FR2468573A1 - Derives du dibenzo (a,d) cycloheptene, leur preparation et medicaments contenant ces substances - Google Patents

Derives du dibenzo (a,d) cycloheptene, leur preparation et medicaments contenant ces substances Download PDF

Info

Publication number
FR2468573A1
FR2468573A1 FR8020814A FR8020814A FR2468573A1 FR 2468573 A1 FR2468573 A1 FR 2468573A1 FR 8020814 A FR8020814 A FR 8020814A FR 8020814 A FR8020814 A FR 8020814A FR 2468573 A1 FR2468573 A1 FR 2468573A1
Authority
FR
France
Prior art keywords
mixture
group
compound
acid
dibenzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8020814A
Other languages
English (en)
French (fr)
Other versions
FR2468573B1 (OSRAM
Inventor
Tetsutaro Hayasaka
Kuniro Saito
Sen-Ichi Narita
Takao Goto
Shin-Ichi Yamada
Teruo Saito
Kazuyoshi Okutani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toa Eiyo Ltd
Original Assignee
Toa Eiyo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toa Eiyo Ltd filed Critical Toa Eiyo Ltd
Publication of FR2468573A1 publication Critical patent/FR2468573A1/fr
Application granted granted Critical
Publication of FR2468573B1 publication Critical patent/FR2468573B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8020814A 1979-09-29 1980-09-29 Derives du dibenzo (a,d) cycloheptene, leur preparation et medicaments contenant ces substances Granted FR2468573A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12474179A JPS5649337A (en) 1979-09-29 1979-09-29 Dibenzo a,d cycloheptene derivative and its preparation

Publications (2)

Publication Number Publication Date
FR2468573A1 true FR2468573A1 (fr) 1981-05-08
FR2468573B1 FR2468573B1 (OSRAM) 1982-11-19

Family

ID=14892958

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8020814A Granted FR2468573A1 (fr) 1979-09-29 1980-09-29 Derives du dibenzo (a,d) cycloheptene, leur preparation et medicaments contenant ces substances

Country Status (10)

Country Link
US (1) US4410716A (OSRAM)
JP (1) JPS5649337A (OSRAM)
AU (1) AU534186B2 (OSRAM)
CH (1) CH648820A5 (OSRAM)
DE (1) DE3036175A1 (OSRAM)
ES (2) ES495386A0 (OSRAM)
FR (1) FR2468573A1 (OSRAM)
GB (1) GB2059964B (OSRAM)
IT (1) IT1209358B (OSRAM)
NL (1) NL8005398A (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI730037B (zh) * 2016-01-26 2021-06-11 日商富士軟片和光純藥股份有限公司 光硬化方法，及用於該光硬化方法之化合物和組成物
CN110678500B (zh) * 2017-06-12 2022-10-14 富士胶片和光纯药株式会社 光或热固化方法及固化性树脂组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4787M (OSRAM) * 1965-06-18 1967-01-30
US3409640A (en) * 1959-07-22 1968-11-05 Schering Corp 5-(3'-dimethylamino-2'-methyl-propyl)dibenzocycloheptenes
US4059611A (en) * 1975-09-08 1977-11-22 Syntex (U.S.A.) Inc. Oxidative process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975437A (en) * 1973-03-02 1976-08-17 Rhone-Poulenc S.A. Dibenzo (a,d) cycloheptene derivatives
OA04603A (fr) * 1973-03-02 1980-06-30 Rhone Poulenc Sa Nouveaux dérivés du dibenzo [a,d] cycloheptene, leurs sels et leur préparation.
US3966820A (en) * 1974-07-05 1976-06-29 Syntex (U.S.A.) Inc. 2-Substituted-5-oxo-5H-dibenzo-[A,D]cycloheptenes, the esters and ethers thereof, having pharmaceutical activity, and methods and compositions for the use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3409640A (en) * 1959-07-22 1968-11-05 Schering Corp 5-(3'-dimethylamino-2'-methyl-propyl)dibenzocycloheptenes
FR4787M (OSRAM) * 1965-06-18 1967-01-30
US4059611A (en) * 1975-09-08 1977-11-22 Syntex (U.S.A.) Inc. Oxidative process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acid

Also Published As

Publication number Publication date
IT1209358B (it) 1989-07-16
US4410716A (en) 1983-10-18
AU6268680A (en) 1981-04-09
NL8005398A (nl) 1981-03-31
ES8106877A1 (es) 1981-09-01
GB2059964B (en) 1983-05-18
DE3036175A1 (de) 1981-04-16
AU534186B2 (en) 1984-01-12
ES495386A0 (es) 1981-09-01
ES8201522A1 (es) 1981-12-16
IT8025000A0 (it) 1980-09-29
FR2468573B1 (OSRAM) 1982-11-19
CH648820A5 (de) 1985-04-15
JPS5649337A (en) 1981-05-02
GB2059964A (en) 1981-04-29
ES498317A0 (es) 1981-12-16

Similar Documents

Publication Publication Date Title
MC1193A1 (fr) Composes polyeniques
CA2481742C (fr) Procedes de preparation de combretastatines
EP0024807B1 (en) Benzocycloheptapyrrolealkanoic acids and their derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS584699B2 (ja) 置換フエニル酢酸誘導体及びその製法
CH640829A5 (fr) Derives d'hydroquinone et leur procede de synthese.
CH630893A5 (fr) Procede de preparation d'o-(2,6-dichloroanilino)phenylacetamides n,n-disubstitues.
CA1121364A (en) 1-hydrocarbylpyrrole-2-acetic acid derivatives and their production
US4410716A (en) Dibenzo[a,d]cycloheptene derivatives and process for production thereof
JPS599536B2 (ja) カンジヨウカゴウブツノ セイゾウホウ
Singh et al. Diels-Alder reaction of 9-anthracenemethanol and dimethylacetylene-dicarboxy-late; potential route for the synthesis of regiospecific products of 9-substituted anthracene with unsymmetrical
FR2487346A1 (fr) Derives de la 4-oximino-1,2,3,4-tetrahydroquinoleine, leur procede de preparation et leur application therapeutique
US4051260A (en) 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes, and derivatives thereof, and methods and compositions for the use thereof
KR100699457B1 (ko) 디벤조티에핀 유도체 및 그 중간체의 제조방법
Verhe et al. Alternative Syntheses of 4‐Ethoxycarbonylchroman‐3‐One
CA1085412A (fr) Acides thienothienylcarbonylphenylalcanoiques, leurs derives, leur preparation et les compositions qui les contiennent
CN1332930C (zh) 制备乙氰菊酯前体的方法
JPS58194837A (ja) ジフエニルメタン誘導体の製法
KR870000585B1 (ko) 시클로 헵탄의 제조 방법
CH476658A (fr) Procédé pour la préparation d'une dihydroxy-dicétone
JPH0129793B2 (OSRAM)
CA1297098C (fr) Composes aromatiques substitues et leur procede de preparation
JP2000344722A (ja) ４−ヒドロキシメチル−１−アミノシクロペント−２−エン誘導体の製造方法
JPS6051463B2 (ja) （２−フルオロ−４−ビフェニリル）ケテンメルカプタ−ルｓ−オキシド類
BE852030A (fr) Derives d'acide acetique aromatique ayant un atome de soufre a la position alpha et procede pour leur preparation
EP0611232A1 (fr) Procédé pour la préparatiuon de dérivés phénylbenzamides

Legal Events

Date Code Title Description
ST Notification of lapse