JPS5677261A - 1 2h isoquinolone derivative and its acid addition salt - Google Patents

1 2h isoquinolone derivative and its acid addition salt

Info

Publication number
JPS5677261A
JPS5677261A JP10549779A JP10549779A JPS5677261A JP S5677261 A JPS5677261 A JP S5677261A JP 10549779 A JP10549779 A JP 10549779A JP 10549779 A JP10549779 A JP 10549779A JP S5677261 A JPS5677261 A JP S5677261A
Authority
JP
Japan
Prior art keywords
formula
acid addition
addition salt
phenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10549779A
Other languages
Japanese (ja)
Inventor
Shigeo Senda
Osamu Otani
Eiichi Kato
Hidekazu Miyake
Kosuke Fujiwara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maruko Pharmaceutical Co Ltd
Taiho Pharmaceutical Co Ltd
Original Assignee
Maruko Pharmaceutical Co Ltd
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maruko Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd filed Critical Maruko Pharmaceutical Co Ltd
Priority to JP10549779A priority Critical patent/JPS5677261A/en
Priority to GB8026405A priority patent/GB2058783B/en
Priority to IT49519/80A priority patent/IT1188988B/en
Priority to CH632480A priority patent/CH646953A5/en
Priority to CA000358717A priority patent/CA1153763A/en
Priority to ES494891A priority patent/ES494891A0/en
Priority to FR8018290A priority patent/FR2463766A1/en
Priority to NL8004736A priority patent/NL8004736A/en
Priority to DE19803031574 priority patent/DE3031574A1/en
Priority to AU61609/80A priority patent/AU532023B2/en
Publication of JPS5677261A publication Critical patent/JPS5677261A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NEW MATERIAL:A compound of formula I (Y is H, Cl or OCH3; Z is 2-4C bivalent saturated aliphatic hydrocarbon group; R1 is cyano, carbamoyl, phenyl, etc.; R2 is H or lower alkyl; R3 is lower alkyl; R2 and R3 may together form a heterocyclic group with adjacent N atom), and its acid addition salt. EXAMPLE:2-(3-N,N-Dimethylaminopropyl)-4-phenyl-1(2H)-isoquinoline tartrate. USE:Drug having excellent analgesic, antireesrpinic, antihistaminic, acetylcholinolytic, gastric juice secretion suppressing, and antiulcer activites. Dose: 0.5-50mg/kg daily for adult in 1-3 doses. PROCESS:The compound of formula I is prepared e.g. by the thermal reaction of a substituted-1(2H)-isoquinolone of formula II with a substituted-aminoalkyl halide of formula III in an organic solvent in the presence of a basic catalyst.
JP10549779A 1979-08-21 1979-08-21 1 2h isoquinolone derivative and its acid addition salt Pending JPS5677261A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP10549779A JPS5677261A (en) 1979-08-21 1979-08-21 1 2h isoquinolone derivative and its acid addition salt
GB8026405A GB2058783B (en) 1979-08-21 1980-08-13 1(2h)-isoquinolone compounds and acid addition salts thereof
IT49519/80A IT1188988B (en) 1979-08-21 1980-08-19 COMPOUNDS 1 (2H) -ISOKINOLONICS AND THEIR ADDITION SALTS WITH ACIDS
CH632480A CH646953A5 (en) 1979-08-21 1980-08-21 1 (2H) -ISOCHINOLONE AND THEIR SALTS WITH ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THE SAME.
CA000358717A CA1153763A (en) 1979-08-21 1980-08-21 1(2h)-isoquinolone compounds and acid addition salts thereof
ES494891A ES494891A0 (en) 1979-08-21 1980-08-21 PROCEDURE FOR THE PREPARATION OF COMPOUNDS 1 (2H) -ISOQUINOLO-NICOS AND SIMILAR
FR8018290A FR2463766A1 (en) 1979-08-21 1980-08-21 NEWS 1 (2H) -ISOQUINOLONES, USEFUL AS ANALGESICS
NL8004736A NL8004736A (en) 1979-08-21 1980-08-21 1 (2H) -ISOCHINOLONE COMPOUNDS AND ACID ADDITION SALTS THEREOF.
DE19803031574 DE3031574A1 (en) 1979-08-21 1980-08-21 1 (2H) -ISOCHINOLONES AND THEIR SALTS WITH ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS.
AU61609/80A AU532023B2 (en) 1979-08-21 1980-08-21 1(2h)-isoquinolone compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10549779A JPS5677261A (en) 1979-08-21 1979-08-21 1 2h isoquinolone derivative and its acid addition salt

Publications (1)

Publication Number Publication Date
JPS5677261A true JPS5677261A (en) 1981-06-25

Family

ID=14409228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10549779A Pending JPS5677261A (en) 1979-08-21 1979-08-21 1 2h isoquinolone derivative and its acid addition salt

Country Status (10)

Country Link
JP (1) JPS5677261A (en)
AU (1) AU532023B2 (en)
CA (1) CA1153763A (en)
CH (1) CH646953A5 (en)
DE (1) DE3031574A1 (en)
ES (1) ES494891A0 (en)
FR (1) FR2463766A1 (en)
GB (1) GB2058783B (en)
IT (1) IT1188988B (en)
NL (1) NL8004736A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58164577A (en) * 1982-03-24 1983-09-29 Taiho Yakuhin Kogyo Kk 4-benzyl-1-(2h)isoquinolone derivative and preparation thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098980B (en) * 1981-03-28 1985-05-15 Taiho Pharmaceutical Co Ltd 1(2h)-isoquinolone compounds and acid addition salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3600394A (en) * 1968-05-17 1971-08-17 Searle & Co 2-aminoalkyl-3-arylisocarbostyrils
SE368009B (en) * 1971-09-16 1974-06-17 Kabi Ab
US3928612A (en) * 1974-10-02 1975-12-23 American Home Prod 1,2-Dihydro- and 1,2,3,4-tetrahydro-1-oxo-3-isoquinolinecarboxylic acid derivatives as anti-allergic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58164577A (en) * 1982-03-24 1983-09-29 Taiho Yakuhin Kogyo Kk 4-benzyl-1-(2h)isoquinolone derivative and preparation thereof

Also Published As

Publication number Publication date
GB2058783A (en) 1981-04-15
IT1188988B (en) 1988-01-28
IT8049519A1 (en) 1982-02-19
AU6160980A (en) 1981-04-09
CH646953A5 (en) 1984-12-28
FR2463766A1 (en) 1981-02-27
GB2058783B (en) 1983-04-07
FR2463766B1 (en) 1983-09-02
NL8004736A (en) 1981-02-24
CA1153763A (en) 1983-09-13
AU532023B2 (en) 1983-09-15
IT8049519A0 (en) 1980-08-19
ES8106501A1 (en) 1981-09-01
ES494891A0 (en) 1981-09-01
DE3031574A1 (en) 1981-03-12

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Legal Events

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A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040510

A072 Dismissal of procedure

Effective date: 20041019

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