FR2427339A1 - Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparation - Google Patents

Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparation

Info

Publication number
FR2427339A1
FR2427339A1 FR7913639A FR7913639A FR2427339A1 FR 2427339 A1 FR2427339 A1 FR 2427339A1 FR 7913639 A FR7913639 A FR 7913639A FR 7913639 A FR7913639 A FR 7913639A FR 2427339 A1 FR2427339 A1 FR 2427339A1
Authority
FR
France
Prior art keywords
oxazaphosphorine
optically active
preparation process
active derivatives
new optically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7913639A
Other languages
English (en)
Other versions
FR2427339B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR2427339A1 publication Critical patent/FR2427339A1/fr
Application granted granted Critical
Publication of FR2427339B1 publication Critical patent/FR2427339B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/26—Amides of acids of phosphorus containing P-halide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nouveau procédé de préparation de dérivés optiquement actifs d'oxazaphosphorine ayant la formule générale :
FR7913639A 1978-05-29 1979-05-29 Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparation Granted FR2427339A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6468178A JPS54157580A (en) 1978-05-29 1978-05-29 Optically active oxazaphosphorine derivative

Publications (2)

Publication Number Publication Date
FR2427339A1 true FR2427339A1 (fr) 1979-12-28
FR2427339B1 FR2427339B1 (fr) 1984-09-14

Family

ID=13265139

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7913639A Granted FR2427339A1 (fr) 1978-05-29 1979-05-29 Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparation

Country Status (14)

Country Link
US (1) US4239709A (fr)
JP (1) JPS54157580A (fr)
AU (1) AU516429B2 (fr)
BE (1) BE876578A (fr)
CA (1) CA1108175A (fr)
CH (1) CH646710A5 (fr)
DE (1) DE2921057C3 (fr)
ES (1) ES481026A1 (fr)
FR (1) FR2427339A1 (fr)
GB (1) GB2021591B (fr)
IT (1) IT1120976B (fr)
NL (1) NL183141C (fr)
SE (1) SE446189B (fr)
SU (1) SU867314A3 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111428A1 (de) * 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
US5380904A (en) * 1984-01-20 1995-01-10 Biocompatibles Ltd. Process for rendering a surface biocompatible, and articles containing the same
GB8401534D0 (en) * 1984-01-20 1984-02-22 Royal Free Hosp School Med Biocompatible surfaces
US5229162A (en) * 1984-01-20 1993-07-20 Biocompatibles Ltd. Article having biocompatible surface
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
FR2567129B1 (fr) * 1984-07-06 1986-12-05 Adir Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5258538A (en) * 1985-08-26 1993-11-02 Applied Biosystems, Inc. 2,3-disubstituted-1,3,2-oxazaphosphacycloalkanes as nucleic acid linking agents
KR900013763A (ko) * 1989-02-28 1990-09-05 안시환 모사전송기의 원고 급지장치
DE19739159C1 (de) * 1997-09-06 1999-01-28 Asta Medica Ag Verfahren zur Herstellung von Oxazaphosphorin-2-aminen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1235022A (en) * 1969-06-04 1971-06-09 Laeaeke Ag A new method for the production of cyclophosphamide
DE2644905A1 (de) * 1975-10-06 1977-04-14 Polska Akad Nauk Centrum Verfahren zur herstellung von optisch aktivem 2- eckige klammer auf bis-(2-chloraethyl)-amino eckige klammer zu -1-oxa-3-aza-2-phosphacyclohexanoxid-2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1203268B (de) * 1961-10-26 1965-10-21 Farmochimica Cutolo Calosi S P Verfahren zur Herstellung von 2-Chlor-3, 4-dimethyl-5-phenyl-1, 3, 2-oxazophospholidin-2-on
US3732340A (en) * 1966-07-11 1973-05-08 Asta Werke Ag Chem Fab N',o-propylene phosphoric acid ester diamides
DE2201675A1 (de) * 1972-01-14 1973-07-19 Asta Werke Ag Chem Fab Alkylsulfonsaeureester 1,3,2-oxazaphospha-cyclischer verbindungen, verfahren zu ihrer herstellung und pharmazeutische praeparate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1235022A (en) * 1969-06-04 1971-06-09 Laeaeke Ag A new method for the production of cyclophosphamide
DE2644905A1 (de) * 1975-10-06 1977-04-14 Polska Akad Nauk Centrum Verfahren zur herstellung von optisch aktivem 2- eckige klammer auf bis-(2-chloraethyl)-amino eckige klammer zu -1-oxa-3-aza-2-phosphacyclohexanoxid-2

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/75 *

Also Published As

Publication number Publication date
US4239709A (en) 1980-12-16
ES481026A1 (es) 1980-02-01
FR2427339B1 (fr) 1984-09-14
AU4747779A (en) 1979-12-06
NL7904215A (nl) 1979-12-03
AU516429B2 (en) 1981-06-04
GB2021591A (en) 1979-12-05
IT7968144A0 (it) 1979-05-28
IT1120976B (it) 1986-03-26
CH646710A5 (de) 1984-12-14
SE7904595L (sv) 1979-11-30
NL183141B (nl) 1988-03-01
SE446189B (sv) 1986-08-18
CA1108175A (fr) 1981-09-01
BE876578A (fr) 1979-11-28
JPS5761360B2 (fr) 1982-12-23
SU867314A3 (ru) 1981-09-23
DE2921057C3 (de) 1981-11-26
DE2921057A1 (de) 1979-12-06
JPS54157580A (en) 1979-12-12
DE2921057B2 (de) 1981-01-15
NL183141C (nl) 1988-08-01
GB2021591B (en) 1982-09-08

Similar Documents

Publication Publication Date Title
FR2364219A1 (fr) Derives de thiazolidine, leur procede de preparation et leur application en therapeutique
FR2427337A1 (fr) Nouveaux derives acyles de la cephalosporine, leur preparation et leurs utilisations therapeutiques
FR2380285A1 (fr) Nouveaux derives insatures d'acides 7-acylamido-3-cephem-4-carboxyliques, utiles notamment comme agents antibacteriens, et leur procede de preparation
FR2355796A1 (fr) Procede de preparation de fluorures d'acides perfluoro-alcoxy-propioniques
FR2368471A1 (fr) Nouveaux amides d'acides omega-amino-carboxyliques et procedes pour leur preparation
FR2427339A1 (fr) Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparation
FR2421901A1 (fr) Procede de preparation de derives du lysergol
FR2394522A1 (fr) Nouveaux derives d'acides (s-phenenyl tris(carbonylimino))-5,5',5''tri-benzene-carboxyliques utiles notamment comme inhibiteurs du complement, et leur procede de preparation
FR2377367A1 (fr) Procede de preparation d'alcoxy-cetones
FR2384775A1 (fr) Derives de la morphine, leur procede de preparation et leur application comme medicament
FR2362841A1 (fr) Derives d'acides heterocyclyl-carboxyliques acyles utiles comme medicaments et procede pour leur preparation
OA06310A (fr) Nouveaux dérivés N-substitués de l'acide aziridinyl-2-carboxylique et leur procédé de préparation.
FR2383941A1 (fr) Nouveaux derives pyrimidinyliques et leur procede de preparation
FR2388789A1 (fr) Derives d'acide benzoique, leur procede de preparation et leur application therapeutique
FR2435466A1 (fr) Derives de l'hydroquinone et leur procede de preparation
FR2431496A1 (fr) Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues
FR2361341A1 (fr) Procede de preparation d'esters de l'acide anthranilique
FR2398047A1 (fr) Procede de preparation d'a-cetocarbonamides n-substitues et produits obtenus par ce procede
FR2419289A1 (fr) Derives de glyoxal-2-oxime et leur procede de preparation
FR2396001A1 (fr) Derives a-acetyleniques et a-vinyliques d'amino-acides utiles comme medicaments et leur procede de preparation
FR2391204A1 (fr) Derives de l'anthraquinone, leur procede de preparation et leur application a la teinture de matieres plastiques
FR2416214A1 (fr) Derives d'acide naphtyl-1 acetique, leur procede de preparation et leur application therapeutique
FR2355839A1 (fr) Derives optiquement actifs d'acide benzoxazolyl-propionique, procede pour leur preparation et compositions therapeutiques les contenant
FR2367065A1 (fr) Nouveaux composes du type 1-amino-2-hydroxy-3-heterocyclyloxy-propane utiles en tant que medicaments et leur procede de preparation
FR2418234A1 (fr) Derives d'acide 7-(2,3-dihydrobenzo-5-furannyl)acetamidocephalosporanique utiles notamment comme antibiotiques et leur procede de preparation

Legal Events

Date Code Title Description
ST Notification of lapse