FR2463766A1 - Nouvelles 1(2h)-isoquinolones, utiles notamment comme analgesiques - Google Patents
Nouvelles 1(2h)-isoquinolones, utiles notamment comme analgesiques Download PDFInfo
- Publication number
- FR2463766A1 FR2463766A1 FR8018290A FR8018290A FR2463766A1 FR 2463766 A1 FR2463766 A1 FR 2463766A1 FR 8018290 A FR8018290 A FR 8018290A FR 8018290 A FR8018290 A FR 8018290A FR 2463766 A1 FR2463766 A1 FR 2463766A1
- Authority
- FR
- France
- Prior art keywords
- isoquinolone
- mixture
- found
- elemental analysis
- recrystallized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940035676 analgesics Drugs 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title abstract 2
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- 239000002253 acid Substances 0.000 abstract description 20
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 18
- 239000000843 powder Substances 0.000 abstract description 15
- 239000000460 chlorine Substances 0.000 abstract description 7
- 239000008187 granular material Substances 0.000 abstract description 7
- 230000000767 anti-ulcer Effects 0.000 abstract description 6
- 239000002775 capsule Substances 0.000 abstract description 6
- 239000001257 hydrogen Substances 0.000 abstract description 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 6
- 239000000739 antihistaminic agent Substances 0.000 abstract description 5
- 229910052801 chlorine Inorganic materials 0.000 abstract description 5
- 239000007924 injection Substances 0.000 abstract description 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract description 4
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- 229940005513 antidepressants Drugs 0.000 abstract description 3
- 150000007513 acids Chemical class 0.000 abstract description 2
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical class O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002731 stomach secretion inhibitor Substances 0.000 abstract 1
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- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical class C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 description 63
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10549779A JPS5677261A (en) | 1979-08-21 | 1979-08-21 | 1 2h isoquinolone derivative and its acid addition salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2463766A1 true FR2463766A1 (fr) | 1981-02-27 |
| FR2463766B1 FR2463766B1 (enExample) | 1983-09-02 |
Family
ID=14409228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8018290A Granted FR2463766A1 (fr) | 1979-08-21 | 1980-08-21 | Nouvelles 1(2h)-isoquinolones, utiles notamment comme analgesiques |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5677261A (enExample) |
| AU (1) | AU532023B2 (enExample) |
| CA (1) | CA1153763A (enExample) |
| CH (1) | CH646953A5 (enExample) |
| DE (1) | DE3031574A1 (enExample) |
| ES (1) | ES494891A0 (enExample) |
| FR (1) | FR2463766A1 (enExample) |
| GB (1) | GB2058783B (enExample) |
| IT (1) | IT1188988B (enExample) |
| NL (1) | NL8004736A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2502619A1 (fr) * | 1981-03-28 | 1982-10-01 | Maruko Pharmaceutical Co | Derives de la 1(2h)-isoquinolone et leurs utilisations therapeutiques notamment dans le traitement des ulceres |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58164577A (ja) * | 1982-03-24 | 1983-09-29 | Taiho Yakuhin Kogyo Kk | ４―ベンジル―１―（２ｈ）イソキノロン誘導体 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3600394A (en) * | 1968-05-17 | 1971-08-17 | Searle & Co | 2-aminoalkyl-3-arylisocarbostyrils |
| FR2154520A1 (enExample) * | 1971-09-16 | 1973-05-11 | Kabi Ab | |
| US3928612A (en) * | 1974-10-02 | 1975-12-23 | American Home Prod | 1,2-Dihydro- and 1,2,3,4-tetrahydro-1-oxo-3-isoquinolinecarboxylic acid derivatives as anti-allergic agents |
-
1979
- 1979-08-21 JP JP10549779A patent/JPS5677261A/ja active Pending
-
1980
- 1980-08-13 GB GB8026405A patent/GB2058783B/en not_active Expired
- 1980-08-19 IT IT49519/80A patent/IT1188988B/it active
- 1980-08-21 FR FR8018290A patent/FR2463766A1/fr active Granted
- 1980-08-21 DE DE19803031574 patent/DE3031574A1/de not_active Withdrawn
- 1980-08-21 ES ES494891A patent/ES494891A0/es active Granted
- 1980-08-21 AU AU61609/80A patent/AU532023B2/en not_active Ceased
- 1980-08-21 CA CA000358717A patent/CA1153763A/en not_active Expired
- 1980-08-21 NL NL8004736A patent/NL8004736A/nl not_active Application Discontinuation
- 1980-08-21 CH CH632480A patent/CH646953A5/de not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3600394A (en) * | 1968-05-17 | 1971-08-17 | Searle & Co | 2-aminoalkyl-3-arylisocarbostyrils |
| FR2154520A1 (enExample) * | 1971-09-16 | 1973-05-11 | Kabi Ab | |
| US3928612A (en) * | 1974-10-02 | 1975-12-23 | American Home Prod | 1,2-Dihydro- and 1,2,3,4-tetrahydro-1-oxo-3-isoquinolinecarboxylic acid derivatives as anti-allergic agents |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2502619A1 (fr) * | 1981-03-28 | 1982-10-01 | Maruko Pharmaceutical Co | Derives de la 1(2h)-isoquinolone et leurs utilisations therapeutiques notamment dans le traitement des ulceres |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1188988B (it) | 1988-01-28 |
| IT8049519A0 (it) | 1980-08-19 |
| GB2058783B (en) | 1983-04-07 |
| FR2463766B1 (enExample) | 1983-09-02 |
| AU6160980A (en) | 1981-04-09 |
| NL8004736A (nl) | 1981-02-24 |
| IT8049519A1 (it) | 1982-02-19 |
| CH646953A5 (de) | 1984-12-28 |
| JPS5677261A (en) | 1981-06-25 |
| AU532023B2 (en) | 1983-09-15 |
| CA1153763A (en) | 1983-09-13 |
| DE3031574A1 (de) | 1981-03-12 |
| ES8106501A1 (es) | 1981-09-01 |
| ES494891A0 (es) | 1981-09-01 |
| GB2058783A (en) | 1981-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |