FR2424286A1 - Procede de preparation de 6-halo-pregnanes - Google Patents

Procede de preparation de 6-halo-pregnanes

Info

Publication number
FR2424286A1
FR2424286A1 FR7910795A FR7910795A FR2424286A1 FR 2424286 A1 FR2424286 A1 FR 2424286A1 FR 7910795 A FR7910795 A FR 7910795A FR 7910795 A FR7910795 A FR 7910795A FR 2424286 A1 FR2424286 A1 FR 2424286A1
Authority
FR
France
Prior art keywords
halo
derivatives
pregnanes
preparation process
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7910795A
Other languages
English (en)
Other versions
FR2424286B1 (fr
Inventor
Pier Paolo Castelli
Bruno Romano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BLASINACHIM SpA
Original Assignee
BLASINACHIM SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BLASINACHIM SpA filed Critical BLASINACHIM SpA
Publication of FR2424286A1 publication Critical patent/FR2424286A1/fr
Application granted granted Critical
Publication of FR2424286B1 publication Critical patent/FR2424286B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDE DE PREPARATION DE DERIVES 6 A-HALO-3-KETO-D -PREGNADIENE PAR SYNTHESE EN DEUX ETAPES FOURNISSANT DIRECTEMENT DES DERIVES 6 A-HALO- EN FAISANT REAGIR DES DERIVES 3-KETO-9 B, 11 B-OXYDO-D -PREGNADIENE AVEC UN AGENT ACYLANT OU ETHERIFIANT APPROPRIE, POUR DONNER LES DERIVES 3-ENOL CORRESPONDANTS, QUI SONT FINALEMENT HALOGENES EN UTILISANT UN AGENT HALOGENANT APPROPRIE.
FR7910795A 1978-04-28 1979-04-27 Procede de preparation de 6-halo-pregnanes Expired FR2424286B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/900,886 US4188322A (en) 1978-04-28 1978-04-28 Process for the preparation of 6-halo-pregnanes

Publications (2)

Publication Number Publication Date
FR2424286A1 true FR2424286A1 (fr) 1979-11-23
FR2424286B1 FR2424286B1 (fr) 1986-01-17

Family

ID=25413247

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7910795A Expired FR2424286B1 (fr) 1978-04-28 1979-04-27 Procede de preparation de 6-halo-pregnanes

Country Status (22)

Country Link
US (1) US4188322A (fr)
JP (1) JPS591720B2 (fr)
AT (1) AT367772B (fr)
AU (1) AU518893B2 (fr)
BE (1) BE875939A (fr)
CA (1) CA1159049A (fr)
CH (1) CH639981A5 (fr)
DE (1) DE2916889C2 (fr)
DK (1) DK173379A (fr)
ES (1) ES479974A1 (fr)
FR (1) FR2424286B1 (fr)
GB (1) GB2019848B (fr)
GR (1) GR65300B (fr)
HU (1) HU180678B (fr)
IE (1) IE48329B1 (fr)
NL (1) NL187533C (fr)
NO (1) NO153431C (fr)
PL (1) PL117180B1 (fr)
PT (1) PT69558A (fr)
SE (1) SE433083B (fr)
SU (1) SU993823A3 (fr)
ZA (1) ZA791977B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0610138A1 (fr) * 1993-02-05 1994-08-10 Roussel Uclaf Nouveau procédé de préparation de stéroides 6alpha,9alpha-difluorés et nouveaux intermédiaires obtenus

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4287129A (en) * 1980-07-28 1981-09-01 Diamond Shamrock Corp. Synthesis of 1α-hydroxy-7-dehydrosteroids
US4383947A (en) * 1981-07-24 1983-05-17 The Upjohn Company Introduction of a fluorine atom
JPS6185637U (fr) * 1984-11-09 1986-06-05
JPH0264662U (fr) * 1988-11-02 1990-05-15
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.
US6569327B2 (en) * 2001-01-23 2003-05-27 Rg Delaware, Inc. Apparatus for directing fluids through a filter system
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
ES2184628B1 (es) * 2001-07-26 2005-02-01 Ragactives, S.L. Procedimiento estereoselectivo para la produccion de 6alfa-fluorpregnanos intermedios.
WO2004052911A1 (fr) * 2002-12-09 2004-06-24 Sicor Inc. Procede de preparation de derives pregnanes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3465011A (en) * 1966-11-09 1969-09-02 American Home Prod 11-oxygenated-8-iso steroids
US3513160A (en) * 1968-02-01 1970-05-19 American Home Prod Process for the preparation of 9alpha-bromo-11beta - hydroxy - 17alpha,20;20,21-bisalkylenedioxy pregnanes
JPS5547700A (en) * 1978-04-05 1980-04-04 Prochem Ets 33acetoxyy9 beta*11 betaaepoxyypregnaa 1*3*55triene and corresponding 3*55diene
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0610138A1 (fr) * 1993-02-05 1994-08-10 Roussel Uclaf Nouveau procédé de préparation de stéroides 6alpha,9alpha-difluorés et nouveaux intermédiaires obtenus
FR2701262A1 (fr) * 1993-02-05 1994-08-12 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
US5478957A (en) * 1993-02-05 1995-12-26 Roussel-Uclaf Preparation of 6α, 9α-difluoro steroids

Also Published As

Publication number Publication date
AT367772B (de) 1982-07-26
ES479974A1 (es) 1980-09-01
GB2019848A (en) 1979-11-07
PT69558A (en) 1979-05-01
NO153431C (no) 1986-03-19
SU993823A3 (ru) 1983-01-30
GR65300B (en) 1980-08-01
NL187533C (nl) 1991-11-01
BE875939A (fr) 1979-08-16
FR2424286B1 (fr) 1986-01-17
IE790869L (en) 1979-10-28
DK173379A (da) 1979-10-29
AU518893B2 (en) 1981-10-22
US4188322A (en) 1980-02-12
JPS591720B2 (ja) 1984-01-13
DE2916889C2 (de) 1985-11-28
NL187533B (nl) 1991-06-03
SE433083B (sv) 1984-05-07
GB2019848B (en) 1983-01-26
NO153431B (no) 1985-12-09
JPS54157554A (en) 1979-12-12
HU180678B (en) 1983-04-29
NL7903413A (nl) 1979-10-30
ATA311179A (de) 1981-12-15
PL117180B1 (en) 1981-07-31
CH639981A5 (it) 1983-12-15
CA1159049A (fr) 1983-12-20
IE48329B1 (en) 1984-12-12
ZA791977B (en) 1980-06-25
PL215209A1 (fr) 1980-01-28
DE2916889A1 (de) 1979-11-08
AU4645579A (en) 1979-11-01
NO791440L (no) 1979-10-30
SE7903713L (sv) 1979-10-29

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Legal Events

Date Code Title Description
TP Transmission of property
CD Change of name or company name
TP Transmission of property