ZA802000B - Total synthesis of novel azetidinones useful as beta-lactamase inhibitors and antibacterial agents - Google Patents

Total synthesis of novel azetidinones useful as beta-lactamase inhibitors and antibacterial agents

Info

Publication number
ZA802000B
ZA802000B ZA00802000A ZA802000A ZA802000B ZA 802000 B ZA802000 B ZA 802000B ZA 00802000 A ZA00802000 A ZA 00802000A ZA 802000 A ZA802000 A ZA 802000A ZA 802000 B ZA802000 B ZA 802000B
Authority
ZA
South Africa
Prior art keywords
beta
antibacterial agents
total synthesis
lactamase inhibitors
azetidinones useful
Prior art date
Application number
ZA00802000A
Other languages
English (en)
Inventor
G Franceschi
P Lombardi
F Arcamone
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of ZA802000B publication Critical patent/ZA802000B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
ZA00802000A 1979-04-06 1980-04-03 Total synthesis of novel azetidinones useful as beta-lactamase inhibitors and antibacterial agents ZA802000B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7912168 1979-04-06

Publications (1)

Publication Number Publication Date
ZA802000B true ZA802000B (en) 1981-04-29

Family

ID=10504396

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00802000A ZA802000B (en) 1979-04-06 1980-04-03 Total synthesis of novel azetidinones useful as beta-lactamase inhibitors and antibacterial agents

Country Status (24)

Country Link
US (1) US4269771A (fr)
JP (1) JPS55139385A (fr)
AT (1) AT369371B (fr)
AU (1) AU536673B2 (fr)
BE (1) BE882621A (fr)
CA (1) CA1148143A (fr)
CH (1) CH645645A5 (fr)
CS (1) CS219273B2 (fr)
DE (1) DE3012975A1 (fr)
DK (1) DK144180A (fr)
FI (1) FI801080A (fr)
FR (1) FR2453162A1 (fr)
GB (1) GB2048857B (fr)
GR (1) GR66673B (fr)
HU (1) HU182118B (fr)
IE (1) IE49656B1 (fr)
IL (1) IL59760A (fr)
IT (1) IT1196407B (fr)
LU (1) LU82320A1 (fr)
NL (1) NL8001919A (fr)
SE (1) SE8002600L (fr)
SU (1) SU1152524A3 (fr)
YU (1) YU93880A (fr)
ZA (1) ZA802000B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500457A (en) * 1977-05-09 1985-02-19 Ciba-Geigy Corporation Process for preparing thia-aza compounds with a beta-lactam ring
US4331677A (en) * 1978-11-24 1982-05-25 Farmitalia Carlo Erba S.P.A. 7-Oxo-4-1-aza-bicyclo-[3,2,0]-heptane derivatives
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
AT379399B (de) * 1981-12-11 1985-12-27 Erba Farmitalia Verfahren zur herstellung von optisch aktiven penemen
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US6720445B2 (en) 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905965A (en) * 1969-10-17 1975-09-16 Roussel Uclaf Process of total synthesis of cephalosporin derivatives and intermediates
US4053468A (en) * 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
LU77306A1 (fr) * 1977-05-09 1979-01-18
EP0000636A1 (fr) * 1977-07-13 1979-02-07 Glaxo Group Limited Composés dérivés pénème, procédés pour leur préparation, leur utilisation dans les compositions pharmaceutiques et les azétidinones utilisées dans leur préparation
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
EP0003415A3 (fr) * 1978-01-20 1979-08-22 Glaxo Group Limited Composés bêta-lactames, procédés pour leur préparation, compositions pharmaceutiques les contenant et les intermédiaires pour leur préparation
GB2014574A (en) * 1978-02-16 1979-08-30 Glaxo Group Ltd Lactam Compounds
EP0010358A1 (fr) * 1978-09-20 1980-04-30 Glaxo Group Limited Composés de bêta-lactame, procédés pour leur préparation, compositions les contenant, intermédiaires utilisables dans leur préparation et méthodes pour leur production

Also Published As

Publication number Publication date
GB2048857B (en) 1983-05-25
DE3012975A1 (de) 1980-10-23
CA1148143A (fr) 1983-06-14
LU82320A1 (fr) 1980-07-02
GB2048857A (en) 1980-12-17
IE800668L (en) 1980-10-06
IL59760A0 (en) 1980-06-30
BE882621A (fr) 1980-10-03
IL59760A (en) 1983-07-31
AU536673B2 (en) 1984-05-17
IT8021099A0 (it) 1980-04-01
GR66673B (fr) 1981-04-08
IE49656B1 (en) 1985-11-13
CH645645A5 (de) 1984-10-15
ATA177480A (de) 1982-05-15
IT1196407B (it) 1988-11-16
AU5701580A (en) 1980-10-09
CS219273B2 (en) 1983-03-25
HU182118B (en) 1983-12-28
AT369371B (de) 1982-12-27
FI801080A (fi) 1980-10-07
US4269771A (en) 1981-05-26
YU93880A (en) 1983-02-28
DK144180A (da) 1980-10-07
SU1152524A3 (en) 1985-04-23
NL8001919A (nl) 1980-10-08
SE8002600L (sv) 1980-10-07
FR2453162A1 (fr) 1980-10-31
JPS55139385A (en) 1980-10-31

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