FR2453162A1 - Procede pour la preparation de derives de 4-acetoxy-azetidine-2-one par condensation avec un b-thiocetoester et composes obtenus - Google Patents

Procede pour la preparation de derives de 4-acetoxy-azetidine-2-one par condensation avec un b-thiocetoester et composes obtenus

Info

Publication number
FR2453162A1
FR2453162A1 FR8007730A FR8007730A FR2453162A1 FR 2453162 A1 FR2453162 A1 FR 2453162A1 FR 8007730 A FR8007730 A FR 8007730A FR 8007730 A FR8007730 A FR 8007730A FR 2453162 A1 FR2453162 A1 FR 2453162A1
Authority
FR
France
Prior art keywords
preparation
thiocetoester
azetidine
acetoxy
condensation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8007730A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2453162A1 publication Critical patent/FR2453162A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Inhibiteurs de beta -lactamase et procédé pour les préparer. Il s'agit de composés répondant à la formule générale (1) suivante :
FR8007730A 1979-04-06 1980-04-04 Procede pour la preparation de derives de 4-acetoxy-azetidine-2-one par condensation avec un b-thiocetoester et composes obtenus Pending FR2453162A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7912168 1979-04-06

Publications (1)

Publication Number Publication Date
FR2453162A1 true FR2453162A1 (fr) 1980-10-31

Family

ID=10504396

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8007730A Pending FR2453162A1 (fr) 1979-04-06 1980-04-04 Procede pour la preparation de derives de 4-acetoxy-azetidine-2-one par condensation avec un b-thiocetoester et composes obtenus

Country Status (24)

Country Link
US (1) US4269771A (fr)
JP (1) JPS55139385A (fr)
AT (1) AT369371B (fr)
AU (1) AU536673B2 (fr)
BE (1) BE882621A (fr)
CA (1) CA1148143A (fr)
CH (1) CH645645A5 (fr)
CS (1) CS219273B2 (fr)
DE (1) DE3012975A1 (fr)
DK (1) DK144180A (fr)
FI (1) FI801080A (fr)
FR (1) FR2453162A1 (fr)
GB (1) GB2048857B (fr)
GR (1) GR66673B (fr)
HU (1) HU182118B (fr)
IE (1) IE49656B1 (fr)
IL (1) IL59760A (fr)
IT (1) IT1196407B (fr)
LU (1) LU82320A1 (fr)
NL (1) NL8001919A (fr)
SE (1) SE8002600L (fr)
SU (1) SU1152524A3 (fr)
YU (1) YU93880A (fr)
ZA (1) ZA802000B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2449092A1 (fr) * 1978-11-24 1980-09-12 Erba Farmitalia Derives de 7-oxo-4-thia-1-aza-bicyclo-(3,2,0)-heptane, procede pour les preparer et leur application comme medicaments
FR2518098A1 (fr) * 1981-12-11 1983-06-17 Erba Farmitalia Procede pour la preparation de derives penem optiquement actifs
FR2550533A1 (fr) * 1983-08-11 1985-02-15 Erba Farmitalia Procede pour la fabrication de derives de type penem

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500457A (en) * 1977-05-09 1985-02-19 Ciba-Geigy Corporation Process for preparing thia-aza compounds with a beta-lactam ring
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
US6720445B2 (en) * 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819655A1 (de) * 1977-05-09 1978-11-23 Ciba Geigy Ag Thia-azaverbindungen mit beta- lactamring
EP0000636A1 (fr) * 1977-07-13 1979-02-07 Glaxo Group Limited Composés dérivés pénème, procédés pour leur préparation, leur utilisation dans les compositions pharmaceutiques et les azétidinones utilisées dans leur préparation
EP0002210A1 (fr) * 1977-11-17 1979-06-13 Merck & Co. Inc. Acides pen-2-em-3-carboxyliques substitués en position 6- et 2- ou en position 6,6- et 2-; leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0003415A2 (fr) * 1978-01-20 1979-08-08 Glaxo Group Limited Composés bêta-lactames, procédés pour leur préparation, compositions pharmaceutiques les contenant et les intermédiaires pour leur préparation
GB2014574A (en) * 1978-02-16 1979-08-30 Glaxo Group Ltd Lactam Compounds
EP0010358A1 (fr) * 1978-09-20 1980-04-30 Glaxo Group Limited Composés de bêta-lactame, procédés pour leur préparation, compositions les contenant, intermédiaires utilisables dans leur préparation et méthodes pour leur production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905965A (en) * 1969-10-17 1975-09-16 Roussel Uclaf Process of total synthesis of cephalosporin derivatives and intermediates
US4053468A (en) * 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819655A1 (de) * 1977-05-09 1978-11-23 Ciba Geigy Ag Thia-azaverbindungen mit beta- lactamring
EP0000636A1 (fr) * 1977-07-13 1979-02-07 Glaxo Group Limited Composés dérivés pénème, procédés pour leur préparation, leur utilisation dans les compositions pharmaceutiques et les azétidinones utilisées dans leur préparation
EP0002210A1 (fr) * 1977-11-17 1979-06-13 Merck & Co. Inc. Acides pen-2-em-3-carboxyliques substitués en position 6- et 2- ou en position 6,6- et 2-; leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0003415A2 (fr) * 1978-01-20 1979-08-08 Glaxo Group Limited Composés bêta-lactames, procédés pour leur préparation, compositions pharmaceutiques les contenant et les intermédiaires pour leur préparation
GB2014574A (en) * 1978-02-16 1979-08-30 Glaxo Group Ltd Lactam Compounds
EP0010358A1 (fr) * 1978-09-20 1980-04-30 Glaxo Group Limited Composés de bêta-lactame, procédés pour leur préparation, compositions les contenant, intermédiaires utilisables dans leur préparation et méthodes pour leur production

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2449092A1 (fr) * 1978-11-24 1980-09-12 Erba Farmitalia Derives de 7-oxo-4-thia-1-aza-bicyclo-(3,2,0)-heptane, procede pour les preparer et leur application comme medicaments
FR2518098A1 (fr) * 1981-12-11 1983-06-17 Erba Farmitalia Procede pour la preparation de derives penem optiquement actifs
FR2550533A1 (fr) * 1983-08-11 1985-02-15 Erba Farmitalia Procede pour la fabrication de derives de type penem

Also Published As

Publication number Publication date
CS219273B2 (en) 1983-03-25
SE8002600L (sv) 1980-10-07
IL59760A0 (en) 1980-06-30
SU1152524A3 (en) 1985-04-23
HU182118B (en) 1983-12-28
IT8021099A0 (it) 1980-04-01
FI801080A (fi) 1980-10-07
US4269771A (en) 1981-05-26
BE882621A (fr) 1980-10-03
YU93880A (en) 1983-02-28
DK144180A (da) 1980-10-07
IT1196407B (it) 1988-11-16
IE800668L (en) 1980-10-06
IE49656B1 (en) 1985-11-13
AT369371B (de) 1982-12-27
CH645645A5 (de) 1984-10-15
GR66673B (fr) 1981-04-08
DE3012975A1 (de) 1980-10-23
ZA802000B (en) 1981-04-29
GB2048857A (en) 1980-12-17
ATA177480A (de) 1982-05-15
AU5701580A (en) 1980-10-09
NL8001919A (nl) 1980-10-08
AU536673B2 (en) 1984-05-17
LU82320A1 (fr) 1980-07-02
IL59760A (en) 1983-07-31
CA1148143A (fr) 1983-06-14
JPS55139385A (en) 1980-10-31
GB2048857B (en) 1983-05-25

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