FR2460914A1 - Derives quinoniques et leur procede de preparation - Google Patents
Derives quinoniques et leur procede de preparation Download PDFInfo
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- FR2460914A1 FR2460914A1 FR8014684A FR8014684A FR2460914A1 FR 2460914 A1 FR2460914 A1 FR 2460914A1 FR 8014684 A FR8014684 A FR 8014684A FR 8014684 A FR8014684 A FR 8014684A FR 2460914 A1 FR2460914 A1 FR 2460914A1
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- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000000034 method Methods 0.000 title claims description 62
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- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 238000007254 oxidation reaction Methods 0.000 claims description 6
- 125000003277 amino group Chemical group 0.000 claims description 5
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
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- 239000000463 material Substances 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract description 2
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- 238000005481 NMR spectroscopy Methods 0.000 description 13
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 13
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- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 6
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- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 description 4
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- AGJSNMGHAVDLRQ-HUUJSLGLSA-N methyl (2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,3-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(=O)N[C@@H](CCSC)C(=O)OC)CC1=CC=C(O)C(C)=C1C AGJSNMGHAVDLRQ-HUUJSLGLSA-N 0.000 description 4
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 4
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- UIXPTCZPFCVOQF-UHFFFAOYSA-N ubiquinone-0 Chemical compound COC1=C(OC)C(=O)C(C)=CC1=O UIXPTCZPFCVOQF-UHFFFAOYSA-N 0.000 description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C66/00—Quinone carboxylic acids
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/38—Quinones containing —CHO or non—quinoid keto groups
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- Chemical & Material Sciences (AREA)
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- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8429179A JPS567737A (en) | 1979-07-02 | 1979-07-02 | Physiologically active quinone and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2460914A1 true FR2460914A1 (fr) | 1981-01-30 |
| FR2460914B1 FR2460914B1 (OSRAM) | 1984-01-27 |
Family
ID=13826357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8014684A Granted FR2460914A1 (fr) | 1979-07-02 | 1980-07-01 | Derives quinoniques et leur procede de preparation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4818441A (OSRAM) |
| JP (1) | JPS567737A (OSRAM) |
| CH (1) | CH647748A5 (OSRAM) |
| DE (1) | DE3024855A1 (OSRAM) |
| FR (1) | FR2460914A1 (OSRAM) |
| GB (1) | GB2055097B (OSRAM) |
| IT (1) | IT1130489B (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3010474A1 (de) * | 1980-03-19 | 1981-10-01 | Basf Ag, 6700 Ludwigshafen | 4-(dihydroxyphen-l-yl)-crotonsaeure und deren derivate sowie verfahren zur herstellung dieser verbindungen |
| JPS56150014A (en) * | 1980-04-21 | 1981-11-20 | Takeda Chem Ind Ltd | Antiallergic agent |
| EP0103361B1 (en) * | 1982-07-09 | 1986-01-29 | Takeda Chemical Industries, Ltd. | Quinone compounds, their production and use |
| JPS60255749A (ja) * | 1984-05-31 | 1985-12-17 | Univ Nagoya | キノン誘導体 |
| EP0201196B1 (en) * | 1985-04-08 | 1991-07-03 | Takeda Chemical Industries, Ltd. | Benzoquinone derivatives, their production and use |
| US4833164A (en) | 1985-05-08 | 1989-05-23 | E. I. Du Pont De Nemours And Company | 2-substituted-1-naphthols, pharmaceutical compositions of, and their use as 5-lipoxygenase inhibitors |
| US5026759A (en) * | 1985-05-08 | 1991-06-25 | Du Pont Merck Pharmaceutical | 2-substituted-1-naphthols as 5-lipoxygenase inhibitors |
| ZA863425B (en) * | 1985-05-08 | 1988-01-27 | Du Pont | 2-substituted-1-naphthols as 5-lipoxygenase inhibitors |
| JPH0635384B2 (ja) * | 1985-06-28 | 1994-05-11 | 名古屋大学長 | キノン誘導体を有効成分とする医薬 |
| JPS62294636A (ja) * | 1986-05-21 | 1987-12-22 | Eisai Co Ltd | ２−メチル−１，４−ナフトキノンの製造法 |
| CA2082004A1 (en) * | 1991-11-20 | 1993-05-21 | David Laffan | Substituted pentaalkylchromans |
| CA2082003A1 (en) * | 1991-11-20 | 1993-05-21 | David Laffan | Process for the preparation of substituted pentaalkylchromenes |
| JP2947503B2 (ja) * | 1994-03-02 | 1999-09-13 | エーザイ株式会社 | アリルキノン誘導体の製造方法および中間体 |
| GB9613309D0 (en) * | 1996-06-25 | 1996-08-28 | Univ Sheffield | Quinone bacterial inhibitors |
| WO1998008837A1 (en) * | 1996-08-28 | 1998-03-05 | Farmacon, Inc. | Phenylbutanol derivatives, methods for their preparation and pharmaceutical compositions thereof |
| KR101270841B1 (ko) * | 2005-02-28 | 2013-06-05 | 가부시키가이샤 메이지 | 히드로퀴논 장쇄 유도체 및／또는 페녹시 장쇄 유도체 및 이들을 함유하는 의약 |
| DK1888059T3 (en) * | 2005-06-01 | 2015-03-30 | Edison Pharmaceuticals Inc | Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers |
| DK1933821T3 (da) * | 2005-09-15 | 2020-10-26 | Ptc Therapeutics Inc | Halevarianter af redox-aktive terapeutika til behandling af mitokondriesygdomme og andre tilstande og modulation af energibiomarkører |
| CA2635280C (en) | 2006-02-22 | 2017-12-12 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| CA2736250C (en) | 2008-09-10 | 2016-12-20 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| EP2868658B1 (en) * | 2013-11-01 | 2018-05-02 | Dilip Mehta | Method of preparation of stereospecific quinone derivatives |
| MX391378B (es) | 2015-12-17 | 2025-03-21 | Ptc Therapeutics Inc | Derivados de fluoroalquil-, fluoroalcoxi-, fenoxi-, heteroariloxi-, alcoxi- y amina-1,4-benzoquinona para tratamiento de trastornos de estres oxidativo. |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2293194A1 (fr) * | 1974-05-02 | 1976-07-02 | Takeda Chemical Industries Ltd | Alcools aralkyliques |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3849453A (en) * | 1970-03-17 | 1974-11-19 | Takeda Chemical Industries Ltd | Quinone derivatives |
| JPS5918379B2 (ja) * | 1973-12-25 | 1984-04-26 | 武田薬品工業株式会社 | キノン酸類の製造法 |
| DE2431198C2 (de) * | 1973-07-02 | 1987-04-30 | Takeda Chemical Industries, Ltd., Osaka | Chinonderivate und sie enthaltende pharmazeutische Zubereitungen |
| JPS5756461B2 (OSRAM) * | 1973-07-02 | 1982-11-30 | ||
| JPS5110229A (ja) * | 1974-07-12 | 1976-01-27 | Hiroyuki Matsuo | Kikaki |
-
1979
- 1979-07-02 JP JP8429179A patent/JPS567737A/ja active Granted
-
1980
- 1980-07-01 FR FR8014684A patent/FR2460914A1/fr active Granted
- 1980-07-01 DE DE19803024855 patent/DE3024855A1/de active Granted
- 1980-07-01 IT IT68036/80A patent/IT1130489B/it active
- 1980-07-01 CH CH5061/80A patent/CH647748A5/de not_active IP Right Cessation
- 1980-07-01 US US06/165,009 patent/US4818441A/en not_active Expired - Lifetime
- 1980-07-02 GB GB8021718A patent/GB2055097B/en not_active Expired
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2293194A1 (fr) * | 1974-05-02 | 1976-07-02 | Takeda Chemical Industries Ltd | Alcools aralkyliques |
Non-Patent Citations (1)
| Title |
|---|
| EXBK/66 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CH647748A5 (de) | 1985-02-15 |
| GB2055097B (en) | 1983-06-22 |
| JPS567737A (en) | 1981-01-27 |
| IT8068036A0 (it) | 1980-07-01 |
| IT1130489B (it) | 1986-06-11 |
| DE3024855A1 (de) | 1981-01-22 |
| JPS6239147B2 (OSRAM) | 1987-08-21 |
| GB2055097A (en) | 1981-02-25 |
| FR2460914B1 (OSRAM) | 1984-01-27 |
| US4818441A (en) | 1989-04-04 |
| DE3024855C2 (OSRAM) | 1990-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |