FR2449092A1 - Derives de 7-oxo-4-thia-1-aza-bicyclo-(3,2,0)-heptane, procede pour les preparer et leur application comme medicaments - Google Patents

Derives de 7-oxo-4-thia-1-aza-bicyclo-(3,2,0)-heptane, procede pour les preparer et leur application comme medicaments

Info

Publication number
FR2449092A1
FR2449092A1 FR7928918A FR7928918A FR2449092A1 FR 2449092 A1 FR2449092 A1 FR 2449092A1 FR 7928918 A FR7928918 A FR 7928918A FR 7928918 A FR7928918 A FR 7928918A FR 2449092 A1 FR2449092 A1 FR 2449092A1
Authority
FR
France
Prior art keywords
thia
aza
bicyclo
medicaments
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7928918A
Other languages
English (en)
Other versions
FR2449092B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2449092A1 publication Critical patent/FR2449092A1/fr
Application granted granted Critical
Publication of FR2449092B1 publication Critical patent/FR2449092B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LES COMPOSES REPONDENT A LA FORMULE 1: (CF DESSIN DANS BOPI) DANS LAQUELLE RH, ALKYLE OU UN RADICAL ANALOGUE, R EST NOTAMMENT -CHOH OU -CHNHCOR, R EST UN ALKYLE, ARYLE OU ARALKYLE OU UN ANNEAU HETEROCYCLE A CINQ OU SIX ELEMENTS CONTENANT UN OU PLUSIEURS HETEROATOMES. ILS SONT UTILISABLES DANS LE TRAITEMENT DES MALADIES INFECTIEUSES.
FR7928918A 1978-11-24 1979-11-23 Derives de 7-oxo-4-thia-1-aza-bicyclo-(3,2,0)-heptane, procede pour les preparer et leur application comme medicaments Granted FR2449092A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7845966 1978-11-24

Publications (2)

Publication Number Publication Date
FR2449092A1 true FR2449092A1 (fr) 1980-09-12
FR2449092B1 FR2449092B1 (fr) 1983-06-03

Family

ID=10501302

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7928918A Granted FR2449092A1 (fr) 1978-11-24 1979-11-23 Derives de 7-oxo-4-thia-1-aza-bicyclo-(3,2,0)-heptane, procede pour les preparer et leur application comme medicaments

Country Status (20)

Country Link
US (1) US4331677A (fr)
JP (1) JPS5573685A (fr)
AT (1) AT365594B (fr)
AU (1) AU529597B2 (fr)
BE (1) BE880153A (fr)
CA (1) CA1139745A (fr)
CH (1) CH644128A5 (fr)
DE (1) DE2947118C2 (fr)
DK (1) DK495879A (fr)
FR (1) FR2449092A1 (fr)
GB (1) GB2093839B (fr)
IE (1) IE49874B1 (fr)
IL (1) IL58750A (fr)
IT (1) IT1209143B (fr)
NL (1) NL7908464A (fr)
NO (1) NO793791L (fr)
SE (1) SE446339B (fr)
SU (1) SU942598A3 (fr)
YU (1) YU287779A (fr)
ZA (1) ZA796333B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361513A (en) * 1980-12-11 1982-11-30 Pfizer Inc. Esters of penicillanic acid sulfone
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
NL8204720A (nl) * 1981-12-11 1983-07-01 Erba Farmitalia Werkwijze voor het bereiden van optisch actieve penemverbindingen.
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
JPS58225091A (ja) * 1982-06-21 1983-12-27 Taiho Yakuhin Kogyo Kk ペニシリン誘導体及びその製造法
US4562073A (en) * 1982-12-24 1985-12-31 Taiho Pharmaceutical Company Limited Penicillin derivatives
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
CN1051702C (zh) * 1987-03-19 2000-04-26 科研制药株式会社 杀真菌组合物的制备方法
DE69225821T2 (de) * 1991-03-13 1998-11-05 Otsuka Kagaku Kk Penamderivate und Verfahren zu deren Herstellung
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
CA2147129A1 (fr) * 1992-10-27 1994-05-11 James B. Doherty Nouvelles azetidinones substituees utilisees comme agents anti-inflammatoires et anti-degeneratifs
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
TW383308B (en) * 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819655A1 (de) * 1977-05-09 1978-11-23 Ciba Geigy Ag Thia-azaverbindungen mit beta- lactamring
EP0000636A1 (fr) * 1977-07-13 1979-02-07 Glaxo Group Limited Composés dérivés pénème, procédés pour leur préparation, leur utilisation dans les compositions pharmaceutiques et les azétidinones utilisées dans leur préparation
EP0002210A1 (fr) * 1977-11-17 1979-06-13 Merck & Co. Inc. Acides pen-2-em-3-carboxyliques substitués en position 6- et 2- ou en position 6,6- et 2-; leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0003415A2 (fr) * 1978-01-20 1979-08-08 Glaxo Group Limited Composés bêta-lactames, procédés pour leur préparation, compositions pharmaceutiques les contenant et les intermédiaires pour leur préparation
GB2014574A (en) * 1978-02-16 1979-08-30 Glaxo Group Ltd Lactam Compounds
EP0010358A1 (fr) * 1978-09-20 1980-04-30 Glaxo Group Limited Composés de bêta-lactame, procédés pour leur préparation, compositions les contenant, intermédiaires utilisables dans leur préparation et méthodes pour leur production
FR2453162A1 (fr) * 1979-04-06 1980-10-31 Erba Farmitalia Procede pour la preparation de derives de 4-acetoxy-azetidine-2-one par condensation avec un b-thiocetoester et composes obtenus

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4207323A (en) * 1975-11-21 1980-06-10 Merck & Co., Inc. 6-Substituted methyl penicillins, derivatives and analogues thereof
US4076826A (en) * 1976-04-12 1978-02-28 Merck & Co., Inc. 3-(.beta.-Hydroxyethylidene)-6-(α-Hydroxyethyl)-7-oxo-4-oxaazabicyclo[3.2.0]heptene-2-carboxylic acid and derivatives thereof
GB1563427A (en) * 1977-03-04 1980-03-26 Beecham Group Ltd Clavulanic acid derivatives
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
US4123539A (en) * 1977-12-29 1978-10-31 Merck & Co., Inc. 6-Ethylpenicillanic acid
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4244965A (en) * 1978-06-15 1981-01-13 Beecham Group Limited Azetidinoyl ethers

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819655A1 (de) * 1977-05-09 1978-11-23 Ciba Geigy Ag Thia-azaverbindungen mit beta- lactamring
EP0000636A1 (fr) * 1977-07-13 1979-02-07 Glaxo Group Limited Composés dérivés pénème, procédés pour leur préparation, leur utilisation dans les compositions pharmaceutiques et les azétidinones utilisées dans leur préparation
EP0002210A1 (fr) * 1977-11-17 1979-06-13 Merck & Co. Inc. Acides pen-2-em-3-carboxyliques substitués en position 6- et 2- ou en position 6,6- et 2-; leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0003415A2 (fr) * 1978-01-20 1979-08-08 Glaxo Group Limited Composés bêta-lactames, procédés pour leur préparation, compositions pharmaceutiques les contenant et les intermédiaires pour leur préparation
GB2014574A (en) * 1978-02-16 1979-08-30 Glaxo Group Ltd Lactam Compounds
EP0010358A1 (fr) * 1978-09-20 1980-04-30 Glaxo Group Limited Composés de bêta-lactame, procédés pour leur préparation, compositions les contenant, intermédiaires utilisables dans leur préparation et méthodes pour leur production
FR2453162A1 (fr) * 1979-04-06 1980-10-31 Erba Farmitalia Procede pour la preparation de derives de 4-acetoxy-azetidine-2-one par condensation avec un b-thiocetoester et composes obtenus

Also Published As

Publication number Publication date
CH644128A5 (de) 1984-07-13
SE7909667L (sv) 1980-05-25
ATA736879A (de) 1981-06-15
GB2093839A (en) 1982-09-08
US4331677A (en) 1982-05-25
FR2449092B1 (fr) 1983-06-03
DE2947118C2 (de) 1984-03-08
IT7927509A0 (it) 1979-11-23
JPS5573685A (en) 1980-06-03
YU287779A (en) 1982-10-31
IE792222L (en) 1980-05-24
CA1139745A (fr) 1983-01-18
SU942598A3 (ru) 1982-07-07
GB2093839B (en) 1983-06-02
IL58750A0 (en) 1980-02-29
IE49874B1 (en) 1986-01-08
DE2947118A1 (de) 1980-06-04
AU529597B2 (en) 1983-06-16
BE880153A (fr) 1980-05-20
IT1209143B (it) 1989-07-10
AT365594B (de) 1982-01-25
DK495879A (da) 1980-05-25
AU5301979A (en) 1980-05-29
NL7908464A (nl) 1980-05-28
SE446339B (sv) 1986-09-01
IL58750A (en) 1983-07-31
ZA796333B (en) 1980-11-26
NO793791L (no) 1980-05-28

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