Inc. 5-Acyl-2-(1H)-pyridinones
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone
DE3685840D1 (de) 1985-04-30 1992-08-06 Dresden Arzneimittel 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
US4785005A (en) * 1986-06-25 1988-11-15 Rorer Pharmaceutical Corporation 6-(6-alkylpyridone)-carbostyril compounds and their cardiotonic uses
GB8809481D0 (en) * 1988-04-21 1988-05-25 Smith Kline French Lab Chemical compounds
US5254571A (en) * 1988-04-21 1993-10-19 Smith Kline & French Laboratories Ltd. Chemical compounds
GB8923131D0 (en) * 1989-10-13 1989-11-29 Smith Kline French Lab Chemical compounds

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355278A (en) * 1961-03-13 1967-11-28 Hooker Chemical Corp Herbicidal composition and method
FR2050940A5 (show.php) * 1969-06-30 1971-04-02 Rhone Poulenc Sa
DE2052536A1 (de) * 1969-10-27 1971-05-06 Union Carbide Corp , New York, N Y (VStA) Verfahren zur Herstellung von 2 Pyndonen und deren Derivaten
FR2073341A1 (show.php) * 1969-11-12 1971-10-01 Merck & Co Inc
FR2073342A1 (show.php) * 1969-11-12 1971-10-01 Merck & Co Inc
US3715358A (en) * 1967-12-01 1973-02-06 Merck & Co Inc Method of treating inflammation
FR2327779A1 (fr) * 1975-10-14 1977-05-13 Sterling Drug Inc Pyridinyl-2(1h)-pyridinones et leur preparation
US4038396A (en) * 1975-02-24 1977-07-26 Merck & Co., Inc. Anti-inflammatory oxazole[4,5-b]pyridines

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355278A (en) * 1961-03-13 1967-11-28 Hooker Chemical Corp Herbicidal composition and method
US3715358A (en) * 1967-12-01 1973-02-06 Merck & Co Inc Method of treating inflammation
FR2050940A5 (show.php) * 1969-06-30 1971-04-02 Rhone Poulenc Sa
DE2052536A1 (de) * 1969-10-27 1971-05-06 Union Carbide Corp , New York, N Y (VStA) Verfahren zur Herstellung von 2 Pyndonen und deren Derivaten
FR2073341A1 (show.php) * 1969-11-12 1971-10-01 Merck & Co Inc
FR2073342A1 (show.php) * 1969-11-12 1971-10-01 Merck & Co Inc
US4038396A (en) * 1975-02-24 1977-07-26 Merck & Co., Inc. Anti-inflammatory oxazole[4,5-b]pyridines
FR2327779A1 (fr) * 1975-10-14 1977-05-13 Sterling Drug Inc Pyridinyl-2(1h)-pyridinones et leur preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074091A3 (en) * 1981-09-08 1983-09-14 Sterling Drug Inc. 2(1h)-pyridinones and preparation thereof
FR2527206A1 (fr) * 1982-05-18 1983-11-25 Sandoz Sa Nouveaux derives de la 2(1h)-pyridinone, leur preparation et leur utilisation comme medicaments
US4526895A (en) * 1982-07-12 1985-07-02 Etablissements Nativelle S.A. 3-Pyridyl-5-alkoxy-pyrazole derivatives and pharmaceutical composition for use as a cardiotonic medication

Also Published As

Publication number Publication date
DE3106460A1 (de) 1982-01-28
CA1183533A (en) 1985-03-05
IL62246A (en) 1984-09-30
ES8301469A1 (es) 1982-12-01
IT1142458B (it) 1986-10-08
IL62246A0 (en) 1981-05-20
PT72596A (en) 1981-04-01
ES499971A0 (es) 1982-12-01
WO1981002575A1 (fr) 1981-09-17
CH652395A5 (de) 1985-11-15
NZ196385A (en) 1983-12-16
FR2477148B1 (show.php) 1983-09-02
GB2070606A (en) 1981-09-09
FI810558A7 (fi) 1981-09-04
PT72596B (en) 1982-07-13
NL8100964A (nl) 1981-10-01
FI810558L (fi) 1981-09-04
YU51581A (en) 1983-12-31
GB2070606B (en) 1984-02-29
DK94481A (da) 1981-09-04
SE8101336L (sv) 1981-09-04
IT8147920A0 (it) 1981-03-02

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