FR2468589A1 - Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive - Google Patents

Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive Download PDF

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Publication number
FR2468589A1
FR2468589A1 FR8010182A FR8010182A FR2468589A1 FR 2468589 A1 FR2468589 A1 FR 2468589A1 FR 8010182 A FR8010182 A FR 8010182A FR 8010182 A FR8010182 A FR 8010182A FR 2468589 A1 FR2468589 A1 FR 2468589A1
Authority
FR
France
Prior art keywords
compound
compound according
proline
oxopropyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8010182A
Other languages
English (en)
French (fr)
Other versions
FR2468589B1 (xx
Inventor
Miguel Angel Ondetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2468589A1 publication Critical patent/FR2468589A1/fr
Application granted granted Critical
Publication of FR2468589B1 publication Critical patent/FR2468589B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR8010182A 1979-05-18 1980-05-07 Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive Granted FR2468589A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4033579A 1979-05-18 1979-05-18

Publications (2)

Publication Number Publication Date
FR2468589A1 true FR2468589A1 (fr) 1981-05-08
FR2468589B1 FR2468589B1 (xx) 1983-07-18

Family

ID=21910442

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8010182A Granted FR2468589A1 (fr) 1979-05-18 1980-05-07 Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive
FR8021415A Granted FR2467198A1 (fr) 1979-05-18 1980-10-07 Derives de mercaptoacyl amino-acides, substitues sur l'atome de soufre par un groupement a-amino ou a-imino a atome d'azote protege

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8021415A Granted FR2467198A1 (fr) 1979-05-18 1980-10-07 Derives de mercaptoacyl amino-acides, substitues sur l'atome de soufre par un groupement a-amino ou a-imino a atome d'azote protege

Country Status (7)

Country Link
JP (1) JPS5612365A (xx)
DE (1) DE3018467A1 (xx)
FR (2) FR2468589A1 (xx)
GB (1) GB2050359B (xx)
IE (1) IE49790B1 (xx)
IT (1) IT1140954B (xx)
ZA (1) ZA802420B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038117A1 (en) * 1980-03-10 1981-10-21 University Of Miami Methods for preparing anti-hypertensive agents
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
AT386603B (de) * 1981-06-19 1988-09-26 Chugai Pharmaceutical Co Ltd Verfahren zur herstellung von neuen prolinderivaten
AT377496B (de) * 1981-06-19 1985-03-25 Voith Gmbh J M Vorrichtung zum anwickeln einer warenbahn auf eine neu eingelegte wickelhuelse in einer doppeltragwalzen-wickelmaschine
JPS57209270A (en) * 1981-06-19 1982-12-22 Chugai Pharmaceut Co Ltd Proline derivative
JPS5839661A (ja) * 1981-09-03 1983-03-08 Chugai Pharmaceut Co Ltd プロリン誘導体の製法
JPS58131968A (ja) * 1981-09-09 1983-08-06 Chugai Pharmaceut Co Ltd チオ−ルエステル化合物
JPS6345252A (ja) * 1987-03-18 1988-02-26 Chugai Pharmaceut Co Ltd プロリン誘導体

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1591598A (xx) * 1967-07-31 1970-05-04
FR2340932A1 (fr) * 1976-02-13 1977-09-09 Squibb & Sons Inc Derives de proline et composes apparentes, utiles pour reduire la tension sanguine
FR2412537A1 (fr) * 1977-12-22 1979-07-20 Science Union & Cie Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
EP0009898A1 (en) * 1978-09-11 1980-04-16 University Of Miami Novel anti-hypertensive mercaptoacylamino acid derivatives, their preparation and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1591598A (xx) * 1967-07-31 1970-05-04
FR2340932A1 (fr) * 1976-02-13 1977-09-09 Squibb & Sons Inc Derives de proline et composes apparentes, utiles pour reduire la tension sanguine
FR2412537A1 (fr) * 1977-12-22 1979-07-20 Science Union & Cie Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
EP0009898A1 (en) * 1978-09-11 1980-04-16 University Of Miami Novel anti-hypertensive mercaptoacylamino acid derivatives, their preparation and use

Also Published As

Publication number Publication date
IE800954L (en) 1980-11-18
FR2467198A1 (fr) 1981-04-17
FR2468589B1 (xx) 1983-07-18
ZA802420B (en) 1981-04-29
GB2050359A (en) 1981-01-07
IT1140954B (it) 1986-10-10
FR2467198B1 (xx) 1983-06-17
JPH0135824B2 (xx) 1989-07-27
JPS5612365A (en) 1981-02-06
GB2050359B (en) 1983-05-18
DE3018467A1 (de) 1981-01-22
IE49790B1 (en) 1985-12-11
IT8022148A0 (it) 1980-05-16

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